Synaptic Activity Regulates Mitochondrial Iron Metabolism to Enhance Neuronal Bioenergetics

Double-edge sword roles of iron in driving energy production versus instigating ferroptosis

(2022) Shuping Zhang et al.   Cell Death & Disease

Tumor heterogeneity in autophagy-dependent ferroptosis

(2021) Jingbo Li et al.   Autophagy

Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

(2021) Wen-Dai Bao et al.   CELL DEATH AND DIFFERENTIATION

Characteristics and Biomarkers of Ferroptosis

(2021) Xin Chen et al.   Frontiers in Cell and Developmental Biology

Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation

(2021) Wanchun Yang et al.   DEVELOPMENTAL CELL

Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children

(2019) Lyudmila Pivina et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export

(2019) Caitlin W. Brown et al.   DEVELOPMENTAL CELL

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

(2018) Mark P. Mattson et al.   Cell Metabolism

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

GLUT4 Mobilization Supports Energetic Demands of Active Synapses

(2017) Ghazaleh Ashrafi et al.   NEURON

A Brief History of Long-Term Potentiation

(2017) Roger A. Nicoll   NEURON

Iron Deficiency Impairs Developing Hippocampal Neuron Gene Expression, Energy Metabolism, and Dendrite Complexity

(2016) Thomas W. Bastian et al.   DEVELOPMENTAL NEUROSCIENCE

Mitochondrial fragmentation in excitotoxicity requires ROCK activation

(2015) Alejandro Martorell-Riera et al.   CELL CYCLE

Depletion of mitoferrins leads to mitochondrial dysfunction and impairment of adipogenic differentiation in 3T3-L1 preadipocytes

(2015) Y.-C. Chen et al.   FREE RADICAL RESEARCH

Synaptic mitochondria: A brain mitochondria cluster with a specific proteome

(2015) Katalin Völgyi et al.   Journal of Proteomics

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

(2015) Paul S. Baxter et al.   Nature Communications

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

(2014) D. A. Patten et al.   EMBO JOURNAL

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Iron in multiple sclerosis: roles in neurodegeneration and repair

(2014) Erin Stephenson et al.   Nature Reviews Neurology

Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes

(2014) R. F. Deighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in Glioblastomas and Epilepsy

(2013) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Nuclear calcium signalling in the regulation of brain function

(2013) Hilmar Bading   NATURE REVIEWS NEUROSCIENCE

Iron metabolism in the CNS: implications for neurodegenerative diseases

(2013) Tracey A. Rouault   NATURE REVIEWS NEUROSCIENCE

NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors

(2013) X Zhou et al.   Cell Death & Disease

The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism

(2012) Roland Lill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure, function, and assembly of heme centers in mitochondrial respiratory complexes

(2012) Hyung J. Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Regulation of glucose transport by insulin: traffic control of GLUT4

(2012) Dara Leto et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR links incretin signaling to HIF induction in pancreatic beta cells

(2011) S. Van de Velde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity

(2010) Ilaria Pelizzoni et al.   AGING CELL

Neuronal Activity Controls the Antagonistic Balance Between Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α and Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptors in Regulating Antioxidant Defenses

(2010) Francesc X. Soriano et al.   ANTIOXIDANTS & REDOX SIGNALING

Suppression of the Intrinsic Apoptosis Pathway by Synaptic Activity

(2010) F. Leveille et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mechanism of Ca2+-Dependent Regulation of Kinesin-Mediated Mitochondrial Motility

(2009) Xinnan Wang et al.   CELL

Inverse Regulation of Plasticity-related Immediate Early Genes by Calcineurin in Hippocampal Neurons

(2009) Brian Yee Hong Lam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy

(2009) Fawzi Boumezbeur et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

(2009) Andrew F. MacAskill et al.   NEURON

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE

From Synapse to Nucleus: Calcium-Dependent Gene Transcription in the Control of Synapse Development and Function

(2008) Paul L. Greer et al.   NEURON