Shellfish Toxins Targeting Voltage-Gated Sodium Channels

Synthesis of palmyrolide A and its cis-isomer and mechanistic insight into trans–cis isomerisation of the enamide macrocycle

(2013) Satish Chandra Philkhana et al.   CHEMICAL COMMUNICATIONS

An Overview on the Marine Neurotoxin, Saxitoxin: Genetics, Molecular Targets, Methods of Detection and Ecological Functions

(2013) Kathleen Cusick et al.   Marine Drugs

Evolution of a Protecting-Group-Free Total Synthesis: Studies en Route to the Neuroactive Marine Macrolide (−)-Palmyrolide A

(2012) Rodolfo Tello-Aburto et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of the Initially Reported and Revised Structures of the Neuroprotective Agent Palmyrolide A

(2012) Andrew D. Wadsworth et al.   ORGANIC LETTERS

Asymmetric Total Synthesis and Absolute Stereochemistry of the Neuroactive Marine Macrolide Palmyrolide A

(2012) Rodolfo Tello-Aburto et al.   ORGANIC LETTERS

Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7)

(2012) J. R. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction

(2011) Karla L. Malloy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 alpha subunits

(2011) Zhengyu Cao et al.   BMC NEUROSCIENCE

Synthesis and Biological Activity of Kalkitoxin and its Analogues

(2011) Taiki Umezawa et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Hoiamide C

(2011) Lei Wang et al.   ORGANIC LETTERS

Mapping the receptor site for  -scorpion toxins on a Na+ channel voltage sensor

(2011) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First report of saxitoxin production by a species of the freshwater benthic cyanobacterium, Scytonema Agardh

(2011) Francine M.J. Smith et al.   TOXICON

Peptide toxins that selectively target insect NaVand CaVchannels

(2010) Glenn F. King et al.   Channels

The Hoiamides, Structurally Intriguing Neurotoxic Lipopeptides from Papua New Guinea Marine Cyanobacteria

(2010) Hyukjae Choi et al.   JOURNAL OF NATURAL PRODUCTS

Crossbyanols A−D, Toxic Brominated Polyphenyl Ethers from the Hawai’ian Bloom-Forming CyanobacteriumLeptolyngbya crossbyana

(2010) Hyukjae Choi et al.   JOURNAL OF NATURAL PRODUCTS

Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders

(2010) Massimo Mantegazza et al.   LANCET NEUROLOGY

On the Chemistry, Toxicology and Genetics of the Cyanobacterial Toxins, Microcystin, Nodularin, Saxitoxin and Cylindrospermopsin

(2010) Leanne Pearson et al.   Marine Drugs

Neurotoxic Alkaloids: Saxitoxin and Its Analogs

(2010) Maria Wiese et al.   Marine Drugs

Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology

(2010) William A. Catterall   NEURON

Electrophysiology and beyond: Multiple roles of Na+ channel β subunits in development and disease

(2010) Gustavo A. Patino et al.   NEUROSCIENCE LETTERS

Palmyrolide A, an Unusually Stabilized Neuroactive Macrolide from Palmyra Atoll Cyanobacteria

(2010) Alban R. Pereira et al.   ORGANIC LETTERS

A renaissance in marine pharmacology: From preclinical curiosity to clinical reality

(2009) Keith B. Glaser et al.   BIOCHEMICAL PHARMACOLOGY

Subtype-selective targeting of voltage-gated sodium channels

(2009) Steve England et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria

(2009) Alban Pereira et al.   CHEMISTRY & BIOLOGY

Palmyramide A, a Cyclic Depsipeptide from a Palmyra Atoll Collection of the Marine CyanobacteriumLyngbya majuscula†

(2009) Masatoshi Taniguchi et al.   JOURNAL OF NATURAL PRODUCTS

Regulation of Persistent Na Current by Interactions between   Subunits of Voltage-Gated Na Channels

(2009) T. K. Aman et al.   JOURNAL OF NEUROSCIENCE

Antillatoxin, a Novel Lipopeptide, Enhances Neurite Outgrowth in Immature Cerebrocortical Neurons through Activation of Voltage-Gated Sodium Channels

(2009) S. V. Jabba et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synthesis of (S)-Jamaicamide C Carboxylic Acid

(2009) Kristin M. Graf et al.   ORGANIC LETTERS

Prolonged duration local anesthesia with minimal toxicity

(2009) H. Epstein-Barash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotoxic cyanobacterial toxins

(2009) Rómulo Aráoz et al.   TOXICON

Voltage-gated Na+channels: Potential for β subunits as therapeutic targets

(2008) William J Brackenbury et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Influence of Lipid-Soluble Gating Modifier Toxins on Sodium Influx in Neocortical Neurons

(2008) Z. Cao et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Characterization of Intracellular and Extracellular Saxitoxin Levels in Both Field and Cultured Alexandrium spp. Samples from Sequim Bay, Washington

(2008) Kathi Lefebvre et al.   Marine Drugs

Neurotoxic Shellfish Poisoning

(2008) Sharon Watkins et al.   Marine Drugs

Neurotoxins from Marine Dinoflagellates: A Brief Review

(2008) Da-Zhi Wang   Marine Drugs

Drug development from marine natural products

(2008) Tadeusz F. Molinski et al.   NATURE REVIEWS DRUG DISCOVERY

Local infiltration of gonyautoxin is safe and effective in treatment of chronic tension-type headache

(2008) K. Lattes et al.   NEUROLOGICAL RESEARCH