Tetrodotoxin (TTX) as a Therapeutic Agent for Pain

Sodium-Calcium Exchanger and Multiple Sodium Channel Isoforms in Intra-Epidermal Nerve Terminals

(2016) Anna-Karin Persson et al.   Molecular Pain

Increased Expression of Sodium Channel Subunit Nav1.1 in the Injured Dorsal Root Ganglion After Peripheral Nerve Injury

(2011) Wei Wang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Intrathecal lidocaine pretreatment attenuates immediate neuropathic pain by modulating Nav1.3expression and decreasing spinal microglial activation

(2011) Kuang-I Cheng et al.   BMC Neurology

Pain as a global public health priority

(2011) Daniel S Goldberg et al.   BMC PUBLIC HEALTH

A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain

(2011) N. A. Hagen et al.   Current Oncology

NaV1.7 accumulates and co-localizes with phosphorylated ERK1/2 within transected axons in early experimental neuromas

(2011) Anna-Karin Persson et al.   EXPERIMENTAL NEUROLOGY

Identification of Sodium Channel Isoforms That Mediate Action Potential Firing in Lamina I/II Spinal Cord Neurons

(2011) Michael E Hildebrand et al.   Molecular Pain

Neuropathic Nav1.3-Mediated Sensitization to P2X Activation is Regulated by Protein Kinase C

(2011) Gary Mo et al.   Molecular Pain

Re-evaluation of the phenotypic changes in L4 dorsal root ganglion neurons after L5 spinal nerve ligation

(2011) Tetsuo Fukuoka et al.   PAIN

The Roles of Sodium Channels in Nociception: Implications for Mechanisms of Neuropathic Pain

(2011) Min Liu et al.   PAIN MEDICINE

Regulatory role of voltage-gated Na+ channel β subunits in sensory neurons

(2011) Mohamed Chahine   Frontiers in Pharmacology

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Bidirectional modulation of isoflurane potency by intrathecal tetrodotoxin and veratridine in rats

(2010) Y Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin

(2010) Chong Hyun Lee et al.   Channels

Antinociceptive action of carbamazepine on thermal hypersensitive pain at spinal level in a rat model of adjuvant-induced chronic inflammation

(2010) Tatsushige Iwamoto et al.   Journal of Anesthesia

What is this thing called pain?

(2010) Clifford J. Woolf   JOURNAL OF CLINICAL INVESTIGATION

The Tetrodotoxin Binding Site Is within the Outer Vestibule of the Sodium Channel

(2010) Harry A. Fozzard et al.   Marine Drugs

Chemotherapy-induced peripheral neurotoxicity

(2010) Guido Cavaletti et al.   Nature Reviews Neurology

Laminae-specific distribution of alpha-subunits of voltage-gated sodium channels in the adult rat spinal cord

(2010) T. Fukuoka et al.   NEUROSCIENCE

TNF-α contributes to up-regulation of Nav1.3 and Nav1.8 in DRG neurons following motor fiber injury

(2010) Xin-Hua He et al.   PAIN

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Autotomy behavior correlates with the DRG and spinal expression of sodium channels in inbred mouse strains

(2009) Anna-Karin Persson et al.   BRAIN RESEARCH

Increased Peripheral Nerve Excitability and Local Nav1.8 RNA Up-Regulation in Painful Neuropathy

(2009) Devang Kashyap Thakor et al.   Molecular Pain

Differential anti-neuropathic pain effects of tetrodotoxin in sciatic nerve- versus infraorbital nerve-ligated rats – Behavioral, pharmacological and immunohistochemical investigations

(2009) Valérie Kayser et al.   NEUROPHARMACOLOGY

Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models

(2009) W. Xie et al.   NEUROSCIENCE

Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3 and Nav1.8 in trigeminal neuralgia

(2009) S.R.D.T. Siqueira et al.   NEUROSCIENCE

Sodium channel blockers for the treatment of neuropathic pain

(2009) Anindya Bhattacharya et al.   Neurotherapeutics

Two novel SCN9A mutations causing insensitivity to pain

(2009) K. B. Nilsen et al.   PAIN

Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: Studies with selective sigma-1 ligands and sigma-1 knockout mice

(2009) José Manuel Entrena et al.   PAIN

Effects of pre-emptive drug treatment on astrocyte activation in the cuneate nucleus following rat median nerve injury

(2009) Jiann-Jy Chen et al.   PAIN

Voltage-Gated Sodium Channels: Therapeutic Targets for Pain

(2009) Sulayman D. Dib-Hajj et al.   PAIN MEDICINE

Cardiac sodium channelopathies

(2009) Ahmad S. Amin et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas

(2008) Joel A. Black et al.   ANNALS OF NEUROLOGY

Subcutaneous tetrodotoxin and inflammatory pain

(2008) L.F. Alguacil et al.   BRITISH JOURNAL OF ANAESTHESIA

Comparative study of the distribution of the α-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons

(2008) Tetsuo Fukuoka et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Continuous  -Opioid Receptor Activation Reduces Neuronal Voltage-Gated Sodium Channel (NaV1.7) Levels through Activation of Protein Kinase C in Painful Diabetic Neuropathy

(2008) M. Chattopadhyay et al.   JOURNAL OF NEUROSCIENCE

Tetrodotoxin for Moderate to Severe Cancer Pain: A Randomized, Double Blind, Parallel Design Multicenter Study

(2008) Neil A. Hagen et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Proteomic Profiling of Neuromas Reveals Alterations in Protein Composition and Local Protein Synthesis in Hyper-Excitable Nerves

(2008) Hong-Lei Huang et al.   Molecular Pain

Nav1.7 Expression is Increased in Painful Human Dental Pulp

(2008) Songjiang Luo et al.   Molecular Pain

Voltage-gated sodium channel expression in rat and human epidermal keratinocytes: Evidence for a role in pain

(2008) Peng Zhao et al.   PAIN

Localization and Targeting of Voltage-Dependent Ion Channels in Mammalian Central Neurons

(2008) Helene Vacher et al.   PHYSIOLOGICAL REVIEWS

Tetrodotoxin

(2008) Toshio NARAHASHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain

(2007) Iain T. Strickland et al.   EUROPEAN JOURNAL OF PAIN

Transcriptional and functional profiles of voltage-gated Na+ channels in injured and non-injured DRG neurons in the SNI model of neuropathic pain

(2007) Temugin Berta et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice

(2007) Francisco Rafael Nieto et al.   PAIN