Intramolecular activity regulation of adhesion GPCRs in light of recent structural and evolutionary information

Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor

(2023) Jia Duan et al.   Nature Communications

The relaxin receptor RXFP1 signals through a mechanism of autoinhibition

(2023) Sarah C. Erlandson et al.   Nature Chemical Biology

Tethered agonist activated ADGRF1 structure and signalling analysis reveal basis for G protein coupling

(2023) Daniel T. D. Jones et al.   Nature Communications

The adhesion GPCRs CELSR1–3 and LPHN3 engage G proteins via distinct activation mechanisms

(2023) Duy Lan Huong Bui et al.   Cell Reports

GPR114/ADGRG5 is activated by its tethered peptide agonist because it is a cleaved adhesion GPCR

(2023) Tyler F. Bernadyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling

(2023) Yingying Nie et al.   Nature Communications

Ligands and Beyond: Mechanosensitive Adhesion GPCRs

(2022) Hsi-Hsien Lin et al.   Pharmaceuticals

Translating the force—mechano-sensing GPCRs

(2022) Caroline Wilde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of the adhesion G protein–coupled receptor GPR133 by antibodies targeting its N-terminus

(2022) Gabriele Stephan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The tethered peptide activation mechanism of adhesion GPCRs

(2022) Ximena Barros-Álvarez et al.   NATURE

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

(2022) Xiangli Qu et al.   NATURE

Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4

(2022) Peng Xiao et al.   NATURE

Structural basis for the tethered peptide activation of adhesion GPCRs

(2022) Yu-Qi Ping et al.   NATURE

Adhesion G Protein-Coupled Receptors: Structure, Signaling, Physiology and Pathophysiology

(2022) Randy A. Hall et al.   PHYSIOLOGICAL REVIEWS

Pathophysiological impact of the adhesion G protein-coupled receptor family

(2022) Jeanette M. Einspahr et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hormone- and antibody-mediated activation of the thyrotropin receptor

(2022) Jia Duan et al.   NATURE

Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling

(2022) Yu Qian et al.   MOLECULAR CELL

Structures of the ADGRG2–Gs complex in apo and ligand-bound forms

(2022) Hui Lin et al.   Nature Chemical Biology

GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation

(2022) Tai-Ying Chu et al.   Nature Communications

Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism

(2022) James P Bridges et al.   eLife

The evolutionary history and spectral tuning of vertebrate visual opsins

(2022) Joanna F.D. Hagen et al.   DEVELOPMENTAL BIOLOGY

Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

(2021) Yu-Qi Ping et al.   NATURE

Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs

(2021) Minghui Niu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide

(2021) Nicolas A. Heyder et al.   CELL RESEARCH

The Evolutionary History of Vertebrate Adhesion GPCRs and Its Implication on Their Classification

(2021) Aline Wittlake et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis for adhesion G protein-coupled receptor Gpr126 function

(2020) Katherine Leon et al.   Nature Communications

The intramolecular agonist is obligate for activation of glycoprotein hormone receptors

(2020) Annelie Schulze et al.   FASEB JOURNAL

Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology

(2020) Yujing Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in G Protein–Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches

(2020) Torsten Schöneberg et al.   PHARMACOLOGICAL REVIEWS

Revisiting the classification of adhesion GPCRs

(2019) Nicole Scholz et al.   Annals of the New York Academy of Sciences

Genetic basis of functional variability in adhesion G protein-coupled receptors

(2019) Alexander Bernd Knierim et al.   Scientific Reports

Beyond the Ligand: Extracellular and Transcellular G Protein–Coupled Receptor Complexes in Physiology and Pharmacology

(2019) Henry A. Dunn et al.   PHARMACOLOGICAL REVIEWS

Helix 8 is the essential structural motif of mechanosensitive GPCRs

(2019) Serap Erdogmus et al.   Nature Communications

The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts

(2018) Ashref El Buri et al.   Oncotarget

Activation of Adhesion G Protein-coupled Receptors

(2017) Lilian M. Demberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

(2017) Nicole Scholz et al.   eLife

Structural–Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work

(2017) Gunnar Kleinau et al.   Frontiers in Endocrinology

Dating early animal evolution using phylogenomic data

(2017) Martin Dohrmann et al.   Scientific Reports

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist

(2016) Caroline Wilde et al.   FASEB JOURNAL

Endogenous N-terminal Domain Cleavage Modulates α1D-Adrenergic Receptor Pharmacodynamics

(2016) Timothy S. Kountz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors

(2016) Li-Hua Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains

(2016) Gabriel S. Salzman et al.   NEURON

What are they waiting for?—Tethered agonism in G protein-coupled receptors

(2016) Torsten Schöneberg et al.   PHARMACOLOGICAL RESEARCH

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

(2016) Ashish Sethi et al.   Nature Communications

Insights into Basal Signaling Regulation, Oligomerization, and Structural Organization of the Human G-Protein Coupled Receptor 83

(2016) Anne Müller et al.   PLoS One

Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

(2015) Lilian M. Demberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases

(2015) Antje Brüser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

(2015) Sarah C. Petersen et al.   NEURON

JPred4: a protein secondary structure prediction server

(2015) Alexey Drozdetskiy et al.   NUCLEIC ACIDS RESEARCH

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion

(2015) Yue C. Lu et al.   STRUCTURE

Structural and Mechanistic Insights into the Latrophilin3-FLRT3 Complex that Mediates Glutamatergic Synapse Development

(2015) Fanomezana M. Ranaivoson et al.   STRUCTURE

The GPCR repertoire in the demosponge Amphimedon queenslandica: insights into the GPCR system at the early divergence of animals

(2014) Arunkumar Krishnan et al.   BMC EVOLUTIONARY BIOLOGY

Crystal structure of a common GPCR-binding interface for G protein and arrestin

(2014) Michal Szczepek et al.   Nature Communications

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Lung Surfactant Levels are Regulated by Ig-Hepta/GPR116 by Monitoring Surfactant Protein D

(2013) Taku Fukuzawa et al.   PLoS One

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

(2013) D. Wootten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse

(2012) Simone Prömel et al.   DEVELOPMENTAL DYNAMICS

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Crystal structure of metarhodopsin II

(2011) Hui-Woog Choe et al.   NATURE

Chemogenomic Analysis of G-Protein Coupled Receptors and Their Ligands Deciphers Locks and Keys Governing Diverse Aspects of Signalling

(2011) Jörg D. Wichard et al.   PLoS One

Structural insights into adrenergic receptor function and pharmacology

(2011) Brian K. Kobilka   TRENDS IN PHARMACOLOGICAL SCIENCES

Thyrotropin and Homologous Glycoprotein Hormone Receptors: Structural and Functional Aspects of Extracellular Signaling Mechanisms

(2009) Gunnar Kleinau et al.   ENDOCRINE REVIEWS

Definition of the G Protein-Coupled Receptor Transmembrane Bundle Binding Pocket and Calculation of Receptor Similarities for Drug Design

(2009) David E. Gloriam et al.   JOURNAL OF MEDICINAL CHEMISTRY

A G protein-coupled receptor at work: the rhodopsin model

(2009) Klaus Peter Hofmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evolution of Dim-Light and Color Vision Pigments

(2008) Shozo Yokoyama   Annual Review of Genomics and Human Genetics

The Secretin GPCRs Descended from the Family of Adhesion GPCRs

(2008) K. J. V. Nordstrom et al.   MOLECULAR BIOLOGY AND EVOLUTION

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular modeling of the second extracellular loop of G-protein coupled receptors and its implication on structure-based virtual screening

(2007) Chris de Graaf et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS