Translating the force—mechano-sensing GPCRs

TRPV4 and PIEZO Channels Mediate the Mechanosensing of Chondrocytes to the Biomechanical Microenvironment

(2022) Min Zhang et al.   Membranes

Adhesion G protein-coupled receptor VLGR1/ADGRV1 regulates cell spreading and migration by mechanosensing at focal adhesions

(2021) Deva Krupakar Kusuluri et al.   iScience

The Cytoskeleton and Connected Elements in Bone Cell Mechano-Transduction

(2021) Nicole R. Gould et al.   BONE

Substrate Stiffness and Stretch Regulate Profibrotic Mechanosignaling in Pulmonary Arterial Adventitial Fibroblasts

(2021) Ariel Wang et al.   Cells

The molecular makeup of peripheral and central baroreceptors: stretching a role for Transient Receptor Potential (TRP), Epithelial Sodium Channel (ENaC), Acid Sensing Ion Channel (ASIC), and Piezo channels

(2021) Hannah Yang et al.   CARDIOVASCULAR RESEARCH

Structures of full-length glycoprotein hormone receptor signalling complexes

(2021) Jia Duan et al.   NATURE

CRITICAL SIGNALING EVENTS IN THE MECHANOACTIVATION OF HUMAN MAST CELLS VIA P.C492Y-ADGRE2

(2020) Andrea N. Naranjo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel

(2020) Jie Geng et al.   NEURON

The intramolecular agonist is obligate for activation of glycoprotein hormone receptors

(2020) Annelie Schulze et al.   FASEB JOURNAL

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

(2020) Jennifer Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination

(2020) Sven Dannhäuser et al.   eLife

Discoveries in structure and physiology of mechanically activated ion channels

(2020) J. M. Kefauver et al.   NATURE

Adhesion G protein-coupled receptors - candidate metabotropic mechanosensors and novel drug targets

(2019) Tobias Langenhan   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

MAGI1 Mediates eNOS Activation and NO Production in Endothelial Cells in Response to Fluid Shear Stress

(2019) Kedar Ghimire et al.   Cells

HMGB1 enhances mechanical stress-induced cardiomyocyte hypertrophy in�vitro via the RAGE/ERK1/2 signaling pathway

(2019) Lei Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure

(2019) Andras Iring et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic basis of functional variability in adhesion G protein-coupled receptors

(2019) Alexander Bernd Knierim et al.   Scientific Reports

Structure and mechanogating of the mammalian tactile channel PIEZO2

(2019) Li Wang et al.   NATURE

Angiotensin II Type I Receptor Blockade is Associated with Decreased Cutaneous Scar Formation in a Rat Model

(2019) Amanda Murphy et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Mammalian TRP ion channels are insensitive to membrane stretch

(2019) Yury A. Nikolaev et al.   JOURNAL OF CELL SCIENCE

Helix 8 is the essential structural motif of mechanosensitive GPCRs

(2019) Serap Erdogmus et al.   Nature Communications

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

GPR68 Senses Flow and Is Essential for Vascular Physiology

(2018) Jie Xu et al.   CELL

The apelin receptor influences biomechanical and morphological properties of endothelial cells

(2018) Anne Strohbach et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation

(2018) William G. Darby et al.   PHARMACOLOGICAL RESEARCH

Cyclic compressive loading activates angiotensin II type 1 receptor in articular chondrocytes and stimulates hypertrophic differentiation through a G-protein-dependent pathway

(2018) Fumihisa Nakamura et al.   FEBS Open Bio

Protective effects of taurine against inflammation, apoptosis, and oxidative stress in brain injury

(2018) Xiaoli Niu et al.   Molecular Medicine Reports

Coincidence Detection of Membrane Stretch and Extracellular pH by the Proton-Sensing Receptor OGR1 (GPR68)

(2018) Wei-Chun Wei et al.   CURRENT BIOLOGY

Losartan inhibits EGFR transactivation in vascular smooth muscle cells

(2018) Mustafa KIRÇA et al.   Turkish Journal Of Medical Sciences

Inhibition of angiotension II type 1 receptor reduced human endothelial inflammation induced by low shear stress

(2017) Yuelin Chao et al.   EXPERIMENTAL CELL RESEARCH

Low shear stress induces endothelial reactive oxygen species via the AT1R/eNOS/NO pathway

(2017) Yuelin Chao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells

(2017) Paulo W. Pires et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

Mechanosensitivity: From Aristotle's sense of touch to cardiac mechano-electric coupling

(2017) Johann P. Kuhtz-Buschbeck et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

(2017) Nicole Scholz et al.   eLife

How cardiomyocytes sense pathophysiological stresses for cardiac remodeling

(2016) Zaffar K. Haque et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist

(2016) Caroline Wilde et al.   FASEB JOURNAL

Physiological and pathological cardiac hypertrophy

(2016) Ippei Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

(2016) Steven E. Boyden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Forcing open TRP channels: Mechanical gating as a unifying activation mechanism

(2015) Chao Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Identification of Amino Acid Residues in Angiotensin II Type 1 Receptor Sensing Mechanical Stretch and Function in Cardiomyocyte Hypertrophy

(2015) Guoliang Jiang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Architecture of the mammalian mechanosensitive Piezo1 channel

(2015) Jingpeng Ge et al.   NATURE

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

(2015) Sarah C. Petersen et al.   NEURON

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Merkel cells and neurons keep in touch

(2015) Seung-Hyun Woo et al.   TRENDS IN CELL BIOLOGY

The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation

(2015) Nicole Scholz et al.   Cell Reports

Stretch–Activation of Angiotensin II Type 1 a Receptors Contributes to the Myogenic Response of Mouse Mesenteric and Renal Arteries

(2014) Johanna Schleifenbaum et al.   CIRCULATION RESEARCH

Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes

(2014) Sviatoslav N. Bagriantsev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Piezo2 is the major transducer of mechanical forces for touch sensation in mice

(2014) Sanjeev S. Ranade et al.   NATURE

Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors

(2014) Srdjan Maksimovic et al.   NATURE

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

PIEZO2 is required for mechanotransduction in human stem cell–derived touch receptors

(2014) Katrin Schrenk-Siemens et al.   NATURE NEUROSCIENCE

Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+channels

(2014) Stephen G. Brohawn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

(2014) J. P. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Shear stress-induced Ang II AT1 receptor activation: G-protein dependent and independent mechanisms

(2013) Valerio G. Barauna et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Shear Stress-Dependent Downregulation of the Adhesion-G Protein-Coupled Receptor CD97 on Circulating Leukocytes upon Contact with Its Ligand CD55

(2013) O. N. Karpus et al.   JOURNAL OF IMMUNOLOGY

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

(2012) Bongnam Jung et al.   DEVELOPMENTAL CELL

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

APJ acts as a dual receptor in cardiac hypertrophy

(2012) Maria Cecilia Scimia et al.   NATURE

Do TRPC-like currents and G protein-coupled receptors interact to facilitate myogenic tone development?

(2011) Yana Anfinogenova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Interstitial fluid flow and cyclic strain differentially regulate cardiac fibroblast activation via AT1R and TGF-β1

(2011) P.A. Galie et al.   EXPERIMENTAL CELL RESEARCH

KCNQ4 K+ channels tune mechanoreceptors for normal touch sensation in mouse and man

(2011) Matthias Heidenreich et al.   NATURE NEUROSCIENCE

Assessment of contractility in intact ventricular cardiomyocytes using the dimensionless ‘Frank–Starling Gain’ index

(2011) Christian Bollensdorff et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

 -Arrestin-Biased Agonism of the Angiotensin Receptor Induced by Mechanical Stress

(2010) K. Rakesh et al.   Science Signaling

Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells

(2009) Yan-Liang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Extracellular osmolarity modulates G protein-coupled receptor-dependent ATP release from 1321N1 astrocytoma cells

(2009) Andrew E. Blum et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Shear Stress Regulates Angiotensin Type 1 Receptor Expression in Endothelial Cells

(2009) Bhama Ramkhelawon et al.   CIRCULATION RESEARCH

Kinetics of G-protein-coupled receptor signals in intact cells

(2008) M J Lohse et al.   BRITISH JOURNAL OF PHARMACOLOGY

Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation

(2008) Noritaka Yasuda et al.   EMBO REPORTS

Physiologic Properties and Regulation of the Actin Cytoskeleton in Vascular Smooth Muscle

(2008) Dale D. Tang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Mechanical Stretch Induced Interleukin‐18 (IL‐18) Expression through Angiotensin Subtype 1 Receptor (AT1R) and Endothelin‐1 in Cardiomyocytes

(2008) Toshio Naka et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Molecular basis of the mammalian pressure-sensitive ion channels: Focus on vascular mechanotransduction

(2008) Joost H.A. Folgering et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY