Review
Biochemistry & Molecular Biology
Jasmine Canlas, Alan L. Myers
Summary: Global estimates indicate that over 600 million individuals worldwide consume the betel nut in some form, which is associated with various oral and systemic ailments. The comprehensive understanding of the metabolic pathways significant to betel quid (BQ) chemicals is lacking. This study identified prominent BQ constituents and examined their interaction with drug disposition proteins.
CURRENT DRUG METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Gabriel Tao, Pavan Kumar Chityala, Li Li, Zhoumeng Lin, Romi Ghose
Summary: In this study, a new physiologically based pharmacokinetic (PBPK) model was established to predict the disposition kinetics of irinotecan. Bile excretion and UDP-glucuronosyltransferases (UGT) were found to play important roles in SN-38 pharmacokinetics. Inflammation significantly affected the metabolism of irinotecan.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Pharmacology & Pharmacy
Christopher M. Conner, Don van Fossan, Kristen Read, Dale O. Cowley, Oscar Alvarez, Shannon Xiang-Ru Xu, David R. Webb, Kurt Jarnagin
Summary: Monoclonal antibodies (mAbs) are rapidly growing drugs, used to treat various diseases. Preclinical pharmacokinetics studies are usually done in non-human primates, but rodent models that mimic human-like pharmacokinetics are being investigated. The production of CRISPR/Cas9-mediated hFCRN transgenic mice, termed SYNB-hFCRN, provides another valuable animal model for preclinical pharmacokinetics studies.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Microbiology
Claudia Demarta-Gatsi, Nicole Andenmatten, Maria-Belen Jimenez-Diaz, Nathalie Gobeau, Mohammed H. Cherkaoui-Rabti, Aline Fuchs, Pablo Diaz, Sandra Berja, Rebeca Sanchez, Hazel Gomez, Estibaliz Ruiz, Paula Sainz, Eider Salazar, Rodrigo Gil-Merino, Luis Manuel Mendoza, Cristina Eguizabal, Didier Leroy, Joerg J. Moehrle, Belen Tornesi, Inigo Angulo-Barturen
Summary: The development of new combinations of antimalarial drugs is urgently needed to prevent the spread of drug-resistant parasites and contribute to malaria control and eradication. In this study, a humanized mouse model of Plasmodium falciparum erythrocyte stages was evaluated for the selection of optimal drug combinations. The replication of P. falciparum in the mouse model was shown to be robust and reproducible, and the analysis of parasite killing in the model was found to be a useful tool for informing the selection of optimal drug combinations.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Luka Svet, Ilse Parijs, Simon Isphording, Bram Lories, Kathleen Marchal, Hans P. Steenackers
Summary: The development of antimicrobial resistance in dense and diverse biofilm communities is different from that in free-living bacteria. In duo-species biofilms, the competition between brewery isolates enhanced antimicrobial tolerance and resistance development in Pseudomonas rhodesiae. The acquired resistance phenotype depends on complex interactions between low-frequency mutations in the genetic background of the strains.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ning-Ning Wang, Xiang-Gui Wang, Guo-Li Xiong, Zi-Yi Yang, Ai-Ping Lu, Xiang Chen, Shao Liu, Ting-Jun Hou, Dong-Sheng Cao
Summary: Drug-drug interactions (DDIs) can cause serious adverse reactions, making it necessary to develop effective in silico methods to predict and evaluate DDIs. In this study, high-performance predictive models for metabolic DDIs were constructed and validated, yielding more reliable predictions. The developed model will greatly contribute to future drug development and clinical pharmacy research.
JOURNAL OF CHEMINFORMATICS
(2022)
Article
Agriculture, Dairy & Animal Science
Weijian Ye, Qingfeng Chen
Summary: As medical and pharmacological technology advances, the use of humanized mouse models in disease modeling and preclinical testing has become increasingly important. These models, which involve engrafting functional human tissues into immunodeficient mice, allow for the study of physiologically relevant disease mechanisms and can facilitate translational medicine.
ANNUAL REVIEW OF ANIMAL BIOSCIENCES
(2022)
Article
Pharmacology & Pharmacy
Josef Skoda, Klara Dohnalova, Karel Chalupsky, Aaron Stahl, Markus Templin, Jana Maixnerova, Stanislav Micuda, Lars Grontved, Albert Braeuning, Petr Pavek
Summary: This study found that TCPOBOP disrupts lipid metabolism in humanized CAR mice and has divergent effects compared to the prototypical CAR-mediated response in WT mice. This suggests the need for appropriate model ligands and humanized animal models when testing endocrine disruption and characterizing adverse outcome pathways.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Hui Yu, ShiYu Zhao, JianYu Shi
Summary: This paper proposes a novel Substructure-aware Tensor Neural Network (STNN-DDI) model for predicting multiple-type drug-drug interactions (DDIs). By learning the associations between the local chemical structures of drugs and their DDI types, the STNN-DDI model achieves accurate DDI prediction and provides explanations for the interaction mechanisms among drugs.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemical Research Methods
Zun Liu, Xing-Nan Wang, Hui Yu, Jian-Yu Shi, Wen-Min Dong
Summary: This paper proposes a cold start prediction model CSMDDI for both single-type and multiple-type drug-drug interactions. CSMDDI can predict not only whether pharmacological reactions occur between two drugs, but also what reaction types they induce in the cold start scenario. The comparison with state-of-the-art methods demonstrates that CSMDDI achieves good performance in DDI prediction in the cold start scenario, both in terms of occurrence prediction and multi-type reaction prediction.
BMC BIOINFORMATICS
(2022)
Article
Oncology
Daniel M. Benjamin, David R. Mandel, Tristan Barnes, Monika K. Krzyzanowska, Natasha Leighl, Ian F. Tannock, Jonathan Kimmelman
Summary: Individual and aggregated expert opinions were found to be unreliable in predicting outcomes of randomized trials in cancer, highlighting the importance of basing decisions on randomized trials rather than expert opinions.
Review
Pharmacology & Pharmacy
Isha Karnik, Zhisheng Her, Shu Hui Neo, Wai Nam Liu, Qingfeng Chen
Summary: Cancer therapeutics have been extensively studied in the past decade, with a focus on targeted modalities and immunotherapy. The adverse side effects of immune checkpoint inhibitors have underlined the need for clinically relevant animal models. Humanized mouse models have emerged as valuable tools for pre-clinical research, enabling the evaluation of efficacy and safety of immunotherapy, as well as the investigation of novel disease mechanisms.
Article
Immunology
Shivkumar Biradar, Yash Agarwal, Michael T. Lotze, Moses T. Bility, Robbie B. Mailliard
Summary: This study characterizes the interactions between gamma-delta T cells and HIV in a mouse model and explores the immunotherapeutic potential of V delta 2 T cells in controlling HIV replication. The findings reveal that HIV infection affects the proportion and ex vivo expansion of V delta 2 T cells in BLT humanized mice, and the adoptive transfer of activated V delta 2 T cells does not control HIV replication but exacerbates viremia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Taiji Miyake, Haruka Tsutsui, Kenta Haraya, Tatsuhiko Tachibana, Kayoko Morimoto, Shoko Takehara, Miho Ayabe, Kaoru Kobayashi, Yasuhiro Kazuki
Summary: The study demonstrates that P-gp-mediated drug-drug interactions and non-linear absorption can be predicted using hMDR1-MAC mice. These mice serve as a valuable in vivo tool for quantitatively predicting P-gp-mediated disposition in drug discovery and development.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Lauren A. Marcath, Colin M. Finley, Siu Fun Wong, Daniel L. Hertz
Summary: Patients with cancer are at increased risk of drug-drug interactions (DDI), with a high prevalence in subjects enrolled in SWOG clinical trials, especially concerning the coadministration of acid suppression therapies with dasatinib. Improved processes for DDI screening are needed to ensure trial subject safety and data accuracy.
