Chemogenomic Analysis of G-Protein Coupled Receptors and Their Ligands Deciphers Locks and Keys Governing Diverse Aspects of Signalling

A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization

(2010) Eelke van der Horst et al.   BMC BIOINFORMATICS

Ligand Binding and Subtype Selectivity of the Human A2AAdenosine Receptor

(2010) Veli-Pekka Jaakola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-specific Conformation of Extracellular Loop-2 in the Angiotensin II Type 1 Receptor

(2010) Hamiyet Unal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric antagonist binding sites in class B GPCRs: corticotropin receptor 1

(2010) Supriyo Bhattacharya et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Evidence that Interaction between Conserved Residues in Transmembrane Helices 2, 3, and 7 Are Crucial for Human VPAC1 Receptor Activation

(2010) A. O. Chugunov et al.   MOLECULAR PHARMACOLOGY

Tracking G-protein-coupled receptor activation using genetically encoded infrared probes

(2010) Shixin Ye et al.   NATURE

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

(2010) Michael P. Bokoch et al.   NATURE

Structural basis of G protein–coupled receptor–G protein interactions

(2010) Jianxin Hu et al.   Nature Chemical Biology

Principles and Determinants of G-Protein Coupling by the Rhodopsin-Like Thyrotropin Receptor

(2010) Gunnar Kleinau et al.   PLoS One

Thyrotropin and Homologous Glycoprotein Hormone Receptors: Structural and Functional Aspects of Extracellular Signaling Mechanisms

(2009) Gunnar Kleinau et al.   ENDOCRINE REVIEWS

Definition of the G Protein-Coupled Receptor Transmembrane Bundle Binding Pocket and Calculation of Receptor Similarities for Drug Design

(2009) David E. Gloriam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of helix 8 in G protein-coupled receptors based on structure–function studies on the type 1 angiotensin receptor

(2009) John Huynh et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Computing Highly Correlated Positions Using Mutual Information and Graph Theory for G Protein-Coupled Receptors

(2009) Sarosh N. Fatakia et al.   PLoS One

A Ligand Channel through the G Protein Coupled Receptor Opsin

(2009) Peter W. Hildebrand et al.   PLoS One

Comparative Sequence and Structural Analyses of G-Protein-Coupled Receptor Crystal Structures and Implications for Molecular Models

(2009) Catherine L. Worth et al.   PLoS One

Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface

(2009) P. Scheerer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural waters define a functional channel mediating activation of the GPCR, rhodopsin

(2009) T. E. Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of New GPCR Biology: One Receptor Structure at a Time

(2009) Michael A. Hanson et al.   STRUCTURE

A G protein-coupled receptor at work: the rhodopsin model

(2009) Klaus Peter Hofmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Multiple Switches in G Protein-Coupled Receptor Activation

(2009) Shivani Ahuja et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Single amino acid of an octopamine receptor as a molecular switch for distinct G protein couplings

(2008) Jia Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein-ligand interaction prediction: an improved chemogenomics approach

(2008) Laurent Jacob et al.   BIOINFORMATICS

G protein βγ subunits: Central mediators of G protein-coupled receptor signaling

(2008) A. V. Smrcka   CELLULAR AND MOLECULAR LIFE SCIENCES

Potential Modes of Interaction of 9-Aminomethyl-9,10-dihydroanthracene (AMDA) Derivatives with the 5-HT2AReceptor: A Ligand Structure-Affinity Relationship, Receptor Mutagenesis and Receptor Modeling Investigation

(2008) Scott P. Runyon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorescence Resonance Energy Transfer Analysis of  2a-Adrenergic Receptor Activation Reveals Distinct Agonist-Specific Conformational Changes

(2008) A. Zurn et al.   MOLECULAR PHARMACOLOGY

Signal transduction: The rhodopsin story continued

(2008) Gebhard F. X. Schertler   NATURE

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor

(2008) Chris J. van Koppen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels

(2008) Anthony J. Harmar et al.   NUCLEIC ACIDS RESEARCH

A Heterozygous Mutation in the Third Transmembrane Domain Causes a Dominant-Negative Effect on Signalling Capability of the MC4R

(2008) Patrick Tarnow et al.   Obesity Facts

Conformational changes involved in G-protein-coupled-receptor activation

(2008) Jürgen Wess et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

New G-protein-coupled receptor crystal structures: insights and limitations

(2008) B KOBILKA et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY