Iron Chelation and Multiple Sclerosis

Clioquinol Decreases Amyloid-β Burden and Reduces Working Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

(2017) Cristina Grossi et al.   JOURNAL OF ALZHEIMERS DISEASE

Treatment of Classic Pantothenate Kinase–Associated Neurodegeneration with Deferiprone and Intrathecal Baclofen

(2013) Napala R. Pratini et al.   AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION

Pathophysiology and Treatment of Neurodegeneration With Brain Iron Accumulation in the Pediatric Population

(2013) Susanne A. Schneider et al.   Current Treatment Options in Neurology

Chronic intranasal deferoxamine ameliorates motor defects and pathology in the α-synuclein rAAV Parkinson's model

(2013) Fabia Febbraro et al.   EXPERIMENTAL NEUROLOGY

Iron accumulation in multiple sclerosis: an early pathogenic event

(2013) Steven M LeVine et al.   Expert Review of Neurotherapeutics

Lipophilic adamantyl- or deferasirox-based conjugates of desferrioxamine B have enhanced neuroprotective capacity: implications for Parkinson disease

(2013) Jeffrey R. Liddell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

(2013) Orly Weinreb et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute-Phase Protein Hemopexin Is a Negative Regulator of Th17 Response and Experimental Autoimmune Encephalomyelitis Development

(2013) S. Rolla et al.   JOURNAL OF IMMUNOLOGY

Co-enzyme Q10and idebenone use in Friedreich's ataxia

(2013) Michael H Parkinson et al.   JOURNAL OF NEUROCHEMISTRY

Glucocorticoid Protection of Oligodendrocytes against Excitotoxin Involving Hypoxia-Inducible Factor-1  in a Cell-Type-Specific Manner

(2013) Y.-Y. Sun et al.   JOURNAL OF NEUROSCIENCE

Visualizing iron in multiple sclerosis

(2013) Francesca Bagnato et al.   MAGNETIC RESONANCE IMAGING

Copper/zinc chelation by clioquinol reduces spinal cord white matter damage and behavioral deficits in a murine MOG-induced multiple sclerosis model

(2013) Bo Young Choi et al.   NEUROBIOLOGY OF DISEASE

Hypoxia inducible factor-1α mediates iron uptake which induces inflammatory response in amoeboid microglial cells in developing periventricular white matter through MAP kinase pathway

(2013) Gurugirijha Rathnasamy et al.   NEUROPHARMACOLOGY

Iron Is a Sensitive Biomarker for Inflammation in Multiple Sclerosis Lesions

(2013) Veela Mehta et al.   PLoS One

A delicate balance: Iron metabolism and diseases of the brain

(2013) Dominic Hare et al.   Frontiers in Aging Neuroscience

Mitochondrial dysfunction and neurodegeneration in multiple sclerosis

(2013) Kimmy Su et al.   Frontiers in Physiology

Targeting B cells in the treatment of multiple sclerosis: recent advances and remaining challenges

(2013) Klaus Lehmann-Horn et al.   Therapeutic Advances in Neurological Disorders

Perihematomal glutamate level is associated with the blood–brain barrier disruption in a rabbit model of intracerebral hemorrhage

(2013) Guofeng Wu et al.   SpringerPlus

Update on a Patient with Superficial Siderosis on Deferiprone: Fig 1.

(2012) M. Levy et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Iron Deposition on SWI-Filtered Phase in the Subcortical Deep Gray Matter of Patients with Clinically Isolated Syndrome May Precede Structure-Specific Atrophy

(2012) J. Hagemeier et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

The role of iron as a mediator of oxidative stress in Alzheimer disease

(2012) Rudy J. Castellani et al.   BIOFACTORS

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Role of the NMDA receptor and iron on free radical production and brain damage following transient middle cerebral artery occlusion

(2012) Doo Soon Im et al.   BRAIN RESEARCH

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia

(2012) Neetu Singh et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-α and TGF-β1

(2012) Khizr I. Rathore et al.   GLIA

DNA triplex structures in neurodegenerative disorder, Friedreich’s ataxia

(2012) Moganty R Rajeswari   JOURNAL OF BIOSCIENCES

Design and Synthesis of Fluorinated Iron Chelators for Metabolic Study and Brain Uptake

(2012) Yongmin Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

The conundrum of iron in multiple sclerosis – time for an individualised approach

(2012) Susan J. van Rensburg et al.   METABOLIC BRAIN DISEASE

Iron–sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia

(2012) Rachael A. Vaubel et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Increased iron accumulation occurs in the earliest stages of demyelinating disease: an ultra-high field susceptibility mapping study in Clinically Isolated Syndrome

(2012) Ali M Al-Radaideh et al.   Multiple Sclerosis Journal

Iron content of the pulvinar nucleus of the thalamus is increased in adolescent multiple sclerosis

(2012) Jesper Hagemeier et al.   Multiple Sclerosis Journal

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

(2012) Chuang Guo et al.   NEUROBIOLOGY OF AGING

Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain

(2012) Chuang Guo et al.   NEUROCHEMISTRY INTERNATIONAL

Iron chelation therapy in the management of transfusion-related cardiac iron overload

(2012) Juliano Lara Fernandes   TRANSFUSION

Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice

(2012) J. M. Fine et al.   EXPERIMENTAL BRAIN RESEARCH

Intranasal delivery of deferoxamine reduces spatial memory loss in APP/PS1 mice

(2012) Leah R. Hanson et al.   Drug Delivery and Translational Research

Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94

(2011) Jin Hyen Baek et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Prevalence of celiac disease in multiple sclerosis

(2011) Luis Rodrigo et al.   BMC Neurology

Iron deposition is independent of cellular inflammation in a cerebral model of multiple sclerosis

(2011) Rachel Williams et al.   BMC NEUROSCIENCE

Tracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla

(2011) F. Bagnato et al.   BRAIN

A pilot trial of deferiprone for neurodegeneration with brain iron accumulation

(2011) G. Abbruzzese et al.   HAEMATOLOGICA

Deferiprone modulates in vitro responses by peripheral blood T cells from control and relapsing–remitting multiple sclerosis subjects

(2011) Matthew E. Sweeney et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Glutamate and ATP signalling in white matter pathology

(2011) Carlos Matute   JOURNAL OF ANATOMY

Prophylactic neuroprotection against stroke: Low-dose, prolonged treatment with deferoxamine or deferasirox establishes prolonged neuroprotection independent of HIF-1 function

(2011) Yanxin Zhao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimer’s disease

(2011) Hans Lassmann   JOURNAL OF NEURAL TRANSMISSION

Pathogenic implications of iron accumulation in multiple sclerosis

(2011) Rachel Williams et al.   JOURNAL OF NEUROCHEMISTRY

Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains

(2011) Zhiren Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Iron Efflux from Oligodendrocytes Is Differentially Regulated in Gray and White Matter

(2011) K. Schulz et al.   JOURNAL OF NEUROSCIENCE

Iron and Iron Regulatory Proteins in Amoeboid Microglial Cells Are Linked to Oligodendrocyte Death in Hypoxic Neonatal Rat Periventricular White Matter through Production of Proinflammatory Cytokines and Reactive Oxygen/Nitrogen Species

(2011) G. Rathnasamy et al.   JOURNAL OF NEUROSCIENCE

Friedreich's ataxia: Pathology, pathogenesis, and molecular genetics

(2011) Arnulf H. Koeppen   JOURNAL OF THE NEUROLOGICAL SCIENCES

Iron-related MRI images in patients with pantothenate kinase-associated neurodegeneration (PKAN) treated with deferiprone: Results of a phase II pilot trial

(2011) Giovanna Zorzi et al.   MOVEMENT DISORDERS

Deep grey matter T2 hypo-intensity in patients with paediatric multiple sclerosis

(2011) Antonia Ceccarelli et al.   Multiple Sclerosis Journal

Serum elements and oxidative status in clinically isolated syndromes: Imbalance and predictivity

(2011) G. Ristori et al.   NEUROLOGY

Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia

(2011) Nootchanat Mairuae et al.   NEUROSCIENCE LETTERS

Iron-Chelating Therapy for Transfusional Iron Overload

(2011) Gary M. Brittenham   NEW ENGLAND JOURNAL OF MEDICINE

Long-term improvement under deferiprone in a case of neurodegeneration with brain iron accumulation

(2011) A. Kwiatkowski et al.   PARKINSONISM & RELATED DISORDERS

Th17 Cell, the New Player of Neuroinflammatory Process in Multiple Sclerosis

(2011) F. Jadidi-Niaragh et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Pilot Safety Trial of Deferiprone in 10 Subjects With Superficial Siderosis

(2011) Michael Levy et al.   STROKE

Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity

(2010) Ilaria Pelizzoni et al.   AGING CELL

Imaging Cortical Lesions in Multiple Sclerosis With Ultra–High-Field Magnetic Resonance Imaging

(2010) David Pitt et al.   ARCHIVES OF NEUROLOGY

Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulationThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Or Kakhlon et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Combined Therapy with Idebenone and Deferiprone in Patients with Friedreich’s Ataxia

(2010) Daniel Velasco-Sánchez et al.   CEREBELLUM

Comorbidities amongst patients with multiple sclerosis: a population-based controlled study

(2010) J.-H. Kang et al.   EUROPEAN JOURNAL OF NEUROLOGY

Changes in parameters of oxidative stress and free iron biomarkers during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndromes

(2010) H. Ghoti et al.   HAEMATOLOGICA

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Nitrative and oxidative modifications of enolase are associated with iron in iron-overload rats and in vitro

(2010) Naihao Lu et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Iron Status in Children With Recurrent Episodes of Tumefactive Cerebral Demyelination

(2010) Ronald van Toorn et al.   JOURNAL OF CHILD NEUROLOGY

Hepatic but not brain iron is rapidly chelated by deferasirox in aceruloplasminemia due to a novel gene mutation

(2010) Armin Finkenstedt et al.   JOURNAL OF HEPATOLOGY

Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging

(2010) E. Mark Haacke et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Glucosylated Deferiprone and Its Brain Uptake: Implications for Developing Glucosylated Hydroxypyridinone Analogues Intended to Cross the Blood−Brain Barrier

(2010) Sourav Roy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Brain iron metabolism and its perturbation in neurological diseases

(2010) Robert R. Crichton et al.   JOURNAL OF NEURAL TRANSMISSION

Clinically available iron chelators induce neuroprotection in the 6-OHDA model of Parkinson’s disease after peripheral administration

(2010) David T. Dexter et al.   JOURNAL OF NEURAL TRANSMISSION

Lower levels of glutathione in the brains of secondary progressive multiple sclerosis patients measured by 1H magnetic resonance chemical shift imaging at 3 T

(2010) I-Y Choi et al.   Multiple Sclerosis Journal

Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease

(2010) Andreana C. Leskovjan et al.   NEUROIMAGE

Accumulation of oxidative DNA damage in brain mitochondria in mouse model of hereditary ferritinopathy

(2010) Xiaoling Deng et al.   NEUROSCIENCE LETTERS

Inactivation of astrocytic glutamine synthetase by hydrogen peroxide requires iron

(2010) S.P. Fernandes et al.   NEUROSCIENCE LETTERS

A Non-Heme Iron-Mediated Chemical Demethylation in DNA and RNA

(2009) Chengqi Yi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Oral Iron Chelators

(2009) Maria Domenica Cappellini et al.   Annual Review of Medicine

Iron Homeostasis and Its Interaction with Prolyl Hydroxylases

(2009) David R. Mole   ANTIOXIDANTS & REDOX SIGNALING

Regulation of neuron mitochondrial biogenesis and relevance to brain health

(2009) Isaac G. Onyango et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Is multiple sclerosis a mitochondrial disease?

(2009) Peizhong Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Optimizing iron chelation strategies in β-thalassaemia major

(2009) John B. Porter   BLOOD REVIEWS

Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson's disease

(2009) Deepinder Kaur et al.   BRAIN RESEARCH

Haptoglobin deficiency facilitates the development of autoimmune inflammation

(2009) Georgina Galicia et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Overview of Iron Chelation Therapy with Desferrioxamine and Deferiprone

(2009) Maria D. Cappellini et al.   HEMOGLOBIN

Elevated metals compromise repair of oxidative DNA damage via the base excision repair pathway: implications of pathologic iron overload in the brain on integrity of neuronal DNA

(2009) Hui Li et al.   JOURNAL OF NEUROCHEMISTRY

Deep Gray Matter Involvement on Brain MRI Scans Is Associated with Clinical Progression in Multiple Sclerosis

(2009) Mohit Neema et al.   JOURNAL OF NEUROIMAGING

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

(2009) L. R. Hanson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis

(2009) Radhika Srinivasan et al.   MAGNETIC RESONANCE IMAGING

Quantitative assessment of brain iron by R2* relaxometry in patients with clinically isolated syndrome and relapsing–remitting multiple sclerosis

(2009) M Khalil et al.   Multiple Sclerosis Journal

T2 hypointensity in the deep gray matter of patients with benign multiple sclerosis

(2009) A Ceccarelli et al.   Multiple Sclerosis Journal

Deep gray matter T2 hypointensity is present in patients with clinically isolated syndromes suggestive of multiple sclerosis

(2009) Antonia Ceccarelli et al.   Multiple Sclerosis Journal

A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

(2009) Pier Giorgio Mastroberardino et al.   NEUROBIOLOGY OF DISEASE

Oligodendrocytes: Susceptibility to injury and involvement in neurologic disease

(2009) E. E. Benarroch   NEUROLOGY

Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke

(2009) Stephen R. Robinson et al.   REDOX REPORT

Blockade of Glutamate Release from Microglia Attenuates Experimental Autoimmune Encephalomyelitis in Mice

(2009) Jin Shijie et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron

(2008) Kathryn E. Hammond et al.   ANNALS OF NEUROLOGY

Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation

(2008) O. Kakhlon et al.   BLOOD

Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons

(2008) Jixu Yu et al.   BRAIN RESEARCH

Alternative treatment paradigm for thalassemia using iron chelators

(2008) Natasha Szuber et al.   EXPERIMENTAL HEMATOLOGY

Oligodendrocytes and myelination: The role of iron

(2008) Bozho Todorich et al.   GLIA

Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells

(2008) Francisco Molina-Holgado et al.   JOURNAL OF NEUROCHEMISTRY

Chelation of Mitochondrial Iron Prevents Seizure-Induced Mitochondrial Dysfunction and Neuronal Injury

(2008) L.-P. Liang et al.   JOURNAL OF NEUROSCIENCE

Preconditioning with cobalt chloride or desferrioxamine protects oligodendrocyte cell line (MO3.13) from tumor necrosis factor-α-mediated cell death

(2008) Song-yi Yao et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Deferroxamine Preconditioning Promotes Long-Lasting Retinal Ischemic Tolerance

(2008) Yanli Zhu et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Regression of symptoms after selective iron chelation therapy in a case of neurodegeneration with brain iron accumulation

(2008) Gian Luca Forni et al.   MOVEMENT DISORDERS

Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

(2008) Shuzhen Zhang et al.   NEUROBIOLOGY OF AGING

Review: Mitochondria and disease progression in multiple sclerosis

(2008) D. Mahad et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Deferoxamine decreases the excitatory amino acid levels and improves the histological outcome in the hippocampus of neonatal rats after hypoxia–ischemia

(2008) Georgios Papazisis et al.   PHARMACOLOGICAL RESEARCH