Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?

High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases

(2019) Moritz J. Strowitzki et al.   BRITISH JOURNAL OF CANCER

FoxO3 activation in hypoxic tubules prevents chronic kidney disease

(2019) Ling Li et al.   JOURNAL OF CLINICAL INVESTIGATION

RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization

(2018) Giel Tanghe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling

(2018) Zi-Hao Qi et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The PHD1 oxygen sensor in health and disease

(2018) Kilian B. Kennel et al.   JOURNAL OF PHYSIOLOGY-LONDON

VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma

(2018) Jing Zhang et al.   SCIENCE

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(2018) Moritz J. Strowitzki et al.   AMERICAN JOURNAL OF PATHOLOGY

RIPK4 promoted the tumorigenicity of nasopharyngeal carcinoma cells

(2018) Yongqian Gong et al.   BIOMEDICINE & PHARMACOTHERAPY

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359

(2018) Javier Rodriguez et al.   Cell Reports

HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism

(2017) Volker H. Haase   Hemodialysis International

Forkhead box O3 (FoxO3) regulates kidney tubular autophagy following urinary tract obstruction

(2017) Ling Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD

(2017) Sophie Van Welden et al.   Nature Reviews Gastroenterology & Hepatology

Phase 2 studies of oral hypoxia-inducible factor prolyl hydroxylase inhibitor FG-4592 for treatment of anemia in China

(2017) Nan Chen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

(2017) Tzu-Lan Yeh et al.   Chemical Science

Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways

(2017) Karim Ullah et al.   Scientific Reports

Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling

(2016) Mario C. Manresa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner

(2016) Susan F. Fitzpatrick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New Insights into Protein Hydroxylation and Its Important Role in Human Diseases

(2016) Giada Zurlo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

pVHL mediates K63-linked ubiquitination of IKKβ, leading to IKKβ inactivation

(2016) Yuxin Wang et al.   CANCER LETTERS

Respiratory gases and the regulation of transcription

(2016) Eoin P. Cummins et al.   EXPERIMENTAL PHYSIOLOGY

The role of HIF in immunity and inflammation

(2016) Eoin P. Cummins et al.   MOLECULAR ASPECTS OF MEDICINE

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways

(2016) Javier Rodriguez et al.   Cell Reports

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1

(2016) Carsten C. Scholz et al.   PLOS BIOLOGY

Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells

(2015) James D. Vasta et al.   ACS Chemical Biology

PHD1 regulates p53-mediated colorectal cancer chemoresistance

(2015) S. Deschoemaeker et al.   EMBO Molecular Medicine

OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo

(2015) Diego Iglesias-Gato et al.   Molecular Cancer

OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance

(2015) U Karunarathna et al.   ONCOGENE

Identification of prolyl hydroxylation modifications in mammalian cell proteins

(2015) Patrick R. Arsenault et al.   PROTEOMICS

Hypoxia-Inducible Factor as an Angiogenic Master Switch

(2015) Takuya Hashimoto et al.   Frontiers in Pediatrics

Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway

(2014) Christina M. Warboys et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

(2014) X. Zheng et al.   GENES & DEVELOPMENT

ERK3 Promotes Endothelial Cell Functions by Upregulating SRC-3/SP1-Mediated VEGFR2 Expression

(2014) Wei Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The application of targeted mass spectrometry-based strategies to the detection and localization of post-translational modifications

(2014) Navin Chicooree et al.   MASS SPECTROMETRY REVIEWS

OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer

(2014) Yi Zhou et al.   Molecular Cancer

Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifies RIPK4 as novel tumor suppressor in human hepatocarcinogenesis

(2014) D Heim et al.   ONCOGENE

Colon cancer bears overexpression of OTUB1

(2014) Xin Liu et al.   PATHOLOGY RESEARCH AND PRACTICE

Proline-Hydroxylated Hypoxia-Inducible Factor 1α (HIF-1α) Upregulation in Human Tumours

(2014) Cameron E. Snell et al.   PLoS One

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Molecular Mechanisms of Action and Therapeutic Uses of Pharmacological Inhibitors of HIF–Prolyl 4-Hydroxylases for Treatment of Ischemic Diseases

(2013) Vaithinathan Selvaraju et al.   ANTIOXIDANTS & REDOX SIGNALING

Collagen prolyl 3-hydroxylation: a major role for a minor post-translational modification?

(2013) David M. Hudson et al.   CONNECTIVE TISSUE RESEARCH

PHD1 Links Cell-Cycle Progression to Oxygen Sensing through Hydroxylation of the Centrosomal Protein Cep192

(2013) Sandra C. Moser et al.   DEVELOPMENTAL CELL

The origins of enzyme kinetics

(2013) Athel Cornish-Bowden   FEBS LETTERS

Differential effect of hypoxia on etoposide-induced DNA damage response and p53 regulation in different cell types

(2013) Audrey Sermeus et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulation of IL-1 -induced NF- B by hydroxylases links key hypoxic and inflammatory signaling pathways

(2013) C. C. Scholz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of Dishevelled by Protein Kinase RIPK4 Regulates Wnt Signaling

(2013) X. Huang et al.   SCIENCE

A Nontranscriptional Role for HIF-1  as a Direct Inhibitor of DNA Replication

(2013) M. E. Hubbi et al.   Science Signaling

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Building a centriole

(2012) Tomer Avidor-Reiss et al.   CURRENT OPINION IN CELL BIOLOGY

Zinc Fingers and Homeoboxes 2 Inhibits Hepatocellular Carcinoma Cell Proliferation and Represses Expression of Cyclins A and E

(2012) Xuetian Yue et al.   GASTROENTEROLOGY

Deubiquitinase FAM/USP9X Interacts with the E3 Ubiquitin Ligase SMURF1 Protein and Protects It from Ligase Activity-dependent Self-degradation

(2012) Yang Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes

(2012) Brian W. Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

(2011) E C Ferber et al.   CELL DEATH AND DIFFERENTIATION

FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function

(2011) Kim Steen Jensen et al.   EMBO JOURNAL

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

(2011) Ya-Min Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma

(2011) Stefan Nagel et al.   LEUKEMIA RESEARCH

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

(2011) Erich A. Nigg et al.   NATURE CELL BIOLOGY

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

The Hydroxylase Inhibitor Dimethyloxallyl Glycine Attenuates Endotoxic Shock Via Alternative Activation of Macrophages and IL-10 Production by B1 Cells

(2011) Emily Hams et al.   SHOCK

Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts

(2010) Baosheng Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3

(2010) Christina Aaen Hansen et al.   CELL CYCLE

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

Acute Hypoxia Induces HIF-Independent Monocyte Adhesion to Endothelial Cells through Increased Intercellular Adhesion Molecule-1 Expression: The Role of Hypoxic Inhibition of Prolyl Hydroxylase Activity for the Induction of NF- B

(2010) S. Winning et al.   JOURNAL OF IMMUNOLOGY

Mechanism of Hypoxia-Induced NF- B

(2010) C. Culver et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of NF-κB in Hypoxia-Induced Gene Expression

(2009) Cormac T. Taylor et al.   Annals of the New York Academy of Sciences

Inhibition of Prolyl Hydroxylase Domain-Containing Protein Suppressed Lipopolysaccharide-Induced TNF-α Expression

(2009) Kotaro Takeda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

(2009) G. L. Semenza   BLOOD

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

(2009) Martin Schneider et al.   GASTROENTEROLOGY

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

(2009) Peter Fraisl et al.   NATURE REVIEWS DRUG DISCOVERY

Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

(2008) Jennifer H. Dao et al.   ANALYTICAL BIOCHEMISTRY

Direct and continuous assay for prolyl 4-hydroxylase

(2008) Kelly L. Gorres et al.   ANALYTICAL BIOCHEMISTRY

Regulation of gene expression by hypoxia

(2008) Niall Steven Kenneth et al.   BIOCHEMICAL JOURNAL

Conformational Preferences of Substrates for Human Prolyl 4-Hydroxylase†

(2008) Kelly L. Gorres et al.   BIOCHEMISTRY

Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins

(2008) Matthew E. Cockman et al.   MOLECULAR & CELLULAR PROTEOMICS

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

The role of oxygen availability in embryonic development and stem cell function

(2008) M. Celeste Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY