Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system

Crystal structure of the dimer of two essentialSalmonella typhimuriumproteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex

(2013) C. E. Nichols et al.   PROTEIN SCIENCE

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

TheO-Carbamoyltransferase TobZ Catalyzes an Ancient Enzymatic Reaction

(2012) Christoph Parthier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism of N6-Threonylcarbamoyladenonsine (t6A) Biosynthesis: Isolation and Characterization of the Intermediate Threonylcarbamoyl-AMP

(2012) Charles T. Lauhon   BIOCHEMISTRY

Biosynthesis of Threonylcarbamoyl Adenosine (t6A), a Universal tRNA Nucleoside

(2012) Christopher Deutsch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cyclic form of N6-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification

(2012) Kenjyo Miyauchi et al.   Nature Chemical Biology

In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya

(2012) Ludovic Perrochia et al.   NUCLEIC ACIDS RESEARCH

The Human EKC/KEOPS Complex Is Recruited to Cullin2 Ubiquitin Ligases by the Human Tumour Antigen PRAME

(2012) Adalberto Costessi et al.   PLoS One

A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification

(2011) Basma El Yacoubi et al.   EMBO JOURNAL

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

(2011) Poulikos I. Poulikakos et al.   NATURE

Crystal structure of sulfolobus tokodaii sua5 complexed with L-threonine and AMPPNP

(2011) Mitsuo Kuratani et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Sua5p is required for telomere recombination in Saccharomyces cerevisiae

(2010) Fei-Long Meng et al.   CELL RESEARCH

The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A

(2010) Madhusudhan Srinivasan et al.   EMBO JOURNAL

Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival

(2010) D. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

tRNA Binds to Cytochrome c and Inhibits Caspase Activation

(2010) Yide Mei et al.   MOLECULAR CELL

The RNA modification database, RNAMDB: 2011 update

(2010) W. A. Cantara et al.   NUCLEIC ACIDS RESEARCH

Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication

(2009) Fei-Long Meng et al.   EMBO JOURNAL

The Sua5 Protein Is Essential for Normal Translational Regulation in Yeast

(2009) C. A. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA

(2009) B. El Yacoubi et al.   NUCLEIC ACIDS RESEARCH

Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance

(2009) Jacques Oberto et al.   NUCLEIC ACIDS RESEARCH

tRNA's modifications bring order to gene expression

(2008) Estella M Gustilo et al.   CURRENT OPINION IN MICROBIOLOGY

Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex

(2008) Arnaud Hecker et al.   EMBO JOURNAL

Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular Machine

(2008) Daniel Y.L. Mao et al.   MOLECULAR CELL