Neurological perspectives on voltage-gated sodium channels

De Novo Pathogenic SCN8A Mutation Identified by Whole-Genome Sequencing of a Family Quartet Affected by Infantile Epileptic Encephalopathy and SUDEP

(2012) Krishna R. Veeramah et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia and acromesomelia in a kindred with a novel NaV1.7 mutation

(2012) Janneke G. J. Hoeijmakers et al.   BRAIN

Interaction of Voltage-gated Sodium Channel Nav1.6 (SCN8A) with Microtubule-associated Protein Map1b

(2012) Janelle E. O'Brien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An AnkyrinG-Binding Motif Is Necessary and Sufficient for Targeting Nav1.6 Sodium Channels to Axon Initial Segments and Nodes of Ranvier

(2012) A. Gasser et al.   JOURNAL OF NEUROSCIENCE

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

(2012) Michael S. Minett et al.   Nature Communications

The Quaternary Lidocaine Derivative, QX-314, Exerts Biphasic Effects on Transient Receptor Potential Vanilloid Subtype 1 Channels In Vitro

(2011) Ricardo E. Rivera-Acevedo et al.   ANESTHESIOLOGY

Gene therapy for pain: Results of a phase I clinical trial

(2011) David J. Fink et al.   ANNALS OF NEUROLOGY

Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review

(2011) DP Roberson et al.   BRITISH JOURNAL OF PHARMACOLOGY

On the relationship between block of the cardiac Na+channel and drug-induced prolongation of the QRS complex

(2011) AR Harmer et al.   BRITISH JOURNAL OF PHARMACOLOGY

A comparison of the systemic toxicity of lidocaine versus its quaternary derivative QX-314 in mice

(2011) Helen M. C. Cheung et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Novel Insights into the Pathomechanisms of Skeletal Muscle Channelopathies

(2011) James A. Burge et al.   Current Neurology and Neuroscience Reports

Nav1.1 dysfunction in genetic epilepsy with febrile seizures-plus or Dravet syndrome

(2011) Linda Volkers et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Overexpression of NaV1.6 channels is associated with the invasion capacity of human cervical cancer

(2011) Everardo Hernandez-Plata et al.   INTERNATIONAL JOURNAL OF CANCER

Alternative Splicing Modulates Inactivation of Type 1 Voltage-gated Sodium Channels by Toggling an Amino Acid in the First S3-S4 Linker

(2011) Emily V. Fletcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary β-subunits

(2011) Juan Zhao et al.   JOURNAL OF NEUROPHYSIOLOGY

Voltage-Gated Na+ Channel  1B: A Secreted Cell Adhesion Molecule Involved in Human Epilepsy

(2011) G. A. Patino et al.   JOURNAL OF NEUROSCIENCE

NaV  Subunits Modulate the Inhibition of NaV1.8 by the Analgesic Gating Modifier  O-Conotoxin MrVIB

(2011) M. J. Wilson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mechanism of Ion Permeation and Selectivity in a Voltage Gated Sodium Channel

(2011) Ben Corry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The pharmacological treatment of epilepsy in adults

(2011) Emilio Perucca et al.   LANCET NEUROLOGY

Loss-of-function mutations in sodium channel Nav1.7 cause anosmia

(2011) Jan Weiss et al.   NATURE

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations

(2011) Brian J O'Roak et al.   NATURE GENETICS

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca2+ channel complex

(2011) Joel M Brittain et al.   NATURE MEDICINE

De novo SCN1A mutations in migrating partial seizures of infancy

(2011) D. Carranza Rojo et al.   NEUROLOGY

β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current

(2011) Tobias Huth et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Acid Solution Is a Suitable Medium for Introducing QX-314 into Nociceptors through TRPV1 Channels to Produce Sensory-Specific Analgesic Effects

(2011) He Liu et al.   PLoS One

Structural basis for gating charge movement in the voltage sensor of a sodium channel

(2011) V. Yarov-Yarovoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage-gated calcium channels are not affected by the novel anti-epileptic drug lacosamide

(2011) Yuying Wang et al.   Translational Neuroscience

Na+ Channel ? Subunits: Overachievers of the Ion Channel Family

(2011) William J. Brackenbury et al.   Frontiers in Pharmacology

Lumbar Intrathecal Administration of the Quaternary Lidocaine Derivative, QX-314, Produces Irritation and Death in Mice

(2010) Stephan K. W. Schwarz et al.   ANESTHESIOLOGY

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population

(2010) Pengyun Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Riluzole protects against cardiac ischaemia and reperfusion damage via block of the persistent sodium current

(2010) S Weiss et al.   BRITISH JOURNAL OF PHARMACOLOGY

Trafficking Defects and Gating Abnormalities of a Novel SCN5A Mutation Question Gene-Specific Therapy in Long QT Syndrome Type 3

(2010) Yanfei Ruan et al.   CIRCULATION RESEARCH

Emerging Oral Therapies in Multiple Sclerosis

(2010) Devon Conway et al.   Current Neurology and Neuroscience Reports

The contribution of spasticity to the movement disorder of cerebral palsy using pathway analysis: does spasticity matter?

(2010) JEAN-PIERRE LIN   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons

(2010) Mark Estacion et al.   EXPERIMENTAL NEUROLOGY

Sudden infant death syndrome–associated mutations in the sodium channel beta subunits

(2010) Bi-Hua Tan et al.   HEART RHYTHM

Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations

(2010) James J. Cox et al.   HUMAN MUTATION

Dysfunction of theScn8aVoltage-gated Sodium Channel Alters Sleep Architecture, Reduces Diurnal Corticosterone Levels, and Enhances Spatial Memory

(2010) Ligia A. Papale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In SilicoDocking and Electrophysiological Characterization of Lacosamide Binding Sites on Collapsin Response Mediator Protein-2 Identifies a Pocket Important in Modulating Sodium Channel Slow Inactivation

(2010) Yuying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium channels gone wild: resurgent current from neuronal and muscle channelopathies

(2010) Stephen C. Cannon et al.   JOURNAL OF CLINICAL INVESTIGATION

Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents

(2010) Brian W. Jarecki et al.   JOURNAL OF CLINICAL INVESTIGATION

Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus

(2010) Verena C. Wimmer et al.   JOURNAL OF CLINICAL INVESTIGATION

Ion permeation and block of the gating pore in the voltage sensor of NaV1.4 channels with hypokalemic periodic paralysis mutations

(2010) Stanislav Sokolov et al.   JOURNAL OF GENERAL PHYSIOLOGY

Efficacy Loss of the Anticonvulsant Carbamazepine in Mice Lacking Sodium Channel   Subunits via Paradoxical Effects on Persistent Sodium Currents

(2010) M. Uebachs et al.   JOURNAL OF NEUROSCIENCE

NaV1.1 channels and epilepsy

(2010) William A. Catterall et al.   JOURNAL OF PHYSIOLOGY-LONDON

Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects

(2010) Miriam H. Meisler et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navβ4 peptide-mediated resurgent sodium currents

(2010) Jonathan W. Theile et al.   JOURNAL OF PHYSIOLOGY-LONDON

Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders

(2010) Massimo Mantegazza et al.   LANCET NEUROLOGY

Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial

(2010) Raju Kapoor et al.   LANCET NEUROLOGY

Genetic variation in SCN10A influences cardiac conduction

(2010) John C Chambers et al.   NATURE GENETICS

SCN2A mutation associated with neonatal epilepsy, late-onset episodic ataxia, myoclonus, and pain

(2010) Y. Liao et al.   NEUROLOGY

Electrophysiology and beyond: Multiple roles of Na+ channel β subunits in development and disease

(2010) Gustavo A. Patino et al.   NEUROSCIENCE LETTERS

Voltage-gated sodium channel organization in neurons: Protein interactions and trafficking pathways

(2010) Christophe Leterrier et al.   NEUROSCIENCE LETTERS

Sodium channelopathies of skeletal muscle result from gain or loss of function

(2010) Karin Jurkat-Rott et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Control of transient, resurgent, and persistent current by open-channel block by Na channel  4 in cultured cerebellar granule neurons

(2010) J. S. Bant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional reciprocity between Na+ channel Nav1.6 and  1 subunits in the coordinated regulation of excitability and neurite outgrowth

(2010) W. J. Brackenbury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties

(2009) P. Hakim et al.   Acta Physiologica

A Peripherally Acting Nav1.7 Sodium Channel Blocker Reverses Hyperalgesia and Allodynia on Rat Models of Inflammatory and Neuropathic Pain

(2009) Erin McGowan et al.   ANESTHESIA AND ANALGESIA

Coapplication of Lidocaine and the Permanently Charged Sodium Channel Blocker QX-314 Produces a Long-lasting Nociceptive Blockade in Rodents

(2009) Alexander M. Binshtok et al.   ANESTHESIOLOGY

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia

(2009) Tanya Z. Fischer et al.   ANNALS OF NEUROLOGY

Experience with oral mexiletine in primary erythromelalgia in children

(2009) Javeed Iqbal et al.   ANNALS OF SAUDI MEDICINE

Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice

(2009) Sandra Leo et al.   BEHAVIOURAL BRAIN RESEARCH

Loss-of-function mutation of the SCN3B-encoded sodium channel  3 subunit associated with a case of idiopathic ventricular fibrillation

(2009) C. R. Valdivia et al.   CARDIOVASCULAR RESEARCH

Mutations in Sodium Channel β1- and β2-Subunits Associated With Atrial Fibrillation

(2009) Hiroshi Watanabe et al.   Circulation-Arrhythmia and Electrophysiology

A Mutation in the β3 Subunit of the Cardiac Sodium Channel Associated With Brugada ECG Phenotype

(2009) Dan Hu et al.   Circulation-Cardiovascular Genetics

Cognitive abilities and behaviour of children exposed to antiepileptic drugs in utero

(2009) Rebecca L Bromley et al.   CURRENT OPINION IN NEUROLOGY

Does aSCN1Agene mutation confer earlier age of onset of febrile seizures in GEFS+?

(2009) Angelique E. J. Sijben et al.   EPILEPSIA

SCN1Aduplications and deletions detected in Dravet syndrome: Implications for molecular diagnosis

(2009) Carla Marini et al.   EPILEPSIA

Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: Clinical potential of neonatal Nav1.5 in breast cancer

(2009) Rustem Onkal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antinociceptive effects of systemic lidocaine: Involvement of the spinal glycinergic system

(2009) Uta Muth-Selbach et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mexiletine-responsive erythromelalgia due to a new Nav1.7 mutation showing use-dependent current fall-off

(2009) Jin-Sung Choi et al.   EXPERIMENTAL NEUROLOGY

Targeting voltage-gated sodium channels for pain therapy

(2009) Jeffrey J Clare   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Analysis of the mouse mutantCloth-earsshows a role for the voltage-gated sodium channelScn8ain peripheral neural hearing loss

(2009) F. E. Mackenzie et al.   GENES BRAIN AND BEHAVIOR

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

(2009) Jamie D. Kapplinger et al.   HEART RHYTHM

Protein–protein interactions involving voltage-gated sodium channels: Post-translational regulation, intracellular trafficking and functional expression

(2009) Dongmin Shao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of Podosome Formation in Macrophages by a Splice Variant of the Sodium ChannelSCN8A

(2009) Michael D. Carrithers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Functional Null Mutation of SCN1B in a Patient with Dravet Syndrome

(2009) G. A. Patino et al.   JOURNAL OF NEUROSCIENCE

A PATIENT WITH EPISODIC ATAXIA AND PARAMYOTONIA CONGENITA DUE TO MUTATIONS IN KCNA1 AND SCN4A

(2009) S. Rajakulendran et al.   NEUROLOGY

Elicited repetitive daily blindness: A new phenotype associated with hemiplegic migraine and SCN1A mutations

(2009) K. Vahedi et al.   NEUROLOGY

A riluzole- and valproate-sensitive persistent sodium current contributes to the resting membrane potential and increases the excitability of sympathetic neurones

(2009) J. Antonio Lamas et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties

(2009) Parvez Hakim et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain

(2008) Irene Drizin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Imidazopyridines: A novel class of hNav1.7 channel blockers

(2008) Clare London et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

How do mutant Nav1.1 sodium channels cause epilepsy?

(2008) David S. Ragsdale   BRAIN RESEARCH REVIEWS

Production of a specific extracellular inhibitor of TRPM3 channels

(2008) J Naylor et al.   BRITISH JOURNAL OF PHARMACOLOGY

Riluzole in the Treatment of Mood and Anxiety Disorders

(2008) Christopher Pittenger et al.   CNS DRUGS

Molecular Pharmacodynamics, Clinical Therapeutics, and Pharmacokinetics of Topiramate

(2008) Richard P. Shank et al.   CNS Neuroscience & Therapeutics

Sodium Channel β1 Regulatory Subunit Deficiency Reduces Pancreatic Islet Glucose-Stimulated Insulin and Glucagon Secretion

(2008) Sara J. Ernst et al.   ENDOCRINOLOGY

Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures

(2008) Sunita N. Misra et al.   EPILEPSIA

Calmodulin Regulation of NaV1.4 Current: Role of Binding to the Carboxyl Terminus

(2008) Subrata Biswas et al.   JOURNAL OF GENERAL PHYSIOLOGY

Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain

(2008) Michael E. Kort et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular aspects of the congenital and acquired Long QT Syndrome: Clinical implications

(2008) J.B. Saenen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Self-Limited Hyperexcitability: Functional Effect of a Familial Hemiplegic Migraine Mutation of the Nav1.1 (SCN1A) Na+ Channel

(2008) S. Cestele et al.   JOURNAL OF NEUROSCIENCE

Differential Block of Sensory Neuronal Voltage-Gated Sodium Channels by Lacosamide [(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide], Lidocaine, and Carbamazepine

(2008) P. L. Sheets et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation

(2008) Brian W. Jarecki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Phenytoin protects central axons in experimental autoimmune encephalomyelitis

(2008) Joel A. Black et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Loss of Na+ channel β2 subunits is neuroprotective in a mouse model of multiple sclerosis

(2008) Heather A. O'Malley et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Paroxysmal Extreme Pain Disorder M1627K Mutation in Human Nav1.7 Renders DRG Neurons Hyperexcitable

(2008) Sulayman D Dib-Hajj et al.   Molecular Pain

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Deconstructing voltage sensor function and pharmacology in sodium channels

(2008) Frank Bosmans et al.   NATURE

Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy

(2008) Katherine D. Holland et al.   NEUROSCIENCE LETTERS

Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo

(2008) Y. J. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological disruption of calcium channel trafficking by the  2  ligand gabapentin

(2008) J. Hendrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SCN5A channelopathies – An update on mutations and mechanisms

(2008) Thomas Zimmer et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

(2008) B. Abrahamsen et al.   SCIENCE

New SCN5A mutation in a SUDEP victim with idiopathic epilepsy

(2008) Dag Aurlien et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

GTP up-regulated persistent Na+current and enhanced nociceptor excitability require NaV1.9

(2007) Johan A. R. Östman et al.   JOURNAL OF PHYSIOLOGY-LONDON