Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism

The tethered peptide activation mechanism of adhesion GPCRs

(2022) Ximena Barros-Álvarez et al.   NATURE

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

(2022) Xiangli Qu et al.   NATURE

Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4

(2022) Peng Xiao et al.   NATURE

Structural basis for the tethered peptide activation of adhesion GPCRs

(2022) Yu-Qi Ping et al.   NATURE

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

(2021) Gerti Beliu et al.   MOLECULAR CELL

Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue

(2021) Anastasia Georgiadi et al.   Nature Communications

Conserved residues in the extracellular loop 2 regulate Stachel-mediated activation of ADGRG2

(2021) Abanoub A. Gad et al.   Scientific Reports

Structural basis of ligand recognition and self-activation of orphan GPR52

(2020) Xi Lin et al.   NATURE

CRITICAL SIGNALING EVENTS IN THE MECHANOACTIVATION OF HUMAN MAST CELLS VIA P.C492Y-ADGRE2

(2020) Andrea N. Naranjo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanisms of Adhesion G protein Coupled Receptor Activation

(2020) Alexander Vizurraga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

(2020) Signe Mathiasen et al.   Nature Chemical Biology

Adhesion-GPCR Gpr116 (ADGRF5) expression inhibits renal acid secretion

(2020) Nathan A. Zaidman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology

(2020) Yujing Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adhesion G-protein coupled receptors: Implications for metabolic function

(2019) Oladapo E. Olaniru et al.   PHARMACOLOGY & THERAPEUTICS

Adhesion G protein-coupled receptors - candidate metabotropic mechanosensors and novel drug targets

(2019) Tobias Langenhan   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

A benchmark study of loop modeling methods applied to G protein-coupled receptors

(2019) Lee H. Wink et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases

(2019) Christopher J. Folts et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia

(2019) Quang T. Le et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Spatial regulation of GPR64/ADGRG2 signaling by β‐arrestins and GPCR kinases

(2019) Pedram Azimzadeh et al.   Annals of the New York Academy of Sciences

Adhesion G protein-coupled receptors: opportunities for drug discovery

(2019) Frederic Bassilana et al.   NATURE REVIEWS DRUG DISCOVERY

GAIN domain–mediated cleavage is required for activation of G protein–coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist

(2019) Beika Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Cell Mechanics: Adhesion G Protein-coupled Receptors in Action?

(2018) Nicole Scholz   Frontiers in Oncology

Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling

(2017) Ayush Kishore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Adhesion G Protein-coupled Receptors

(2017) Lilian M. Demberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPR56/ADGRG1 Activation Promotes Melanoma Cell Migration via NTF Dissociation and CTF-Mediated Gα 12/13 /RhoA Signaling

(2017) Nien-Yi Chiang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

(2017) Nicole Scholz et al.   eLife

Getting from A to B—exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112

(2016) Miriam C. Peeters et al.   FASEB JOURNAL

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist

(2016) Caroline Wilde et al.   FASEB JOURNAL

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

(2016) Steven E. Boyden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications

(2016) Vaclav Cvicek et al.   PLoS Computational Biology

Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

(2015) Lilian M. Demberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration

(2015) Miriam C. Peeters et al.   CELLULAR SIGNALLING

Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)

(2015) Ayush Kishore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium

(2015) Colin Niaudet et al.   PLoS One

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationally engineered Cas9 nucleases with improved specificity

(2015) I. M. Slaymaker et al.   SCIENCE

Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1

(2015) Antje Müller et al.   PLoS Genetics

Generating genetically modified mice using CRISPR/Cas-mediated genome engineering

(2014) Hui Yang et al.   Nature Protocols

Mechanism for Adhesion G Protein-Coupled Receptor GPR56-Mediated RhoA Activation Induced By Collagen III Stimulation

(2014) Rong Luo et al.   PLoS One

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Orphan G Protein–Coupled Receptor GPR116 Regulates Pulmonary Surfactant Pool Size

(2013) James P. Bridges et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Protter: interactive protein feature visualization and integration with experimental proteomic data

(2013) Ulrich Omasits et al.   BIOINFORMATICS

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

Lung Surfactant Levels are Regulated by Ig-Hepta/GPR116 by Monitoring Surfactant Protein D

(2013) Taku Fukuzawa et al.   PLoS One

Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116

(2013) Mi Young Yang et al.   Cell Reports

Lifting the lid on GPCRs: the role of extracellular loops

(2012) M Wheatley et al.   BRITISH JOURNAL OF PHARMACOLOGY

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors

(2012) Simone Prömel et al.   Cell Reports

Alanine Scanning Mutagenesis of the Second Extracellular Loop of Type 1 Corticotropin-Releasing Factor Receptor Revealed Residues Critical for Peptide Binding

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