Article
Neurosciences
Michael McMahon, Shaohong Ding, Lourdes P. Acosta-Jimenez, Tania G. Frangova, Colin J. Henderson, C. Roland Wolf
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Toxicology
C. E. Wilson, A. P. Dickie, K. Schreiter, R. Wehr, E. M. Wilson, J. Bial, N. Scheer, I. D. Wilson, R. J. Riley
ARCHIVES OF TOXICOLOGY
(2018)
Article
Pharmacology & Pharmacy
Michael McMahon, Shaohong Ding, Lourdes Acosta Jimenez, Remi Terranova, Marie-Apolline Gerard, Antonio Vitobello, Jonathan Moggs, Colin J. Henderson, C. Roland Wolf
MOLECULAR PHARMACOLOGY
(2019)
Article
Multidisciplinary Sciences
Yasuhiro Kazuki, Kaoru Kobayashi, Masumi Hirabayashi, Satoshi Abe, Naoyo Kajitani, Kanako Kazuki, Shoko Takehara, Masato Takiguchi, Daisuke Satoh, Jiro Kuze, Tetsushi Sakuma, Takehito Kaneko, Tomoji Mashimo, Minori Osamura, Mari Hashimoto, Riko Wakatsuki, Rika Hirashima, Ryoichi Fujiwara, Tsuneo Deguchi, Atsushi Kurihara, Yasuko Tsukazaki, Naoto Senda, Takashi Yamamoto, Nico Scheer, Mitsuo Oshimura
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Pharmacology & Pharmacy
Lindsay Reed, Radek Indra, Iveta Mrizova, Michaela Moserova, Heinz H. Schmeiser, C. Roland Wolf, Colin J. Henderson, Marie Stiborova, David H. Phillips, Volker M. Arlt
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Article
Toxicology
Valerie Stock, Linda Boehmert, Elisa Lisicki, Rafael Block, Julia Cara-Carmona, Laura Kim Pack, Regina Selb, Dajana Lichtenstein, Linn Voss, Colin J. Henderson, Elke Zabinsky, Holger Sieg, Albert Braeuning, Alfonso Lampen
ARCHIVES OF TOXICOLOGY
(2019)
Article
Pharmacology & Pharmacy
Y. Kapelyukh, C. J. Henderson, N. Scheer, A. Rode, C. R. Wolf
DRUG METABOLISM AND DISPOSITION
(2019)
Article
Toxicology
Stefanie Hessel-Pras, Albert Braeuning, Georgia Guenther, Alshaimaa Adawy, Anne-Margarethe Enge, Johanna Ebmeyer, Colin J. Henderson, Jan G. Hengstler, Alfonso Lampen, Raymond Reif
ARCHIVES OF TOXICOLOGY
(2020)
Article
Environmental Sciences
Francisco Inesta-Vaquera, Panida Navasumrit, Colin J. Henderson, Tanya G. Frangova, Tadashi Honda, Albena T. Dinkova-Kostova, Mathuros Ruchirawat, C. Roland Wolf
Summary: Inorganic arsenic (iAs) is a naturally occurring metalloid that poses a global health risk, with links to various diseases including cognitive impairment, cardiovascular failure, and cancer. Despite laboratory studies on iAs toxicity mechanisms, the lack of reliable in vivo biomarkers has hindered comprehensive analysis of its effects. The use of stress reporter models, such as the HOTT reporter mice, shows promise in serving as surrogate biomarkers for iAs-induced oxidative stress and could aid in the development of treatments to combat arsenicosis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Oncology
Sara J. Hamis, Yury Kapelyukh, Aileen McLaren, Colin J. Henderson, C. Roland Wolf, Mark A. J. Chaplain
Summary: The study developed a mechanistic mathematical model to describe the synergistic action of dabrafenib and trametinib on ERK activity in BRAFV600E-mutant melanoma cells, elucidating the molecular mechanism underlying vertical inhibition of the BRAF-MEK-ERK cascade.
BRITISH JOURNAL OF CANCER
(2021)
Meeting Abstract
Oncology
Colin J. Henderson, Nico Scheer, Yury Kapelyukh, Aileen McLaren, Kenneth MacLeod, Anja Rode, De Lin, C. Roland Wolf
Meeting Abstract
Oncology
Colin Henderson, Yury Kapelyukh, Kenneth MacLeod, De Lin, Aileen McLaren, Roland Wolf
BRITISH JOURNAL OF CANCER
(2018)