Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling

The tethered peptide activation mechanism of adhesion GPCRs

(2022) Ximena Barros-Álvarez et al.   NATURE

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

(2022) Xiangli Qu et al.   NATURE

Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4

(2022) Peng Xiao et al.   NATURE

Structural basis for the tethered peptide activation of adhesion GPCRs

(2022) Yu-Qi Ping et al.   NATURE

Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH)

(2022) Xinzhi Li et al.   Nature Communications

Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

(2021) Yu-Qi Ping et al.   NATURE

Cryo-EM structure of the human histamine H1 receptor/Gq complex

(2021) Ruixue Xia et al.   Nature Communications

Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor

(2021) Shanshan Ma et al.   CELL RESEARCH

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Molecular basis for kinin selectivity and activation of the human bradykinin receptors

(2021) Yu-Ling Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantitative assessment of constitutive G protein–coupled receptor activity with BRET-based G protein biosensors

(2021) Hannes Schihada et al.   Science Signaling

Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor

(2021) Yue Wang et al.   Nature Communications

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing

(2021) Ruben Sanchez-Garcia et al.   Communications Biology

GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis

(2021) Kaixin Ding et al.   FASEB JOURNAL

Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism

(2021) Zhenmei Xu et al.   Nature Chemical Biology

The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression

(2021) Xinzhi Li et al.   Nature Communications

Structural basis of ligand recognition and self-activation of orphan GPR52

(2020) Xi Lin et al.   NATURE

CHARMM-GUI supports the Amber force fields

(2020) Jumin Lee et al.   JOURNAL OF CHEMICAL PHYSICS

Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane

(2020) Jie Yin et al.   NATURE

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

(2020) Signe Mathiasen et al.   Nature Chemical Biology

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

(2020) Jia Duan et al.   Nature Communications

Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone

(2020) Dohyun Im et al.   Nature Communications

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

(2019) Kaavya Krishna Kumar et al.   CELL

ADGRL3 (LPHN3) variants predict substance use disorder

(2019) Mauricio Arcos-Burgos et al.   Translational Psychiatry

Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins

(2019) Richard Sando et al.   SCIENCE

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Adhesion G Protein–Coupled Receptors as Drug Targets

(2018) Ryan H. Purcell et al.   Annual Review of Pharmacology and Toxicology

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

(2018) Christopher J. Draper-Joyce et al.   NATURE

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis

(2018) Jasenko Zivanov et al.   IUCrJ

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

(2017) Yi-Lynn Liang et al.   NATURE

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

(2017) Yan Zhang et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

GPCRdb in 2018: adding GPCR structure models and ligands

(2017) Gáspár Pándy-Szekeres et al.   NUCLEIC ACIDS RESEARCH

Mini-G proteins: Novel tools for studying GPCRs in their active conformation

(2017) Rony Nehmé et al.   PLoS One

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

(2016) David M. Thal et al.   NATURE

Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta

(2016) Ray Yu-Ruei Wang et al.   eLife

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Generic GPCR residue numbers – aligning topology maps while minding the gaps

(2015) Vignir Isberg et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

CRTC3 links catecholamine signalling to energy balance

(2010) Youngsup Song et al.   NATURE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY