Article
Infectious Diseases
Pieter C. Steketee, Federica Giordani, Isabel M. Vincent, Kathryn Crouch, Fiona Achcar, Nicholas J. Dickens, Liam J. Morrison, Annette Macleod, Michael P. Barrett
Summary: Acoziborole, a newly developed benzoxaborole, shows promise in treating Human African Trypanosomiasis and potentially reducing drug resistance.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Parasitology
Catherine N. Mutuku, Rosemary Bateta, Martin K. Rono, James M. Njunge, Erick O. Awuoche, Kariuki Ndung'u, Clarence M. Mang'era, Modesta O. Akoth, Vincent O. Adung'a, Bartholomew N. Ondigo, Paul O. Mireji
Summary: This study assessed suramin response, drug resistance, and pathogenicity of Tbr parasite strains isolated from HAT patients in Uganda, revealing potential mechanisms of suramin treatment failure and resistance in Tbr parasites.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2021)
Article
Nanoscience & Nanotechnology
Madalitso M. Mlozen, Jacqueline Van Marwijk, Brendan Shane Wilhelmi, Chris Whiteley
Summary: The increasing number of reported cases of human African trypanosomiasis (HAT) is mainly due to drug resistant Trypanosoma brucei (Tb). Therefore, finding new anti-trypanosomal drugs is crucial. A study showed that silver nanoparticles (AgNPs) selectively inhibited TbHK, which could be used for the development of new drugs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Annagiulia Favaro, Giovanni Bolcato, Marcelo A. A. Comini, Stefano Moro, Massimo Bellanda, Mattia Sturlese
Summary: Researchers conducted two different screenings for the peculiar redox system of Trypanosoma brucei parasite and discovered a small molecule that binds at the glutathione binding site. This finding represents an important step in developing a new strategy to interfere with the Trypanosoma Brucei redox system, potentially shedding light on the perturbation of this biochemical machinery and offering novel therapeutic possibilities.
Article
Biology
Sara Silva Pereira, Mariana De Niz, Karine Serre, Marie Ouarne, Joana E. Coelho, Claudio A. Franco, Luisa M. Figueiredo
Summary: This study established a mouse model of acute cerebral Trypanosomiasis, revealing the key roles of parasite sequestration in brain vasculature and ICAM1-mediated T cell accumulation in brain parenchyma in the pathogenesis of cerebral Trypanosomiasis.
Article
Multidisciplinary Sciences
Raymond E. Mdachi, Kennedy O. Ogolla, Joanna E. Auma, Florence N. Wamwiri, Richard K. Kurgat, Kennedy B. Wanjala, Lawrence G. Mugunieri, Phylis M. Alusi, Judith K. Chemuliti, Phoebe W. Mukiria, Sylvance O. Okoth
Summary: This study evaluated the sensitivity of Trypanosoma evansi field isolates collected from two counties in Kenya. Drug resistance was found in all study sites with infected camels. Camel management practices were found to influence the prevalence and degree of drug resistance.
Article
Microbiology
Gongguan Liu, Osama Abas, Ashley B. Strickland, Yanli Chen, Meiqing Shi
Summary: Infection by Trypanosoma brucei induces depletion and repopulation of liver macrophages, along with substantial accumulation of CXCR6(+)CD4(+) T cells in the liver. Disruption of CXCR6 signaling enhances the survival of infected mice, attributing to reduced inflammation and liver injury. CXCR6(+)CD4(+) T cells promote mortality during T. brucei infection by promoting liver injury.
Review
Veterinary Sciences
Keneth Iceland Kasozi, Ewan Thomas MacLeod, Susan Christina Welburn
Summary: The resistance of African animal trypanocide is a continuous threat to the elimination of African trypanosomiasis. This study investigated the threat by using major chemotherapeutic agents and found multi-drug cross-resistance, emphasizing the need to revise policies for disease control.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Mohamed A. Dkhil, Felwa A. Thagfan, Esam M. Al-Shaebi, Saleh N. Maodaa, Rewaida Abdel-Gaber, Taghreed A. Hafiz, Murad A. Mubaraki, Saleh Al-Quraishy
Summary: This study investigated the impact of Trypanosoma evansi parasite infection on the behavioral changes and neurochemical alterations in mouse brains. The results showed that the infection significantly reduced locomotor activity and grip strength, as well as causing oxidative imbalance in the brain. Additionally, the infection induced histopathological changes and increased concentrations of dopamine and serotonin in the brains of mice.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Miebaka Jamabo, Maduma Mahlalela, Adrienne L. L. Edkins, Aileen Boshoff
Summary: Human African trypanosomiasis, caused by Trypanosoma brucei, is a neglected tropical disease targeted for eradication by 2030. The COVID-19 pandemic has disrupted control programs, extending the time frame. Vaccine development has been challenging due to antigenic variation and B cell depletion. Control relies on screening and drugs, with fexinidazole being a recent major breakthrough. Diagnosis, compliance, and resistance pose challenges, while ongoing drug discovery and addressing eradication challenges are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Oluyomi Stephen Adeyemi, Nthatisi Innocentia Molefe-Nyembe, Abiodun Omokehinde Eseola, Winfried Plass, Oluwatosin Kudirat Shittu, Ibrahim Olatunji Yunusa, Olubunmi Atolani, Ikponmwosa Owen Evbuomwan, Oluwakemi J. Awakan, Keisuke Suganuma, Kentaro Kato
Summary: This study demonstrated the potential of a new series of imidazoles to effectively clear the systemic parasite burden in infected rats, showing promising anti-parasitic prospects for these derivatives.
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2021)
Review
Microbiology
Anders Hofer
Summary: African sleeping sickness, Chagas disease, and leishmaniasis are serious diseases caused by different members of the trypanosomatid family. The nucleotide metabolism in T. brucei, the cause of African sleeping sickness, has unique features that can be targeted for drug development. Understanding the differences and similarities in nucleotide metabolism between T. brucei and other trypanosomatids is crucial for developing effective treatments.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Veterinary Sciences
Jael Soares Batista, Wanderson Lucas Alves dos Santos, Ana Caroline Freitas Caetano de Sousa, Tiago da Silva Teofilo, Ana Carla Diogenes Suassuna Bezerra, Victor Hugo Vieira Rodrigues, Jose Ailton da Silva Filho, Tania Vasconcelos Cavalcante, Kizzy Millenn de Freitas Mendonca Costa, Geysa Almeida Viana
Summary: The main effects of trypanosomosis in Brazil are related to reproductive alterations, with a study in the semiarid region of Northeastern Brazil showing that abortions in goats and sheeps were associated with Trypanosoma vivax infection. PCR analysis identified 100% infection rate of T. vivax in aborted animals, along with the presence of the parasite DNA in the blood of fetuses, confirming congenital transmission. High parasitemia and clinical signs of trypanosomosis were observed in the aborted animals.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Medicinal
Yang Zheng, Magali van den Kerkhof, Tiffany van der Meer, Sheraz Gul, Maria Kuzikov, Bernhard Ellinger, Iwan J. P. de Esch, Marco Siderius, An Matheeussen, Louis Maes, Geert Jan Sterk, Guy Caljon, Rob Leurs
Summary: The discovery of 5-phenylpyrazolopyrimidinone analogs as a novel series of antitrypanosomal agents shows promise for developing new medications to treat Human African Trypanosomiasis (HAT). The most potent compound, 30, has a low toxicity potential and exhibits high in vitro and in vivo antitrypanosomal activity against T. b. brucei.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Koichi Narita, Keisuke Suganuma, Toshihiro Murata, Ryutaro Kondo, Hiroka Satoh, Kazuhiro Watanabe, Kenroh Sasaki, Noboru Inoue, Yuichi Yoshimura
Summary: Research on the synthesized 2,5-diphenyloxazole analogs showed that they exhibited trypanocidal activity against various trypanosome species, with some derivatives showing strong resistance against T. congolense, but also leading to cytotoxicity in cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)