GPR114/ADGRG5 is activated by its tethered peptide agonist because it is a cleaved adhesion GPCR

Hexahydroquinoline Derivatives Are Selective Agonists for the Adhesion G Protein-Coupled Receptor ADGRG1/GPR56

(2023) Alexander L. Vizurraga et al.   MOLECULAR PHARMACOLOGY

The tethered peptide activation mechanism of adhesion GPCRs

(2022) Ximena Barros-Álvarez et al.   NATURE

Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1

(2022) Xiangli Qu et al.   NATURE

Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4

(2022) Peng Xiao et al.   NATURE

Structural basis for the tethered peptide activation of adhesion GPCRs

(2022) Yu-Qi Ping et al.   NATURE

Disentangling autoproteolytic cleavage from tethered agonist-dependent activation of the adhesion receptor ADGRL3

(2022) Nicole A. Perry-Hauser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

(2021) Gerti Beliu et al.   MOLECULAR CELL

Mechanisms of Adhesion G protein Coupled Receptor Activation

(2020) Alexander Vizurraga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

(2020) Signe Mathiasen et al.   Nature Chemical Biology

GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

(2020) Jennifer Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR56 Drives Colorectal Tumor Growth and Promotes Drug Resistance through Upregulation of MDR1 Expression via a RhoA-Mediated Mechanism

(2019) Sheng Zhang et al.   MOLECULAR CANCER RESEARCH

Eosinophils and eosinophil-associated diseases: An update

(2018) Jeremy A. O'Sullivan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility

(2018) Dao-Lai Zhang et al.   eLife

The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions

(2018) Cheng-Chih Hsiao et al.   Frontiers in Immunology

Activation of Adhesion G Protein-coupled Receptors

(2017) Lilian M. Demberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eosinophils in Autoimmune Diseases

(2017) Nicola L. Diny et al.   Frontiers in Immunology

The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist

(2016) Caroline Wilde et al.   FASEB JOURNAL

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains

(2016) Gabriel S. Salzman et al.   NEURON

Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

(2015) Lilian M. Demberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

(2015) Sarah C. Petersen et al.   NEURON

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cAMP Promotes Cell Migration Through Cell Junctional Complex Dynamics and Actin Cytoskeleton Remodeling: Implications in Skin Wound Healing

(2015) Mi Ok Kim et al.   STEM CELLS AND DEVELOPMENT

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

(2014) K. J. Paavola et al.   Science Signaling

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

The Druggable Genome: Evaluation of Drug Targets in Clinical Trials Suggests Major Shifts in Molecular Class and Indication

(2013) Mathias Rask-Andersen et al.   Annual Review of Pharmacology and Toxicology

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Specific expression of GPR56 by human cytotoxic lymphocytes

(2011) Yen-Ming Peng et al.   JOURNAL OF LEUKOCYTE BIOLOGY