Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

The Association of Common Variants in PCSK1 With Obesity: A HuGE Review and Meta-Analysis

(2014) Pieter Stijnen et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Congenital Proprotein Convertase 1/3 Deficiency Causes Malabsorptive Diarrhea and Other Endocrinopathies in a Pediatric Cohort

(2013) Martín G. Martín et al.   GASTROENTEROLOGY

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

(2013) Keri L Monda et al.   NATURE GENETICS

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

(2013) Sonja I Berndt et al.   NATURE GENETICS

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity

(2013) Eleanor Wheeler et al.   NATURE GENETICS

Functional Consequences of a Novel Variant of PCSK1

(2013) Lindsay A. Pickett et al.   PLoS One

Contribution of Common PCSK1 Genetic Variants to Obesity in 8,359 Subjects from Multi-Ethnic American Population

(2013) Hélène Choquet et al.   PLoS One

Meta-analysis of genetic association studies under heterogeneity

(2012) Binod Neupane et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The obesity-related polymorphism PCSK1 rs6235 is associated with essential hypertension in the Han Chinese population

(2012) Xiao-mu Li et al.   HYPERTENSION RESEARCH

Challenges in reproducibility of genetic association studies: lessons learned from the obesity field

(2012) A Li et al.   INTERNATIONAL JOURNAL OF OBESITY

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations

(2012) Yukinori Okada et al.   NATURE GENETICS

Meta-analysis identifies common variants associated with body mass index in east Asians

(2012) Wanqing Wen et al.   NATURE GENETICS

A genome-wide association meta-analysis identifies new childhood obesity loci

(2012)   NATURE GENETICS

PCSK1 rs6232 Is Associated with Childhood and Adult Class III Obesity in the Mexican Population

(2012) Marisela Villalobos-Comparán et al.   PLoS One

Genome wide association study identifies KCNMA1contributing to human obesity

(2011) Hong Jiao et al.   BMC Medical Genomics

FTO gene polymorphisms and obesity risk: a meta-analysis

(2011) Sihua Peng et al.   BMC Medicine

Heterozygous Mutations Causing Partial Prohormone Convertase 1 Deficiency Contribute to Human Obesity

(2011) J. W. M. Creemers et al.   DIABETES

Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

(2011) R. J. Strawbridge et al.   DIABETES

Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models

(2011) Carolin Pütter et al.   HUMAN HEREDITY

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

(2011) Mariel M Finucane et al.   LANCET

Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity

(2011) Majambu Mbikay et al.   MOLECULAR GENETICS AND METABOLISM

The future of obesity medicine: where do we go from here?

(2011) Suzanne M. Wright et al.   Nature Reviews Endocrinology

The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

(2011) Lei Chen et al.   Nature Reviews Endocrinology

Common Variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 Show Evidence of Association With Adult Obesity in the Greek Population

(2011) Konstantinos Rouskas et al.   Obesity

A Genome-Wide Association Study on Obesity and Obesity-Related Traits

(2011) Kai Wang et al.   PLoS One

Genome-Wide Population-Based Association Study of Extremely Overweight Young Adults – The GOYA Study

(2011) Lavinia Paternoster et al.   PLoS One

The Effect of PCSK1 Variants on Waist, Waist-Hip Ratio and Glucose Metabolism Is Modified by Sex and Glucose Tolerance Status

(2011) Anette P. Gjesing et al.   PLoS One

Evaluation of Genetic Susceptibility Loci for Obesity in Chinese Women

(2010) Jiajun Shi et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Association of obesity risk SNPs in PCSK1with insulin sensitivity and proinsulin conversion

(2010) Martin Heni et al.   BMC Medical Genetics

Combined Analyses of 20 Common Obesity Susceptibility Variants

(2010) C. H. Sandholt et al.   DIABETES

Anthropometric measures and glucose levels in a large multi-ethnic cohort of individuals at risk of developing type 2 diabetes

(2010) L. de Koning et al.   DIABETOLOGIA

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Association of PCSK1 rs6234 with Obesity and Related Traits in a Chinese Han Population

(2010) Qibin Qi et al.   PLoS One

Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups

(2010) André Scherag et al.   PLoS Genetics

Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study

(2009) T. O. Kilpelainen et al.   HUMAN MOLECULAR GENETICS

Common body mass index-associated variants confer risk of extreme obesity

(2009) Chris Cotsapas et al.   HUMAN MOLECULAR GENETICS

Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden

(2009) Frida Renström et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

Common PCSK1 Haplotypes Are Associated With Obesity in the Chinese Population

(2009) Yi-Cheng Chang et al.   Obesity

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design?

(2009) Iris M. Heid et al.   PLoS Genetics

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

(2008) A. D. Johnson et al.   BIOINFORMATICS

The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals

(2008) N Kurokawa et al.   INTERNATIONAL JOURNAL OF OBESITY

Common nonsynonymous variants in PCSK1 confer risk of obesity

(2008) Michael Benzinou et al.   NATURE GENETICS

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

(2008) Brendan J. Keating et al.   PLoS One