标题
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
作者
关键词
-
出版物
Nature Microbiology
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-07-14
DOI
10.1038/s41564-020-0745-6
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Properties of FDA-approved small molecule protein kinase inhibitors
- (2019) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition
- (2019) Susan Wyllie et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase
- (2019) Leah S. Torrie et al. PLoS One
- Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target
- (2019) Mahmood M. Alam et al. SCIENCE
- Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial
- (2018) Victor Kande Betu Ku Mesu et al. LANCET
- Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype
- (2018) Anne Walter et al. PLoS One
- Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
- (2018) Susan Wyllie et al. NATURE
- Drug Discovery for Kinetoplastid Diseases: Future Directions
- (2018) Srinivasa P. S. Rao et al. ACS Infectious Diseases
- TrypTag.org: A Trypanosome Genome-wide Protein Localisation Resource
- (2017) Samuel Dean et al. TRENDS IN PARASITOLOGY
- Chromosome Segregation: Reconstituting the Kinetochore
- (2016) Frederick G. Westhorpe et al. CURRENT BIOLOGY
- Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes
- (2016) Simon D’Archivio et al. JOURNAL OF CELL BIOLOGY
- Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers
- (2016) Gérald Lelais et al. JOURNAL OF MEDICINAL CHEMISTRY
- Conditional gene deletion with DiCre demonstrates an essential role for CRK3 inLeishmania mexicanacell cycle regulation
- (2016) Samuel M. Duncan et al. MOLECULAR MICROBIOLOGY
- Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
- (2016) Shilpi Khare et al. NATURE
- Drug Target Identification Using a Trypanosome Overexpression Library
- (2014) Daniela Begolo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Discovery of Unconventional Kinetochores in Kinetoplastids
- (2014) Bungo Akiyoshi et al. CELL
- Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen
- (2014) Nathaniel G. Jones et al. PLoS Pathogens
- How good are my data and what is the resolution?
- (2013) Philip R. Evans et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Developing Irreversible Inhibitors of the Protein Kinase Cysteinome
- (2013) Qingsong Liu et al. CHEMISTRY & BIOLOGY
- Targeting Plasmodium PI(4)K to eliminate malaria
- (2013) Case W. McNamara et al. NATURE
- In Vivo Imaging of Trypanosome-Brain Interactions and Development of a Rapid Screening Test for Drugs against CNS Stage Trypanosomiasis
- (2013) Elmarie Myburgh et al. PLoS Neglected Tropical Diseases
- Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei
- (2013) Mari Nishino et al. eLife
- Antitrypanosomal Activity of Fexinidazole, a New Oral Nitroimidazole Drug Candidate for Treatment of Sleeping Sickness
- (2011) Marcel Kaiser et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- High-Throughput Analysis of an RNAi Library Identifies Novel Kinase Targets in Trypanosoma brucei
- (2011) Zachary B. Mackey et al. Chemical Biology & Drug Design
- XDS
- (2010) Wolfgang Kabsch ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- xia2: an expert system for macromolecular crystallography data reduction
- (2009) G. Winter JOURNAL OF APPLIED CRYSTALLOGRAPHY
- Cell-cycle synchronisation of bloodstream forms of Trypanosoma brucei using Vybrant DyeCycle Violet-based sorting
- (2009) Sarah Kabani et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
- Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis
- (2008) J.K. Thuita et al. ACTA TROPICA
- Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding
- (2008) Nigel J. Waters et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei
- (2008) Sam Alsford et al. MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started