Article
Biochemistry & Molecular Biology
Naiara Dutra Barroso Gomes, Emanuel Paula Magalhaes, Lyanna Rodrigues Ribeiro, John Washington Cavalcante, Marcelo Morais Gomes Maia, Felipe Ramon Cunha da Silva, Arif Ali, Marcia Machado Marinho, Emmanuel Silva Marinho, Helcio Silva dos Santos, Alice Maria Costa Martins, Ramon Roseo Paula Pessoa Bezerra de Menezes
Summary: This study evaluated the activity of synthetic p-aminochalcones against T. cruzi and found that they have a trypanocidal effect by causing membrane damage and oxidative stress. Their mechanism of action may be related to inhibition of cruzain and TR.
BIOORGANIC CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Carmo P. Nunes, Lewis F. Buss, Jose Luiz P. Silva, Larissa Natany A. Martins, Claudia Di Lorenzo Oliveira, Clareci Silva Cardoso, Bruno Oliveira de Figueiredo Brito, Ariela Mota Ferreira, Lea Campos Oliveira, Ana Luiza Bierrenbach, Fabio Fernandes, Michael P. Busch, Viviane Tiemi Hotta, Luiz Mario Baptista Martinelli, Maria Carolina F. Almeida Soeiro, Adriana Brentegani, Vera M. C. Salemi, Marcia M. Menezes, Antonio Luiz P. Ribeiro, Ester Cerdeira Sabino
Summary: This study provides a comprehensive description of the natural history of T. cruzi seropositivity in a contemporary patient population, highlighting the central importance of anti-T. cruzi antibody titer as a marker of Chagas disease activity and risk of progression.
Article
Microbiology
Sergio Castaneda, Marina Munoz, Peter J. Hotez, Maria Elena Bottazzi, Alberto E. Paniz-Mondolfi, Kathryn M. Jones, Rojelio Mejia, Cristina Poveda, Juan David Ramirez
Summary: Chagas disease is caused by Trypanosoma cruzi and has a profound impact on the gastrointestinal tract. Alterations in the gut microbiome caused by the parasite may play a crucial role in host-parasite interactions and immune responses. Understanding this interaction could provide valuable insights into the pathophysiology of the disease and the development of new treatments.
MICROBIOLOGY SPECTRUM
(2023)
Article
Pharmacology & Pharmacy
Leonardo da Silva Lara, Guilherme Curty Lechuga, Lorraine Martins Rocha Orlando, Byanca Silva Ferreira, Bernardo Araujo Souto, Mauricio Silva dos Santos, Mirian Claudia de Souza Pereira
Summary: Chagas disease is a long-standing disease that primarily affects impoverished populations in Latin America. The available drugs have limited effectiveness and intense side effects. This study explores the biological activity of two new series of pyrazole-thiazoline derivatives with potential therapeutic options against Trypanosoma cruzi. These derivatives show potent activity with good oral bioavailability and low cytotoxicity, making them potential candidates for Chagas disease therapy.
Article
Infectious Diseases
A. Abras, C. Ballart, A. Fernandez-Arevalo, T. Llovet, M. Gallego, C. Munoz
Summary: The study evaluated two algorithms for the diagnosis of chronic and congenital Chagas disease, with CMIA showing potential as a single diagnostic test in non-endemic countries and the revised algorithm with the >= 6 S/CO proving to be an efficient method for chronic CD diagnosis. For infants with congenital infection, CMIA could potentially be used as a single test for screening at 10 months or earlier, but further research is needed.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Pharmacology & Pharmacy
Mariana C. Pagotti, Herbert J. Dias, Ana Carolina B. B. Candido, Thais A. S. Oliveira, Alexandre Borges, Nicoli D. Oliveira, Carla D. Lopes, Renato P. Orenha, Renato L. T. Parreira, Antonio E. M. Crotti, Lizandra G. Magalhaes
Summary: Chagas disease, a neglected tropical disease, affects over 8 million people. Although current therapies have limited effectiveness and high toxicity, the search for new drugs remains important. In this study, neolignans were synthesized and evaluated for their activity against Trypanosoma cruzi strains. Four neolignans demonstrated activity against the T. cruzi strain, with DBN 1 exhibiting the highest activity. In silico analysis showed that these compounds could destabilize tubulin-microtubule interactions. These compounds have potential as molecular prototypes for developing new antiparasitic drugs.
Article
Pharmacology & Pharmacy
Johny Wysllas de Freitas Oliveira, Mariana Farias Alves da Silva, Igor Zumba Damasceno, Hugo Alexandre Oliveira Rocha, Arnobio Antonio da Silva Junior, Marcelo Sousa Silva
Summary: This study investigated the encapsulation of sodium diethyldithiocarbamate (DETC) by poly-lactic acid (PLA) in nanoparticles for the treatment of Chagas disease caused by Trypanosoma cruzi. The nanoparticles showed reduced toxicity against cells and maintained antiparasitic activity. The physical characterization of the nanoparticles demonstrated a small size and negative zeta potential. The encapsulated DETC exhibited similar efficacy against T. cruzi as the free form.
Article
Biochemistry & Molecular Biology
Natalia Lins da Silva-Gomes, Leonardo Alexandre de Souza Ruivo, Claudia Moreira, Marcelo Meuser-Batista, Cristiane Franca da Silva, Denise da Gama Jaen Batista, Stenio Fragoso, Gabriel Melo de Oliveira, Maria de Nazare Correia Soeiro, Otacilio C. Moreira
Summary: In this study, genetically modified strains of Trypanosoma cruzi were used to evaluate the role of NTPDases in parasite infectivity. The results showed that parasites overexpressing TcNTPDase-1 had higher infectivity, while hemi-knockout parasites had lower infectivity and no significant electrocardiographic changes. These findings highlight the potential of NTPDases as a therapeutic target for Chagas disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gevanio Bezerra de Oliveira Filho, Marcos Verissimo de Oliveira Cardoso, Aline Caroline da Silva Santos, Thiago Andre Ramos dos Santos, Ana Catarina Cristovao-Silva, Laura Gonzalez Rubio, Luiz da Silva Maia Neto, Paulo Gaio Leite, Fabiana Simao Machado, Luiz Carlos Alves, Fabio Andre Brayner, Valeria Rego Alves Pereira, Ana Cristina Lima Leite
Summary: Chagas disease is causing more deaths in the Americas than any other parasitic disease and is increasingly becoming a global health problem. A novel series of 4-thiazolidinones derivatives have shown increased anti-T. cruzi activity, indicating potential for treating the disease.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Public, Environmental & Occupational Health
Jorge Vasconez-Gonzalez, Juan S. Izquierdo-Condoy, Raul Fernandez-Naranjo, Esteban Gamez-Rivera, Andrea Tello-De-la-Torre, Galo S. Guerrero-Castillo, Carlos Ruiz-Sosa, Esteban Ortiz-Prado
Summary: Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi, transmitted through contact with triatomine insect feces and urine. It infects approximately 6-7 million people worldwide, causing at least 14,000 deaths annually. In Ecuador, it has been reported in 20 out of 24 provinces, with El Oro, Guayas, and Loja being the most affected.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Fanny Mathias, Youssef Kabri, Damien Brun, Nicolas Primas, Carole Di Giorgio, Patrice Vanelle
Summary: Chagas disease caused by T. cruzi infection is a major public health problem in Latin America, resulting in 7000 annual deaths. This study synthesized ten new 1-substituted 2-nitropyrrole compounds and evaluated their biological activity. The derivatives showed good selectivity and activity against T. cruzi, but the maximum effect was lower than the reference drug.
Article
Ecology
Zeinab Parsons, Shadi Banitaan
Summary: This research focuses on the automatic identification of Chagas Disease (CD) and proposes four different automated CD vector identification approaches. By utilizing data mining-based methods and convolutional neural networks, the proposed approaches achieved high accuracy rates in classifying kissing bugs. By achieving 100% accuracy rates for the most common dataset of kissing bugs, this study takes a significant step towards overcoming this fatal disease.
