Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

Structure- and function-based design of Plasmodium-selective proteasome inhibitors

(2016) Hao Li et al.   NATURE

Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease

(2015) Shilpi Khare et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy

(2015) Carlos A. Morillo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chagas’ Disease

(2015) Caryn Bern   NEW ENGLAND JOURNAL OF MEDICINE

Overcoming neglect of kinetoplastid diseases

(2015) G. Bilbe   SCIENCE

Combating the next lethal epidemic

(2015) P. J. Hotez   SCIENCE

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

(2015) Shilpi Khare et al.   PLoS Pathogens

An update on pharmacotherapy for leishmaniasis

(2014) Shyam Sundar et al.   EXPERT OPINION ON PHARMACOTHERAPY

Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease

(2014) Israel Molina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Towards a Paradigm Shift in the Treatment of Chronic Chagas Disease

(2013) R. Viotti et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Chagas Disease

(2013) Maria Carmo Pereira Nunes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Leishmaniasis: clinical syndromes and treatment

(2013) B. S. McGwire et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

In Vivo Imaging of Trypanosome-Brain Interactions and Development of a Rapid Screening Test for Drugs against CNS Stage Trypanosomiasis

(2013) Elmarie Myburgh et al.   PLoS Neglected Tropical Diseases

Highly Sensitive In Vivo Imaging of Trypanosoma brucei Expressing “Red-Shifted” Luciferase

(2013) Alex P. McLatchie et al.   PLoS Neglected Tropical Diseases

A modern in vivo pharmacokinetic paradigm: combining snapshot, rapid and full PK approaches to optimize and expedite early drug discovery

(2012) Chun Li et al.   DRUG DISCOVERY TODAY

Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)

(2012) Peter GE Kennedy   LANCET NEUROLOGY

Antitrypanosomal Therapy for Chronic Chagas' Disease

(2011) Caryn Bern   NEW ENGLAND JOURNAL OF MEDICINE

GeneDB--an annotation database for pathogens

(2011) F. J. Logan-Klumpler et al.   NUCLEIC ACIDS RESEARCH

Chagas disease: 100 years after its discovery. A systemic review

(2010) José Rodrigues Coura et al.   ACTA TROPICA

Effect of Noncompetitive Proteasome Inhibition on Bortezomib Resistance

(2010) Xiaoming Li et al.   JNCI-Journal of the National Cancer Institute

Recent Advances in Physicochemical and ADMET Profiling in Drug Discovery

(2009) Jianling Wang et al.   CHEMISTRY & BIODIVERSITY

Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities

(2009) Rodolfo Viotti et al.   Expert Review of Anti-Infective Therapy

Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib

(2009) Dietmar Steverding et al.   Parasites & Vectors

Pharmacokinetics of Miltefosine in Old World Cutaneous Leishmaniasis Patients

(2008) T. P. C. Dorlo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding

(2008) Nigel J. Waters et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease

(2008) Juan M Bustamante et al.   NATURE MEDICINE