Editorial Material
Medicine, General & Internal
Ryan A. Denu, Daniel H. Solomon, Richard N. Mitchell, Yee-Ping Sun, Joseph Loscalzo
Summary: A 50-year-old woman with a history of asthma presented to the emergency department with chest pain and worsening dyspnea.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Justin Y. Toh, Agathe Nkouawa, Saul Rojas Sanchez, Huafang Shi, Nikolay G. Kolev, Christian Tschudi
Summary: By targeting 86 transcripts through RNAi, 22 genes that positively or negatively regulate the progression towards infectivity in Trypanosoma brucei have been identified, including the previously unknown nucleic acid binding proteins CSD1 and CSD2. The study suggests a considerable overlap between the genes that regulate stumpy bloodstream form Trypanosoma and those that govern the development of metacyclic form parasites.
SCIENTIFIC REPORTS
(2021)
Letter
Biology
Keith R. Matthews, Stephen Larcombe
Summary: The study finds that both slender and stumpy forms of trypanosomes can infect tsetse flies, but stumpy forms are more likely to be successful. Stumpy forms are defined by molecular adaptations for life-cycle progression and dominate in chronic infections.
Article
Immunology
Manon Geerts, Nick Van Reet, Sander Leyten, Raf Berghmans, Kat S. Rock, Theresa H. T. Coetzer, Lauren E-A Eyssen, Philippe Buscher
Summary: The newly developed T. b. gambiense inhibition ELISA (g-iELISA) based on the principle of antibody binding showed high specificity and sensitivity, making it suitable for regional laboratories in gHAT endemic countries for monitoring and surveillance.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Biotechnology & Applied Microbiology
Laura Bierhansl, Hans-Peter Hartung, Orhan Aktas, Tobias Ruck, Michael Roden, Sven G. Meuth
Summary: This article highlights five non-canonical targets in preclinical MS research: oligodendrocytes; the blood-brain barrier; metabolites and cellular metabolism; the coagulation system; and tolerance induction. Recent findings in these areas may guide the field towards novel targets for future therapeutic approaches in MS.
NATURE REVIEWS DRUG DISCOVERY
(2022)
Review
Behavioral Sciences
Thomas H. Costello, Leor Zmigrod, Arber Tasimi
Summary: Political psychology requires the establishment of a multidimensional, non-hierarchical, internally diverse, and contextually influenced academic terminology system to investigate individual variation and belief systems in politics in a more rigorous, replicable, and richer way.
TRENDS IN COGNITIVE SCIENCES
(2023)
Review
Cell Biology
Bibo Li
Summary: Telomeres and subtelomeres play crucial roles in maintaining chromosome stability and adapting to environmental changes, particularly in the case of the Trypanosoma brucei parasite. The similarities and differences in telomere factors between T. brucei, human, and yeast cells are important for understanding genome stability mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Joseph T. Smith Jr, Brianna Tylec, Arunasalam Naguleswaran, Isabel Roditi, Laurie K. Read
Summary: This study reveals the importance of mitochondrial mRNA editing in the developmental regulation of Trypanosoma brucei. The researchers found that temperature reduction and depletion of the differentiation-repressive kinase RDK1 can affect the metabolism of Trypanosoma brucei by altering the editing of mitochondrial cytochrome mRNAs.
Article
Infectious Diseases
Fatihu Ahmad Rufa'i, Daniel Baecker, Muhammad Dauda Mukhtar
Summary: Trypanosomiasis is a serious disease that affects humans and animals, causing social and economic losses. Researchers investigated the phytochemical screening of a methanolic extract of Garcinia kola nuts and evaluated its biological activity on rats infected with Trypanosoma brucei brucei. The extract showed evident efficacy based on physiological changes and survival rates.
Article
Biochemistry & Molecular Biology
Brian S. Mantilla, Leticia D. Do Amaral, Henning J. Jessen, Roberto Docampo
Summary: The study highlights the importance of highly phosphorylated IPs in the life cycle of T. cruzi, identifying new highly phosphorylated IPs and the kinases involved in their synthesis.
ACS CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Samya S. Alenezi, Naif D. Alenezi, Godwin U. Ebiloma, Manal J. Natto, Marzuq A. Ungogo, John O. Igoli, Valerie A. Ferro, Alexander I. Gray, James Fearnley, Harry P. de Koning, David G. Watson
Summary: Propolis is a resin gathered by bees from plant exudates, and its composition depends on the nearby plants. It acts as an anti-infective and has anti-protozoal properties. Red Nigerian propolis was found to be highly active against Trypanosoma brucei and T. congolense, and four isoflavonoids isolated from the propolis displayed high activity against the parasites.
Article
Biology
Desislava P. Staneva, Stefan Bresson, Tatsiana Auchynnikava, Christos Spanos, Juri Rappsilber, A. Arockia Jeyaprakash, David Tollervey, Keith R. Matthews, Robin C. Allshire
Summary: This study reveals the unique gene expression regulation mechanism in kinetoplastids, a highly divergent lineage of eukaryotes. The researchers identified a complex called SPARC, which consists of SET27 and CRD1, among other components, that is involved in establishing accurate promoter position and directionality.
Article
Cell Biology
Naiwen Zhang, Ning Jiang, Liying Yu, Tiandong Guan, Xiaoyu Sang, Ying Feng, Ran Chen, Qijun Chen
Summary: The study provides the first comprehensive investigation of lactylated sites in Trypanosoma brucei, revealing the regulatory roles of protein lactylation in energy metabolism and gene expression in this parasite. It was found that glucose metabolism critically regulates protein lactylation in T. brucei, and a unique lactate production pathway is involved in the decrease of protein lactylation levels when glucose concentration increases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Eliane Tihon, Karinna Rubio-Pena, Annick Dujeancourt-Henry, Aline Crouzols, Brice Rotureau, Lucy Glover
Summary: The life cycle of Trypanosoma brucei alternates between the tsetse fly vector and the mammalian host, and the infectivity to the host depends on the expression of metacyclic variant surface glycoprotein genes. This study reveals the role of VEX1 in the metacyclic differentiation process and its impact on the infectivity of T. brucei to mammalian hosts.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Plant Sciences
Kathleen K. Treseder
Summary: This study conducted a synthesis of empirical studies to test the applicability of Grime's triangle of competitive, stress tolerance, and ruderal ecological strategies to microbes. The results showed broad support for the triangle, but inconsistent relationships were found between ecological strategies and shifts in microbial communities under environmental changes. It suggests the need to investigate and develop more relevant ecological strategies for microbes based on fine spatiotemporal scales.
JOURNAL OF ECOLOGY
(2023)
Article
Multidisciplinary Sciences
Monica R. Mugnier, George A. M. Cross, F. Nina Papavasiliou
Article
Biochemistry & Molecular Biology
Danae Schulz, Monica R. Mugnier, Eda-Margaret Paulsen, Hee-Sook Kim, Chun-wa W. Chung, David F. Tough, Inmaculada Rioja, Rab K. Prinjha, F. Nina Papavasiliou, Erik W. Debler
Editorial Material
Parasitology
Monica R. Mugnier, F. Nina Papavasiliou, Danae Schulz
TRENDS IN PARASITOLOGY
(2016)
Article
Genetics & Heredity
Galadriel Hovel-Miner, Monica R. Mugnier, Benjamin Goldwater, George A. M. Cross, F. Nina Papavasiliou
Article
Microbiology
Monica R. Mugnier, C. Erec Stebbins, F. Nina Papavasiliou
Article
Multidisciplinary Sciences
Danae Schulz, Monica R. Mugnier, Catherine E. Boothroyd, F. Nina Papavasiliou
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2016)
Article
Gastroenterology & Hepatology
Randolph P. Matthews, Steven F. EauClaire, Monica Mugnier, Kristin Lorent, Shuang Cui, Megan M. Ross, Zhe Zhang, Pierre Russo, Michael Pack
Article
Immunology
Tanja A. Schwickert, Gabriel D. Victora, David R. Fooksman, Alice O. Kamphorst, Monica R. Mugnier, Alexander D. Gitlin, Michael L. Dustin, Michel C. Nussenzweig
JOURNAL OF EXPERIMENTAL MEDICINE
(2011)
Article
Immunology
Alexandra Bortnick, Irene Chernova, William J. Quinn, Monica Mugnier, Michael P. Cancro, David Allman
JOURNAL OF IMMUNOLOGY
(2012)
Article
Microbiology
Galadriel A. Hovel-Miner, Catharine E. Boothroyd, Monica Mugnier, Oliver Dreesen, George A. M. Cross, F. Nina Papavasiliou
Article
Multidisciplinary Sciences
Kirsty R. McWilliam, Alasdair Ivens, Liam J. Morrison, Monica R. Mugnier, Keith R. Matthews
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Microbiology
Jaime So, Sarah Sudlow, Abeer Sayeed, Tanner Grudda, Stijn Deborggraeve, Dieudonne Mumba Ngoyi, Didier Kashiama Desamber, Bill Wickstead, Veerle Lejon, Monica R. Mugnier
Summary: This study analyzed the expressed VSGs in the blood of patients infected with T. b. gambiense and found a bias towards expression of type B N termini. The expressed T. b. gambiense VSGs also showed little similarity to sequences from T. b. gambiense whole-genome sequencing data sets, indicating strong selective pressure on the antigen repertoire to diversify.
Article
Microbiology
Monica R. R. Mugnier, Chi-Min Ho
Summary: This article discusses the experiences of Drs. Monica Mugnier and Chi-Min Ho as cochairs of the Young Investigators in Parasitology (YIPs) meeting. YIPs is a biennial meeting for new PIs in parasitology, aimed at helping them establish and manage their labs and build a community among new group leaders in the field of parasitology. The article also provides tips for organizing and running similar meetings, with the hope that other fields can replicate their model.