Journal
MARINE DRUGS
Volume 15, Issue 6, Pages -Publisher
MDPI AG
DOI: 10.3390/md15060157
Keywords
amphidinol; amphidinol-related polyketide; Amphidinium; dinoflagellate; glycolate; polyketide biosynthesis; PKS; antifungal polyketide; Candida albicans; SHAM
Categories
Funding
- National Research Council of Italy (CNR) [DCM.AD003.051]
- [PON01_00117]
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Two new members of the amphidinol family, amphidinol A (1) and its 7-sulfate derivative amphidinol B (2), were isolated from a strain of Amphidinium carterae of Lake Fusaro, near Naples (Italy), and chemically identified by spectroscopic and spectrometric methods. Amphidinol A showed antifungal activity against Candida albicans (MIC = 19 mu g/mL). Biosynthetic experiments with stable isotope-labelled acetate allowed defining the elongation process in 1. For the first time the use of glycolate as a starter unit in the polyketide biosynthesis of amphidinol metabolites was unambiguously demonstrated.
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