Iron Responsive Element-Mediated Responses to Iron Dyshomeostasis in Alzheimer’s Disease

Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2

(2020) Nhi Hin et al.   PLoS One

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Amyloidogenic processing of Alzheimer’s disease β-amyloid precursor protein induces cellular iron retention

(2020) Andrew Tsatsanis et al.   MOLECULAR PSYCHIATRY

Lysosomal dysfunction in Down syndrome is APP-dependent and mediated by APP-βCTF (C99)

(2019) Jiang Ying et al.   JOURNAL OF NEUROSCIENCE

Synthesis and breakdown of universal metabolic precursors promoted by iron

(2019) Kamila B. Muchowska et al.   NATURE

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Imaging beta amyloid aggregation and iron accumulation in Alzheimer's disease using quantitative susceptibility mapping MRI

(2019) Nan-Jie Gong et al.   NEUROIMAGE

Brain transcriptome analysis of a familial Alzheimer’s disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production

(2019) Morgan Newman et al.   Molecular Brain

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

(2019) Lisa Vermunt et al.   Alzheimers & Dementia

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

(2019) Zoë P. Van Acker et al.   Molecular Neurodegeneration

Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses

(2019) Yuhang Jiang et al.   Nature Communications

The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease

(2019) Luke W. Bonham et al.   Frontiers in Immunology

Impact of Autophagy and Aging on Iron Load and Ferritin in Drosophila Brain

(2019) Anne-Claire Jacomin et al.   Frontiers in Cell and Developmental Biology

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

(2019) King Faisal Yambire et al.   eLife

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in cognitive impairment diseases

(2018) Veronica Tisato et al.   PLoS One

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH

(2018) Hari Prasad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manganese causes neurotoxic iron accumulation via translational repression of Amyloid Precursor Protein (APP) and H-Ferritin

(2018) Vivek Venkataramani et al.   JOURNAL OF NEUROCHEMISTRY

Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer’s Disease

(2018) Amanda L. Lumsden et al.   Frontiers in Neuroscience

The roles of hypoxia-inducible Factor-1 and iron regulatory protein 1 in iron uptake induced by acute hypoxia

(2018) Lei Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: A multi-omic analysis

(2018) Joseph L. Bundy et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease

(2018) Justin M. Long et al.   MOLECULAR PSYCHIATRY

Cortical Iron Reflects Severity of Alzheimer’s Disease

(2017) Sara van Duijn et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

(2016) Martina Pigoni et al.   Molecular Neurodegeneration

Near-optimal probabilistic RNA-seq quantification

(2016) Nicolas L Bray et al.   NATURE BIOTECHNOLOGY

Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms

(2016) Sherry Freiesleben et al.   Scientific Reports

Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

(2016) Mariet Allen et al.   Scientific Data

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease

(2015) Dan Xia et al.   NEURON

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

A Central Role for JNK/AP-1 Pathway in the Pro-Oxidant Effect of Pyrrolidine Dithiocarbamate through Superoxide Dismutase 1 Gene Repression and Reactive Oxygen Species Generation in Hematopoietic Human Cancer Cell Line U937

(2015) Humberto Riera et al.   PLoS One

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

(2014) R. C. McCarthy et al.   EMBO REPORTS

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

(2014) Véréna Landel et al.   Molecular Neurodegeneration

MRI for Iron Mapping in Alzheimer's Disease

(2014) Christian Langkammer et al.   Neurodegenerative Diseases

Targeting the Prodromal Stage of Alzheimer’s Disease: Bioenergetic and Mitochondrial Opportunities

(2014) Charles C. Caldwell et al.   Neurotherapeutics

Systematic Analysis of the Role of RNA-Binding Proteins in the Regulation of RNA Stability

(2014) Ayesha Hasan et al.   PLoS Genetics

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Influence of microRNA on the Maintenance of Human Iron Metabolism

(2013) McKale Davis et al.   Nutrients

Iron-Responsive miR-485-3p Regulates Cellular Iron Homeostasis by Targeting Ferroportin

(2013) Carolyn Sangokoya et al.   PLoS Genetics

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Camera: a competitive gene set test accounting for inter-gene correlation

(2012) Di Wu et al.   NUCLEIC ACIDS RESEARCH

Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism, and Hippocampal Volume in Cognitively Normal, Late-Middle-Aged Persons at 3 Levels of Genetic Risk for Alzheimer Disease

(2012) Hillary D. Protas et al.   JAMA Neurology

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins

(2011) M. Sanchez et al.   BLOOD

Interactions Between Ferroportin and Hephaestin in Rat Enterocytes Are Reduced After Iron Ingestion

(2011) Kwo–Yih Yeh et al.   GASTROENTEROLOGY

Cellular Iron Depletion Stimulates the JNK and p38 MAPK Signaling Transduction Pathways, Dissociation of ASK1-Thioredoxin, and Activation of ASK1

(2011) Yu Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid imaging in prodromal Alzheimer's disease

(2011) Rik Ossenkoppele et al.   Alzheimers Research & Therapy

Human MRCKα is regulated by cellular iron levels and interferes with transferrin iron uptake

(2010) Radek Cmejla et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ROAST: rotation gene set tests for complex microarray experiments

(2010) Di Wu et al.   BIOINFORMATICS

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells

(2010) I. Andolfo et al.   HAEMATOLOGICA

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Increased brain iron coincides with early plaque formation in a mouse model of Alzheimer's disease

(2010) Andreana C. Leskovjan et al.   NEUROIMAGE

SIREs: searching for iron-responsive elements

(2010) M. Campillos et al.   NUCLEIC ACIDS RESEARCH

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

BioMart – biological queries made easy

(2009) Damian Smedley et al.   BMC GENOMICS

Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders

(2009) Eric Mills et al.   Future Medicinal Chemistry

Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease

(2009) Bei Ding et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Multiple determinants within iron-responsive elements dictate iron regulatory protein binding and regulatory hierarchy

(2009) J. B. Goforth et al.   RNA

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition