Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids

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Microglia innately develop within cerebral organoids

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Defective PITRM1 mitochondrial peptidase is associated with A  amyloidotic neurodegeneration

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Cerebral organoids model human brain development and microcephaly

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Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

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The metalloendopeptidase genePitrm1is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors

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The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

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