The adhesion GPCRs CELSR1–3 and LPHN3 engage G proteins via distinct activation mechanisms

Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons

(2023) Daniel T Pederick et al.   eLife

Convergent selective signaling impairment exposes the pathogenicity of latrophilin-3 missense variants linked to inheritable ADHD susceptibility

(2022) Ana L. Moreno-Salinas et al.   MOLECULAR PSYCHIATRY

The tethered peptide activation mechanism of adhesion GPCRs

(2022) Ximena Barros-Álvarez et al.   NATURE

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

(2022) Xiangli Qu et al.   NATURE

Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4

(2022) Peng Xiao et al.   NATURE

Structural basis for the tethered peptide activation of adhesion GPCRs

(2022) Yu-Qi Ping et al.   NATURE

Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands

(2022) Xuchen Zhang et al.   Nature Communications

Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3

(2022) Nicole A. Perry-Hauser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling

(2022) Yu Qian et al.   MOLECULAR CELL

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

(2021) Gerti Beliu et al.   MOLECULAR CELL

Latrophilin GPCR signaling mediates synapse formation

(2021) Richard Sando et al.   eLife

LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion

(2021) Chiara Camillo et al.   JOURNAL OF CELL BIOLOGY

Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance of Migrating Neurons

(2020) Daniel del Toro et al.   CELL

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

(2020) Reid H. J. Olsen et al.   Nature Chemical Biology

New Insights into Arrestin Recruitment to GPCRs

(2020) Martin Spillmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of Adhesion G protein Coupled Receptor Activation

(2020) Alexander Vizurraga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

(2020) Signe Mathiasen et al.   Nature Chemical Biology

A synthetic method to assay adhesion-family G-protein coupled receptors. Determination of the G-protein coupling profile of ADGRG6(GPR126)

(2020) Enric Lizano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins

(2019) Richard Sando et al.   SCIENCE

Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases

(2019) Christopher J. Folts et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors

(2019) Rory K. Morgan et al.   Annals of the New York Academy of Sciences

Alternative splicing event modifying ADGRL1/latrophilin‐1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways

(2019) José‐Carlos Ovando‐Zambrano et al.   Annals of the New York Academy of Sciences

Teneurin-3 controls topographic circuit assembly in the hippocampus

(2018) Dominic S. Berns et al.   NATURE

Lack of beta-arrestin signaling in the absence of active G proteins

(2018) Manuel Grundmann et al.   Nature Communications

Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly

(2017) Garret R. Anderson et al.   JOURNAL OF CELL BIOLOGY

Discovery of new GPCR ligands to illuminate new biology

(2017) Bryan L Roth et al.   Nature Chemical Biology

Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region

(2017) Gabriel S. Salzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seven pass Cadherins CELSR1-3

(2017) Andre M. Goffinet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

(2017) Nicole Scholz et al.   eLife

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist

(2016) Caroline Wilde et al.   FASEB JOURNAL

Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling

(2016) Elisa Alvarez-Curto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)

(2015) Ayush Kishore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion

(2015) Yue C. Lu et al.   STRUCTURE

Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1

(2015) Antje Müller et al.   PLoS Genetics

New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors

(2014) Ines Liebscher et al.   Annals of the New York Academy of Sciences

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

C. elegans fmi-1/flamingo and Wnt pathway components interact genetically to control the anteroposterior neurite growth of the VD GABAergic neurons

(2013) Elvis Huarcaya Najarro et al.   DEVELOPMENTAL BIOLOGY

Planar Cell Polarity Links Axes of Spatial Dynamics in Neural-Tube Closure

(2012) Tamako Nishimura et al.   CELL

Cadherin complexity: recent insights into cadherin superfamily function in C. elegans

(2012) Timothy Loveless et al.   CURRENT OPINION IN CELL BIOLOGY

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Caenorhabditis elegans Flamingo Cadherin fmi-1 Regulates GABAergic Neuronal Development

(2012) E. H. Najarro et al.   JOURNAL OF NEUROSCIENCE

FLRT Proteins Are Endogenous Latrophilin Ligands and Regulate Excitatory Synapse Development

(2012) Matthew L. O'Sullivan et al.   NEURON

The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors

(2012) Simone Prömel et al.   Cell Reports

The core planar cell polarity gene prickle interacts with flamingo to promote sensory axon advance in the Drosophila embryo

(2011) Eli M. Mrkusich et al.   DEVELOPMENTAL BIOLOGY

Cell Adhesion Receptor GPR133 Couples to GsProtein

(2011) Jens Bohnekamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans

(2010) A. Steimel et al.   DEVELOPMENT

The atypical cadherin Flamingo is required for sensory axon advance beyond intermediate target cells

(2008) Martin C. Steinel et al.   DEVELOPMENTAL BIOLOGY

The Cadherin Flamingo Mediates Level-Dependent Interactions that Guide Photoreceptor Target Choice in Drosophila

(2008) Pei-Ling Chen et al.   NEURON