Ligands and Beyond: Mechanosensitive Adhesion GPCRs

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

(2021) Gerti Beliu et al.   MOLECULAR CELL

Stimulation of Vibratory Urticaria-Associated Adhesion-GPCR, EMR2/ADGRE2, Triggers the NLRP3 Inflammasome Activation Signal in Human Monocytes

(2021) Kuan-Yu I et al.   Frontiers in Immunology

Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions

(2021) Deva Krupakar Kusuluri et al.   iScience

The adhesion GPCR Adgrg6 (Gpr126): Insights from the zebrafish model

(2021) Sarah Baxendale et al.   GENESIS

Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs

(2021) Minghui Niu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of GPR56/ADGRG1 in health and disease

(2021) Abhishek Kumar Singh et al.   Biomedical Journal

CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD

(2021) Ondrej Cerny et al.   PLoS Pathogens

An adhesion G protein-coupled receptor is required in cartilaginous and dense connective tissues to maintain spine alignment

(2021) Zhaoyang Liu et al.   eLife

A guide to adhesion GPCR research

(2021) Ines Liebscher et al.   FEBS Journal

Adhesion G protein–coupled receptor Gpr126/Adgrg6 is essential for placental development

(2021) Rebeca Torregrosa-Carrión et al.   Science Advances

Structural basis for adhesion G protein-coupled receptor Gpr126 function

(2020) Katherine Leon et al.   Nature Communications

A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding

(2020) Tao Li et al.   EMBO JOURNAL

Regulation of body length and bone mass by Gpr126/Adgrg6

(2020) Peng Sun et al.   Science Advances

Mechanisms of Adhesion G protein Coupled Receptor Activation

(2020) Alexander Vizurraga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

(2020) Jennifer Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination

(2020) Sven Dannhäuser et al.   eLife

A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

(2019) Haiwei Chen et al.   CELL

Gpr126 (Adgrg6) is expressed in cell types known to be exposed to mechanical stimuli

(2019) Gentian Musa et al.   Annals of the New York Academy of Sciences

Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases

(2019) Helena Kuivaniemi et al.   GENE

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

(2019) Sarah Irmscher et al.   Nature Communications

The ion channel function of polycystin‐1 in the polycystin‐1/polycystin‐2 complex

(2019) Zhifei Wang et al.   EMBO REPORTS

Mechanosensing through immunoreceptors

(2019) Cheng Zhu et al.   NATURE IMMUNOLOGY

Latrophilins: A Neuro-Centric View of an Evolutionary Conserved Adhesion G Protein-Coupled Receptor Subfamily

(2019) Ana L. Moreno-Salinas et al.   Frontiers in Neuroscience

GAIN domain–mediated cleavage is required for activation of G protein–coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist

(2019) Beika Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Helix 8 is the essential structural motif of mechanosensitive GPCRs

(2019) Serap Erdogmus et al.   Nature Communications

BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation

(2018) Dan Zhu et al.   CANCER CELL

GPR68 Senses Flow and Is Essential for Vascular Physiology

(2018) Jie Xu et al.   CELL

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

(2018) Hannah M. Stoveken et al.   MOLECULAR PHARMACOLOGY

Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

(2018) Stefanie Giera et al.   eLife

Mechano-Dependent Phosphorylation of the PDZ-Binding Motif of CD97/ADGRE5 Modulates Cellular Detachment

(2018) Doris Hilbig et al.   Cell Reports

GPR126 : A novel candidate gene implicated in autosomal recessive intellectual disability

(2018) Masoumeh Hosseini et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

GPR56/ADGRG1 Activation Promotes Melanoma Cell Migration via NTF Dissociation and CTF-Mediated Gα 12/13 /RhoA Signaling

(2017) Nien-Yi Chiang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis

(2017) Guangchun Jin et al.   Oncotarget

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

(2017) Nicole Scholz et al.   eLife

Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways

(2017) Kuan-Yu I et al.   Frontiers in Immunology

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist

(2016) Caroline Wilde et al.   FASEB JOURNAL

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Heparin interacts with the adhesion GPCR GPR56, reduces receptor shedding, and promotes cell adhesion and motility

(2016) Nien-Yi Chiang et al.   JOURNAL OF CELL SCIENCE

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

(2016) Alexander Küffer et al.   NATURE

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains

(2016) Gabriel S. Salzman et al.   NEURON

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

(2016) Steven E. Boyden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients

(2016) Chien-Hao Huang et al.   Scientific Reports

The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells

(2016) Gin-Wen Chang et al.   Cell Reports

The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease

(2016) Marie Trudel et al.   Cells

Mutations of GPR126 Are Responsible for Severe Arthrogryposis Multiplex Congenita

(2015) Gianina Ravenscroft et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Usher syndrome: Hearing loss, retinal degeneration and associated abnormalities

(2015) Pranav Mathur et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Expression of CD11c and EMR2 on neutrophils: potential diagnostic biomarkers for sepsis and systemic inflammation

(2015) S. M. Lewis et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation

(2015) Torsten Schöneberg et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

(2015) Sarah C. Petersen et al.   NEURON

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical biology of human brain development

(2015) Silvia Budday et al.   Frontiers in Cellular Neuroscience

The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation

(2015) Nicole Scholz et al.   Cell Reports

Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo: Role in Polycystic Kidney Disease

(2014) A. Kurbegovic et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanism for Adhesion G Protein-Coupled Receptor GPR56-Mediated RhoA Activation Induced By Collagen III Stimulation

(2014) Rong Luo et al.   PLoS One

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

(2014) J. P. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

(2014) K. J. Paavola et al.   Science Signaling

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Shear Stress-Dependent Downregulation of the Adhesion-G Protein-Coupled Receptor CD97 on Circulating Leukocytes upon Contact with Its Ligand CD55

(2013) O. N. Karpus et al.   JOURNAL OF IMMUNOLOGY

Gpr126 Functions in Schwann Cells to Control Differentiation and Myelination via G-Protein Activation

(2013) A. Mogha et al.   JOURNAL OF NEUROSCIENCE

Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis

(2013) Ikuyo Kou et al.   NATURE GENETICS

Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent

(2013) C. Patra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins

(2013) Simone Prömel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inside-out, outside-in, and inside–outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction

(2012) Bo Shen et al.   CURRENT OPINION IN CELL BIOLOGY

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Schwann cell myelination requires integration of laminin activities

(2012) K. K. McKee et al.   JOURNAL OF CELL SCIENCE

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model

(2012) Y Ward et al.   ONCOGENE

Gpr126 is essential for peripheral nerve development and myelination in mammals

(2011) K. R. Monk et al.   DEVELOPMENT

The N Terminus of the Adhesion G Protein-coupled Receptor GPR56 Controls Receptor Signaling Activity

(2011) Kevin J. Paavola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thy-1 (CD90) Is an Interacting Partner for CD97 on Activated Endothelial Cells

(2011) E. Wandel et al.   JOURNAL OF IMMUNOLOGY

Specific expression of GPR56 by human cytotoxic lymphocytes

(2011) Yen-Ming Peng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination

(2011) R. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR56 is essential for testis development and male fertility in mice

(2010) Guangchun Chen et al.   DEVELOPMENTAL DYNAMICS

Polycystin-1 and -2 Dosage Regulates Pressure Sensing

(2009) Reza Sharif-Naeini et al.   CELL

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

The Secretin GPCRs Descended from the Family of Adhesion GPCRs

(2008) K. J. V. Nordstrom et al.   MOLECULAR BIOLOGY AND EVOLUTION

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adhesion-GPCRs: emerging roles for novel receptors

(2008) Simon Yona et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function

(2007) Simon Yona et al.   FASEB JOURNAL