Accurate target identification for Mycobacterium tuberculosis endoribonuclease toxins requires expression in their native host

Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology

(2018) Alexander Harms et al.   MOLECULAR CELL

VapC proteins from Mycobacterium tuberculosis share ribonuclease sequence specificity but differ in regulation and toxicity

(2018) Abigail Sharrock et al.   PLoS One

Structural, functional and biological insights into the role of Mycobacterium tuberculosis VapBC11 toxin–antitoxin system: targeting a tRNase to tackle mycobacterial adaptation

(2018) Amar Deep et al.   NUCLEIC ACIDS RESEARCH

Co-expression network analysis of toxin-antitoxin loci in Mycobacterium tuberculosis reveals key modulators of cellular stress

(2017) Amita Gupta et al.   Scientific Reports

VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation

(2016) Kristoffer Winther et al.   NUCLEIC ACIDS RESEARCH

tRNA is a new target for cleavage by a MazF toxin

(2016) Jason M. Schifano et al.   NUCLEIC ACIDS RESEARCH

tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence

(2016) Yok Hian Chionh et al.   Nature Communications

Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase

(2015) Jonathan W. Cruz et al.   Nature Communications

MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs

(2015) Prabhakar Tiwari et al.   Nature Communications

An RNA-seq method for defining endoribonuclease cleavage specificity identifies dual rRNA substrates for toxin MazF-mt3

(2014) Jason M. Schifano et al.   Nature Communications

Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis

(2014) Ambre Sala et al.   Toxins

Proteomic Profiling ofMycobacterium tuberculosisIdentifies Nutrient-starvation-responsive Toxin–antitoxin Systems

(2013) Jakob Albrethsen et al.   MOLECULAR & CELLULAR PROTEOMICS

VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

(2013) Kristoffer S. Winther et al.   Nature Communications

Genome-wide Mapping of Transcriptional Start Sites Defines an Extensive Leaderless Transcriptome in Mycobacterium tuberculosis

(2013) Teresa Cortes et al.   Cell Reports

A VapBC Toxin-Antitoxin Module Is a Posttranscriptional Regulator of Metabolic Flux in Mycobacteria

(2012) J. L. McKenzie et al.   JOURNAL OF BACTERIOLOGY

Growth and Translation Inhibition through Sequence-specific RNA Binding byMycobacterium tuberculosisVapC Toxin

(2012) Jared D. Sharp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry

(2012) J. L. McKenzie et al.   RNA

VapC Toxins from Mycobacterium tuberculosis Are Ribonucleases that Differentially Inhibit Growth and Are Neutralized by Cognate VapB Antitoxins

(2011) Bintou Ahmadou Ahidjo et al.   PLoS One

Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

(2011) K. S. Winther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance

(2010) R. Singh et al.   JOURNAL OF BACTERIOLOGY

The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array

(2010) V. L. Arcus et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Global transcriptional response to vancomycin in Mycobacterium tuberculosis

(2009) R. Provvedi et al.   MICROBIOLOGY-SGM

Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

(2009) Holly R. Ramage et al.   PLoS Genetics

Three Mycobacterium tuberculosis Rel Toxin-Antitoxin Modules Inhibit Mycobacterial Growth and Are Expressed in Infected Human Macrophages

(2008) S. B. Korch et al.   JOURNAL OF BACTERIOLOGY

The Enduring Hypoxic Response of Mycobacterium tuberculosis

(2008) Tige R. Rustad et al.   PLoS One