Structural basis for the tethered peptide activation of adhesion GPCRs

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

(2021) Gerti Beliu et al.   MOLECULAR CELL

Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

(2021) Yu-Qi Ping et al.   NATURE

Molecular basis of ligand recognition and activation of human V2 vasopressin receptor

(2021) Fulai Zhou et al.   CELL RESEARCH

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Structures of full-length glycoprotein hormone receptor signalling complexes

(2021) Jia Duan et al.   NATURE

Structure, function and pharmacology of human itch receptor complexes

(2021) Fan Yang et al.   NATURE

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1

(2020) Jasenko Zivanov et al.   IUCrJ

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

(2020) Reid H. J. Olsen et al.   Nature Chemical Biology

Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions

(2020) Andrey D. Bondarev et al.   Expert Opinion on Drug Discovery

Structural basis of GPBAR activation and bile acid recognition

(2020) Fan Yang et al.   NATURE

Structural insights into differences in G protein activation by family A and family B GPCRs

(2020) Daniel Hilger et al.   SCIENCE

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

(2020) Jennifer Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures

(2020) Roberto Melero et al.   IUCrJ

Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant

(2019) Elvira Diamantopoulou et al.   eLife

In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development

(2019) Ethan C. Bradley et al.   Annals of the New York Academy of Sciences

Adhesion G protein-coupled receptors: opportunities for drug discovery

(2019) Frederic Bassilana et al.   NATURE REVIEWS DRUG DISCOVERY

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

(2018) Hannah M. Stoveken et al.   MOLECULAR PHARMACOLOGY

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

A molecular mechanism for Wnt ligand-specific signaling

(2018) Marie Eubelen et al.   SCIENCE

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility

(2018) Dao-Lai Zhang et al.   eLife

Activation of Adhesion G Protein-coupled Receptors

(2017) Lilian M. Demberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

(2017) Nicole Scholz et al.   eLife

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist

(2016) Caroline Wilde et al.   FASEB JOURNAL

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

(2015) Sarah C. Petersen et al.   NEURON

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Covalent docking using autodock: Two-point attractor and flexible side chain methods

(2015) Giulia Bianco et al.   PROTEIN SCIENCE

Generic GPCR residue numbers – aligning topology maps while minding the gaps

(2015) Vignir Isberg et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)

(2014) Ryan T. Strachan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

(2013) D. Wootten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sticky Signaling--Adhesion Class G Protein-Coupled Receptors Take the Stage

(2013) T. Langenhan et al.   Science Signaling

Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse

(2012) Simone Prömel et al.   DEVELOPMENTAL DYNAMICS

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Signaling property study of adhesion G-protein-coupled receptors

(2012) Jamila Gupte et al.   FEBS LETTERS

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY