Biotechnological and Pharmacological Applications of Biotoxins and Other Bioactive Molecules from Dinoflagellates

Structures of the Largest Amphidinol Homologues from the Dinoflagellate Amphidinium carterae and Structure–Activity Relationships

(2017) Masayuki Satake et al.   JOURNAL OF NATURAL PRODUCTS

The Missing Piece in Biosynthesis of Amphidinols: First Evidence of Glycolate as a Starter Unit in New Polyketides from Amphidinium carterae

(2017) Adele Cutignano et al.   Marine Drugs

Maitotoxin Is a Potential Selective Activator of the Endogenous Transient Receptor Potential Canonical Type 1 Channel in Xenopus laevis Oocytes

(2017) Pedro Flores et al.   Marine Drugs

Maitotoxin-4, a Novel MTX Analog Produced by Gambierdiscus excentricus

(2017) Francesco Pisapia et al.   Marine Drugs

An Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health Management

(2017) Melissa Friedman et al.   Marine Drugs

Flashing light in microalgae biotechnology

(2016) Said Abu-Ghosh et al.   BIORESOURCE TECHNOLOGY

Pilot-scale bubble column photobioreactor culture of a marine dinoflagellate microalga illuminated with light emission diodes

(2016) L. López-Rosales et al.   BIORESOURCE TECHNOLOGY

Long-term dinoflagellate culture performance in a commercial photobioreactor: Amphidinium carterae case

(2016) C. Fuentes-Grünewald et al.   BIORESOURCE TECHNOLOGY

Search for New Bioactive Marine Natural Products and Application to Drug Development

(2016) Jun’ichi Kobayashi   CHEMICAL & PHARMACEUTICAL BULLETIN

Low dose extended exposure to saxitoxin and its potential neurodevelopmental effects: A review

(2016) Katie O’Neill et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Toxigenic algae and associated phycotoxins in two coastal embayments in the Ebro Delta (NW Mediterranean)

(2016) Julia A. Busch et al.   HARMFUL ALGAE

Two new karlotoxins found in Karlodinium veneficum (strain GM2) from the East China Sea

(2016) Pengjie Cai et al.   HARMFUL ALGAE

Synthesis of the ABCDEF and FGHI ring system of yessotoxin and adriatoxin

(2016) Yuan Zhang et al.   JOURNAL OF ANTIBIOTICS

Paralytic shellfish toxin biosynthesis in cyanobacteria and dinoflagellates: A molecular overview

(2016) Da-Zhi Wang et al.   Journal of Proteomics

Yessotoxin, a Promising Therapeutic Tool

(2016) Amparo Alfonso et al.   Marine Drugs

Paralytic shellfish toxin production by the dinoflagellate Alexandrium pacificum (Chinhae Bay, Korea) in axenic, nutrient-limited chemostat cultures and nutrient-enriched batch cultures

(2016) Myungsoo Han et al.   MARINE POLLUTION BULLETIN

Cytotoxicity of goniodomin A and B in non contractile cells

(2016) Begoña Espiña et al.   TOXICOLOGY LETTERS

First report of goniodomin A production by the dinoflagellate Alexandrium pseudogonyaulax developing in southern Mediterranean (Bizerte Lagoon, Tunisia)

(2016) Habiba Zmerli Triki et al.   TOXICON

Identification of gymnodimine D and presence of gymnodimine variants in the dinoflagellate Alexandrium ostenfeldii from the Baltic Sea

(2016) Kirsi Harju et al.   TOXICON

An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A)

(2016) Diana N. Obanda et al.   Scientific Reports

The Dinoflagellate Toxin 20-Methyl Spirolide-G Potently Blocks Skeletal Muscle and Neuronal Nicotinic Acetylcholine Receptors

(2016) Aurélie Couesnon et al.   Toxins

The Mechanism of Diarrhetic Shellfish Poisoning Toxin Production in Prorocentrum spp.: Physiological and Molecular Perspectives

(2016) Thomas Lee et al.   Toxins

Docking Simulation of the Binding Interactions of Saxitoxin Analogs Produced by the Marine Dinoflagellate Gymnodinium catenatum to the Voltage-Gated Sodium Channel Nav1.4

(2016) Lorena Durán-Riveroll et al.   Toxins

Artificial neural network modeling for predicting the growth of the microalga Karlodinium veneficum

(2016) F. García-Camacho et al.   Algal Research-Biomass Biofuels and Bioproducts

The Vitamin B1 and B12 Required by the Marine Dinoflagellate Lingulodinium polyedrum Can be Provided by its Associated Bacterial Community in Culture

(2016) Ricardo Cruz-López et al.   Frontiers in Microbiology

Pro-inflammatory effects of palytoxin: an in vitro study on human keratinocytes and inflammatory cells

(2016) Marco Pelin et al.   Toxicology Research

A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions

(2016) Siân Baker et al.   Acta Neuropathologica Communications

Yessotoxin, a Marine Toxin, Exhibits Anti-Allergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model

(2016) Araceli Tobío et al.   PLoS One

Stereochemical Studies of the Karlotoxin Class Using NMR Spectroscopy and DP4 Chemical-Shift Analysis: Insights into their Mechanism of Action

(2015) Amanda L. Waters et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The cytotoxic mechanism of karlotoxin 2 (KmTx 2) from Karlodinium veneficum (Dinophyceae)

(2015) Jonathan R. Deeds et al.   AQUATIC TOXICOLOGY

Cultivation of the benthic microalga Prorocentrum lima for the production of diarrhetic shellfish poisoning toxins in a vertical flat photobioreactor

(2015) Shuai Wang et al.   BIORESOURCE TECHNOLOGY

An optimisation approach for culturing shear-sensitive dinoflagellate microalgae in bench-scale bubble column photobioreactors

(2015) L. López-Rosales et al.   BIORESOURCE TECHNOLOGY

Ichthyotoxic Karlodinium veneficum (Ballantine) J Larsen in the Upper Swan River Estuary (Western Australia): Ecological conditions leading to a fish kill

(2015) Jason E. Adolf et al.   HARMFUL ALGAE

Toxic potential of palytoxin

(2015) Jiří Patocka et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Comparing the diel vertical migration of Karlodinium veneficum (dinophyceae) and Chattonella subsalsa (Raphidophyceae): PSII photochemistry, circadian control, and carbon assimilation

(2015) Charles L. Tilney et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Potential Threats Posed by New or Emerging Marine Biotoxins in UK Waters and Examination of Detection Methodologies Used for Their Control: Cyclic Imines

(2015) Keith Davidson et al.   Marine Drugs

Occurrence of Lipophilic Marine Toxins in Shellfish from Galicia (NW of Spain) and Synergies among Them

(2015) Laura Rodríguez et al.   Marine Drugs

Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses

(2015) Jorge Lago et al.   Marine Drugs

Structure Elucidation and in Vitro Toxicity of New Azaspiracids Isolated from the Marine Dinoflagellate Azadinium poporum

(2015) Bernd Krock et al.   Marine Drugs

Marine Polysaccharides from Algae with Potential Biomedical Applications

(2015) Maria de Jesus Raposo et al.   Marine Drugs

Sulforaphane Ameliorates Okadaic Acid-Induced Memory Impairment in Rats by Activating the Nrf2/HO-1 Antioxidant Pathway

(2015) Subhash Dwivedi et al.   MOLECULAR NEUROBIOLOGY

Key role of phosphodiesterase 4A (PDE4A) in autophagy triggered by yessotoxin

(2015) A. Fernández-Araujo et al.   TOXICOLOGY

Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases

(2015) Yipeng Zhao et al.   Toxins

An optimal culture medium for growing Karlodinium veneficum : Progress towards a microalgal dinoflagellate-based bioprocess

(2015) L. López-Rosales et al.   Algal Research-Biomass Biofuels and Bioproducts

Concise synthesis of the A/BCD-ring fragment of gambieric acid A

(2015) Haruhiko Fuwa et al.   Frontiers in Chemistry

Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation

(2014) J. A. Rubiolo et al.   ARCHIVES OF TOXICOLOGY

Direct and Stereospecific Interaction of Amphidinol 3 with Sterol in Lipid Bilayers

(2014) Rafael Atillo Espiritu et al.   BIOCHEMISTRY

Total Synthesis and Complete Structural Assignment of Gambieric Acid A, a Large Polycyclic Ether Marine Natural Product

(2014) Makoto Sasaki et al.   CHEMICAL RECORD

Production of ciguatoxin and maitotoxin by strains of Gambierdiscus australes, G. pacificus and G. polynesiensis (Dinophyceae) isolated from Rarotonga, Cook Islands

(2014) Lesley Rhodes et al.   HARMFUL ALGAE

Evaluation of the effects of light intensity on growth of the benthic dinoflagellate Ostreopsis sp. 1 using a newly developed photoirradiation-culture system and a novel regression analytical method

(2014) Haruo Yamaguchi et al.   HARMFUL ALGAE

Antifungal Amphidinol 18 and Its 7-Sulfate Derivative from the Marine Dinoflagellate Amphidinium carterae

(2014) Genoveffa Nuzzo et al.   JOURNAL OF NATURAL PRODUCTS

Immobilized Growth of the Peridinin-Producing Marine Dinoflagellate Symbiodinium in a Simple Biofilm Photobioreactor

(2014) Ruben Maximilian Benstein et al.   MARINE BIOTECHNOLOGY

Isolation, structural determination and synthetic approaches toward amphidinol 3

(2014) Charlélie Bensoussan et al.   NATURAL PRODUCT REPORTS

Involvement of both sodium influx and potassium efflux in ciguatoxin-induced nodal swelling of frog myelinated axons

(2014) César Mattei et al.   NEUROPHARMACOLOGY

Amphirionin-4 with Potent Proliferation-Promoting Activity on Bone Marrow Stromal Cells from a Marine Dinoflagellate Amphidinium Species

(2014) Mika Minamida et al.   ORGANIC LETTERS

Iriomoteolide-13a, a cytotoxic 22-membered macrolide from a marine dinoflagellate Amphidinium species

(2014) Mai Akakabe et al.   TETRAHEDRON

Amphirionin-5, a novel linear polyketide from a cultured marine dinoflagellate Amphidinium species with a potent cell proliferation-promoting activity

(2014) Mai Akakabe et al.   TETRAHEDRON LETTERS

Yessotoxin triggers ribotoxic stress

(2014) Mónica Suárez Korsnes et al.   TOXICOLOGY IN VITRO

The voltage-gated sodium channel: A major target of marine neurotoxins

(2014) César Mattei et al.   TOXICON

Light emitting diodes (LEDs) applied to microalgal production

(2014) Peter S.C. Schulze et al.   TRENDS IN BIOTECHNOLOGY

Simultaneous Effect of Temperature and Irradiance on Growth and Okadaic Acid Production from the Marine Dinoflagellate Prorocentrum belizeanum

(2014) Lorenzo López-Rosales et al.   Toxins

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

(2014) Vaishali Bane et al.   Toxins

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Modelling of multi-nutrient interactions in growth of the dinoflagellate microalga Protoceratium reticulatum using artificial neural networks

(2013) L. López-Rosales et al.   BIORESOURCE TECHNOLOGY

Yessotoxin induces ER-stress followed by autophagic cell death in glioma cells mediated by mTOR and BNIP3

(2013) J.A. Rubiolo et al.   CELLULAR SIGNALLING

The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state

(2013) Ivan Kopljar et al.   JOURNAL OF GENERAL PHYSIOLOGY

A new potentially toxicAzadiniumspecies (Dinophyceae) from the Mediterranean Sea,A. dexteroporumsp. nov.

(2013) Isabella Percopo et al.   JOURNAL OF PHYCOLOGY

Self-Association of Okadaic Acid: Structural and Pharmacological Significance

(2013) Patricia Cruz et al.   Marine Drugs

Shellfish Toxins Targeting Voltage-Gated Sodium Channels

(2013) Fan Zhang et al.   Marine Drugs

Influence of Environmental Factors on the Paralytic Shellfish Toxin Content and Profile of Alexandrium catenella (Dinophyceae) Isolated from the Mediterranean Sea

(2013) Mohamed Laabir et al.   Marine Drugs

Okadaic Acid: More than a Diarrheic Toxin

(2013) Vanessa Valdiglesias et al.   Marine Drugs

An Overview on the Marine Neurotoxin, Saxitoxin: Genetics, Molecular Targets, Methods of Detection and Ecological Functions

(2013) Kathleen Cusick et al.   Marine Drugs

Okadaic acid induced neurotoxicity: An emerging tool to study Alzheimer's disease pathology

(2013) Pradip K. Kamat et al.   NEUROTOXICOLOGY

Increased Toxicity of Karenia brevis during Phosphate Limited Growth: Ecological and Evolutionary Implications

(2013) Donnie Ransom Hardison et al.   PLoS One

Acute toxicities of saxitoxin, neosaxitoxin, decarbamoyl saxitoxin and gonyautoxins 1&4 and 2&3 to mice by various routes of administration

(2013) Rex Munday et al.   TOXICON

In vitro studies of anti-inflammatory and anticancer activities of organic solvent extracts from cultured marine microalgae

(2013) Kalpa W. Samarakoon et al.   ALGAE

Bioactives from microalgal dinoflagellates

(2012) J. Gallardo-Rodríguez et al.   BIOTECHNOLOGY ADVANCES

Flow cytometry for the development of biotechnological processes with microalgae

(2012) P. Hyka et al.   BIOTECHNOLOGY ADVANCES

Neurological perspectives on voltage-gated sodium channels

(2012) N. Eijkelkamp et al.   BRAIN

Induction of Apoptosis Pathways in Several Cell Lines following Exposure to the Marine Algal Toxin Azaspiracid

(2012) Michael J. Twiner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Effect of Gambierol and Its Tetracyclic and Heptacyclic Analogues in Cultured Cerebellar Neurons: A Structure–Activity Relationships Study

(2012) Sheila Pérez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Marine Algal Toxin Azaspiracid Is an Open-State Blocker of hERG Potassium Channels

(2012) Michael J. Twiner et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

(2012) Irina Vetter et al.   EMBO JOURNAL

Prevalence and persistence of gymnodimines in clams from the Gulf of Gabes (Tunisia) studied by mouse bioassay and LC–MS/MS

(2012) Idriss Ben Naila et al.   HARMFUL ALGAE

Growth and toxicity responses of Mediterranean Ostreopsis cf. ovata to seasonal irradiance and temperature conditions

(2012) Eleonora Scalco et al.   HARMFUL ALGAE

Confirmation of the Absolute Configuration at C45 of Amphidinol 3

(2012) Yoshiyuki Manabe et al.   JOURNAL OF NATURAL PRODUCTS

Total Synthesis and Complete Stereostructure of Gambieric Acid A

(2012) Haruhiko Fuwa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A study on neuroinflammatory marker in brain areas of okadaic acid (ICV) induced memory impaired rats

(2012) Pradeep Kumar Kamat et al.   LIFE SCIENCES

Biomass and Lipid Production of Dinoflagellates and Raphidophytes in Indoor and Outdoor Photobioreactors

(2012) C. Fuentes-Grünewald et al.   MARINE BIOTECHNOLOGY

Production and Isolation of Azaspiracid-1 and -2 from Azadinium spinosum Culture in Pilot Scale Photobioreactors

(2012) Thierry Jauffrais et al.   Marine Drugs

Tetrodotoxin (TTX) as a Therapeutic Agent for Pain

(2012) Francisco Rafael Nieto et al.   Marine Drugs

Comparison of acetylcholine receptor interactions of the marine toxins, 13-desmethylspirolide C and gymnodimine

(2012) Terry A. Hauser et al.   NEUROPHARMACOLOGY

Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity

(2012) J. George et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7)

(2012) J. R. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytotoxicity of yessotoxin and okadaic acid in mouse T lymphocyte cell line EL-4

(2012) Alicia Martín-López et al.   TOXICON

The molecular mystique of tetrodotoxin

(2012) Edward G. Moczydlowski   TOXICON

On the origins and biosynthesis of tetrodotoxin

(2011) Rocky Chau et al.   AQUATIC TOXICOLOGY

The Cholinergic Antagonist Gymnodimine Improves Aβ and Tau Neuropathology in an in Vitro Model of Alzheimer Disease

(2011) Eva Alonso et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Tetrodotoxin alleviates acute heroin withdrawal syndrome: A multicentre, randomized, double-blind, placebo-controlled study

(2011) Hui Song et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Genetic algorithm-based medium optimization for a toxic dinoflagellate microalga

(2011) F. García-Camacho et al.   HARMFUL ALGAE

Alexandrium ostenfeldii growth and spirolide production in batch culture and photobioreactor

(2011) Walid Medhioub et al.   HARMFUL ALGAE

Nitrogen and phosphorus limitation effects on cell growth, biovolume, and toxin production in Ostreopsis cf. ovata

(2011) Silvana Vanucci et al.   HARMFUL ALGAE

Karlodinium veneficum—The little dinoflagellate with a big bite

(2011) Allen R. Place et al.   HARMFUL ALGAE

Maitotoxin: An Inspiration for Synthesis

(2011) K. C. Nicolaou et al.   ISRAEL JOURNAL OF CHEMISTRY

Optimization of growth and production of toxins by three dinoflagellates in photobioreactor cultures

(2011) Veronica Beuzenberg et al.   JOURNAL OF APPLIED PHYCOLOGY

Tetrodotoxin-Bupivacaine-Epinephrine Combinations for Prolonged Local Anesthesia

(2011) Charles B. Berde et al.   Marine Drugs

Comparative Genomic and Transcriptomic Characterization of the Toxigenic Marine Dinoflagellate Alexandrium ostenfeldii

(2011) Nina Jaeckisch et al.   PLoS One

Photobioreactor scale-up for a shear-sensitive dinoflagellate microalga

(2011) F. García Camacho et al.   PROCESS BIOCHEMISTRY

Genomic understanding of dinoflagellates

(2011) Senjie Lin   RESEARCH IN MICROBIOLOGY

Occurrence of 12-methylgymnodimine in a spirolide-producing dinoflagellate Alexandrium peruvianum and the biogenetic implications

(2011) Ryan M. Van Wagoner et al.   TETRAHEDRON LETTERS

Immunoregulatory potential of marine algal toxins yessotoxin and okadaic acid in mouse T lymphocyte cell line EL-4

(2011) Alicia Martín López et al.   TOXICOLOGY LETTERS

Yessotoxin as an apoptotic inducer

(2011) Mónica Suárez Korsnes et al.   TOXICON

Dinoflagellate Genome Evolution

(2010) Jennifer H. Wisecaver et al.   Annual Review of Microbiology

Marine brevetoxin induces IgE-independent mast cell activation

(2010) Susana C. Hilderbrand et al.   ARCHIVES OF TOXICOLOGY

The opening of maitotoxin-sensitive calcium channels induces the acrosome reaction in human spermatozoa: differences from the zona pellucida

(2010) Julio C Chávez et al.   ASIAN JOURNAL OF ANDROLOGY

Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance

(2010) Respati T. Swasono et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin

(2010) Chong Hyun Lee et al.   Channels

Impact of the Pectenotoxin C-43 Oxidation Degree on Its Cytotoxic Effect on Rat Hepatocytes

(2010) Begoña Espiña et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Toxicity comparison between Chattonella marina and Karenia brevis using marine medaka (Oryzias melastigma): Evidence against the suspected ichthyotoxins of Chattonella marina

(2010) Min Shen et al.   CHEMOSPHERE

The expanding role of marine microbes in pharmaceutical development

(2010) Amanda L Waters et al.   CURRENT OPINION IN BIOTECHNOLOGY

Genetic Engineering of Algae for Enhanced Biofuel Production

(2010) Randor Radakovits et al.   EUKARYOTIC CELL

Brevetoxin-2 induces an inflammatory response in an alveolar macrophage cell line

(2010) Kelli M. Sas et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Calcium oscillations induced by gambierol in cerebellar granule cells

(2010) E. Alonso et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Structure and Relative Potency of Several Karlotoxins fromKarlodinium veneficum

(2010) Ryan M. Van Wagoner et al.   JOURNAL OF NATURAL PRODUCTS

Structure and Absolute Configuration of Karlotoxin-2, an Ichthyotoxin from the Marine DinoflagellateKarlodinium veneficum

(2010) Jiangnan Peng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targets and Effects of Yessotoxin, Okadaic Acid and Palytoxin: A Differential Review

(2010) Antonella Franchini et al.   Marine Drugs

Palytoxin and Analogs: Biological and Ecological Effects

(2010) Vítor Ramos et al.   Marine Drugs

Neurotoxic Alkaloids: Saxitoxin and Its Analogs

(2010) Maria Wiese et al.   Marine Drugs

Biosynthesis and Molecular Genetics of Polyketides in Marine Dinoflagellates

(2010) Ralf Kellmann et al.   Marine Drugs

Spiroimine shellfish poisoning (SSP) and the spirolide family of shellfish toxins: Isolation, structure, biological activity and synthesis

(2010) Stéphanie M. Guéret et al.   NATURAL PRODUCT REPORTS

Chemical ecology of the marine plankton

(2010) R. Drew Sieg et al.   NATURAL PRODUCT REPORTS

Esculetin inhibits cell proliferation through the Ras/ERK1/2 pathway in human colon cancer cells

(2010) Moon   ONCOLOGY REPORTS

Culture of dinoflagellates in a fed-batch and continuous stirred-tank photobioreactors: Growth, oxidative stress and toxin production

(2010) J.J. Gallardo Rodríguez et al.   PROCESS BIOCHEMISTRY

Involvement of Caspase Activation in Azaspiracid-Induced Neurotoxicity in Neocortical Neurons

(2010) Zhengyu Cao et al.   TOXICOLOGICAL SCIENCES

Palytoxin action on the Na+,K+-ATPase and the disruption of ion equilibria in biological systems

(2010) Gian Paolo Rossini et al.   TOXICON

Marine Toxins: Chemistry, Toxicity, Occurrence and Detection, with Special Reference to the Dutch Situation

(2010) Arjen Gerssen et al.   Toxins

Brevetoxins 2, 3, 6, and 9 show variability in potency and cause significant induction of DNA damage and apoptosis in Jurkat E6-1 cells

(2009) Rachel N. Murrell et al.   ARCHIVES OF TOXICOLOGY

A renaissance in marine pharmacology: From preclinical curiosity to clinical reality

(2009) Keith B. Glaser et al.   BIOCHEMICAL PHARMACOLOGY

Causes of shear sensitivity of the toxic dinoflagellateProtoceratium reticulatum

(2009) J. J. Gallardo Rodríguez et al.   BIOTECHNOLOGY PROGRESS

Ostreocin-D Impact on Globular Actin of Intact Cells

(2009) Isabel R. Ares et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Engineering algae for biohydrogen and biofuel production

(2009) Laura L Beer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Azadinium spinosumgen. et sp. nov. (Dinophyceae) identified as a primary producer of azaspiracid toxins

(2009) Urban Tillmann et al.   EUROPEAN JOURNAL OF PHYCOLOGY

Haemolytic activity within the species Fibrocapsa japonica (Raphidophyceae)

(2009) M. Karin de Boer et al.   HARMFUL ALGAE

Amphidinolides and Its Related Macrolides from Marine Dinoflagellates

(2009) Jun'ichi Kobayashi   JOURNAL OF ANTIBIOTICS

Synthetic Ciguatoxins Selectively Activate Nav1.8-derived Chimeric Sodium Channels Expressed in HEK293 Cells

(2009) Kaoru Yamaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a Dispiroketal Spirolide Subclass fromAlexandrium ostenfeldii

(2009) Joy S. Roach et al.   JOURNAL OF NATURAL PRODUCTS

Prolonged duration local anesthesia with minimal toxicity

(2009) H. Epstein-Barash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Volume Decrease as a Link between Azaspiracid-Induced Cytotoxicity and c-Jun-N-Terminal Kinase Activation in Cultured Neurons

(2009) Carmen Vale et al.   TOXICOLOGICAL SCIENCES

Yessotoxin inhibits phagocytic activity of macrophages

(2009) Carlotta Francesca Orsi et al.   TOXICON

Advances in monitoring and toxicity assessment of brevetoxins in molluscan shellfish

(2009) Steven M. Plakas et al.   TOXICON

Yessotoxins: A toxicological overview

(2009) A. Tubaro et al.   TOXICON

Okadaic acid promotes angiogenesis via activation of hypoxia-inducible factor-1

(2008) Young-Sun Kim et al.   CANCER LETTERS

Marine toxins and the cytoskeleton: a new view of palytoxin toxicity

(2008) M. Carmen Louzao et al.   FEBS Journal

Marine toxins and the cytoskeleton: azaspiracids

(2008) Natalia Vilariño   FEBS Journal

Marine toxins and the cytoskeleton: pectenotoxins, unusual macrolides that disrupt actin

(2008) Begoña Espiña et al.   FEBS Journal

Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid

(2008) Michael J. Twiner et al.   GENOMICS

Morphogenetic diversity and biotoxin composition of Alexandrium (Dinophyceae) in Irish coastal waters

(2008) Nicolas Touzet et al.   HARMFUL ALGAE

Macronutrients requirements of the dinoflagellate Protoceratium reticulatum

(2008) Juan José Gallardo Rodríguez et al.   HARMFUL ALGAE

Crypthecodinium cohnii with emphasis on DHA production: a review

(2008) Ana Mendes et al.   JOURNAL OF APPLIED PHYCOLOGY

Nuclear Genome Sequence Survey of the DinoflagellateHeterocapsa triquetra

(2008) MICHELLE McEWAN et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

The marine phycotoxin gymnodimine targets muscular and neuronal nicotinic acetylcholine receptor subtypes with high affinity

(2008) Riadh Kharrat et al.   JOURNAL OF NEUROCHEMISTRY

Tetrodotoxin for Moderate to Severe Cancer Pain: A Randomized, Double Blind, Parallel Design Multicenter Study

(2008) Neil A. Hagen et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Influence of Lipid-Soluble Gating Modifier Toxins on Sodium Influx in Neocortical Neurons

(2008) Z. Cao et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effects of in vitro Brevetoxin Exposure on Apoptosis and Cellular Metabolism in a Leukemic T Cell Line (Jurkat)

(2008) Catherine Walsh et al.   Marine Drugs

Yessotoxins, a Group of Marine Polyether Toxins: an Overview

(2008) Beatriz Paz et al.   Marine Drugs

Neurotoxins from Marine Dinoflagellates: A Brief Review

(2008) Da-Zhi Wang   Marine Drugs

Cadherins in development and cancer

(2008) Marc P. Stemmler   Molecular BioSystems

Local infiltration of gonyautoxin is safe and effective in treatment of chronic tension-type headache

(2008) K. Lattes et al.   NEUROLOGICAL RESEARCH

Assignment of the Absolute Configuration of Goniodomin A by NMR Spectroscopy and Synthesis of Model Compounds

(2008) Yoshiyuki Takeda et al.   ORGANIC LETTERS

Brevenal Inhibits Pacific Ciguatoxin-1B-Induced Neurosecretion from Bovine Chromaffin Cells

(2008) César Mattei et al.   PLoS One

Isolation and characterization of karlotoxin 1, a new amphipathic toxin from Karlodinium veneficum

(2008) Ryan M. Van Wagoner et al.   TETRAHEDRON LETTERS

Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels

(2008) Eva Cuypers et al.   TOXICON

Characterization and quantification of karlotoxins by liquid chromatography–mass spectrometry

(2007) Tsvetan R. Bachvaroff et al.   HARMFUL ALGAE