The Azalea Hypothesis of Alzheimer Disease: A Functional Iron Deficiency Promotes Neurodegeneration

Dysregulation of Iron Metabolism-Linked Genes at Myocardial Tissue and Cell Levels in Dilated Cardiomyopathy

(2023) Ilaria Massaiu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics

(2023) Paula Tena-Morraja et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Iron Metabolism, Lipid Metabolism, and Redox Homeostasis in Alzheimer’s Disease: from the Perspective of Ferroptosis

(2023) Linyu Wu et al.   MOLECULAR NEUROBIOLOGY

Iron response elements (IREs)-mRNA of Alzheimer's amyloid precursor protein binding to iron regulatory protein (IRP1): a combined molecular docking and spectroscopic approach

(2023) Mateen A. Khan et al.   Scientific Reports

Exploring Whether Iron Sequestration within the CNS of Patients with Alzheimer’s Disease Causes a Functional Iron Deficiency That Advances Neurodegeneration

(2023) Steven M. LeVine et al.   Brain Sciences

Aging, Cellular Senescence, and Alzheimer’s Disease

(2022) Rui-Ming Liu   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

APOE ɛ4 dose associates with increased brain iron and β-amyloid via blood–brain barrier dysfunction

(2022) Yuto Uchida et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The amyloid precursor protein: a converging point in Alzheimer’s disease

(2022) Alexandré Delport et al.   MOLECULAR NEUROBIOLOGY

Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy

(2022) Abdel Ali Belaidi et al.   MOLECULAR PSYCHIATRY

Exploring links between 2‐oxoglutarate‐dependent oxygenases and Alzheimer's disease

(2022) Haotian Liu et al.   Alzheimers & Dementia

Iron and Alzheimer’s Disease: From Pathology to Imaging

(2022) Dean Tran et al.   Frontiers in Human Neuroscience

Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion

(2022) Courtney Alexander et al.   MOLECULAR PSYCHIATRY

Associations of cortical iron accumulation with cognition and cerebral atrophy in Alzheimer’s disease

(2022) Aocai Yang et al.   Quantitative Imaging in Medicine and Surgery

Trial of Deferiprone in Parkinson’s Disease

(2022) David Devos et al.   NEW ENGLAND JOURNAL OF MEDICINE

The low ferric chelate reductase activity and high apoplastic pH in leaves cause iron deficiency chlorosis in ‘Huangguan’ pears grafted onto quince A grown in calcareous soil

(2022) Yanyan Zhao et al.   SCIENTIA HORTICULTURAE

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

(2021) Wen-Dai Bao et al.   CELL DEATH AND DIFFERENTIATION

Iron-Deficiency Anemia Results in Transcriptional and Metabolic Remodeling in the Heart Toward a Glycolytic Phenotype

(2021) Yu Jin Chung et al.   Frontiers in Cardiovascular Medicine

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

(2021) Md. Jakaria et al.   JOURNAL OF NEUROCHEMISTRY

Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery

(2021) Bing Bai et al.   Molecular Neurodegeneration

Iron Deficiency Leads to Chlorosis Through Impacting Chlorophyll Synthesis and Nitrogen Metabolism in Areca catechu L.

(2021) Jia Li et al.   Frontiers in Plant Science

Role of PITRM1 in Mitochondrial Dysfunction and Neurodegeneration

(2021) Dario Brunetti et al.   Biomedicines

Iron Responsive Element-Mediated Responses to Iron Dyshomeostasis in Alzheimer’s Disease

(2021) Nhi Hin et al.   JOURNAL OF ALZHEIMERS DISEASE

Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology

(2021) Ridha Alnuwaysir et al.   Journal of Clinical Medicine

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

(2020) Ross A. Weber et al.   MOLECULAR CELL

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis

(2020) Azhaar Ashraf et al.   Redox Biology

Amyloidogenic processing of Alzheimer’s disease β-amyloid precursor protein induces cellular iron retention

(2020) Andrew Tsatsanis et al.   MOLECULAR PSYCHIATRY

The roles of iron and HFE genotype in neurological diseases

(2020) Yunsung Kim et al.   MOLECULAR ASPECTS OF MEDICINE

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids

(2020) María José Pérez et al.   MOLECULAR PSYCHIATRY

Iron loss triggers mitophagy through induction of mitochondrial ferritin

(2020) Yuichi Hara et al.   EMBO REPORTS

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

(2020) Raffaella Nativio et al.   NATURE GENETICS

Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease

(2020) Karissa Barthelson et al.   Molecular Brain

Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks

(2020) Paola Pizzo et al.   Cells

Targeting the Iron-Response Elements of the mRNAs for the Alzheimer’s Amyloid Precursor Protein and Ferritin to Treat Acute Lead and Manganese Neurotoxicity

(2019) Jack Rogers et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association Between Earliest Amyloid Uptake and Functional Connectivity in Cognitively Unimpaired Elderly

(2019) Andreas Hahn et al.   CEREBRAL CORTEX

Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds

(2019) Li Gong et al.   CELL TRANSPLANTATION

Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99)

(2019) Jiang Ying et al.   JOURNAL OF NEUROSCIENCE

Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

(2019) Strowitzki et al.   Cells

Brain iron transport

(2019) Zhong‐Ming Qian et al.   BIOLOGICAL REVIEWS

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

(2019) King Faisal Yambire et al.   eLife

Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates with Decreased Cognitive Function in Alzheimer’s Disease

(2018) Lei Du et al.   ACS Chemical Neuroscience

Biosynthesis of human myeloperoxidase

(2018) William M. Nauseef   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH

(2018) Hari Prasad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

(2018) Shashank Masaldan et al.   Redox Biology

Ageing, Cellular Senescence and Neurodegenerative Disease

(2018) Marios Kritsilis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Decreased Proteolytic Activity of the Mitochondrial Amyloid-β Degrading Enzyme, PreP Peptidasome, in Alzheimer's Disease Brain Mitochondria

(2018) Nyosha Alikhani et al.   JOURNAL OF ALZHEIMERS DISEASE

Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects

(2018) Xia Xiao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The human iron-proteome

(2018) Claudia Andreini et al.   Metallomics

Untangling Tau and Iron: Exploring the Interaction Between Iron and Tau in Neurodegeneration

(2018) Shalini S. Rao et al.   Frontiers in Molecular Neuroscience

Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer’s Disease

(2018) Amanda L. Lumsden et al.   Frontiers in Neuroscience

Chronic energy depletion due to iron deficiency impairs dendritic mitochondrial motility during hippocampal neuron development

(2018) Thomas W. Bastian et al.   JOURNAL OF NEUROSCIENCE

Adaptation to iron deficiency and high pH in evergreen azaleas (Rhododendron spp.): potential resources for breeding

(2017) Sonia Demasi et al.   EUPHYTICA

Cortical Iron Reflects Severity of Alzheimer’s Disease

(2017) Sara van Duijn et al.   JOURNAL OF ALZHEIMERS DISEASE

The elemental role of iron in DNA synthesis and repair

(2017) Sergi Puig et al.   Metallomics

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Progressive modulation of the human olfactory bulb transcriptome during Alzheimer´s disease evolution: novel insights into the olfactory signaling across proteinopathies

(2017) Mercedes Lachen-Montes et al.   Oncotarget

Jmjd6, a JmjC Dioxygenase with Many Interaction Partners and Pleiotropic Functions

(2017) Janice Kwok et al.   Frontiers in Genetics

Enhanced Histochemical Detection of Iron in Paraffin Sections of Mouse Central Nervous System Tissue

(2016) Scott A. Sands et al.   ASN Neuro

Mitochondria and Synaptic Plasticity in the Mature and Aging Nervous System

(2016) Vyara Todorova et al.   Current Neuropharmacology

Endothelial nitric oxide synthase: From biochemistry and gene structure to clinical implications of NOS3 polymorphisms

(2016) Gustavo H. Oliveira-Paula et al.   GENE

Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes

(2016) He Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

Iron Deprivation Induces Transcriptional Regulation of Mitochondrial Biogenesis

(2016) Jarred W. Rensvold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Experience With Deferiprone Treatment for Friedreich Ataxia

(2016) Sandra Elincx-Benizri et al.   JOURNAL OF CHILD NEUROLOGY

Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex

(2016) Dominic J. Hare et al.   NEUROIMAGE

JMJD6 and U2AF65 co-regulate alternative splicing in both JMJD6 enzymatic activity dependent and independent manner

(2016) Jia Yi et al.   NUCLEIC ACIDS RESEARCH

Fe2+binding on amyloid β-peptide promotes aggregation

(2016) Subramaniam Boopathi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific

(2016) Ioannis Dafnis et al.   Scientific Reports

Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment

(2016) J. M. G. van Bergen et al.   Scientific Reports

Metabolism and epigenetics in the nervous system: Creating cellular fitness and resistance to neuronal death in neurological conditions via modulation of oxygen-, iron-, and 2-oxoglutarate-dependent dioxygenases

(2015) Saravanan S. Karuppagounder et al.   BRAIN RESEARCH

Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats

(2015) Terrance D Barrett et al.   BRITISH JOURNAL OF PHARMACOLOGY

Defective PITRM1 mitochondrial peptidase is associated with A  amyloidotic neurodegeneration

(2015) D. Brunetti et al.   EMBO Molecular Medicine

Age-related changes of brain iron load changes in the frontal cortex in APPswe/PS1ΔE9 transgenic mouse model of Alzheimer's disease

(2015) Dong Xian-hui et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite

(2015) Luciano F. Huergo et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

(2015) Scott Ayton et al.   Nature Communications

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Complex regulation of γ-secretase: from obligatory to modulatory subunits

(2015) Natalya Gertsik et al.   Frontiers in Aging Neuroscience

Deferiprone in Friedreich ataxia: A 6-Month randomized controlled trial

(2014) Massimo Pandolfo et al.   ANNALS OF NEUROLOGY

Iron Chelation and Multiple Sclerosis

(2014) Kelsey J. Weigel et al.   ASN Neuro

Mitochondrial import and degradation of amyloid-β peptide

(2014) Catarina Moreira Pinho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

MRI for Iron Mapping in Alzheimer's Disease

(2014) Christian Langkammer et al.   Neurodegenerative Diseases

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Shredding the signal: targeting peptide degradation in mitochondria and chloroplasts

(2014) Beata Kmiec et al.   TRENDS IN PLANT SCIENCE

Iron availability modulates aberrant splicing of ferrochelatase through the iron- and 2-oxoglutarate dependent dioxygenase Jmjd6 and U2AF65

(2013) Jasmin Barman-Aksözen et al.   BLOOD CELLS MOLECULES AND DISEASES

The essential nature of iron usage and regulation

(2013) Jerry Kaplan et al.   CURRENT BIOLOGY

Key Role of Mitochondria in Alzheimer’s Disease Synaptic Dysfunction

(2013) Virve Cavallucci et al.   CURRENT PHARMACEUTICAL DESIGN

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

(2013) Devin M. Wolfe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders

(2013) H. Nam et al.   HAEMATOLOGICA

Comparison of Histological Techniques to Visualize Iron in Paraffin-embedded Brain Tissue of Patients with Alzheimer’s Disease

(2013) Sara van Duijn et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Mitochondrial ferritin in neurodegenerative diseases

(2013) Hongkuan Yang et al.   NEUROSCIENCE RESEARCH

Assembly factors for the membrane arm of human complex I

(2013) B. Andrews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A delicate balance: Iron metabolism and diseases of the brain

(2013) Dominic Hare et al.   Frontiers in Aging Neuroscience

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

(2013) Animesh Raha et al.   Acta Neuropathologica Communications

Iron Uptake, Translocation, and Regulation in Higher Plants

(2012) Takanori Kobayashi et al.   Annual Review of Plant Biology

Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain

(2012) Chuang Guo et al.   NEUROCHEMISTRY INTERNATIONAL

Single particle analysis of tau oligomer formation induced by metal ions and organic solvents

(2011) Benedikt Bader et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Iron MediatesN-Methyl-d-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity

(2011) Pablo Muñoz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells

(2011) T. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

Expression and Localization of Mitochondrial Ferritin mRNA in Alzheimer's Disease Cerebral Cortex

(2011) Ligang Wang et al.   PLoS One

Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulationThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Or Kakhlon et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1

(2010) Hyun-Hee Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron Homeostasis and Its Interaction with Prolyl Hydroxylases

(2009) David R. Mole   ANTIOXIDANTS & REDOX SIGNALING

Iron uptake mechanisms in plants: Functions of the FRO family of ferric reductases

(2009) Jeeyon Jeong et al.   PLANT SCIENCE

Homing in on iron homeostasis in plants

(2009) Jeeyon Jeong et al.   TRENDS IN PLANT SCIENCE

Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

(2008) Jack T. Rogers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS