标题
Anti-trypanosomatid drug discovery: progress and challenges
作者
关键词
-
出版物
NATURE REVIEWS MICROBIOLOGY
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-08-22
DOI
10.1038/s41579-022-00777-y
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids
- (2022) Simone Altmann et al. NUCLEIC ACIDS RESEARCH
- An Update on African Trypanocide Pharmaceutics and Resistance
- (2022) Keneth Iceland Kasozi et al. Frontiers in Veterinary Science
- Characterization of a new Leishmania major strain for use in a controlled human infection model
- (2021) Helen Ashwin et al. Nature Communications
- Domestic Mammals as Reservoirs for Leishmania donovani on the Indian Subcontinent: Possibility and Consequences on Elimination
- (2021) Anurag Kumar Kushwaha et al. Transboundary and Emerging Diseases
- Modeling Relapsing Malaria: Emerging Technologies to Study Parasite-Host Interactions in the Liver
- (2021) Annemarie Voorberg-van der Wel et al. Frontiers in Cellular and Infection Microbiology
- Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis
- (2021) Michael Thomas et al. JOURNAL OF MEDICINAL CHEMISTRY
- New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial
- (2021) Faustino Torrico et al. LANCET INFECTIOUS DISEASES
- Bioluminescent Imaging Identifies Thymus, As Overlooked Colonized Organ, in a Chronic Model of Leishmania donovani Mouse Visceral Leishmaniasis
- (2021) Bárbara Domínguez-Asenjo et al. ACS Infectious Diseases
- Highly accurate protein structure prediction with AlphaFold
- (2021) John Jumper et al. NATURE
- An invariant Trypanosoma vivax vaccine antigen induces protective immunity
- (2021) Delphine Autheman et al. NATURE
- Organotypic endothelial adhesion molecules are key for Trypanosoma brucei tropism and virulence
- (2021) Mariana De Niz et al. Cell Reports
- Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei
- (2021) Nathan P. Crilly et al. PLoS Pathogens
- Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study
- (2021) Victor Kande Betu Ku Mesu et al. Lancet Global Health
- From Magic Bullet to Magic Bomb: Reductive Bioactivation of Antiparasitic Agents
- (2021) Sergio Wittlin et al. ACS Infectious Diseases
- Ex Vivo Phenotypic Screening of Two Small Repurposing Drug Collections Identifies Nifuratel as a Potential New Treatment against Visceral and Cutaneous Leishmaniasis
- (2021) Bárbara Domínguez-Asenjo et al. ACS Infectious Diseases
- A Systematic Review (1990–2021) of Wild Animals Infected with Zoonotic Leishmania
- (2021) Iris Azami-Conesa et al. Microorganisms
- Diversity and Epidemiology of Bat Trypanosomes: A One Health Perspective
- (2021) Jill M. Austen et al. Pathogens
- Ten-year follow-up of the largest oral Chagas disease outbreak. Laboratory biomarkers of infection as indicators of therapeutic failure
- (2021) Zoraida Díaz-Bello et al. ACTA TROPICA
- Overcoming roadblocks in the development of vaccines for leishmaniasis
- (2021) Paul M. Kaye et al. Expert Review of Vaccines
- DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis
- (2021) Charles E. Mowbray et al. JOURNAL OF MEDICINAL CHEMISTRY
- Genome-scale RNAi screens in African trypanosomes
- (2021) David Horn TRENDS IN PARASITOLOGY
- Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis
- (2021) Alexandre Girard et al. PLoS Pathogens
- CpG ODN D35 improves the response to abbreviated low-dose pentavalent antimonial treatment in non-human primate model of cutaneous leishmaniasis
- (2020) Seth G. Thacker et al. PLoS Neglected Tropical Diseases
- The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani
- (2020) Richard J. Wall et al. ACS Infectious Diseases
- Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases
- (2020) Jorge Alvar et al. Seminars in Immunopathology
- Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial
- (2020) D. Molina-Morant et al. Trials
- Monitoring the elimination of human African trypanosomiasis at continental and country level: Update to 2018
- (2020) José R. Franco et al. PLoS Neglected Tropical Diseases
- C57BL/6 α-1,3-Galactosyltransferase Knockout Mouse as an Animal Model for Experimental Chagas Disease
- (2020) Edward Valencia Ayala et al. ACS Infectious Diseases
- The Bradyzoite: A Key Developmental Stage for the Persistence and Pathogenesis of Toxoplasmosis
- (2020) Aude Cerutti et al. Pathogens
- New scheme of intermittent benznidazole administration in patients chronically infected with Trypanosoma cruzi: Clinical, parasitological and serological assessment after three years of follow-up.
- (2020) María Gabriela Álvarez et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Extravascular dermal trypanosomes in suspected and confirmed cases of gambiense Human African Trypanosomiasis
- (2020) Mariame Camara et al. CLINICAL INFECTIOUS DISEASES
- A TLR9-adjuvanted vaccine formulated into dissolvable microneedle patches or cationic liposomes protects against leishmaniasis after skin or subcutaneous immunization
- (2020) Juliane S. Lanza et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases
- (2020) Advait Nagle et al. JOURNAL OF MEDICINAL CHEMISTRY
- Challenges in Chagas Disease Drug Development
- (2020) Amanda F. Francisco et al. MOLECULES
- In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution
- (2020) Alexander I. Ward et al. mBio
- Long-term incidence of relapse and post-kala-azar dermal leishmaniasis after three different visceral leishmaniasis treatment regimens in Bihar, India
- (2020) Vishal Goyal et al. PLoS Neglected Tropical Diseases
- Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
- (2020) Manuel Saldivia et al. Nature Microbiology
- Mutations in an aquaglyceroporin as a proven marker of antimony clinical resistance in the parasite Leishmania donovani
- (2020) Jade-Eva Potvin et al. CLINICAL INFECTIOUS DISEASES
- Animal models of Chagas disease and their translational value to drug development
- (2020) Eric Chatelain et al. Expert Opinion on Drug Discovery
- Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate
- (2020) Alexander I. Ward et al. Open Biology
- Resolving the apparent transmission paradox of African sleeping sickness
- (2019) Paul Capewell et al. PLOS BIOLOGY
- The relevance of persisters in tuberculosis drug discovery
- (2019) Soma Mandal et al. MICROBIOLOGY-SGM
- American Trypanosomiasis (Chagas Disease)
- (2019) Luis E. Echeverria et al. INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
- An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials
- (2019) Colin James Henderson et al. DRUG METABOLISM AND DISPOSITION
- Definitions and guidelines for research on antibiotic persistence
- (2019) Nathalie Q. Balaban et al. NATURE REVIEWS MICROBIOLOGY
- Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
- (2019) Susan Wyllie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pharmacokinetics and pharmacodynamics of the nitroimidazole DNDI-0690 in mouse models of cutaneous leishmaniasis
- (2019) Gert-Jan Wijnant et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis
- (2019) Eliana Rodríguez-Monguí et al. Parasites & Vectors
- Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
- (2019) Diana Caridha et al. International Journal for Parasitology-Drugs and Drug Resistance
- Protozoan persister-like cells and drug treatment failure
- (2019) Michael P. Barrett et al. NATURE REVIEWS MICROBIOLOGY
- Murine infection with bioluminescent Leishmania infantum axenic amastigotes applied to drug discovery
- (2019) David Mendes Costa et al. Scientific Reports
- Anti-trypanosomal 8-hydroxyl naphthyridines are chelators of divalent transition metals
- (2018) Richard J. Wall et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles
- (2018) Katrien Van Bocxlaer et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Estimation of clinical trial success rates and related parameters
- (2018) Chi Heem Wong et al. BIOSTATISTICS
- Pharmacokinetics and disposition of miltefosine in healthy mice and hamsters experimentally infected with Leishmania infantum
- (2018) M. Dolores Jiménez-Antón et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Leishmaniasis Recidivans by Leishmania tropica in Central Rift Valley Region in Kenya
- (2018) Joseph Wambugu Gitari et al. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
- Chagas disease
- (2018) José A Pérez-Molina et al. LANCET
- Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial
- (2018) Faustino Torrico et al. LANCET INFECTIOUS DISEASES
- Trypanosoma cruzi infection of human induced pluripotent stem cell-derived cardiomyocytes: an in vitro model for drug screening for Chagas disease
- (2018) Leonardo da Silva Lara et al. MICROBES AND INFECTION
- Melarsoprol Resistance in African Trypanosomiasis
- (2018) Alan H. Fairlamb et al. TRENDS IN PARASITOLOGY
- A large-scale field randomized trial demonstrates safety and efficacy of the vaccine LetiFend® against canine leishmaniosis
- (2018) Javier Fernández Cotrina et al. VACCINE
- Stress-Induced Proliferation and Cell Cycle Plasticity of Intracellular Trypanosoma cruzi Amastigotes
- (2018) Peter C. Dumoulin et al. mBio
- Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery
- (2018) Lorna M. MacLean et al. PLoS Neglected Tropical Diseases
- High-throughput Cos-Seq screen with intracellular Leishmania infantum for the discovery of novel drug-resistance mechanisms
- (2018) Christopher Fernandez-Prada et al. International Journal for Parasitology-Drugs and Drug Resistance
- In vitro and in vivo pharmacodynamics of three novel antileishmanial lead series
- (2018) M. Van den Kerkhof et al. International Journal for Parasitology-Drugs and Drug Resistance
- Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects
- (2018) Nathaniel G. Jones et al. ACS Infectious Diseases
- Leishmaniasis
- (2018) Sakib Burza et al. LANCET
- Challenges and recent progress in drug discovery for tropical diseases
- (2018) Manu De Rycker et al. NATURE
- Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
- (2018) Susan Wyllie et al. NATURE
- Trypanosoma cruzi transmission in the wild and its most important reservoir hosts in Brazil
- (2018) Ana Maria Jansen et al. Parasites & Vectors
- Clinical and veterinary trypanocidal benzoxaboroles target CPSF3
- (2018) Richard J. Wall et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Host-Directed Drug Therapies for Neglected Tropical Diseases Caused by Protozoan Parasites
- (2018) Sanjay Varikuti et al. Frontiers in Microbiology
- Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani
- (2018) Victoriano Corpas-Lopez et al. ACS Infectious Diseases
- Drug Discovery for Kinetoplastid Diseases: Future Directions
- (2018) Srinivasa P. S. Rao et al. ACS Infectious Diseases
- Pathology and Pathogenesis of Chagas Heart Disease
- (2018) Kevin M. Bonney et al. Annual Review of Pathology-Mechanisms of Disease
- Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers
- (2017) Carlos A. Morillo et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Human African trypanosomiasis
- (2017) Philippe Büscher et al. LANCET
- Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
- (2017) Mark C. Field et al. NATURE REVIEWS MICROBIOLOGY
- Persistent bacterial infections and persister cells
- (2017) Robert A. Fisher et al. NATURE REVIEWS MICROBIOLOGY
- The history of leishmaniasis
- (2017) Dietmar Steverding Parasites & Vectors
- Continual renewal and replication of persistentLeishmania majorparasites in concomitantly immune hosts
- (2017) Michael A. Mandell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin
- (2017) Moran Shalev-Benami et al. Nature Communications
- A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH
- (2017) Mohamed Osman et al. PLoS Neglected Tropical Diseases
- The enemy within: Targeting host–parasite interaction for antileishmanial drug discovery
- (2017) Suzanne Lamotte et al. PLoS Neglected Tropical Diseases
- A ReplicativeIn VitroAssay for Drug Discovery against Leishmania donovani
- (2016) Diana Tegazzini et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice
- (2016) Sandra Trindade et al. Cell Host & Microbe
- Drug permeation and barrier damage inLeishmania-infected mouse skin
- (2016) Katrien Van Bocxlaer et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Topical formulations of miltefosine for cutaneous leishmaniasis in a BALB/c mouse model
- (2016) Katrien Van Bocxlaer et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Host-directed therapies for infectious diseases: current status, recent progress, and future prospects
- (2016) Alimuddin Zumla et al. LANCET INFECTIOUS DISEASES
- Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
- (2016) Shilpi Khare et al. NATURE
- Putting Infection Dynamics at the Heart of Chagas Disease
- (2016) Michael D. Lewis et al. TRENDS IN PARASITOLOGY
- The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes
- (2016) Paul Capewell et al. eLife
- An Overview of Trypanosoma brucei Infections: An Intense Host–Parasite Interaction
- (2016) Alicia Ponte-Sucre Frontiers in Microbiology
- Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly SensitiveIn VivoImaging
- (2015) Amanda Fortes Francisco et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy
- (2015) Carlos A. Morillo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Translational challenges of animal models in Chagas disease drug development: a review
- (2015) Eric Chatelain et al. Drug Design Development and Therapy
- Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease
- (2015) Jennifer Riley et al. PLoS Neglected Tropical Diseases
- A Review: The Current In Vivo Models for the Discovery and Utility of New Anti-leishmanial Drugs Targeting Cutaneous Leishmaniasis
- (2015) Emily Rose Mears et al. PLoS Neglected Tropical Diseases
- Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity
- (2015) Andrea Nühs et al. PLoS Neglected Tropical Diseases
- Characterization of Metabolically Quiescent Leishmania Parasites in Murine Lesions Using Heavy Water Labeling
- (2015) Joachim Kloehn et al. PLoS Pathogens
- Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates
- (2015) Fabrice E. Graf et al. International Journal for Parasitology-Drugs and Drug Resistance
- Bioluminescence imaging of chronicTrypanosoma cruziinfections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection
- (2014) Michael D. Lewis et al. CELLULAR MICROBIOLOGY
- A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis
- (2014) H. Burrell-Saward et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease
- (2014) Israel Molina et al. NEW ENGLAND JOURNAL OF MEDICINE
- ANIMAL MODELS FOR THE STUDY OF LEISHMANIASIS IMMUNOLOGY
- (2014) Elsy Nalleli Loria-Cervera et al. REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO
- Development of anEx VivoLymph Node Explant Model for Identification of Novel Molecules Active against Leishmania major
- (2013) Alex G. Peniche et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis
- (2013) M. R. Perry et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes
- (2012) N. Baker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes
- (2012) Manu De Rycker et al. PLoS Neglected Tropical Diseases
- Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51
- (2012) Shamila S. Gunatilleke et al. PLoS Neglected Tropical Diseases
- Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors
- (2011) Stephen Brand et al. JOURNAL OF MEDICINAL CHEMISTRY
- Mouse models for pathogenic African trypanosomes: unravelling the immunology of host-parasite-vector interactions
- (2011) S. MAGEZ et al. PARASITE IMMUNOLOGY
- Acute Chagas' disease in postrenal transplant and treatment with benzonidazole
- (2009) Alex Eduardo Silva et al. Annals of Diagnostic Pathology
- First-Line Therapy for Human Cutaneous Leishmaniasis in Peru Using the TLR7 Agonist Imiquimod in Combination with Pentavalent Antimony
- (2009) Cesar Miranda-Verastegui et al. PLoS Neglected Tropical Diseases
- Contributions of experimental mouse models to the understanding of African trypanosomiasis
- (2008) Nicolas Antoine-Moussiaux et al. TRENDS IN PARASITOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started