The life and times of a tRNA

Structural basis of regulated m7G tRNA modification by METTL1–WDR4

(2023) Jiazhi Li et al.   NATURE

Structures and mechanisms of tRNA methylation by METTL1–WDR4

(2023) Victor M. Ruiz-Arroyo et al.   NATURE

Identification of RNA helicases with unwinding activity on angiogenin-processed tRNAs

(2023) Aleksej Drino et al.   NUCLEIC ACIDS RESEARCH

Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids

(2023) Bruno Costa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease

(2023) Xiaofeng Zhang et al.   MOLECULAR CELL

A standardized ontology for naming tRNA-derived RNAs based on molecular origin

(2023) Andrew D. Holmes et al.   NATURE METHODS

Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex

(2023) Cassandra K. Hayne et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN

(2023) Samoil Sekulovski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transfer RNA halves are found as nicked tRNAs in cells: evidence that nicked tRNAs regulate expression of an RNA repair operon

(2023) Xinguo Chen et al.   RNA

Recent insights into the structure, function, and regulation of the eukaryotic transfer RNA splicing endonuclease complex

(2022) Cassandra K. Hayne et al.   Wiley Interdisciplinary Reviews-RNA

THUMPD1 bi-allelic variants cause loss of tRNA acetylation and a syndromic neurodevelopmental disorder

(2022) Martin Broly et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Methyltransferase METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs

(2022) Jenna M. Lentini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer

(2022) Zhangli Su et al.   Nature Communications

Crystal structures and insights into precursor tRNA 5’-end processing by prokaryotic minimal protein-only RNase P

(2022) Yangyang Li et al.   Nature Communications

Identification of a Trm732 Motif Required for 2′-O-methylation of the tRNA Anticodon Loop by Trm7

(2022) Holly M. Funk et al.   ACS Omega

Transfer RNA processing – from a structural and disease perspective

(2022) Samoil Sekulovski et al.   BIOLOGICAL CHEMISTRY

Initiator tRNA lacking 1-methyladenosine is targeted by the rapid tRNA decay pathway in evolutionarily distant yeast species

(2022) Monika Tasak et al.   PLoS Genetics

Three tRNA nuclear exporters in S. cerevisiae: parallel pathways, preferences, and precision

(2022) Kunal Chatterjee et al.   NUCLEIC ACIDS RESEARCH

Arsenite toxicity is regulated by queuine availability and oxidation-induced reprogramming of the human tRNA epitranscriptome

(2022) Sabrina M. Huber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

tRNA-derived fragments (tRFs) in cancer

(2022) Yuri Pekarsky et al.   Journal of Cell Communication and Signaling

tRNA derived small RNAs—Small players with big roles

(2022) Suja George et al.   Frontiers in Genetics

Transfer RNAs-derived small RNAs and their application potential in multiple diseases

(2022) Xiaohua Chu et al.   Frontiers in Cell and Developmental Biology

The expanding world of tRNA modifications and their disease relevance

(2021) Tsutomu Suzuki   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comparative parallel analysis of RNA ends identifies mRNA substrates of a tRNA splicing endonuclease-initiated mRNA decay pathway

(2021) Jennifer E. Hurtig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of 3'-PO4/5'-OH RNA ligase RtcB in complex with a 5'-OH oligonucleotide

(2021) Ankan Banerjee et al.   RNA

Revisiting tRNA chaperones: New players in an ancient game

(2021) Jennifer Porat et al.   RNA

The rice RNase P protein subunit Rpp30 confers broad‐spectrum resistance to fungal and bacterial pathogens

(2021) Wei Li et al.   PLANT BIOTECHNOLOGY JOURNAL

N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression

(2021) Zihao Dai et al.   MOLECULAR CELL

METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation

(2021) Esteban A. Orellana et al.   MOLECULAR CELL

Structural basis of RNA processing by human mitochondrial RNase P

(2021) Arjun Bhatta et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination

(2021) Elizabeth Ramos-Morales et al.   NUCLEIC ACIDS RESEARCH

The Clp1 R140H mutation alters tRNA metabolism and mRNA 3′ processing in mouse models of pontocerebellar hypoplasia

(2021) Caitlin E. Monaghan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The many faces of RNA-based RNase P, an RNA-world relic

(2021) Hong-Duc Phan et al.   TRENDS IN BIOCHEMICAL SCIENCES

The 3’tsRNAs are aminoacylated: Implications for their biogenesis

(2021) Ziwei Liu et al.   PLoS Genetics

Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression

(2021) Isao Masuda et al.   eLife

MODOMICS: a database of RNA modification pathways. 2021 update

(2021) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

Computational methods for RNA modification detection from nanopore direct RNA sequencing data

(2021) Mattia Furlan et al.   RNA Biology

Canary in a coal mine: collided ribosomes as sensors of cellular conditions

(2021) Kyusik Q. Kim et al.   TRENDS IN BIOCHEMICAL SCIENCES

Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

(2021) Samoil Sekulovski et al.   Nature Communications

Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells

(2021) Miao Chen et al.   PLoS Genetics

An intellectual disability‐associated missense variant in TRMT1 impairs tRNA modification and reconstitution of enzymatic activity

(2020) Kejia Zhang et al.   HUMAN MUTATION

AtTRM61/AtTRM6 complex is a bona fide tRNA N1-methyladenosine methyltransferase in Arabidopsis

(2020) Jun Tang et al.   JOURNAL OF EXPERIMENTAL BOTANY

tRNA 2′-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila

(2020) Margarita T Angelova et al.   NUCLEIC ACIDS RESEARCH

Novel insights into the emerging roles of tRNA-derived fragments in mammalian development

(2020) Nicola Guzzi et al.   RNA Biology

5’ tRNA halves are highly expressed in the primate hippocampus and might sequence-specifically regulate gene expression

(2020) Julia Jehn et al.   RNA

Absence of AfuXpot, the yeast Los1 homologue, limits Aspergillus fumigatus growth under amino acid deprived condition

(2020) Alireza Azizi et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control

(2020) Matthew C.J. Yip et al.   Cell Reports

Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast

(2020) Leticia Pollo-Oliveira et al.   Biomolecules

The nature of the purine at position 34 in tRNAs of 4-codon boxes is correlated with nucleotides at positions 32 and 38 to maintain decoding fidelity

(2020) Ketty Pernod et al.   NUCLEIC ACIDS RESEARCH

Functional characterization of the human tRNA methyltransferases TRMT10A and TRMT10B

(2020) Elisa Vilardo et al.   NUCLEIC ACIDS RESEARCH

Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage

(2020) Cassandra K Hayne et al.   NUCLEIC ACIDS RESEARCH

Coordination of mRNA and tRNA methylations by TRMT10A

(2020) R. Jordan Ontiveros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aminoacyl-tRNA Synthetases

(2020) Miguel Angel Rubio Gomez et al.   RNA

2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations

(2020) Carole Trzaska et al.   Nature Communications

Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP

(2020) P. Daniela Garcia et al.   Nature Communications

DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification

(2020) Jenna M. Lentini et al.   Nature Communications

Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

(2020) Colin Chih-Chien Wu et al.   CELL

Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping

(2020) Aldema Sas-Chen et al.   NATURE

ANGEL2 is a member of the CCR4 family of deadenylases with 2′,3′-cyclic phosphatase activity

(2020) Paola H. Pinto et al.   SCIENCE

Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP

(2020) Anna Perederina et al.   Nature Communications

Transfer RNA-Derived Small RNAs: Another Layer of Gene Regulation and Novel Targets for Disease Therapeutics

(2020) Hak Kyun Kim et al.   MOLECULAR THERAPY

A novel assay provides insight into tRNAPhe retrograde nuclear import and re-export in S. cerevisiae

(2020) Regina T Nostramo et al.   NUCLEIC ACIDS RESEARCH

Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences

(2020) Thareendra De Zoysa et al.   PLoS Genetics

Crystal structure of the yeast heterodimeric ADAT2/3 deaminase

(2020) Xiwen Liu et al.   BMC BIOLOGY

Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes

(2020) Liewei L. Yan et al.   MOLECULAR CELL

tRNA 3′ shortening by LCCR4 as a response to stress in Trypanosoma brucei

(2020) Marina Cristodero et al.   NUCLEIC ACIDS RESEARCH

Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast

(2019) Martin Müller et al.   RNA Biology

A tRNA half modulates translation as stress response in Trypanosoma brucei

(2019) Roger Fricker et al.   Nature Communications

Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2′-PO4 recognition and ADP-ribosylation

(2019) Ankan Banerjee et al.   Nature Communications

Recent Insights Into the Structure, Function, and Evolution of the RNA-Splicing Endonucleases

(2019) Akira Hirata   Frontiers in Genetics

The Role of 3′ to 5′ Reverse RNA Polymerization in tRNA Fidelity and Repair

(2019) Allan W. Chen et al.   Genes

Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response

(2019) Hagen Schwenzer et al.   Cell Reports

Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator

(2019) Rościsław Krutyhołowa et al.   NUCLEIC ACIDS RESEARCH

Queuine links translational control in eukaryotes to a micronutrient from bacteria

(2019) Martin Müller et al.   NUCLEIC ACIDS RESEARCH

Importance of tRNA anticodon loop modification and a conserved, noncanonical anticodon stem pairing in tRNAProCGG for decoding

(2019) Ha An Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Temporal Order in 5′- and 3′- Processing of Eukaryotic tRNAHis

(2019) Marie-Theres Pöhler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

5’‐end sequencing in Saccharomyces cerevisiae offers new insights into 5’‐ends of tRNA H is and snoRNAs

(2019) Samantha Dodbele et al.   FEBS LETTERS

Unbiased screen of RNA tailing activities reveals a poly(UG) polymerase

(2019) Melanie A. Preston et al.   NATURE METHODS

Mechanism for recycling tRNAs on stalled ribosomes

(2019) Matthew C. J. Yip et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Impact of intron removal from tRNA genes on Saccharomyces cerevisiae

(2019) Sachiko Hayashi et al.   NUCLEIC ACIDS RESEARCH

Molecular determinants of metazoan tricRNA biogenesis

(2019) Casey A Schmidt et al.   NUCLEIC ACIDS RESEARCH

Conformational communication mediates the reset step in t6A biosynthesis

(2019) Amit Luthra et al.   NUCLEIC ACIDS RESEARCH

NAD+-dependent RNA terminal 2' and 3' phosphomonoesterase activity of a sub-set of Tpt1 enzymes

(2019) Annum Munir et al.   RNA

Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response

(2019) Patrick D Cherry et al.   eLife

Dynamic expression of tRNA‐derived small RNAs define cellular states

(2019) Srikar Krishna et al.   EMBO REPORTS

Cooperative 2′-O-methylation of the wobble cytidine of human elongator tRNAMet(CAT) by a nucleolar and a Cajal body-specific box C/D RNP

(2019) Patrice Vitali et al.   GENES & DEVELOPMENT

Formation of tRNA wobble inosine in humans is disrupted by a millennia-old mutation causing intellectual disability

(2019) Jillian Ramos et al.   MOLECULAR AND CELLULAR BIOLOGY

Reversible ADP-ribosylation of RNA

(2019) Deeksha Munnur et al.   NUCLEIC ACIDS RESEARCH

Naturally occurring dual recognition of tRNAHis substrates with and without a universal identity element

(2019) Yi-Hsueh Lee et al.   RNA Biology

Distinct substrate specificities of the human tRNA methyltransferases TRMT10A and TRMT10B

(2019) Nathan W Howell et al.   RNA

Accurate target identification for Mycobacterium tuberculosis endoribonuclease toxins requires expression in their native host

(2019) Melvilí Cintrón et al.   Scientific Reports

Cytosine-5 RNA methylation links protein synthesis to cell metabolism

(2019) Nikoletta A. Gkatza et al.   PLOS BIOLOGY

BCDIN3D regulates tRNAHis 3’ fragment processing

(2019) Calder W. Reinsborough et al.   PLoS Genetics

A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

(2019) Ritu Gupta et al.   eLife

tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay

(2019) Jirka Peschek et al.   eLife

Reciprocal regulation of TORC signaling and tRNA modifications by Elongator enforces nutrient-dependent cell fate

(2019) Julie Candiracci et al.   Science Advances

RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay

(2019) Ying Yang et al.   MOLECULAR CELL

The general mRNA exporters Mex67 and Mtr2 play distinct roles in nuclear export of tRNAs in Trypanosoma brucei

(2019) Eva Hegedűsová et al.   NUCLEIC ACIDS RESEARCH

A nuclear role for the DEAD-box protein Dbp5 in tRNA export

(2019) Azra Lari et al.   eLife

tRNA wobble-uridine modifications as amino acid sensors and regulators of cellular metabolic state

(2019) Ritu Gupta et al.   CURRENT GENETICS

Angiogenin generates specific stress-induced tRNA halves and is not involved in tRF-3–mediated gene silencing

(2019) Zhangli Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition

(2019) Akira Hirata et al.   NUCLEIC ACIDS RESEARCH

Deep sequencing of tRNA′s 3′-termini sheds light on CCA-tail integrity and maturation

(2019) Andreas Czech   RNA

Mutations in the anticodon stem of tRNA cause accumulation and Met22-dependent decay of pre-tRNA in yeast

(2019) Matthew J. Payea et al.   RNA

Accurate detection of m6A RNA modifications in native RNA sequences

(2019) Huanle Liu et al.   Nature Communications

Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome

(2019) Christelle Arrondel et al.   Nature Communications

A tRNA-Derived Small RNA Regulates Ribosomal Protein S28 Protein Levels after Translation Initiation in Humans and Mice

(2019) Hak Kyun Kim et al.   Cell Reports

tRNA introns: Presence, processing, and purpose

(2019) Casey A. Schmidt et al.   Wiley Interdisciplinary Reviews-RNA

Regulation of tRNA synthesis by the general transcription factors of RNA polymerase III - TFIIIB and TFIIIC, and by the MAF1 protein

(2018) Damian Graczyk et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

tRNA dynamics between the nucleus, cytoplasm and mitochondrial surface: Location, location, location

(2018) Kunal Chatterjee et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells

(2018) Nicola Guzzi et al.   CELL

Mettl1/Wdr4-Mediated m 7 G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation

(2018) Shuibin Lin et al.   MOLECULAR CELL

A 2´-O-methyltransferase responsible for tRNA Anticodon Modification is Pivotal for Resistance to Pseudomonas syringae DC3000 in Arabidopsis

(2018) Vicente Ramirez et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

(2018) Yunfang Zhang et al.   NATURE CELL BIOLOGY

The RNA-splicing endonuclease from the euryarchaeaon Methanopyrus kandleri is a heterotetramer with constrained substrate specificity

(2018) Ayano Kaneta et al.   NUCLEIC ACIDS RESEARCH

Drosophila tsRNAs preferentially suppress general translation machinery via antisense pairing and participate in cellular starvation response

(2018) Shiqi Luo et al.   NUCLEIC ACIDS RESEARCH

Structure and mechanism of a bacterial t6A biosynthesis system

(2018) Amit Luthra et al.   NUCLEIC ACIDS RESEARCH

In vitro reconstitution and analysis of eukaryotic RNase P RNPs

(2018) Anna Perederina et al.   NUCLEIC ACIDS RESEARCH

The structure of the TsaB/TsaD/TsaE complex reveals an unexpected mechanism for the bacterial t6A tRNA-modification

(2018) Sophia Missoury et al.   NUCLEIC ACIDS RESEARCH

General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4

(2018) Caia D. S. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-step mechanism and step-arrest mutants of Runella slithyformis NAD+-dependent tRNA 2'-phosphotransferase Tpt1

(2018) Annum Munir et al.   RNA

Queuosine modification protects cognate tRNAs against ribonuclease cleavage

(2018) Xiaoyun Wang et al.   RNA

Structural and biochemical analysis of the dual-specificity Trm10 enzyme fromThermococcus kodakaraensisprompts reconsideration of its catalytic mechanism

(2018) Ranjan Kumar Singh et al.   RNA

tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner

(2018) Canan Kuscu et al.   RNA

A rationale for tRNA modification circuits in the anticodon loop

(2018) Lu Han et al.   RNA

Tie-Break: Host and Retrotransposons Play tRNA

(2018) Andrea J. Schorn et al.   TRENDS IN CELL BIOLOGY

Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway

(2018) Lu Han et al.   PLoS Genetics

Molecular mechanism for the inhibition of DXO by adenosine 3′,5′-bisphosphate

(2018) Ji-Sook Yun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biochemical analysis of human tRNAHis guanylyltransferase in mitochondrial tRNAHis maturation

(2018) Akiyoshi Nakamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Queuosine‐modified tRNAs confer nutritional control of protein translation

(2018) Francesca Tuorto et al.   EMBO JOURNAL

The role of RNA modifications in the regulation of tRNA cleavage

(2018) Shawn M. Lyons et al.   FEBS LETTERS

From powerhouse to processing plant: conserved roles of mitochondrial outer membrane proteins in tRNA splicing

(2018) Yao Wan et al.   GENES & DEVELOPMENT

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

NAD+-dependent synthesis of a 5′-phospho-ADP-ribosylated RNA/DNA cap by RNA 2′-phosphotransferase Tpt1

(2018) Annum Munir et al.   NUCLEIC ACIDS RESEARCH

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

(2018) Cristina Cosentino et al.   NUCLEIC ACIDS RESEARCH

Structural insight into precursor tRNA processing by yeast ribonuclease P

(2018) Pengfei Lan et al.   SCIENCE

RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis

(2018) Uwe Richter et al.   Nature Communications

Toxins targeting transfer RNAs: Translation inhibition by bacterial toxin-antitoxin systems

(2018) Lauren R. Walling et al.   Wiley Interdisciplinary Reviews-RNA

Mutations in the tRNA methyltransferase 1 gene TRMT1 cause congenital microcephaly, isolated inferior vermian hypoplasia and cystic leukomalacia in addition to intellectual disability

(2018) Kathrin Blaesius et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A Family Divided: Distinct Structural and Mechanistic Features of the SpoU-TrmD (SPOUT) Methyltransferase Superfamily

(2018) Aiswarya Krishnamohan et al.   BIOCHEMISTRY

The emerging impact of tRNA modifications in the brain and nervous system

(2018) Jillian Ramos et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

(2018) Lars R. Jensen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cryo-EM Structure of the Human Ribonuclease P Holoenzyme

(2018) Jian Wu et al.   CELL

A null variant in PUS3 confirms its involvement in intellectual disability and further delineates the associated neurodevelopmental disease

(2018) Hanadi A. Abdelrahman et al.   CLINICAL GENETICS

7-Methylguanosine Modifications in Transfer RNA (tRNA)

(2018) Chie Tomikawa   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Plant RNases T2, but not Dicer-like proteins, are major players of tRNA-derived fragments biogenesis

(2018) Cyrille Megel et al.   NUCLEIC ACIDS RESEARCH

Dynamics of intracellular stress-induced tRNA trafficking

(2018) Rabin Dhakal et al.   NUCLEIC ACIDS RESEARCH

Structure and two-metal mechanism of fungal tRNA ligase

(2018) Ankan Banerjee et al.   NUCLEIC ACIDS RESEARCH

Both kinds of RNase P in all domains of life: Surprises galore

(2018) Charles J. Daniels et al.   RNA

tRNA-Derived Small RNAs: Biogenesis, Modification, Function and Potential Impact on Human Disease Development

(2018) Vera Oberbauer et al.   Genes

tRNA N6-adenosine threonylcarbamoyltransferase defect due to KAE1/TCS3 (OSGEP) mutation manifest by neurodegeneration and renal tubulopathy

(2017) Simon Edvardson et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Maf1-mediated regulation of yeast RNA polymerase III is correlated with CCA addition at the 3′ end of tRNA precursors

(2017) Dominika Foretek et al.   GENE

Sharing the load: Mex67–Mtr2 cofunctions with Los1 in primary tRNA nuclear export

(2017) Kunal Chatterjee et al.   GENES & DEVELOPMENT

Three distinct 3-methylcytidine (m 3 C) methyltransferases modify tRNA and mRNA in mice and humans

(2017) Luang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thio-Modification of tRNA at the Wobble Position as Regulator of the Kinetics of Decoding and Translocation on the Ribosome

(2017) Namit Ranjan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival

(2017) Joshua M. Dewe et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation

(2017) Hsin-Jung Chou et al.   MOLECULAR CELL

A transfer-RNA-derived small RNA regulates ribosome biogenesis

(2017) Hak Kyun Kim et al.   NATURE

Editing and methylation at a single site by functionally interdependent activities

(2017) Mary Anne T. Rubio et al.   NATURE

Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly

(2017) Daniela A Braun et al.   NATURE GENETICS

The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis

(2017) Paul Schimmel   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hydroxylation of a conserved tRNA modification establishes non-universal genetic code in echinoderm mitochondria

(2017) Asuteka Nagao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic features of the atypical tRNA m1G9 SPOUT methyltransferase, Trm10

(2017) Aiswarya Krishnamohan et al.   NUCLEIC ACIDS RESEARCH

Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase

(2017) Barbara S. Remus et al.   NUCLEIC ACIDS RESEARCH

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

tRNA-derived small RNAs target transposable element transcripts

(2017) German Martinez et al.   NUCLEIC ACIDS RESEARCH

Transcriptome-Wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and Noncoding RNAs

(2017) Rakesh David et al.   PLANT CELL

Minimal and RNA-free RNase P inAquifex aeolicus

(2017) Astrid I. Nickel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrograde nuclear transport from the cytoplasm is required for tRNATyr maturation in T. brucei

(2017) Alan C. Kessler et al.   RNA Biology

Minimal requirements for reverse polymerization and tRNA repair by tRNAHis guanylyltransferase

(2017) Riddhi Desai et al.   RNA Biology

Rapid RNase L–driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery

(2017) Jesse Donovan et al.   RNA

Binding synergy as an essential step for tRNA editing and modification enzyme codependence in Trypanosoma brucei

(2017) Katherine M. McKenney et al.   RNA

Genetic bypass of essential RNA repair enzymes in budding yeast

(2017) Patrick D. Cherry et al.   RNA

Examining tRNA 3′-ends in Escherichia coli : teamwork between CCA-adding enzyme, RNase T, and RNase R

(2017) Karolin Wellner et al.   RNA

Widespread temperature sensitivity and tRNA decay due to mutations in a yeast tRNA

(2017) Matthew J. Payea et al.   RNA

Roles of RNase P and Its Subunits

(2017) Nayef Jarrous   TRENDS IN GENETICS

Hydroxylation of a conserved tRNA modification establishes non-universal genetic code in echinoderm mitochondria

(2017) Asuteka Nagao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells

(2017) Yuko Ueda et al.   Scientific Reports

Autosomal-Recessive Mutations in the tRNA Splicing Endonuclease Subunit TSEN15 Cause Pontocerebellar Hypoplasia and Progressive Microcephaly

(2016) Martin W. Breuss et al.   AMERICAN JOURNAL OF HUMAN GENETICS

tRNA-targeting ribonucleases: molecular mechanisms and insights into their physiological roles

(2016) Tetsuhiro Ogawa   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

ALKBH1-Mediated tRNA Demethylation Regulates Translation

(2016) Fange Liu et al.   CELL

Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP

(2016) Bruno Lemieux et al.   CELL

A homozygous truncating mutation in PUS3 expands the role of tRNA modification in normal cognition

(2016) Ranad Shaheen et al.   HUMAN GENETICS

Precursors of tRNAs are stabilized by methylguanosine cap structures

(2016) Takayuki Ohira et al.   Nature Chemical Biology

A mutation in the THG1L gene in a family with cerebellar ataxia and developmental delay

(2016) Simon Edvardson et al.   NEUROGENETICS

An integrated, structure- and energy-based view of the genetic code

(2016) Henri Grosjean et al.   NUCLEIC ACIDS RESEARCH

Identification of distinct biological functions for four 3′-5′ RNA polymerases

(2016) Yicheng Long et al.   NUCLEIC ACIDS RESEARCH

Genome-wide identification and characterization of tRNA-derived RNA fragments in land plants

(2016) Cristiane S. Alves et al.   PLANT MOLECULAR BIOLOGY

Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer

(2016) Yuri Pekarsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation

(2016) Albert Jeltsch et al.   RNA Biology

A tRNA-derived fragment competes with mRNA for ribosome binding and regulates translation during stress

(2016) Jennifer Gebetsberger et al.   RNA Biology

Lack of tRNA-i6A modification causes mitochondrial-like metabolic deficiency inS. pombeby limiting activity of cytosolic tRNATyr, not mito-tRNA

(2016) Tek N. Lamichhane et al.   RNA

The essential function of theTrypanosoma bruceiTrl1 homolog in procyclic cells is maturation of the intron-containing tRNATyr

(2016) Raphael R.S. Lopes et al.   RNA

tRNA base methylation identification and quantification via high-throughput sequencing

(2016) Wesley C. Clark et al.   RNA

Evolving specificity of tRNA 3-methyl-cytidine-32 (m3C32) modification: a subset of tRNAsSerrequiresN6-isopentenylation of A37

(2016) Aneeshkumar G. Arimbasseri et al.   RNA

S. cerevisiaeTrm140 has two recognition modes for 3-methylcytidine modification of the anticodon loop of tRNA substrates

(2016) Lu Han et al.   RNA

New Structural Insights into Translational Miscoding

(2016) Alexey Rozov et al.   TRENDS IN BIOCHEMICAL SCIENCES

Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)

(2016) Pankaj Kumar et al.   TRENDS IN BIOCHEMICAL SCIENCES

A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei

(2016) Ian M. C. Fleming et al.   Scientific Reports

TRMT5 Mutations Cause a Defect in Post-transcriptional Modification of Mitochondrial tRNA Associated with Multiple Respiratory-Chain Deficiencies

(2015) Christopher A. Powell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme

(2015) Claus-D. Kuhn et al.   CELL

Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

(2015) Danny D. Nedialkova et al.   CELL

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

tRNA processing defects induce replication stress and Chk2-dependent disruption of piRNA transcription

(2015) A. Molla-Herman et al.   EMBO JOURNAL

The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis

(2015) F. Tuorto et al.   EMBO JOURNAL

In vivo biochemical analyses reveal distinct roles of β-importins and eEF1A in tRNA subcellular traffic

(2015) Hsiao-Yun Huang et al.   GENES & DEVELOPMENT

The 3′ addition of CCA to mitochondrial tRNASer(AGY) is specifically impaired in patients with mutations in the tRNA nucleotidyl transferase TRNT1

(2015) Florin Sasarman et al.   HUMAN MOLECULAR GENETICS

Defects in tRNA Anticodon Loop 2′-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations inFTSJ1

(2015) Michael P. Guy et al.   HUMAN MUTATION

The tRNA Splicing Endonuclease Complex Cleaves the Mitochondria-localizedCBP1mRNA

(2015) Tatsuhisa Tsuboi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Human tRNA m1A58 Methyltransferase–tRNA3Lys Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target

(2015) Janet Finer-Moore et al.   JOURNAL OF MOLECULAR BIOLOGY

Distribution of Ribonucleoprotein and Protein-Only RNase P in Eukarya

(2015) Marcus Lechner et al.   MOLECULAR BIOLOGY AND EVOLUTION

tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae

(2015) Jadyn R. Damon et al.   MOLECULAR BIOLOGY OF THE CELL

Essentiality of threonylcarbamoyladenosine (t6A), a universal tRNA modification, in bacteria

(2015) Patrick C. Thiaville et al.   MOLECULAR MICROBIOLOGY

ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

(2015) Aaron E Cozen et al.   NATURE METHODS

GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes

(2015) Patricia P. Chan et al.   NUCLEIC ACIDS RESEARCH

A common tRNA modification at an unusual location: the discovery of wyosine biosynthesis in mitochondria

(2015) Paul J. Sample et al.   NUCLEIC ACIDS RESEARCH

Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1

(2015) Sunny Sharma et al.   NUCLEIC ACIDS RESEARCH

Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine

(2015) Martin Müller et al.   NUCLEIC ACIDS RESEARCH

TRM6/61 connects PKCα with translational control through tRNAiMet stabilization: impact on tumorigenesis

(2015) F Macari et al.   ONCOGENE

Coevolution of RtcB and Archease created a multiple-turnover RNA ligase

(2015) Kevin K. Desai et al.   RNA

Metazoan tRNA introns generate stable circular RNAs in vivo

(2015) Zhipeng Lu et al.   RNA

An extensive allelic series ofDrosophila kae1mutants reveals diverse and tissue-specific requirements for t6A biogenesis

(2015) Ching-Jung Lin et al.   RNA

RNA modification: the Golden Period 1995–2015

(2015) Henri Grosjean   RNA

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

The Human Nuclear Exosome Targeting Complex Is Loaded onto Newly Synthesized RNA to Direct Early Ribonucleolysis

(2015) Michal Lubas et al.   Cell Reports

Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast

(2015) Wael Abdel-Fattah et al.   PLoS Genetics

Controlling translation via modulation of tRNA levels

(2015) Jeremy E. Wilusz   Wiley Interdisciplinary Reviews-RNA

Cytosolic Hsp70 and co-chaperones constitute a novel system for tRNA import into the nucleus

(2015) Akira Takano et al.   eLife

The Role of a Novel TRMT1 Gene Mutation and Rare GRM1 Gene Defect in Intellectual Disability in Two Azeri Families

(2015) Behzad Davarniya et al.   PLoS One

Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t6A), a universal modification of tRNA

(2015) Patrick C Thiaville et al.   RNA Biology

Elongator, a conserved complex required for wobble uridine modifications in Eukaryotes

(2015) Tony Karlsborn et al.   RNA Biology

Distribution and frequencies of post-transcriptional modifications in tRNAs

(2015) Magdalena A Machnicka et al.   RNA Biology

Familial dysautonomia (FD) patients have reduced levels of the modified wobble nucleoside mcm5s2U in tRNA

(2014) Tony Karlsborn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Saccharomyces cerevisiae Thg1 Uses 5′-Pyrophosphate Removal To Control Addition of Nucleotides to tRNAHis

(2014) Brian A. Smith et al.   BIOCHEMISTRY

Keeping the eIF2 alpha kinase Gcn2 in check

(2014) Beatriz A. Castilho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets

(2014) Pankaj Kumar et al.   BMC BIOLOGY

Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function

(2014) Ender Karaca et al.   CELL

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

(2014) Ashleigh E. Schaffer et al.   CELL

piRNAs

(2014) Bo W. Han et al.   CURRENT BIOLOGY

The eukaryotic RNA exosome

(2014) Kurt Januszyk et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

IHG-1 Increases Mitochondrial Fusion and Bioenergetic Function

(2014) F. B. Hickey et al.   DIABETES

The mammalian tRNA ligase complex mediates splicing ofXBP1mRNA and controls antibody secretion in plasma cells

(2014) Jennifer Jurkin et al.   EMBO JOURNAL

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

mTOR regulates the nucleoplasmic diffusion of Xrn2 under conditions of heat stress

(2014) Kazunori Watanabe et al.   FEBS LETTERS

tRNA fragments in human health and disease

(2014) Paul Anderson et al.   FEBS LETTERS

Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1

(2014) J. Wu et al.   GENES & DEVELOPMENT

Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis

(2014) Michael P. Guy et al.   GENES & DEVELOPMENT

TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly

(2014) David Gillis et al.   JOURNAL OF MEDICAL GENETICS

Small Noncoding RNAs in Cells Transformed by Human T-Cell Leukemia Virus Type 1: a Role for a tRNA Fragment as a Primer for Reverse Transcriptase

(2014) K. Ruggero et al.   JOURNAL OF VIROLOGY

Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

(2014) M. Saikia et al.   MOLECULAR AND CELLULAR BIOLOGY

Separate responses of karyopherins to glucose and amino acid availability regulate nucleocytoplasmic transport

(2014) Hsiao-Yun Huang et al.   MOLECULAR BIOLOGY OF THE CELL

A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB

(2014) Yanyan Lu et al.   MOLECULAR CELL

An mRNA-Derived Noncoding RNA Targets and Regulates the Ribosome

(2014) Andreas Pircher et al.   MOLECULAR CELL

Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors

(2014) Johannes Popow et al.   NATURE

Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism

(2014) Kiruthika Selvadurai et al.   Nature Chemical Biology

Coupling mRNA processing with transcription in time and space

(2014) David L. Bentley   NATURE REVIEWS GENETICS

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation

(2014) Kevin K. Desai et al.   NUCLEIC ACIDS RESEARCH

A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs

(2014) T. Suzuki et al.   NUCLEIC ACIDS RESEARCH

Life without post-transcriptional addition of G−1: two alternatives for tRNAHisidentity in Eukarya

(2014) Bhalchandra S. Rao et al.   RNA

Conservation of an intricate circuit for crucial modifications of the tRNAPheanticodon loop in eukaryotes

(2014) Michael P. Guy et al.   RNA

An evolutionary approach uncovers a diverse response of tRNA 2-thiolation to elevated temperatures in yeast

(2014) Fiona Alings et al.   RNA

Functional importance of Ψ38and Ψ39in distinct tRNAs, amplified for tRNAGln(UUG)by unexpected temperature sensitivity of the s2U modification in yeast

(2014) Lu Han et al.   RNA

Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

(2014) R. Ishimura et al.   SCIENCE

Playing RNase P Evolution: Swapping the RNA Catalyst for a Protein Reveals Functional Uniformity of Highly Divergent Enzyme Forms

(2014) Christoph Weber et al.   PLoS Genetics

Defective i6A37 Modification of Mitochondrial and Cytosolic tRNAs Results from Pathogenic Mutations in TRIT1 and Its Substrate tRNA

(2014) John W. Yarham et al.   PLoS Genetics

tRNAs as regulators of biological processes

(2014) Medha Raina et al.   Frontiers in Genetics

Handling tRNA introns, archaeal way and eukaryotic way

(2014) Tohru Yoshihisa   Frontiers in Genetics

Structures of the Noncanonical RNA Ligase RtcB Reveal the Mechanism of Histidine Guanylylation

(2013) Kevin K. Desai et al.   BIOCHEMISTRY

Sulfur Amino Acids Regulate Translational Capacity and Metabolic Homeostasis through Modulation of tRNA Thiolation

(2013) Sunil Laxman et al.   CELL

Posttranscriptional RNA Modifications: Playing Metabolic Games in a Cell’s Chemical Legoland

(2013) Mark Helm et al.   CHEMISTRY & BIOLOGY

Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2

(2013) Zeljko Durdevic et al.   EMBO REPORTS

Transfer RNA Post-Transcriptional Processing, Turnover, and Subcellular Dynamics in the YeastSaccharomyces cerevisiae

(2013) Anita K. Hopper   GENETICS

Partitioning of the Nuclear and Mitochondrial tRNA 3′-End Processing Activities between Two different Proteins inSchizosaccharomyces pombe

(2013) Xiaojie Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutation inADAT3, encoding adenosine deaminase acting on transfer RNA, causes intellectual disability and strabismus

(2013) Anas M Alazami et al.   JOURNAL OF MEDICAL GENETICS

The Mouse Cytosine-5 RNA Methyltransferase NSun2 Is a Component of the Chromatoid Body and Required for Testis Differentiation

(2013) S. Hussain et al.   MOLECULAR AND CELLULAR BIOLOGY

Lack of tRNA Modification Isopentenyl-A37 Alters mRNA Decoding and Causes Metabolic Deficiencies in Fission Yeast

(2013) T. N. Lamichhane et al.   MOLECULAR AND CELLULAR BIOLOGY

Unusual Noncanonical Intron Editing Is Important for tRNA Splicing in Trypanosoma brucei

(2013) Mary Anne T. Rubio et al.   MOLECULAR CELL

CLP1 links tRNA metabolism to progressive motor-neuron loss

(2013) Toshikatsu Hanada et al.   NATURE

Degradation of initiator tRNA Met by Xrn1/2 via its accumulation in the nucleus of heat-treated HeLa cells

(2013) Kazunori Watanabe et al.   NUCLEIC ACIDS RESEARCH

Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t 6 A tRNA modification

(2013) Ludovic Perrochia et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate

(2013) Zhenhua Shao et al.   NUCLEIC ACIDS RESEARCH

Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system

(2013) Leo C. K. Wan et al.   NUCLEIC ACIDS RESEARCH

tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding

(2013) V. A. N. Rezgui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma

(2013) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of reverse nucleotide polymerization

(2013) A. Nakamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrograde transfer RNA nuclear import provides a new level of tRNA quality control in Saccharomyces cerevisiae

(2013) E. B. Kramer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing

(2013) M. Pratt-Hyatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dnmt2-dependent methylomes lack defined DNA methylation patterns

(2013) G. Raddatz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The T. brucei TRM5 methyltransferase plays an essential role in mitochondrial protein synthesis and function

(2013) Z. Paris et al.   RNA

Unexpected expansion of tRNA substrate recognition by the yeast m1G9 methyltransferase Trm10

(2013) W. E. Swinehart et al.   RNA

tRNA 3' processing in yeast involves tRNase Z, Rex1, and Rrp6

(2013) E. Skowronek et al.   RNA

A kinetic framework for tRNA ligase and enforcement of a 2'-phosphate requirement for ligation highlights the design logic of an RNA repair machine

(2013) B. S. Remus et al.   RNA

The RNA Methyltransferase Dnmt2 Is Required for Efficient Dicer-2-Dependent siRNA Pathway Activity in Drosophila

(2013) Zeljko Durdevic et al.   Cell Reports

A Genetic Screen for High Copy Number Suppressors of the Synthetic Lethality Between elg1Δ and srs2Δ in Yeast

(2013) Inbal Gazy et al.   G3-Genes Genomes Genetics

Ikbkap/Elp1 Deficiency Causes Male Infertility by Disrupting Meiotic Progression

(2013) Fu-Jung Lin et al.   PLoS Genetics

RNA–Mediated Epigenetic Heredity Requires the Cytosine Methyltransferase Dnmt2

(2013) Jafar Kiani et al.   PLoS Genetics

Reversible and Rapid Transfer-RNA Deactivation as a Mechanism of Translational Repression in Stress

(2013) Andreas Czech et al.   PLoS Genetics

Modification of tRNALysUUU by Elongator Is Essential for Efficient Translation of Stress mRNAs

(2013) Jorge Fernández-Vázquez et al.   PLoS Genetics

Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling

(2013) Boris Zinshteyn et al.   PLoS Genetics

tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans

(2013) Mariana Igoillo-Esteve et al.   PLoS Genetics

Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity

(2013) Karyn Schmidt et al.   Wiley Interdisciplinary Reviews-RNA

Mutation in NSUN2, which Encodes an RNA Methyltransferase, Causes Autosomal-Recessive Intellectual Disability

(2012) Muzammil Ahmad Khan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in NSUN2 Cause Autosomal- Recessive Intellectual Disability

(2012) Lia Abbasi-Moheb et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Biosynthesis and Function of Posttranscriptional Modifications of Transfer RNAs

(2012) Basma El Yacoubi et al.   Annual Review of Genetics

Formation of tRNA granules in the nucleus of heat-induced human cells

(2012) Ryu Miyagawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanism of N6-Threonylcarbamoyladenonsine (t6A) Biosynthesis: Isolation and Characterization of the Intermediate Threonylcarbamoyl-AMP

(2012) Charles T. Lauhon   BIOCHEMISTRY

Diversity and roles of (t)RNA ligases

(2012) Johannes Popow et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PRORP proteins support RNase P activity in both organelles and the nucleus in Arabidopsis

(2012) B. Gutmann et al.   GENES & DEVELOPMENT

Beyond tRNA cleavage: novel essential function for yeast tRNA splicing endonuclease unrelated to tRNA processing

(2012) N. Dhungel et al.   GENES & DEVELOPMENT

Whole exome sequencing identifies a splicing mutation inNSUN2as a cause of a Dubowitz-like syndrome

(2012) Fernando Jose Martinez et al.   JOURNAL OF MEDICAL GENETICS

A Tetrahymena Piwi Bound to Mature tRNA 3′ Fragments Activates the Exonuclease Xrn2 for RNA Processing in the Nucleus

(2012) Mary T. Couvillion et al.   MOLECULAR CELL

Extensive Degradation of RNA Precursors by the Exosome in Wild-Type Cells

(2012) Rajani Kanth Gudipati et al.   MOLECULAR CELL

A new understanding of the decoding principle on the ribosome

(2012) Natalia Demeshkina et al.   NATURE

A cyclic form of N6-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification

(2012) Kenjyo Miyauchi et al.   Nature Chemical Biology

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

(2012) Francesca Tuorto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs

(2012) Zhihua Li et al.   NUCLEIC ACIDS RESEARCH

Absence of a universal element for tRNAHis identity in Acanthamoeba castellanii

(2012) Bhalchandra S. Rao et al.   NUCLEIC ACIDS RESEARCH

Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling

(2012) Maria Becker et al.   NUCLEIC ACIDS RESEARCH

In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya

(2012) Ludovic Perrochia et al.   NUCLEIC ACIDS RESEARCH

The sequential 2',3'-cyclic phosphodiesterase and 3'-phosphate/5'-OH ligation steps of the RtcB RNA splicing pathway are GTP-dependent

(2012) A. K. Chakravarty et al.   NUCLEIC ACIDS RESEARCH

A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase—extensive moonlighting in mitochondrial tRNA biogenesis

(2012) Elisa Vilardo et al.   NUCLEIC ACIDS RESEARCH

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

(2012) Jeffrey E. Squires et al.   NUCLEIC ACIDS RESEARCH

GAMETOPHYTE DEFECTIVE 1, a Putative Subunit of RNases P/MRP, Is Essential for Female Gametogenesis and Male Competence in Arabidopsis

(2012) Si-Qi Wang et al.   PLoS One

A Genetic Investigation of the KEOPS Complex in Halophilic Archaea

(2012) Adit Naor et al.   PLoS One

Structure-Function Analysis of Rny1 in tRNA Cleavage and Growth Inhibition

(2012) Natalie Luhtala et al.   PLoS One

RNA ligase RtcB splices 3'-phosphate and 5'-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3')pp(5')G intermediates

(2012) A. K. Chakravarty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH

(2012) M. Englert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

tRNAHis 5-methylcytidine levels increase in response to several growth arrest conditions in Saccharomyces cerevisiae

(2012) M. A. Preston et al.   RNA

Doing it in reverse: 3'-to-5' polymerization by the Thg1 superfamily

(2012) J. E. Jackman et al.   RNA

Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop

(2012) M. P. Guy et al.   RNA

The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications

(2012) J. M. Dewe et al.   RNA

Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway

(2012) T. W. Turowski et al.   RNA

A Yeast Prion, Mod5, Promotes Acquired Drug Resistance and Cell Survival Under Environmental Stress

(2012) G. Suzuki et al.   SCIENCE

Nuclear noncoding RNA surveillance: is the end in sight?

(2012) Sandra L. Wolin et al.   TRENDS IN GENETICS

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

(2012) Clement T.Y. Chan et al.   Nature Communications

Nuclear RNase P of Trypanosoma brucei: A Single Protein in Place of the Multicomponent RNA-Protein Complex

(2012) Andreas Taschner et al.   Cell Reports

Kinetic Analysis of 3′–5′ Nucleotide Addition Catalyzed by Eukaryotic tRNAHis Guanylyltransferase

(2011) Brian A. Smith et al.   BIOCHEMISTRY

A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification

(2011) Basma El Yacoubi et al.   EMBO JOURNAL

The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA

(2011) J. M. Whipple et al.   GENES & DEVELOPMENT

Role of Elongator Subunit Elp3 in Drosophila melanogaster Larval Development and Immunity

(2011) J. Walker et al.   GENETICS

Novel Mechanism of RNA Repair by RtcB via Sequential 2′,3′-Cyclic Phosphodiesterase and 3′-Phosphate/5′-Hydroxyl Ligation Reactions

(2011) Naoko Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RtcB, a Novel RNA Ligase, Can Catalyze tRNA Splicing andHAC1mRNA Splicingin Vivo

(2011) Naoko Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RtcB Is the RNA Ligase Component of anEscherichia coliRNA Repair Operon

(2011) Naoko Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformation Effects of Base Modification on the Anticodon Stem–Loop of Bacillus subtilis tRNATyr

(2011) Andria P. Denmon et al.   JOURNAL OF MOLECULAR BIOLOGY

Human tRNALys3UUU Is Pre-Structured by Natural Modifications for Cognate and Wobble Codon Binding through Keto–Enol Tautomerism

(2011) Franck A.P. Vendeix et al.   JOURNAL OF MOLECULAR BIOLOGY

Two novel WD40 domain–containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway

(2011) Yufeng Shi et al.   MOLECULAR BIOLOGY OF THE CELL

Several RNase T2 enzymes function in induced tRNA and rRNA turnover in the ciliate Tetrahymena

(2011) Kasper L. Andersen et al.   MOLECULAR BIOLOGY OF THE CELL

Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p

(2011) Vera Cherkasova et al.   MOLECULAR BIOLOGY OF THE CELL

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex

(2011) Michal Lubas et al.   MOLECULAR CELL

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

Cleavage of intron from the standard or non-standard position of the precursor tRNA by the splicing endonuclease of Aeropyrum pernix, a hyper-thermophilic Crenarchaeon, involves a novel RNA recognition site in the Crenarchaea specific loop

(2011) Akira Hirata et al.   NUCLEIC ACIDS RESEARCH

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs

(2011) Marie-Claire Daugeron et al.   NUCLEIC ACIDS RESEARCH

Quantitative single cell monitoring of protein synthesis at subcellular resolution using fluorescently labeled tRNA

(2011) Sima Barhoom et al.   NUCLEIC ACIDS RESEARCH

Unexpected Accumulation of ncm5U and ncm5s2U in a trm9 Mutant Suggests an Additional Step in the Synthesis of mcm5U and mcm5s2U

(2011) Changchun Chen et al.   PLoS One

Estimating the timing of early eukaryotic diversification with multigene molecular clocks

(2011) L. W. Parfrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrograde nuclear import of tRNA precursors is required for modified base biogenesis in yeast

(2011) T. Ohira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation

(2011) M. Englert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The intron of tRNA-TrpCCA is dispensable for growth and translation of Saccharomyces cerevisiae

(2011) S. Mori et al.   RNA

A role for tRNAHis guanylyltransferase (Thg1)-like proteins from Dictyostelium discoideum in mitochondrial 5'-tRNA editing

(2011) M. G. Abad et al.   RNA

Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae

(2011) A. Noma et al.   RNA

A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop

(2011) S. D'Silva et al.   RNA

Plasticity and diversity of tRNA anticodon determinants of substrate recognition by eukaryotic A37 isopentenyltransferases

(2011) T. N. Lamichhane et al.   RNA

tRNAs Marked with CCACCA Are Targeted for Degradation

(2011) J. E. Wilusz et al.   SCIENCE

HSPC117 Is the Essential Subunit of a Human tRNA Splicing Ligase Complex

(2011) J. Popow et al.   SCIENCE

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA

(2011) Erwin van den Born et al.   Nature Communications

Elongator Complex Influences Telomeric Gene Silencing and DNA Damage Response by Its Role in Wobble Uridine tRNA Modification

(2011) Changchun Chen et al.   PLoS Genetics

Variants in SUP45 and TRM10 Underlie Natural Variation in Translation Termination Efficiency in Saccharomyces cerevisiae

(2011) Noorossadat Torabi et al.   PLoS Genetics

The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

(2011) Sandra Blanco et al.   PLoS Genetics

Transportin 3 Promotes a Nuclear Maturation Step Required for Efficient HIV-1 Integration

(2011) Lihong Zhou et al.   PLoS Pathogens

Structure of transfer RNAs: similarity and variability

(2011) Richard Giegé et al.   Wiley Interdisciplinary Reviews-RNA

p38α as an inducer of aneuploidy in p53-/-tetraploid cells

(2010) Laura Carrassa   CELL CYCLE

The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A

(2010) Madhusudhan Srinivasan et al.   EMBO JOURNAL

3′-5′ tRNAHisguanylyltransferase in bacteria

(2010) Ilka U. Heinemann et al.   FEBS LETTERS

tRNA biology charges to the front

(2010) E. M. Phizicky et al.   GENES & DEVELOPMENT

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

Allele-Specific Suppressors of lin-1(R175Opal) Identify Functions of MOC-3 and DPH-3 in tRNA Modification Complexes in Caenorhabditis elegans

(2010) S. Kim et al.   GENETICS

Trm112p Is a 15-kDa Zinc Finger Protein Essential for the Activity of Two tRNA and One Protein Methyltransferases in Yeast

(2010) Marie-Hélène Mazauric et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian ALKBH8 Possesses tRNA Methyltransferase Activity Required for the Biogenesis of Multiple Wobble Uridine Modifications Implicated in Translational Decoding

(2010) L. Songe-Moller et al.   MOLECULAR AND CELLULAR BIOLOGY

Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

(2010) D. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

Dual Functions of Yeast tRNA Ligase in the Unfolded Protein Response: Unconventional Cytoplasmic Splicing of HAC1 Pre-mRNA Is Not Sufficient to Release Translational Attenuation

(2010) Takao Mori et al.   MOLECULAR BIOLOGY OF THE CELL

Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe

(2010) Dong-Uk Kim et al.   NATURE BIOTECHNOLOGY

Lack of evidence for DNA methylation of Invader4 retroelements in Drosophila and implications for Dnmt2-mediated epigenetic regulation

(2010) Matthias Schaefer et al.   NATURE GENETICS

A single Arabidopsis organellar protein has RNase P activity

(2010) Anthony Gobert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pontocerebellar hypoplasia: Clinical, pathologic, and genetic studies

(2010) D. Cassandrini et al.   NEUROLOGY

tRNA 5′-end repair activities of tRNA His guanylyltransferase (Thg1)-like proteins from Bacteria and Archaea

(2010) Bhalchandra S. Rao et al.   NUCLEIC ACIDS RESEARCH

Archaeal/Eukaryal RNase P: subunits, functions and RNA diversification

(2010) Nayef Jarrous et al.   NUCLEIC ACIDS RESEARCH

New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA

(2010) M. Kempenaers et al.   NUCLEIC ACIDS RESEARCH

Branchiostoma floridae has separate healing and sealing enzymes for 5'-phosphate RNA ligation

(2010) M. Englert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases

(2010) S. J. Hyde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The requirement for the highly conserved G-1 residue of Saccharomyces cerevisiae tRNAHis can be circumvented by overexpression of tRNAHis and its synthetase

(2010) M. A. Preston et al.   RNA

Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs

(2010) M. Saikia et al.   RNA

Human tRNA-derived small RNAs in the global regulation of RNA silencing

(2010) D. Haussecker et al.   RNA

How the CCA-Adding Enzyme Selects Adenine over Cytosine at Position 76 of tRNA

(2010) B. Pan et al.   SCIENCE

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

(2010) Clement T. Y. Chan et al.   PLoS Genetics

The Many Pathways of RNA Degradation

(2009) Jonathan Houseley et al.   CELL

RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon

(2009) Sarin Chimnaronk et al.   EMBO JOURNAL

Do all modifications benefit all tRNAs?

(2009) Eric M. Phizicky et al.   FEBS LETTERS

Eukaryotic initiator tRNA: Finely tuned and ready for action

(2009) Sarah E. Kolitz et al.   FEBS LETTERS

The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress inSaccharomyces cerevisiae

(2009) Debrah M. Thompson et al.   JOURNAL OF CELL BIOLOGY

Regulation of tRNA Bidirectional Nuclear-Cytoplasmic Trafficking in Saccharomyces cerevisiae

(2009) Athulaprabha Murthi et al.   MOLECULAR BIOLOGY OF THE CELL

Elongator function depends on antagonistic regulation by casein kinase Hrr25 and protein phosphatase Sit4

(2009) Constance Mehlgarten et al.   MOLECULAR MICROBIOLOGY

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

(2009) Sebastian Leidel et al.   NATURE

Structures of the tRNA export factor in the nuclear and cytosolic states

(2009) Atlanta G. Cook et al.   NATURE

A sequence element that tunes Escherichia coli tRNAAlaGGC to ensure accurate decoding

(2009) Sarah Ledoux et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA

(2009) B. El Yacoubi et al.   NUCLEIC ACIDS RESEARCH

Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions

(2009) Akiko Noma et al.   NUCLEIC ACIDS RESEARCH

The appearance of pyrrolysine in tRNAHisguanylyltransferase by neutral evolution

(2009) Ilka U. Heinemann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Template-dependent 3'-5' nucleotide addition is a shared feature of tRNAHis guanylyltransferase enzymes from multiple domains of life

(2009) M. G. Abad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

(2009) C. Cole et al.   RNA

Messenger RNA Export from the Nucleus: A Series of Molecular Wardrobe Changes

(2009) Seth M. Kelly et al.   TRAFFIC

Defects in tRNA Modification Associated with Neurological and Developmental Dysfunctions in Caenorhabditis elegans Elongator Mutants

(2009) Changchun Chen et al.   PLoS Genetics

The Elongator Complex Interacts with PCNA and Modulates Transcriptional Silencing and Sensitivity to DNA Damage Agents

(2009) Qing Li et al.   PLoS Genetics

Probing the Catalytic Triad of an Archaeal RNA Splicing Endonuclease†

(2008) Kate Calvin et al.   BIOCHEMISTRY

RNase P without RNA: Identification and Functional Reconstitution of the Human Mitochondrial tRNA Processing Enzyme

(2008) Johann Holzmann et al.   CELL

The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon

(2008) Yoshiho Ikeuchi et al.   EMBO JOURNAL

Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1

(2008) I. Chernyakov et al.   GENES & DEVELOPMENT

Chromatin-Associated Genes Protect the Yeast Genome From Ty1 Insertional Mutagenesis

(2008) Katherine M. Nyswaner et al.   GENETICS

Modified Uridines with C5-methylene Substituents at the First Position of the tRNA Anticodon Stabilize U·G Wobble Pairing during Decoding

(2008) Shinya Kurata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thio-modification of Yeast Cytosolic tRNA Requires a Ubiquitin-related System That Resembles Bacterial Sulfur Transfer Systems

(2008) Yumi Nakai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Int6/eIF3e Promotes General Translation and Atf1 Abundance to Modulate Sty1 MAPK-dependent Stress Response in Fission Yeast

(2008) Tsuyoshi Udagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Mouse Ikbkap, a Subunit of Elongator, Leads to Transcriptional Deficits and Embryonic Lethality That Can Be Rescued by Human IKBKAP

(2008) Y.-T. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Eukaryotic Wobble Uridine Modifications Promote a Functionally Redundant Decoding System

(2008) M. J. O. Johansson et al.   MOLECULAR AND CELLULAR BIOLOGY

The primary target of the killer toxin fromPichia acaciaeis tRNAGln

(2008) Roland Klassen et al.   MOLECULAR MICROBIOLOGY

tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia

(2008) Birgit S Budde et al.   NATURE GENETICS

Rex1p deficiency leads to accumulation of precursor initiator tRNAMet and polyadenylation of substrate RNAs in Saccharomyces cerevisiae

(2008) S. G. Ozanick et al.   NUCLEIC ACIDS RESEARCH

RNA cytosine methylation analysis by bisulfite sequencing

(2008) M. Schaefer et al.   NUCLEIC ACIDS RESEARCH

tRNAdb 2009: compilation of tRNA sequences and tRNA genes

(2008) F. Juhling et al.   NUCLEIC ACIDS RESEARCH

The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity

(2008) M. Dewez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallographic snapshots of eukaryotic dimethylallyltransferase acting on tRNA: Insight into tRNA recognition and reaction mechanism

(2008) C. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae

(2008) B. Huang et al.   RNA

Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo

(2008) A. Ramirez et al.   RNA

Competition between the Rex1 exonuclease and the La protein affects both Trf4p-mediated RNA quality control and pre-tRNA maturation

(2008) L. A. Copela et al.   RNA

Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast

(2008) M. Gustavsson et al.   RNA

Human DNMT2 methylates tRNAAsp molecules using a DNA methyltransferase-like catalytic mechanism

(2008) T. P. Jurkowski et al.   RNA

Structure of the Yeast tRNA m7G Methylation Complex

(2008) Nicolas Leulliot et al.   STRUCTURE

A loss-of-function mutation in theFTSJ1 gene causes nonsyndromic X-linked mental retardation in a japanese family

(2007) Kyoko Takano et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS