Review
Cell Biology
Chenxing Jiang, Tomohiko Okazaki
Summary: Peroxisomes are organelles that play a role in various metabolic pathways. Their biogenesis is controlled by a group of proteins, and mutations in these proteins can cause metabolic disorders. Recent research has shown that peroxisomes are involved in regulating cell apoptosis and fusion processes, and disruption of these processes may be related to the pathogenesis of specific diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vivek Kumar Sharma, Thakur Gurjeet Singh, Shareen Singh, Nikhil Garg, Sonia Dhiman
Summary: Apoptosis is a crucial biochemical process that regulates cell survival and disease progression, particularly in neurodegenerative disorders like Alzheimer's disease. Dysregulated apoptosis can lead to neuronal loss and is a key factor in the pathological progression of the disease. Identifying potential targets related to apoptosis may be valuable in developing therapeutics for Alzheimer's disease.
NEUROCHEMICAL RESEARCH
(2021)
Article
Microbiology
Madeline M. Vroom, Angel Troncoso-Garcia, Alexandrea A. Duscher, Jamie S. Foster
Summary: The study found that modeled microgravity alters the apoptotic cell death process induced by beneficial microbes, by increasing the activity of caspases. However, this increase can be mitigated by using caspase inhibitors, which may have implications for maintaining animal-microbial homeostasis in spaceflight.
Review
Biochemistry & Molecular Biology
Camila Castillo Ferrer, Kevin Berthenet, Gabriel Ichim
Summary: Recent studies have shown that apoptosis, traditionally believed to suppress tumors, may paradoxically promote tumor growth and metastasis in some cases. This phenomenon may be achieved through various mechanisms, including the interaction of apoptotic cells with their microenvironment and the abnormal roles of apoptosis effectors.
Article
Biochemistry & Molecular Biology
Fatma A. M. Mohamed, Hesham A. M. Gomaa, O. M. Hendawy, Asmaa T. Ali, Hatem S. Farghaly, Ahmed M. Gouda, Ahmed H. Abdelazeem, Mostafa H. Abdelrahman, Laurent Trembleau, Bahaa G. M. Youssif
Summary: The new series of EGFR inhibitors showed promising antiproliferative activity against cancer cell lines, with para-substituted phenethyl derivatives displaying superior activity. Some compounds also exhibited potential EGFR inhibitory activity, modulation of apoptosis-related proteins, and cell cycle arrest effects.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Varda Shoshan-Barmatz, Tasleem Arif, Anna Shteinfer-Kuzmine
Summary: Apoptosis is a regulated cell death process that maintains tissue integrity. It involves two major pathways: the extrinsic pathway, activated by external signals, and the intrinsic pathway, activated by DNA damage or stress. However, apoptotic proteins also have non-death-related functions, particularly in non-cancer cells. This review highlights the unconventional roles of apoptotic proteins, focusing on VDAC1 and SMAC/Diablo, mitochondrial proteins that are overexpressed in cancer cells.
Article
Agriculture, Dairy & Animal Science
Boin Lee, Jae-Yeong Kim, Young-Min Choi
Summary: This study investigated the association between the expression levels of apoptosis-related molecules and tenderness variation in Hanwoo beef. The results showed that the combination of apoptotic and anti-apoptotic factors at 45 min post-mortem were associated with beef tenderness attributes. However, the impact of these factors on tenderness diminished at 24 h post-mortem.
Review
Cell Biology
Trang Thi Minh Nguyen, Germain Gillet, Nikolay Popgeorgiev
Summary: The caspase family of cysteine proteases plays critical roles in shaping embryonic structures, particularly in the development of the central nervous system (CNS). Apart from their involvement in apoptosis, caspases are also implicated in various other neurodevelopmental processes, raising questions about how neurons regulate the decision-making between cell death and proper development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Miguel Alpalha, David Botequim, Joao Ferreira, Rene Santus, Paulo Filipe
Summary: Vemurafenib (VB), a BRAF inhibitor used for melanoma, has strong phototoxicity to normal skin cells. Low concentrations of VB can sensitize skin cells to low doses of UVA, leading to decreased cell viability. This phototoxicity is caused by reactive oxygen species (ROS), which result in peroxidation of cellular lipids. In vivo experiments show that UVA-induced VB-photosensitization damages the plasma membrane, mitochondria, endoplasmic reticulum, lysosomes, and actin filaments, leading to mitochondrial impairment, caspase 3/7 activation, and apoptosis.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Julie Bas, Trang Nguyen, Germain Gillet
Summary: Bcl-2 family proteins, known for their role in regulating apoptosis, also have non-canonical functions in the CNS. Bcl-xL, a close homolog of Bcl-2, plays a crucial role in neuronal development, promoting ATP generation in mitochondria and contributing to synaptic transmission without causing cell death. Understanding the roles of cell death machinery in neurons may have important clinical implications for degenerative diseases and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Gautam Sethi, Prangya Rath, Abhishek Chauhan, Anuj Ranjan, Renuka Choudhary, Seema Ramniwas, Katrin Sak, Diwakar Aggarwal, Isha Rani, Hardeep Singh Tuli
Summary: Due to the rising incidence rates of liver cancer and concerns regarding toxicity of current chemotherapy drugs, there is an increasing need for alternative treatment methods. Quercetin, a flavonoid found in fruits, vegetables, and herbs, has shown promising results in inducing apoptotic cell death in cancer cells. It targets apoptosis-related proteins and has the potential for chemoprevention. This review discusses the mechanisms of action, nanodelivery strategies, and other potential cellular effects of quercetin in liver cancer.
Article
Biochemistry & Molecular Biology
Jingjing Pan, Yanfeng Wei, Linlin Ni, Xiaoyang Li, Yu Deng, Bin Xu, Tianyao Yang, Jingyi Sun, Wei Liu
Summary: This study investigates the role of calcium ion (Ca2+) homeostasis in MeHg-induced neurotoxicity. The results suggest that MeHg causes cell damage and increases Ca2+ release from the ER as well as free Ca2+ levels in the cytoplasm and mitochondria. Ca2+ channel inhibitors and Ca2+ chelator can partially inhibit MeHg-induced mitochondrial damage and apoptosis.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Cell Biology
Chung-Yuan Lee, Yi-Hsuan Hsiao, Pei-Ni Chen, Heng-Hsiung Wu, Chih-Yun Lu, Shun-Fa Yang, Po-Hui Wang
Summary: This study investigated the effects and mechanism of action of CLEFMA, a synthetic derivative of curcumin, on cervical cancer cells. The results showed that CLEFMA negatively regulated cell viability and induced apoptosis in cervical cancer cells. Treatment with CLEFMA increased the expression of cleaved caspase-3, cleaved poly(adenosine diphosphate-ribose) polymerase, cleaved caspase-8, and cleaved caspase-9. Co-treatment with inhibitors of ERK1/2 and p38 significantly reduced the expression of cleaved caspase-8, -9, and -3. In conclusion, CLEFMA activates both extrinsic and intrinsic apoptotic pathways through ERK1/2 and p38 signal transduction in cervical cancer cells.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Fisheries
Hao Chen, Xiaomin Wu, Zhaoyan Gu, Shouwen Chen, Xiangshan Zhou, Yuanxing Zhang, Qin Liu, Zhuang Wang, Dahai Yang
Summary: The study revealed that zebrafish Gsdmea/b can be cleaved by different types of caspases, including inflammatory and apoptotic ones. These findings provide insights into the activation mechanism of pyroptosis in zebrafish.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Cell Biology
Barbora Vesela, Michael Killinger, Kamila Rihova, Petr Benes, Eva Svandova, Adela Kratochvilova, Filip Trcka, Karel Kleparnik, Eva Matalova
Summary: In this study, caspase-8 was eliminated in MC3T3-E1 cells using CRISPR/cas9 technology, and the consequences of caspase-8 deficiency on non-apoptotic pathways in osteoblastic cells were investigated. The results showed that caspase-8 deficiency inhibited osteogenic differentiation and affected the expression of osteogenic genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Toxicology
Monica Suarez Korsnes, Hilde Kolstad, Charlotte Ramstad Kleiveland, Reinert Korsnes, Elin Ormen
TOXICOLOGY IN VITRO
(2016)
Article
Oncology
Monica Suarez Korsnes, Reinert Korsnes
FRONTIERS IN ONCOLOGY
(2018)
Article
Toxicology
Monica Suarez Korsnes, Arild Espenes, Dyveke Lem Hetland, Lene C. Hermansen
TOXICOLOGY IN VITRO
(2011)
Article
Toxicology
Monica Suarez Korsnes, Arild Espenes, Lene C. Hermansen, Jared I. Loader, Christopher O. Miles
TOXICOLOGY IN VITRO
(2013)
Article
Toxicology
Monica Suarez Korsnes, Susan Skogtvedt Roed, Michael A. Tranulis, Arild Espenes, Berit Christophersen
TOXICOLOGY IN VITRO
(2014)
Editorial Material
Food Science & Technology
Monica Suarez Korsnes
Review
Pharmacology & Pharmacy
Luca Andrei, Sandor Kasas, Ignacio Ochoa Garrido, Tijana Stankovic, Monica Suarez Korsnes, Radka Vaclavikova, Yehuda G. Assaraf, Milica Pesic
DRUG RESISTANCE UPDATES
(2020)
Article
Cell Biology
Monica Suarez Korsnes, Reinert Korsnes
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2017)
Article
Toxicology
Monica Suarez Korsnes, Dyveke Lem Hetland, Arild Espenes, Tore Aune
TOXICOLOGY IN VITRO
(2007)
Article
Toxicology
Monica Suarez Korsnes, Dyveke Lem Hetland, Arild Espenes, Tore Aune
TOXICOLOGY IN VITRO
(2006)
Article
Toxicology
Monica Suarez Korsnes, Dyveke Lem Hetland, Arild Espenes, Michael A. Tranulis, Tore Aune
TOXICOLOGY IN VITRO
(2006)
Article
Biotechnology & Applied Microbiology
Monica Suarez Korsnes, Reinert Korsnes
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2015)
Article
Pharmacology & Pharmacy
Mohammadhossein Movassaghghazani, Nazanin Shabansalmani
Summary: The study revealed high levels of AFM1 in both breast milk and powdered milk samples in Tehran, with some samples exceeding the established limits. Therefore, monitoring and regulating toxin levels in these products is crucial for maternal and infant health.
Article
Pharmacology & Pharmacy
Defeng Wen, Wantong Han, Quan Chen, Guanhui Qi, Mengling Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qirong Lu, Yinsheng Qiu
Summary: Luteolin can inhibit FB1-induced intestinal inflammatory injury by inhibiting the activation of NF-kappa B and ERK signaling pathways, according to network pharmacology and in vitro experiments.
