Article
Medicine, General & Internal
Mutong Zhao, Ying Liu, Zhihai Hu, Juan Sun, Zhou Yang, Li Wei, Zigang Xu, Lin Ma
Summary: This case report describes a rare case of a young girl with coexisting Takayasu arteritis and leishmaniasis infection. The patient's condition was controlled, but complications of Takayasu arteritis arose during treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Parasitology
Gabriela Fuentes-Nava, Andres Tirado-Sanchez, Edith A. Fernandez-Figueroa, Sokani Sanchez-Montes, Ingeborg Becker, Alexandro Bonifaz
Summary: Cutaneous leishmaniasis (CL) presents challenges in terms of diagnosis due to the lack of a gold standard test. A 22-year-old patient who had visited Oaxaca, Mexico, developed CL symptoms and was effectively treated with imiquimod, showing no relapse after 2 months. Treatment with imiquimod may be a viable option for CL caused by L. mexicana.
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2021)
Article
Biochemistry & Molecular Biology
Miriam Thomalla, Andreas Schmid, Julia Hehner, Sebastian Koehler, Elena Neumann, Ulf Mueller-Ladner, Andreas Schaeffler, Thomas Karrasch
Summary: The expression of TLR7 is strongly induced during adipocyte differentiation. The TLR7 agonist imiquimod can modulate adipokine concentration and gene expression profile in adipocytes, while adipocyte-derived cfDNA can lower adiponectin and resistin levels and potentially inhibit Glut4 gene expression. Obesity-related cfDNA from adipocytes plays a role in modulating adipose tissue immune and metabolic homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Juliane S. Lanza, Virginia M. R. Vallejos, Guilherme S. Ramos, Ana Carolina B. de Oliveira, Cynthia Demicheli, Luis Rivas, Sebastien Pomel, Philippe M. Loiseau, Frederic Frezard
Summary: This study evaluates the effectiveness of nanoassemblies made from antimony(V) complexes with octanoyl-N-methylglucamide (SbL8) or decanoyl-N-methylglucamide (SbL10) in targeting infection sites in visceral and cutaneous leishmaniases. The results show that these nanoassemblies are stable at neutral pH and effectively accumulate in macrophages and the liver. SbL10 exhibits higher activity against intramacrophage Leishmania amastigotes and can be further enhanced with co-incorporated miltefosine. In vivo, NanoSb demonstrates high antileishmanial activity in murine models of VL and CL. This study supports the potential of NanoSb as a better delivery system for antimony and co-incorporated drugs compared to conventional antimonial Glucantime (R).
Article
Microbiology
Aurora Diotallevi, Gloria Buffi, Giovanni Corbelli, Marcello Ceccarelli, Margherita Ortalli, Stefania Varani, Mauro Magnani, Luca Galluzzi
Summary: An autochthonous case of Cutaneous leishmaniasis in central Italy showed reduced susceptibility to SbIII after unsatisfactory response to treatment with Meglumine Antimoniate, confirmed through in vitro testing. The patient achieved complete healing after a new treatment course with intravenous liposomal Amphotericin B. Further studies are required to confirm the epidemiological and clinical relevance of this reduced susceptibility in Italy.
Article
Immunology
Monica Franca, Luiz H. Guimaraes, Mauricio T. Nascimento, Paulo N. Rocha, Lucas P. Carvalho
Summary: High levels of pro-inflammatory cytokines in cutaneous leishmaniasis patients are associated with tissue damage and ulcer development, but do not influence therapeutic failure in response to pentavalent antimony treatment.
MICROBES AND INFECTION
(2021)
Article
Multidisciplinary Sciences
Hermali Silva, Achala Liyanage, Theja Deerasinghe, Vasana Chandrasekara, Kalaivani Chellappan, Nadira D. Karunaweera
Summary: This study is the first detailed investigation of treatment failures in CL in Sri Lanka, revealing a relatively high rate of treatment failure especially in patients over 20 years old. It underscores the importance of further research into the pathogenesis of treatment failures and the need to review existing treatment protocols to introduce more effective strategies.
Article
Immunology
Paulo R. L. Machado, Fernanda V. O. Prates, Viviane Boaventura, Taina Lago, Luiz H. Guimaraes, Albert Schriefer, Temis W. F. Corte, Gerson Penna, Aldina Barral, Manoel Barral-Netto, Edgar M. Carvalho
Summary: The study showed that miltefosine is more effective than pentavalent antimony for treating cutaneous leishmaniasis caused by L. braziliensis in Brazil, and it accelerates healing time. However, combining miltefosine with GM-CSF did not improve therapeutic outcome but did shorten the healing time.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Nidhi Yadav, Bhushan Madke
Summary: Diffuse cutaneous leishmaniasis (DCL) is a rare parasitic infection caused by the Leishmania species. It commonly presents as non-ulcerating papules and nodules over the face, neck, and arms. A middle-aged female presented with multiple nodular lesions on her face, neck, and chest region, and was successfully treated with a combination course of rifampicin and fluconazole. This is the first case of DCL reported in north India, a non-endemic area for cutaneous leishmaniasis.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Article
Oncology
Yanhong Chu, Rutian Li, Lingyu Qian, Fangcen Liu, Ruihan Xu, Fanyan Meng, Yaohua Ke, Jie Shao, Lixia Yu, Qin Liu, Baorui Liu
Summary: The novel in situ vaccine induced systemic tumor-specific responses in mice with hepatic carcinoma, suppressed both injected and distant tumors, had minimal impact on normal organs, and provided long-term protection against tumor rechallenge.
Article
Biotechnology & Applied Microbiology
Kashif Iqbal, Sidra Khalid, Craig A. McElroy, Muhammad Adnan, Gul Majid Khan, M. Junaid Dar
Summary: This study developed and evaluated detergent-free nanovesicles, H-ENVs, for the topical treatment of cutaneous leishmaniasis. The results showed that H-ENVs improved the efficacy of the drugs and could be a safe choice for the treatment of cutaneous leishmaniasis.
Article
Immunology
Yosuke Ota, Yasuhiro Nagai, Yuko Hirose, Seiji Hori, Erina Koga-Yamakawa, Ken Eguchi, Kentaro Sumida, Masashi Murata, Hiroki Umehara, Setsuko Yamamoto
Summary: In this study, a new small-molecule TLR7 agonist DSP-0509 was identified and characterized. It activated bone marrow-derived dendritic cells (BMDCs) and induced the production of inflammatory cytokines. In mouse models, DSP-0509 inhibited tumor growth and showed synergistic anti-tumor effects when combined with an anti-PD-1 antibody. The results suggested that DSP-0509 could enhance anti-tumor immune responses by activating dendritic cells and CTLs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Kovy Arteaga-Livias, Mijael Santos-Huerta, Bernardo Damaso-Mata, Vicky Panduro-Correa, Jose A. Gonzales-Zamora, Alfonso J. Rodriguez-Morales
Summary: Leishmaniasis is a predominantly tropical disease considered one of the primary neglected diseases, affecting individuals of low socioeconomic status. Disseminated cutaneous leishmaniasis is becoming increasingly important, especially in the pediatric population, with multiple cases observed in adults but still little described in children.
JOURNAL OF TROPICAL PEDIATRICS
(2021)
Article
Immunology
Mauricio T. Nascimento, Ravena S. O. Cordeiro, Cayo Abreu, Camila P. Santos, Fabio Peixoto, Gabriela A. Duarte, Thiago Cardoso, Camila I. de Oliveira, Edgar M. Carvalho, Lucas P. Carvalho
Summary: Patients with cutaneous leishmaniasis caused by Leishmania braziliensis infection suffer from an exaggerated inflammatory response. Pioglitazone, a drug used to treat diabetes, can help reduce inflammation without affecting the clearance of L. braziliensis by monocytes. Pioglitazone may serve as an adjunctive treatment for CL caused by L. braziliensis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Lorena Usero, Lorna Leal, Carmen Elena Gomez, Laia Miralles, Elena Aurrecoechea, Ignasi Esteban, Berta Torres, Alexy Inciarte, Beatriz Perdiguero, Mariano Esteban, Felipe Garcia, Montserrat Plana
Summary: Researchers tested a novel HIV therapeutic vaccine using unmodified mRNA (TMEP-B) and mRNA modified by 1-methyl-3'-pseudouridylyl (TMEP-Bmod) that expressed sequences from Gag, Pol, and Nef proteins in transfected monocyte-derived dendritic cells (MDDCs) obtained from HIV-infected patients. In vitro experiments were conducted to test the mRNAs alone and in combination with immunomodulators to enhance HIV-specific cellular immune responses. The combination of mRNAs with immunomodulators increased HIV-specific T-cell responses and the secretion of mediators involved in viral control, suggesting that these mRNA vaccines could potentially achieve a functional cure for HIV patients when combined with Vesatolimod and/or Nivolumab.
Article
Immunology
William O'Riordan, Alison McManus, Juri Teras, Ivan Poromanski, Maria Cruz-Saldariagga, Megan Quintas, Laura Lawrence, ShuJui Liang, Sue Cammarata
CLINICAL INFECTIOUS DISEASES
(2018)
Article
Immunology
Ivan Best, Angela Privat-Maldonado, Maria Cruz, Mirko Zimic, Rachel Bras-Goncalves, Jean-Loup Lemesre, Jorge Arevalo
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Editorial Material
Dermatology
Maria C. Ferrufino-Schmidt, Francisco Bravo, Braulio M. Valencia, Alejandro Llanos-Cuentas, Andrea K. Boggild, Philip E. LeBoit
JOURNAL OF CUTANEOUS PATHOLOGY
(2019)
Article
Medicine, General & Internal
A. Llanos-Cuentas, M. V. G. Lacerda, T. T. Hien, I. D. Velez, C. Namaik-Iarp, C. S. Chu, M. F. Villegas, F. Val, W. M. Monteiro, M. A. M. Brito, M. R. F. Costa, R. Chuquiyauri, M. Casapia, C. H. Nguyen, S. Aruachan, R. Papwijitsil, F. H. Nosten, G. Bancone, B. Angus, S. Duparc, G. Craig, V. M. Rousell, S. W. Jones, E. Hardaker, D. D. Clover, L. Kendall, K. Mohamed, G. C. K. W. Koh, V. M. Wilches, J. J. Breton, J. A. Green
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Medicine, General & Internal
M. V. G. Lacerda, A. Llanos-Cuentas, S. Krudsood, C. Lon, D. L. Saunders, R. Mohammed, D. Yilma, D. Batista Pereira, F. E. J. Espino, R. Z. Mia, R. Chuquiyauri, F. Val, M. Casapia, W. M. Monteiro, M. A. M. Brito, M. R. F. Costa, N. Buathong, H. Noedl, E. Diro, S. Getie, K. M. Wubie, A. Abdissa, A. Zeynudin, C. Abebe, M. S. Tada, F. Brand, H. -P. Beck, B. Angus, S. Duparc, J. -P. Kleim, L. M. Kellam, V. M. Rousell, S. W. Jones, E. Hardaker, K. Mohamed, D. D. Clover, K. Fletcher, J. J. Breton, C. O. Ugwuegbulam, J. A. Green, G. C. K. W. Koh
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Multidisciplinary Sciences
Gabriel Carrasco-Escobar, Marcia C. Castro, Jose Luis Barboza, Jorge Ruiz-Cabrejos, Alejandro Llanos-Cuentas, Joseph M. Vinetz, Dionicia Gamboa
Letter
Dermatology
A. C. Saavedra, B. M. Valencia, P. Tueros, X. Wortsman, A. Llanos-Cuentas, R. J. Lavarello
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Article
Infectious Diseases
Jason Rosado, Michael T. White, Rhea J. Longley, Marcus Lacerda, Wuelton Monteiro, Jessica Brewster, Jetsumon Sattabongkot, Mitchel Guzman-Guzman, Alejandro Llanos-Cuentas, Joseph M. Vinetz, Dionicia Gamboa, Ivo Mueller
Summary: The study showed that transmission intensity plays a key role in the antibody response to P. vivax, with P. vivax SEMs accurately identifying recent infections in low transmission settings but having reduced effectiveness in high transmission settings.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Infectious Diseases
Liliana Lopez, Fiorela Alvarez, Ana Pilar Ramos, Alejandro Llanos-Cuentas, Juan Echevarria, Ivan Velez, Marina Boni, Joelle Rode, Juliana Quintero, Alejandra Jimenez, Yulied Tabares, Claudia Mendez, Byron Arana
Summary: The combination of thermotherapy (TT) plus a short course of miltefosine (MLT) has shown to be significantly better than TT alone for the treatment of uncomplicated cutaneous leishmaniasis in the New World, with higher cure rates and improved efficacy.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Jason Rosado, Gabriel Carrasco-Escobar, Oscar Nolasco, Katherine Garro, Hugo Rodriguez-Ferruci, Mitchel Guzman-Guzman, Alejandro Llanos-Cuentas, Joseph M. Vinetz, Narimane Nekkab, Michael T. White, Ivo Mueller, Dionicia Gamboa
Summary: The study measured antibody responses against serological exposure markers to identify individuals recently exposed to Plasmodium vivax. Low local transmission was detected by qPCR, while seroprevalence data indicated higher exposure in certain communities. Age and gender were associated with increased odds of seropositivity.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Microbiology
Eva Duenas, Jose A. Nakamoto, Luis Cabrera-Sosa, Percy Huaihua, Maria Cruz, Jorge Arevalo, Pohl Milon, Vanessa Adaui
Summary: This study developed CRISPR-based assays for molecular detection of Leishmania spp., with high specificity and sensitivity. These assays show potential applicability for first-line diagnosis of Leishmania infections at the genus and L. (Viannia) subgenus levels.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Tiana Bressan, Andrea Valdivia-Gago, Rosa M. Silvera-Ccallo, Alejandro Llanos-Cuentas, Daniel F. Condor, Pierre G. Padilla-Huamantinco, Stalin Vilcarromero, J. Jaime Miranda, Carol Zavaleta-Cortijo
Summary: This study highlights the significant challenges faced by researchers who use biomedical technologies in the Peruvian Amazon, including design issues, transportation difficulties, environmental impacts, and cultural factors. Respecting local cultures and health priorities, understanding contextual challenges, and engaging in co-design efforts are crucial for improving access to healthcare in remote Amazon communities.
INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
(2022)
Article
Endocrinology & Metabolism
Julio A. Chirinos, Patricio Lopez-Jaramillo, Evangelos J. Giamarellos-Bourboulis, Gonzalo H. Davila-del-Carpio, Abdul Rahman Bizri, Jaime F. Andrade-Villanueva, Oday Salman, Carlos Cure-Cure, Nelson R. Rosado-Santander, Mario P. Cornejo Giraldo, Luz A. Gonzalez-Hernandez, Rima Moghnieh, Rapti Angeliki, Maria E. Cruz Saldarriaga, Marcos Pariona, Carola Medina, Ioannis Dimitroulis, Charalambos Vlachopoulos, Corina Gutierrez, Juan E. Rodriguez-Mori, Edgar Gomez-Laiton, Rosa Cotrina Pereyra, Jorge Luis Ravelo Hernandez, Hugo Arbanil, Jose Accini-Mendoza, Maritza Perez-Mayorga, Charalampos Milionis, Garyfallia Poulakou, Gregorio Sanchez, Renzo Valdivia-Vega, Mirko Villavicencio-Carranza, Ricardo J. Ayala-Garcia, Carlos A. Castro-Callirgos, Rosa M. Alfaro Carrasco, Willy Garrido Lecca Danos, Tiffany Sharkoski, Katherine Greene, Bianca Pourmussa, Candy Greczylo, Juan Ortega-Legaspi, Douglas Jacoby, Jesse Chittams, Paraskevi Katsaounou, Zoi Alexiou, Styliani Sympardi, Nancy K. Sweitzer, Mary Putt, Jordana B. Cohen
Summary: Fenofibrate has no significant effect on clinically relevant outcomes in patients with COVID-19.
Article
Engineering, Biomedical
Omar Zenteno, Eduardo Gonzalez, Sylvie Treuillet, Braulio M. Valencia, Benjamin Castaneda, Alejandro Llanos-Cuentas, Yves Lucas
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2019)
Article
Tropical Medicine
Ruwandi Kariyawasam, Avinash N. Mukkala, Rachel Lau, Braulio M. Valencia, Alejandro Llanos-Cuentas, Andrea K. Boggild
TROPICAL MEDICINE AND HEALTH
(2019)