Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks

Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer’s Disease-Related Models

(2020) Alice Rossi et al.   Cell Reports

ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells

(2020) Elena Scremin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta

(2020) Sara Hijazi et al.   iScience

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

(2020) Maud Gratuze et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacological Interventions to Attenuate Alzheimer’s Disease Progression: The Story So Far

(2019) Firas H. Bazzari et al.   Current Alzheimer Research

PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis

(2019) Chiara Fedeli et al.   Autophagy

Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons

(2019) Pierre Theurey et al.   AGING CELL

Familial Alzheimer’s disease-linked presenilin mutants and intracellular Ca2+ handling: A single-organelle, FRET-based analysis

(2019) Elisa Greotti et al.   CELL CALCIUM

The role of APOE in transgenic mouse models of AD

(2019) Deebika Balu et al.   NEUROSCIENCE LETTERS

CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission

(2019) Anna B. Toth et al.   Science Signaling

Substrate recognition and processing by γ-secretase

(2019) Michael S. Wolfe   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondrial NCKX5 regulates melanosomal biogenesis and pigment production

(2019) Zhao Zhang et al.   JOURNAL OF CELL SCIENCE

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

Store-operated Ca2+ entry-dependent Ca2+ refilling in the endoplasmic reticulum in astrocytes

(2019) Yohei Okubo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dampened Slow Oscillation Connectivity Anticipates Amyloid Deposition in the PS2APP Mouse Model of Alzheimer’s Disease

(2019) Alessandro Leparulo et al.   Cells

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

(2018) Benedikt Zott et al.   Annual Review of Neuroscience

Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8 + T Cells

(2018) Glenn R. Bantug et al.   IMMUNITY

Calcium signaling in Alzheimer's disease & therapies

(2018) Benjamin Chun-Kit Tong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Amyloid-β Peptides are Generated in Mitochondria-Associated Endoplasmic Reticulum Membranes

(2018) Bernadette Schreiner et al.   JOURNAL OF ALZHEIMERS DISEASE

STIM1 deficiency is linked to Alzheimer’s disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry

(2018) Carlos Pascual-Caro et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The zebrafish orthologue of familial Alzheimer’s disease gene PRESENILIN 2 is required for normal adult melanotic skin pigmentation

(2018) Haowei Jiang et al.   PLoS One

Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics

(2018) Alice Rossi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Diversity and Specificity of Astrocyte–neuron Communication

(2018) Caitlin A. Durkee et al.   NEUROSCIENCE

Orai1 plays a crucial role in central sensitization by modulating neuronal excitability

(2017) Yannong Dou et al.   JOURNAL OF NEUROSCIENCE

Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway

(2017) Sang Hun Lee et al.   Molecular Neurodegeneration

Practical considerations for choosing a mouse model of Alzheimer’s disease

(2017) Joanna L. Jankowsky et al.   Molecular Neurodegeneration

Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

(2017) Alice D Lam et al.   NATURE MEDICINE

Early hippocampal hyperexcitability in PS2APP mice: role of mutant PS2 and APP

(2017) Roberto Fontana et al.   NEUROBIOLOGY OF AGING

Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer’s Disease

(2017) Ksenia V. Kastanenka et al.   PLoS One

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

(2017) Martin Vaeth et al.   Nature Communications

Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology

(2017) Sabrina Contino et al.   Frontiers in Physiology

Endoplasmic reticulum-mitochondria tethering in neurodegenerative diseases

(2017) Yi Liu et al.   Translational Neurodegeneration

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

Impaired mitochondrial function due to familial Alzheimer's disease-causing presenilins mutants via Ca2+ disruptions

(2016) Patrick Toglia et al.   CELL CALCIUM

When, where and how? Focus on neuronal calcium dysfunctions in Alzheimer’s Disease

(2016) Mario Agostini et al.   CELL CALCIUM

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

(2016) Mojtaba Golpich et al.   CNS Neuroscience & Therapeutics

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments

(2016) Xavier Meckler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment

(2016) Hua Zhang et al.   JOURNAL OF NEUROSCIENCE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Human cortical–hippocampal dialogue in wake and slow-wave sleep

(2016) Anish Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

Characterization of the ER-Targeted Low Affinity Ca2+ Probe D4ER

(2016) Elisa Greotti et al.   SENSORS

Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency

(2016) Kavya Reddy et al.   Cell Reports

Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2

(2016) Riccardo Filadi et al.   Cell Reports

Familial Alzheimer’s disease–associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+entry

(2016) Benjamin Chun-Kit Tong et al.   Science Signaling

Store-operated calcium entry: Mechanisms and modulation

(2015) Patrick G. Hogan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease

(2015) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

(2015) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

The storm before the quiet: neuronal hyperactivity and Aβ in the presymptomatic stages of Alzheimer's disease

(2015) Anita Stargardt et al.   NEUROBIOLOGY OF AGING

Aβ42 oligomers selectively disrupt neuronal calcium release

(2015) Cristian Lazzari et al.   NEUROBIOLOGY OF AGING

Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain

(2015) David M. Bolduc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stim and Orai proteins in neuronal Ca2+ signaling and excitability

(2015) Francesco Moccia et al.   Frontiers in Cellular Neuroscience

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance

(2015) Arnold Bakker et al.   NeuroImage-Clinical

Cross-Sectional Comparison of Small Animal [18F]-Florbetaben Amyloid-PET between Transgenic AD Mouse Models

(2015) Matthias Brendel et al.   PLoS One

Pen-2 Is Essential for γ-Secretase Complex Stability and Trafficking but Partially Dispensable for Endoproteolysis

(2014) Oliver Holmes et al.   BIOCHEMISTRY

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

Familial Alzheimer’s disease–associated presenilin-1 alters cerebellar activity and calcium homeostasis

(2014) Diego Sepulveda-Falla et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppression of InsP3 Receptor-Mediated Ca2+ Signaling Alleviates Mutant Presenilin-Linked Familial Alzheimer's Disease Pathogenesis

(2014) D. Shilling et al.   JOURNAL OF NEUROSCIENCE

Ryanodine receptors: physiological function and deregulation in Alzheimer disease

(2014) Dolores Del Prete et al.   Molecular Neurodegeneration

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

(2014) Suya Sun et al.   NEURON

GSK-3β, a pivotal kinase in Alzheimer disease

(2014) María Llorens-Marítin et al.   Frontiers in Molecular Neuroscience

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

(2013) Shreaya Chakroborty et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Presenilin influences glycogen synthase kinase-3 β (GSK-3β) for kinesin-1 and dynein function during axonal transport

(2013) Kunsang Dolma et al.   HUMAN MOLECULAR GENETICS

Ca2+Influx through Store-operated Ca2+Channels Reduces Alzheimer Disease β-Amyloid Peptide Secretion

(2013) William Zeiger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Altered Metabolic Pathways in Plasma and CSF in Mild Cognitive Impairment and Alzheimer’s Disease Using Metabolomics

(2013) Eugenia Trushina et al.   PLoS One

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models

(2013) L. Hedskog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogeneity of Ca2+ handling among and within Golgi compartments

(2013) Andrea K. C. Wong et al.   Journal of Molecular Cell Biology

Ca2+dysregulation in neurons from transgenic mice expressing mutant presenilin 2

(2012) Maulilio J. Kipanyula et al.   AGING CELL

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels

(2012) Dustin Shilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

(2012) Katrijn Coen et al.   JOURNAL OF CELL BIOLOGY

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Ryanodine Receptor Blockade Reduces Amyloid-  Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

(2012) B. Oules et al.   JOURNAL OF NEUROSCIENCE

Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors

(2012) Gael Barthet et al.   NEUROBIOLOGY OF AGING

Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy

(2012) Desirée Loreth et al.   NEUROBIOLOGY OF DISEASE

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytic regulation of cortical UP states

(2011) K. E. Poskanzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2

(2010) Suman Jayadev et al.   BRAIN

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway

(2010) Young Jung Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhanced dentate gyrus synaptic plasticity but reduced neurogenesis in a mouse model of amyloidosis

(2010) Raphaël Poirier et al.   NEUROBIOLOGY OF DISEASE

Presenilin 2 Is the Predominant γ-Secretase in Microglia and Modulates Cytokine Release

(2010) Suman Jayadev et al.   PLoS One

Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment

(2010) V. Lissandron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CRAC Channel Activator STIM1 Binds and Inhibits L-Type Voltage-Gated Calcium Channels

(2010) C. Y. Park et al.   SCIENCE

The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and CaV1.2 Channels

(2010) Y. Wang et al.   SCIENCE

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

Slow-wave sleep and the consolidation of long-term memory

(2010) Jan Born   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes

(2009) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake

(2009) Lucia Brunello et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

(2009) S. Chakroborty et al.   JOURNAL OF NEUROSCIENCE

Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer's disease: Comprehensive phenotyping of vascular and tissular parameters by MRI

(2009) Claudia Weidensteiner et al.   MAGNETIC RESONANCE IN MEDICINE

Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice

(2009) Fiona Grueninger et al.   NEUROBIOLOGY OF DISEASE

Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo

(2009) T. Fellin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease

(2008) Lukasz Bojarski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein–protein interaction

(2008) Volodya Hayrapetyan et al.   CELL CALCIUM

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

(2008) Kim N. Green et al.   JOURNAL OF CELL BIOLOGY

Reduced anxiety in the mice expressing mutant (N141I) presenilin 2

(2008) Dong Yeon Yuk et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Expression of Transgenic APP mRNA Is the Key Determinant for Beta-Amyloid Deposition in PS2APP Transgenic Mice

(2008) Laurence Ozmen et al.   Neurodegenerative Diseases

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Role of capacitative calcium entry on glutamate-induced calcium influx in type-I rat cortical astrocytes

(2003) Paola Pizzo et al.   JOURNAL OF NEUROCHEMISTRY