Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy

Regional brain iron associated with deterioration in Alzheimer's disease: A large cohort study and theoretical significance

(2021) Scott Ayton et al.   Alzheimers & Dementia

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

(2021) Grzegorz Sienski et al.   Science Translational Medicine

Characterization of Selenium Compounds for Anti-ferroptotic Activity in Neuronal Cells and After Cerebral Ischemia–Reperfusion Injury

(2021) Qing-Zhang Tuo et al.   Neurotherapeutics

Biogenic metallic elements in the human brain?

(2021) James Everett et al.   Science Advances

Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer’s Disease Cooperative Study-Sponsored DHA Clinical Trial

(2020) Natalie Tomaszewski et al.   JOURNAL OF ALZHEIMERS DISEASE

Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells

(2020) Marcos A. Perez et al.   DEVELOPMENTAL CELL

Quantitative MRI and laser ablation-inductively coupled plasma-mass spectrometry imaging of iron in the frontal cortex of healthy controls and Alzheimer’s disease patients

(2020) Marjolein Bulk et al.   NEUROIMAGE

Cross-sectional and Longitudinal Assessment of Brain Iron Level in Alzheimer Disease Using 3-T MRI

(2020) Anna Damulina et al.   RADIOLOGY

Acute phase markers in CSF reveal inflammatory changes in Alzheimer’s disease that intersect with pathology, APOE ε4, sex and age

(2020) Scott Ayton et al.   PROGRESS IN NEUROBIOLOGY

Treating Alzheimer's disease by targeting iron

(2019) Sara Nikseresht et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology

(2019) Scott Ayton et al.   MOLECULAR PSYCHIATRY

Apolipoprotein E associated with reconstituted high‐density lipoprotein‐like particles is protected from aggregation

(2019) Ellen Hubin et al.   FEBS LETTERS

Cu II (atsm) inhibits ferroptosis: implications for treatment of neurodegenerative disease

(2019) Authors Adam Southon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

(2018) Paul A. Parcon et al.   Alzheimers & Dementia

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

n–3 Fatty acid erythrocyte membrane content, APOE ε4, and cognitive variation: an observational follow-up study in late adulthood

(2018) Lawrence J Whalley et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

(2018) Abdel A. Belaidi et al.   Neurotherapeutics

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology

(2018) Ibrahima Diouf et al.   NEUROBIOLOGY OF DISEASE

Evidence that iron accelerates Alzheimer’s pathology: a CSF biomarker study

(2017) Scott Ayton et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-ε4 Carriers

(2017) Scott Ayton et al.   JAMA Neurology

Oxidative Damage and Progression to Alzheimer's Disease in Patients with Mild Cognitive Impairment

(2017) Inês Baldeiras et al.   JOURNAL OF ALZHEIMERS DISEASE

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Impaired Autophagy in APOE4 Astrocytes

(2016) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

The Complex Role of Apolipoprotein E in Alzheimer’s Disease: an Overview and Update

(2016) Laura Mahoney-Sanchez et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

(2016) Abdel A. Belaidi et al.   JOURNAL OF NEUROCHEMISTRY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment

(2016) J. M. G. van Bergen et al.   Scientific Reports

Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease

(2015) Pravat K. Mandal et al.   BIOLOGICAL PSYCHIATRY

Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way

(2015) He Xu et al.   NEUROBIOLOGY OF DISEASE

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

(2015) Scott Ayton et al.   Nature Communications

CSF Apo-E levels associate with cognitive decline and MRI changes

(2014) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele

(2013) R. Chouinard-Watkins et al.   BRITISH JOURNAL OF NUTRITION

Overview and Findings from the Rush Memory and Aging Project

(2013) David A. Bennett et al.   Current Alzheimer Research

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

(2012) Carlos Cruchaga et al.   HUMAN MOLECULAR GENETICS

Total ApoE and ApoE4 Isoform Assays in an Alzheimer's Disease Case-control Study by Targeted Mass Spectrometry (n= 669): A Pilot Assay for Methionine-containing Proteotypic Peptides

(2012) Romain Simon et al.   MOLECULAR & CELLULAR PROTEOMICS

Plasma apolipoprotein E and Alzheimer disease risk: The AIBL study of aging

(2011) V. B. Gupta et al.   NEUROLOGY

Apolipoprotein E reduces food intake via PI3K/Akt signaling pathway in the hypothalamus

(2011) Ling Shen et al.   PHYSIOLOGY & BEHAVIOR

A simple approach for human recombinant apolipoprotein E4 expression and purification

(2011) Letta Argyri et al.   PROTEIN EXPRESSION AND PURIFICATION

Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease

(2010) M.A. Bradley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease

(2010) Joseph F. Quinn et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex

(2010) Mubeen A. Ansari et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Omega-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depression

(2010) Cécilia Samieri et al.   NEUROBIOLOGY OF AGING

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

(2008) D. R. Riddell et al.   JOURNAL OF NEUROSCIENCE

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

(2008) Tanea Reed et al.   NEUROBIOLOGY OF DISEASE

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA