Structures of the ADGRG2–Gs complex in apo and ligand-bound forms

Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism

(2022) Jie Cheng et al.   Cell Metabolism

CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells

(2022) Dan Liu et al.   SCIENCE

The tethered peptide activation mechanism of adhesion GPCRs

(2022) Ximena Barros-Álvarez et al.   NATURE

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

(2022) Xiangli Qu et al.   NATURE

Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4

(2022) Peng Xiao et al.   NATURE

Structural basis for the tethered peptide activation of adhesion GPCRs

(2022) Yu-Qi Ping et al.   NATURE

Progesterone activates GPR126 to promote breast cancer development via the Gi pathway

(2022) Wentao An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

(2021) Yu-Qi Ping et al.   NATURE

Cryo-EM structure of the AVP–vasopressin receptor 2–Gs signaling complex

(2021) Lei Wang et al.   CELL RESEARCH

Molecular basis of ligand recognition and activation of human V2 vasopressin receptor

(2021) Fulai Zhou et al.   CELL RESEARCH

RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development

(2021) Jie Wang et al.   CELL

Structure, function and pharmacology of human itch receptor complexes

(2021) Fan Yang et al.   NATURE

Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions

(2020) Andrey D. Bondarev et al.   Expert Opinion on Drug Discovery

Structural basis of GPBAR activation and bile acid recognition

(2020) Fan Yang et al.   NATURE

Structural insights into differences in G protein activation by family A and family B GPCRs

(2020) Daniel Hilger et al.   SCIENCE

Function and therapeutic potential of GPCRs in epididymis

(2020) Daolai Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of GPR56, a novel adhesion GPCR, is necessary for nuclear androgen receptor signaling in prostate cells

(2020) Julie Pratibha Singh et al.   PLoS One

Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology

(2020) Yujing Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial regulation of GPR64/ADGRG2 signaling by β‐arrestins and GPCR kinases

(2019) Pedram Azimzadeh et al.   Annals of the New York Academy of Sciences

Adhesion G protein-coupled receptors: opportunities for drug discovery

(2019) Frederic Bassilana et al.   NATURE REVIEWS DRUG DISCOVERY

Adhesion G Protein–Coupled Receptors as Drug Targets

(2018) Ryan H. Purcell et al.   Annual Review of Pharmacology and Toxicology

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

(2018) Hannah M. Stoveken et al.   MOLECULAR PHARMACOLOGY

A molecular mechanism for Wnt ligand-specific signaling

(2018) Marie Eubelen et al.   SCIENCE

Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

(2018) Tuoyi Li et al.   Nature Communications

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility

(2018) Dao-Lai Zhang et al.   eLife

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

(2018) Yi-Lynn Liang et al.   NATURE

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Activation of Adhesion G Protein-coupled Receptors

(2017) Lilian M. Demberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Truncating Mutations in the Adhesion G Protein-Coupled Receptor G2 Gene ADGRG2 Cause an X-Linked Congenital Bilateral Absence of Vas Deferens

(2016) Olivier Patat et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GPCR Dynamics: Structures in Motion

(2016) Naomi R. Latorraca et al.   CHEMICAL REVIEWS

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

(2016) Alexander Küffer et al.   NATURE

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions

(2016) Mi-Hye Lee et al.   NATURE

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

(2016) Steven E. Boyden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

(2015) Lilian M. Demberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis

(2013) Ikuyo Kou et al.   NATURE GENETICS

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

(2013) D. Wootten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling property study of adhesion G-protein-coupled receptors

(2012) Jamila Gupte et al.   FEBS LETTERS

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors

(2012) Simone Prömel et al.   Cell Reports

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication

(2010) M Arcos-Burgos et al.   MOLECULAR PSYCHIATRY

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

(2010) Michael P. Bokoch et al.   NATURE

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY