Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology

Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins

(2019) Richard Sando et al.   SCIENCE

Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases

(2019) Christopher J. Folts et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Spatial regulation of GPR64/ADGRG2 signaling by β‐arrestins and GPCR kinases

(2019) Pedram Azimzadeh et al.   Annals of the New York Academy of Sciences

Adhesion G Protein–Coupled Receptors as Drug Targets

(2018) Ryan H. Purcell et al.   Annual Review of Pharmacology and Toxicology

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility

(2018) Dao-Lai Zhang et al.   eLife

Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling

(2017) Ayush Kishore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling

(2017) Chun-Hua Liu et al.   Nature Communications

Dopamine Receptor DAMB Signals via Gq to Mediate Forgetting in Drosophila

(2017) Sophie Himmelreich et al.   Cell Reports

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

(2017) Nicole Scholz et al.   eLife

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

(2016) Alex R.B. Thomsen et al.   CELL

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist

(2016) Caroline Wilde et al.   FASEB JOURNAL

Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling

(2016) Elisa Alvarez-Curto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling

(2016) Nariman Balenga et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

(2015) Lilian M. Demberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Application of BRET to monitor ligand binding to GPCRs

(2015) Leigh A Stoddart et al.   NATURE METHODS

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2015) Ines Liebscher et al.   Cell Reports

Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1

(2015) Antje Müller et al.   PLoS Genetics

Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

(2015) Ikuo Masuho et al.   Science Signaling

A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1

(2014) Hong-Mei Wang et al.   DIABETOLOGIA

Constitutive GαiCoupling Activity of Very Large G Protein-coupled Receptor 1 (VLGR1) and Its Regulation by PDZD7 Protein

(2014) Qiao-Xia Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding cadherin EGF LAG seven-pass G-type receptors

(2014) Xiao-Jing Wang et al.   JOURNAL OF NEUROCHEMISTRY

Progress in demystification of adhesion G protein-coupled receptors

(2013) Ines Liebscher et al.   BIOLOGICAL CHEMISTRY

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

(2013) D. Wootten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

The Very Large G Protein Coupled Receptor (Vlgr1) in Hair Cells

(2012) Jin-Peng Sun et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors

(2012) Simone Prömel et al.   Cell Reports

The N Terminus of the Adhesion G Protein-coupled Receptor GPR56 Controls Receptor Signaling Activity

(2011) Kevin J. Paavola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineered luciferases for molecular sensing in living cells

(2009) Brock Binkowski et al.   CURRENT OPINION IN BIOTECHNOLOGY

Structural Determinants of G-protein α Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

(2009) Adam J. Kimple et al.   JOURNAL OF BIOLOGICAL CHEMISTRY