Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

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Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

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Cryo-EM structure of the AVP–vasopressin receptor 2–Gs signaling complex

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Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit

(2021) Enrica Bianchi et al.   Nature Communications

Molecular basis of ligand recognition and activation of human V2 vasopressin receptor

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The adhesion GPCR Adgrg6 (Gpr126): Insights from the zebrafish model

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Functional impact of intramolecular cleavage and dissociation of adhesion G protein-coupled receptor GPR133 (ADGRD1) on canonical signaling

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Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2

(2021) Qing-Tao He et al.   Nature Communications

Highly accurate protein structure prediction with AlphaFold

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Structure, function and pharmacology of human itch receptor complexes

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Structural basis for adhesion G protein-coupled receptor Gpr126 function

(2020) Katherine Leon et al.   Nature Communications

Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions

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Mechanisms of Adhesion G protein Coupled Receptor Activation

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Structural basis of GPBAR activation and bile acid recognition

(2020) Fan Yang et al.   NATURE

Function and therapeutic potential of GPCRs in epididymis

(2020) Daolai Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

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DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe

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Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology

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Adhesion G protein-coupled receptors: opportunities for drug discovery

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A python script to design site‐directed mutagenesis primers

(2019) Chuyun Bi et al.   PROTEIN SCIENCE

Adhesion G Protein–Coupled Receptors as Drug Targets

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Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

(2018) Hannah M. Stoveken et al.   MOLECULAR PHARMACOLOGY

SWISS-MODEL: homology modelling of protein structures and complexes

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A molecular mechanism for Wnt ligand-specific signaling

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Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility

(2018) Dao-Lai Zhang et al.   eLife

Activation of Adhesion G Protein-coupled Receptors

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MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

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Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

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Getting from A to B—exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112

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The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist

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Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

(2016) Alexander Küffer et al.   NATURE

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

In vitro expression and analysis of the 826 human G protein-coupled receptors

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Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

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CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

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The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

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Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

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Constitutive GαiCoupling Activity of Very Large G Protein-coupled Receptor 1 (VLGR1) and Its Regulation by PDZD7 Protein

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g_mmpbsa—A GROMACS Tool for High-Throughput MM-PBSA Calculations

(2014) Rashmi Kumari et al.   Journal of Chemical Information and Modeling

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

(2014) K. J. Paavola et al.   Science Signaling

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

(2013) D. Wootten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sticky Signaling--Adhesion Class G Protein-Coupled Receptors Take the Stage

(2013) T. Langenhan et al.   Science Signaling

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Signaling property study of adhesion G-protein-coupled receptors

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RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors

(2012) Simone Prömel et al.   Cell Reports

LPA Receptor Heterodimerizes with CD97 to Amplify LPA-Initiated RHO-Dependent Signaling and Invasion in Prostate Cancer Cells

(2011) Y. Ward et al.   CANCER RESEARCH

Disease-associated GPR56 Mutations Cause Bilateral Frontoparietal Polymicrogyria via Multiple Mechanisms

(2011) Nien-Yi Chiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination

(2011) R. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

(2010) Michael P. Bokoch et al.   NATURE

Therapeutic Antibody Targeting of CD97 in Experimental Arthritis: the Role of Antigen Expression, Shedding, and Internalization on the Pharmacokinetics of Anti-CD97 Monoclonal Antibody 1B2

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