ECOLOGICAL INFORMATICS
(2021)
Article
Immunology
Juliana Magalhaes Chaves Barbosa, Yasmin Pedra-Rezende, Luiza Dantas Pereira, Tatiana Galvao de Melo, Helene Santos Barbosa, Joseli Lannes-Vieira, Solange Lisboa de Castro, Anissa Daliry, Kelly Salomao
Summary: The combination treatment of Bz + AMD can attenuate the damage caused by T. cruzi infection in cardiac cells and have a certain control effect on parasite replication.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Emily A. Kelly, Christina A. Bulman, Emma L. Gunderson, Amanda M. Irish, Rebecca L. Townsend, Judy A. Sakanari, Susan L. Stramer, Caryn Bern, Jeffrey D. Whitman
Summary: The latest-generation CD serology tests may improve diagnostic sensitivity without affecting specificity. Reactivity and sensitivity were highest in samples from donors born in South America and lowest in specimens from those born in Mexico, with intermediate results in specimens from Central American donors.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Biology
Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Guilherme Curty Lechuga, Giseli Capaci Rodrigues, Omar Ginoble Pandoli, Druval Santos de Sa, Mirian Claudia de Souza Pereira
Summary: Therapeutic alternatives for Chagas disease are urgently needed due to limitations and adverse effects of current drugs. Triazole analogues show promise in treating T. cruzi.
Article
Oncology
Anthony N. Karnezis, Yemin Wang, Pilar Ramos, William P. D. Hendricks, Esther Oliva, Emanuela D'Angelo, Jaime Prat, Marisa R. Nucci, Torsten O. Nielsen, Christine Chow, Samuel Leung, Friedrich Kommoss, Stefan Kommoss, Annacarolina Silva, Brigitte M. Ronnett, Joseph T. Rabban, David D. Bowtell, Bernard E. Weissman, Jeffrey M. Trent, C. Blake Gilks, David G. Huntsman
JOURNAL OF PATHOLOGY
(2016)
Article
Pathology
Niamh Conlon, Anne M. Schultheis, Salvatore Piscuoglio, Annacarolin. A. Silva, Esther Guerra, Carmen Tornos, Victor E. Reuter, Robert A. Soslow, Robert H. Young, Esther Oliva, Britta Weigelt
Article
Pathology
Niamh Conlon, Annacarolina Silva, Esther Guerra, Petar Jelinic, Brooke A. Schlappe, Narciso Olvera, Jennifer J. Mueller, Carmen Tornos, Achim A. Jungbluth, Robert H. Young, Esther Oliva, Douglas Levine, Robert A. Soslow
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2016)
Article
Oncology
Kosuke Mima, Reiko Nishihara, Juhong Yang, Ruoxu Dou, Yohei Masugi, Yan Shi, Annacarolina da Silva, Yin Cao, Mingyang Song, Jonathan Nowak, Mancang Gu, Wanwan Li, Teppei Morikawa, Xuehong Zhang, Kana Wu, Hideo Baba, Edward L. Giovannucci, Jeffrey A. Meyerhardt, Andrew T. Chan, Charles S. Fuchs, Zhi Rong Qian, Shuji Ogino
CLINICAL CANCER RESEARCH
(2016)
Article
Gastroenterology & Hepatology
Raaj S. Mehta, Mingyang Song, Reiko Nishihara, David A. Drew, Kana Wu, Zhi Rong Qian, Teresa T. Fung, Tsuyoshi Hamada, Yohei Masugi, Annacarolina da Silva, Yan Shi, Wanwan Li, Mancang Gu, Walter C. Willett, Charles S. Fuchs, Edward L. Giovannucci, Shuji Ogino, Andrew T. Chan
Article
Pathology
Keisuke Kosumi, Tsuyoshi Hamada, Hideo Koh, Jennifer Borowsky, Susan Bullman, Tyler S. Twombly, Daniel Nevo, Yohei Masugi, Li Liu, Annacarolina da Silva, Yang Chen, Chunxia Du, Mancang Gu, Chenxi Li, Wanwan Li, Hongli Liu, Yan Shi, Kosuke Mima, Mingyang Song, Katsuhiko Nosho, Jonathan A. Nowak, Reiko Nishihara, Hideo Baba, Xuehong Zhang, Kana Wu, Molin Wang, Curtis Huttenhower, Wendy S. Garrett, Matthew L. Meyerson, Jochen K. Lennerz, Marios Giannakis, Andrew T. Chan, Jeffrey A. Meyerhardt, Charles S. Fuchs, Shuji Ogino
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Pathology
Luciana Santos Ramalho, Livia Ferreira Oliveira, Camila Lourencini Cavellani, Mara Lucia da Fonseca Ferraz, Flavia Aparecida de Oliveira, Rosana Rosa Miranda Correa, Vicente de Paula Antunes Teixeira, Sanivia Aparecida De Lima Pereira
ANNALS OF DIAGNOSTIC PATHOLOGY
(2013)
Article
Immunology
Janainna Grazielle Pacheco Olegario, Marcos Vinicius Silva, Juliana Reis Machado, Laura Penna Rocha, Marlene Antonia Reis, Camila Souza de Oliveira Guimaraes, Rosana Rosa Miranda Correa
CLINICAL & DEVELOPMENTAL IMMUNOLOGY
(2013)
Article
Pathology
Camila Souze de Oliveira Guimaraes, Fabiola Cristina Santos Tavares, Marilia Neves Santos, Gregorio Correa Guimaraes, Janainna Grazielle Pacheco Olegario, Laura Penna Rocha, Luiz Carlos Reis, Marlene Antonia dos Reis, Eumenia Costa da Cunha Castro, Rosana Rosa Miranda Correa
FETAL AND PEDIATRIC PATHOLOGY
(2013)
Article
Oncology
Chunxia Du, Annacarolina Silva, Vicente Morales-Oyarvide, Andressa Dias Costa, Margaret M. Kozak, Richard F. Dunne, Douglas A. Rubinson, Kimberly Perez, Yohei Masugi, Tsuyoshi Hamada, Lauren K. Brais, Chen Yuan, Ana Babic, Matthew D. Ducar, Aaron R. Thorner, Andrew Aguirre, Matthew H. Kulke, Kimmie Ng, Thomas E. Clancy, Jennifer J. Findeis-Hosey, Daniel T. Chang, Jason L. Hornick, Charles S. Fuchs, Shuji Ogino, Albert C. Koong, Aram F. Hezel, Brian M. Wolpin, Jonathan A. Nowak
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Pathology
David B. Chapel, Elizabeth K. Lee, Annacarolina F. L. Da Silva, Nathan Teschan, Colleen Feltmate, Ursula A. Matulonis, Christopher P. Crum, Lynette M. Sholl, Panagiotis A. Konstantinopoulos, Marisa R. Nucci
Summary: Mucinous ovarian tumors rarely have mural nodules, which have historically been classified as sarcoma-like, anaplastic carcinomatous, or sarcomatous. Genetic evidence shows that mural nodules are clonally related to associated tumors, indicating they are a morphologic spectrum of clonal neoplasms rather than distinct entities. Recurrent genetic alterations associated with mural nodule development or differences based on morphology were not identified.
Article
Oncology
Jennifer Borowsky, Koichiro Haruki, Mai Chan Lau, Andressa Dias Costa, Juha P. Vayrynen, Tomotaka Ugai, Kota Arima, Annacarolina da Silva, Kristen D. Felt, Melissa Zhao, Carino Gurjao, Tyler S. Twombly, Kenji Fujiyoshi, Sara A. Vayrynen, Tsuyoshi Hamada, Kosuke Mima, Susan Bullman, Tabitha A. Harrison, Amanda Phipps, Ulrike Peters, Kimmie Ng, Jeffrey A. Meyerhardt, Mingyang Song, Edward L. Giovannucci, Kana Wu, Xuehong Zhang, Gordon J. Freeman, Curtis Huttenhower, Wendy S. Garrett, Andrew T. Chan, Barbara A. Leggett, Vicki L. J. Whitehall, Neal Walker, Ian Brown, Mark Bettington, Reiko Nishihara, Charles S. Fuchs, Jochen K. Lennerz, Marios Giannakis, Jonathan A. Nowak, Shuji Ogino
Summary: The study demonstrates an inverse association between F. nucleatum and stromal memory helper T cells in colorectal carcinoma. This relationship is consistent across different tumor characteristics such as microsatellite instability status, neoantigen load, and tumor mutational burden. F. nucleatum was not found to be significantly associated with intraepithelial T cells or M1/M2 TAMs in the tumor microenvironment.
CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Mariana Silva Oliveira, Bianca Goncalves da Silva Torquato, Simone Yumi Tsuji, Laura Sanches Aguiar, Guilherme Ribeiro Juliano, Luciano Alves Matias da Silveira, Rosana Rosa Miranda Correa, Lenaldo Branco Rocha, Mara Lucia da Fonseca Ferraz
Summary: Chronic HIV infection is associated with vascular inflammation and endothelial dysfunction, potentially leading to alterations in aortic collagen fibers and progression of atherosclerosis. HIV patients, especially those with atherosclerosis, showed higher levels of mast cells and collagen fibers in the aorta.
CURRENT HIV RESEARCH
(2021)
Article
Oncology
Shannon M. Liudahl, Courtney B. Betts, Shamilene Sivagnanam, Vicente Morales-Oyarvide, Annacarolina da Silva, Chen Yuan, Samuel Hwang, Alison Grossblatt-Wait, Kenna R. Leis, William Larson, Meghan B. Lavoie, Padraic Robinson, Andressa Dias Costa, Sara A. Vayrynen, Thomas E. Clancy, Douglas A. Rubinson, Jason Link, Dove Keith, Wesley Horton, Margaret A. Tempero, Robert H. Vonderheide, Elizabeth M. Jaffee, Brett Sheppard, Jeremy Goecks, Rosalie C. Sears, Byung S. Park, Motomi Mori, Jonathan A. Nowak, Brian M. Wolpin, Lisa M. Coussens
Summary: Researchers have established an immune atlas of PDAC through single-cell resolution profiling, identifying leukocyte features correlated with clinical outcomes, which can serve as a valuable reference for PDAC treatment. The data can aid in deeper understanding of the PDAC immune ecosystem, identifying additional therapeutic targets, and providing predictive biomarkers for therapeutic response and resistance monitoring.
Letter
Orthopedics
U. Akgun, M. Sener
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2017)
Article
Pathology
Georgi Galev, Richard A. Prayson
ANNALS OF DIAGNOSTIC PATHOLOGY
(2024)
Article
Pathology
Jianmin Zhu, Xiuming Miao, Xin Li, Yang Zhang, Yuan Lou, Hanhan Chen, Xiaofei Liu
Summary: Granulomatous lobular mastitis (GLM) is a rare and benign chronic breast disease that can be mistaken for early-onset breast cancer. This report describes three cases in which GLM coexisted with ductal carcinoma in situ (DCIS), highlighting how GLM may obscure the presence of concurrent DCIS based on clinical imaging and manifestations.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2024)
Article
Pathology
Richard B. Mertens, Elias P. Makhoul, Xiaomo Li, Farnaz Dadmanesh
Summary: This study compared the expression of TROP2 in different molecular subtypes of breast cancer and found that a majority of carcinomas in each subtype showed intermediate to high levels of TROP2 expression with a wide range of expression. These observations support further investigation of the efficacy of sacituzumab govitecan in all molecular subtypes of breast carcinoma. The wide range of TROP2 expression suggests its potential utility as a biomarker for predicting responsiveness to sacituzumab govitecan. Immunohistochemical staining for TROP2 is critical for identifying patients who are completely negative for TROP2 and may be least likely or unlikely to respond to this agent.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2024)
Article
Pathology
Yulong He, Lei Zhao, Xiaorong Tang, Qinling Jiang, Xianling Zhao, Yilin Cao
Summary: This study explores the correlation between the expression of immunohistochemical markers and clinicopathological characteristics of pulmonary high-grade neuroendocrine carcinomas (HGNEC), and its impact on clinical outcomes. The results suggest that positive expression of certain markers is associated with reduced survival in HGNEC patients, and tumor stage is an important predictive factor for prognosis.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2024)
