Article
Pharmacology & Pharmacy
Kristyna Dvorakova, Petr Stepanek, Jirina Kroupova, Jarmila Zbytovska
Summary: Transdermal drug delivery is a non-invasive method with advantages over conventional routes of administration. However, the skin barrier needs to be modulated with enhancers, and currently there is a lack of enhancers with low toxicity and reversible effects. A study found that a series of new N-alkylmorpholines showed enhanced transdermal and dermal delivery, with the most effective derivatives having 10-14 carbons. The enhancers interacted predominantly with stratum corneum lipids.
Article
Chemistry, Physical
Beibei Lu, Tianqi Liu, Hao Wang, Chengyu Wu, Hanjun Chen, Zhe Liu, Jiaheng Zhang
Summary: Transdermal drug delivery system has several advantages, and ionic liquids play an important role in transdermal drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Ahlam Zaid Alkilani, Rania Hamed, Hajer Abdo, Lubna Swellmeen, Haneen A. Basheer, Walaa Wahdan, Amani D. Abu Kwiak
Summary: This study investigates the use of niosomes, a type of nanocarrier, to enhance the transdermal permeability of azithromycin, a BCS class III drug. The results show that niosomal gel can significantly improve the drug release rate compared to conventional gel formulations. These findings suggest that niosomal gel could be a promising alternative route of administration for azithromycin.
Article
Biochemical Research Methods
Inbar Yariv, Sriram Kannan, Yifat Harel, Esthy Levy, Hamootal Duadi, Jean-Paul Lellouche, Shulamit Michaeli, Dror Fixler
Summary: A noninvasive nanophotonics iterative multi-plane optical property extraction (IMOPE) technique was proposed to detect novel iron-based NPs in leishmaniasis lesions, providing accurate measurement of topical drug penetration depth in different tissue layers.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Pharmacology & Pharmacy
Kalvatala Sudhakar, Vijay Mishra, Sanjay Jain, Narayana Charyulu Rompicherla, Neelesh Malviya, Murtaza M. Tambuwala
Summary: This study prepared vesicular carriers such as ethosomes and transethosomes by the thin-film hydration method and evaluated their performance in non-invasive transdermal drug delivery. The results showed that these carriers exhibited smaller size, improved deformity, changed skin phase for better penetration, and sustained release of drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Deepak Kulkarni, Fouad Damiri, Satish Rojekar, Mehrukh Zehravi, Sarker Ramproshad, Dipali Dhoke, Shubham Musale, Ashiya A. Mulani, Pranav Modak, Roshani Paradhi, Jyotsna Vitore, Md Habibur Rahman, Mohammed Berrada, Prabhanjan S. Giram, Simona Cavalu
Summary: Microneedle (MNs) technology is a recent advancement in biomedical science that has gained popularity worldwide due to its multifaceted and broad-spectrum applications in drug delivery. The limitations of conventional drug delivery, such as poor absorption and bioavailability, can be overcome by MN-based drug delivery. Nanotechnology has played a significant role in the fabrication techniques and design of microneedles.
Article
Pharmacology & Pharmacy
Wanessa S. C. Quintao, Amandda E. Silva-Carvalho, Leandro A. Hilgert, Tais Gratieri, Marcilio Cunha-Filho, Felipe Saldanha-Araujo, Guilherme M. Gelfuso
Summary: This study aims to develop a chitosan-based film for the transdermal delivery of naringenin, a bioflavonoid with anti-inflammatory activity, for long-term treatment of inflammatory conditions. The study found that naringenin has anti-inflammatory effects and can inhibit T-cell proliferation. A chitosan film was successfully developed, which can continuously release naringenin across the skin over 72 hours.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Jiuheng Ruan, Chao Liu, Haoyuan Song, Ting Zhong, Peng Quan, Liang Fang
Summary: Skin pharmacokinetics (SPK) can explain the different effects of permeation enhancers on drug permeation at the kinetic level. SPK of permeation enhancers can be classified into lateral elimination and longitudinal elimination, and evaluated using the diffusion ratio (DRSC-EP). The linear relationship between parameters such as ke-enhancer and Delta Cmax-drug, MRTenhancer and Delta Tmax-drug, and AUCt-enhancer and Delta AUCt-drug suggests that SPK precisely controls drug permeation in vivo.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Renata Pinho Morais, Sabrina Hochheim, Carolina C. de Oliveira, Izabel C. Riegel-Vidotti, Claudia E. B. Marino
Summary: This article reviews significant findings on silica nanoparticles (SNPs) and their interactions with the skin, including synthesis, functionalization methods, skin characteristics, permeation mechanisms, and toxicity assessments. It also discusses the research progress on the use of SNPs in therapeutic and cosmetic products.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Martina Romeo, Elisabetta Mazzotta, Ida Daniela Perrotta, Rita Muzzalupo
Summary: Lidocaine can self-associate into vesicular carriers, showing excellent local permeation performance and prolonged drug release, making it suitable for local therapy.
Article
Pharmacology & Pharmacy
Jin Sil Lee, Hyeryeon Oh, Sunghyun Kim, Jeung-Hoon Lee, Yong Chul Shin, Won Il Choi
Summary: The development of a novel chitosan nanosponge has the potential to enhance drug penetration through human skin for efficient transepidermal drug delivery.
Article
Pharmacology & Pharmacy
Angela Abruzzo, Carola Parolin, Elisa Corazza, Barbara Giordani, Massimiliano Pio di Cagno, Teresa Cerchiara, Federica Bigucci, Beatrice Vitali, Barbara Luppi
Summary: The study found that two biosurfactants could enhance drug permeation through the skin at certain concentrations, potentially serving as new green excipients.
Article
Chemistry, Multidisciplinary
Takamasa Suzuki, Tomohiro Aoki, Masato Saito, Ichiro Hijikuro, Shoko Itakura, Hiroaki Todo, Kenji Sugibayashi
Summary: Penetration enhancers, such as non-lamellar liquid crystal (NLLC) forming lipids, are crucial for overcoming the barrier function of the stratum corneum in topical formulations development. In this study, the use of acryl-base pressure-sensitive adhesive (PSA) tape containing NLLC forming lipids like mono-O-(5,9,13-trimethyl-4-tetradecenyl) glycerol ester (MGE) or phytantriol (PHY) significantly enhanced the permeation of hydrophilic drug fluorescein sodium (FL-Na) through the skin. The addition of MGE into the formulation led to improved skin permeation of drugs that are typically difficult to permeate through the skin.
PHARMACEUTICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mang Xiao, Xianghong Li, Li Wang, Bin Lin, Min Zhai, Lisa Hull, Alex Zizzo, Wanchang Cui, Juliann G. Kiang
Summary: This study evaluated the inflammatory responses induced by radiation injury and radiation combined with skin injury in the mouse brain. The results showed that radiation combined with skin injury caused more severe animal death and body weight loss compared to radiation alone, and delayed wound healing. Furthermore, both radiation alone and combined with skin injury activated astrocytes and endothelial cells, leading to blood-brain barrier leakage and neural cell damage. These findings suggest that inflammatory pathways play a role in brain injury induced by radiation combined with skin injury, with the latter exacerbating neural cell damage more than radiation alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Ekta Jagtiani, Mihika Yeolekar, Shivraj Naik, Vandana Patravale
Summary: Understanding the BBB enables the development of new techniques for CNS medication and improvement of existing models. In vitro BBB models have been formed to study the pathology of BBB and its mechanism of action in CNS disorders. The microfluidics-based BBB-on-Chip model has been developed for realistic simulation and drug permeability testing. Evaluating in vitro BBB models is critical for developing CNS treatments with improved BBB penetrability.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Microbiology
Katrien Van Bocxlaer, Eric Gaukel, Deirdre Hauser, Seong Hee Park, Sara Schock, Vanessa Yardley, Ryan Randolph, Jacob J. Plattner, Tejal Merchant, Simon L. Croft, Robert T. Jacobs, Stephen A. Wring
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Chemistry, Medicinal
Catherine Fagundez, Diver Sellanes, Stella Pena, Laura Scarone, Anna C. C. Aguiar, Juliana O. de Souza, Rafael V. C. Guido, Lindsay Stewart, Vanessa Yardley, Sabine Ottilie, Elizabeth A. Winzeler, Francisco-J. Gamo, Laura M. Sanz, Gloria L. Serra
ACS MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Parasitology
Katrien Van Bocxlaer, Diana Caridha, Chad Black, Brian Vesely, Susan Leed, Richard J. Sciotti, Gert-Jan Wijnant, Vanessa Yardley, Stephanie Braillard, Charles E. Mowbray, Jean-Robert Ioset, Simon L. Croft
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2019)
Article
Infectious Diseases
Paula MacGregor, Andrea L. Gonzalez-Munoz, Fatoumatta Jobe, Martin C. Taylor, Steven Rust, Alan M. Sandercock, Olivia J. S. Macleod, Katrien Van Bocxlaer, Amanda F. Francisco, Francois D'Hooge, Arnaud Tiberghien, Conor S. Barry, Philip Howard, Matthew K. Higgins, Tristan J. Vaughan, Ralph Minter, Mark Carrington
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Microbiology
Gert-Jan Wijnant, Simon L. Croft, Raul de la Flor, Mo Alavijeh, Vanessa Yardley, Stephanie Braillard, Charles Mowbray, Katrien Van Bocxlaer
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Review
Parasitology
Diana Caridha, Brian Vesely, Katrien van Bocxlaer, Byron Arana, Charles E. Mowbray, Sima Rafati, Silvia Uliana, Rosa Reguera, Mara Kreishman-Deitrick, Richard Sciotti, Pierre Buffet, Simon L. Croft
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2019)
Article
Biochemical Research Methods
David J. Clark, Catherine M. Moore, Marc Flanagan, Katrien Van Bocxlaer, Evangelia-Theophano Piperaki, Vanessa Yardley, Simon L. Croft, John Tyson, Sam P. Whitehouse, Jonathan O'Halloran, Sanjeev Krishna, Henry M. Staines
Review
Immunology
Paul M. Kaye, Israel Cruz, Albert Picado, Katrien Van Bocxlaer, Simon L. Croft
SEMINARS IN IMMUNOPATHOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Alaa Riezk, Katrien Van Bocxlaer, Vanessa Yardley, Sudaxshina Murdan, Simon L. Croft
Article
Multidisciplinary Sciences
Helen Ashwin, Jovana Sadlova, Barbora Vojtkova, Tomas Becvar, Patrick Lypaczewski, Eli Schwartz, Elizabeth Greensted, Katrien Van Bocxlaer, Marion Pasin, Kai S. Lipinski, Vivak Parkash, Greg Matlashewski, Alison M. Layton, Charles J. Lacey, Charles L. Jaffe, Petr Volf, Paul M. Kaye
Summary: Leishmaniasis is considered a vaccine-preventable disease, but costs and uncertainty hinder progress in vaccine development. Controlled human infection models offer a way to speed up vaccine development and gain better understanding of disease pathogenesis.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Katrien Van Bocxlaer, Kerri-Nicola McArthur, Andy Harris, Mo Alavijeh, Stephanie Braillard, Charles E. Mowbray, Simon L. Croft
Summary: In cutaneous leishmaniasis, using film-forming systems for drug delivery shows potential advantages in reducing adverse effects and improving treatment adherence. However, the efficacy of specific compounds like DNDI-0690 using this system requires further investigation and consideration.
Article
Infectious Diseases
Katrien Van Bocxlaer, Jodie Dixon, Johannes J. Platteeuw, Dennie van den Heuvel, Kerri-Nicola Mcarthur, Andy Harris, Mo Alavijeh, Simon L. Croft, Vanessa Yardley
Summary: A drug called OLPC has demonstrated potent activity against CL-causing Leishmania species, and could be a promising alternative to miltefosine treatment for cutaneous leishmaniasis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Katrien Van Bocxlaer, Simon L. Croft
Summary: Treatment of cutaneous leishmaniasis involves the release, permeation and accumulation of active compounds in the skin. Evaluating the pharmacodynamic activity of drugs against parasites is relatively straightforward, but understanding the pharmacokinetic processes within the skin is more complex due to various factors such as skin structure and drug distribution.
RSC MEDICINAL CHEMISTRY
(2021)
Article
Microbiology
Gert-Jan Wijnant, Katrien Van Bocxlaer, Vanessa Yardley, Andy Harris, Sudaxshina Murdan, Simon L. Croft
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)