The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis

EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice

(2017) Abul Arif et al.   NATURE

Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells

(2016) Kevin A. Goncalves et al.   CELL

ALKBH1-Mediated tRNA Demethylation Regulates Translation

(2016) Fange Liu et al.   CELL

Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression

(2016) Hani Goodarzi et al.   CELL

Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition

(2016) Ariel A Bazzini et al.   EMBO JOURNAL

Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair

(2016) Litao Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stem cell function and stress response are controlled by protein synthesis

(2016) Sandra Blanco et al.   NATURE

Mastering the game of Go with deep neural networks and tree search

(2016) David Silver et al.   NATURE

Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

(2016) Qi Chen et al.   NATURE REVIEWS GENETICS

YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression

(2016) Shawn M. Lyons et al.   NUCLEIC ACIDS RESEARCH

tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers

(2016) Ling-Ling Zheng et al.   NUCLEIC ACIDS RESEARCH

Translation quality control is critical for bacterial responses to amino acid stress

(2016) Tammy J. Bullwinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer

(2016) Yuri Pekarsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

tRNA base methylation identification and quantification via high-throughput sequencing

(2016) Wesley C. Clark et al.   RNA

Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)

(2016) Pankaj Kumar et al.   TRENDS IN BIOCHEMICAL SCIENCES

Small RNA Modifications: Integral to Function and Disease

(2016) Xudong Zhang et al.   TRENDS IN MOLECULAR MEDICINE

tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence

(2016) Yok Hian Chionh et al.   Nature Communications

Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States

(2016) Konrad L. M. Rudolph et al.   PLoS Genetics

Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection

(2016) Young Ha Ahn et al.   Nature Microbiology

Saturation of recognition elements blocks evolution of new tRNA identities

(2016) A. Saint-Leger et al.   Science Advances

tRNA-Derived Small Non-Coding RNAs in Response to Ischemia Inhibit Angiogenesis

(2016) Qing Li et al.   Scientific Reports

Identification of aberrant tRNA-halves expression patterns in clear cell renal cell carcinoma

(2016) Malin Nientiedt et al.   Scientific Reports

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement

(2015) Hani Goodarzi et al.   CELL

Codon Optimality Is a Major Determinant of mRNA Stability

(2015) Vladimir Presnyak et al.   CELL

Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

(2015) Jeremy M. Shea et al.   DEVELOPMENTAL CELL

Efficient and quantitative high-throughput tRNA sequencing

(2015) Guanqun Zheng et al.   NATURE METHODS

ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

(2015) Aaron E Cozen et al.   NATURE METHODS

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

(2015) Bastian Linder et al.   NATURE METHODS

Protein mistranslation protects bacteria against oxidative stress

(2015) Yongqiang Fan et al.   NUCLEIC ACIDS RESEARCH

Temperature dependent mistranslation in a hyperthermophile adapts proteins to lower temperatures

(2015) Michael H. Schwartz et al.   NUCLEIC ACIDS RESEARCH

Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers

(2015) Shozo Honda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification

(2015) Aneeshkumar G. Arimbasseri et al.   PLoS Genetics

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

Promiscuous methionyl-tRNA synthetase mediates adaptive mistranslation to protect cells against oxidative stress

(2014) J. Y. Lee et al.   JOURNAL OF CELL SCIENCE

Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage

(2014) E. Mishima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

(2014) M. Saikia et al.   MOLECULAR AND CELLULAR BIOLOGY

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease

(2014) Sebastian Kirchner et al.   NATURE REVIEWS GENETICS

A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs

(2014) T. Suzuki et al.   NUCLEIC ACIDS RESEARCH

Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops

(2014) T. Maehigashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance

(2014) B. Javid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity of human tRNA genes from the 1000-genomes project

(2014) Marc Parisien et al.   RNA Biology

Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

(2014) R. Ishimura et al.   SCIENCE

Human tRNA synthetase catalytic nulls with diverse functions

(2014) W.-S. Lo et al.   SCIENCE

Role of tRNA modifications in human diseases

(2014) Adrian Gabriel Torres et al.   TRENDS IN MOLECULAR MEDICINE

Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection

(2014) Yunfang Zhang et al.   Journal of Molecular Cell Biology

Regulation of Mouse Retroelement MuERV-L/MERVL Expression by REX1 and Epigenetic Control of Stem Cell Potency

(2014) Jon Schoorlemmer et al.   Frontiers in Oncology

5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

(2013) Joseph M Dhahbi et al.   BMC GENOMICS

Aminoacyl-tRNA synthetases in medicine and disease

(2013) Peng Yao et al.   EMBO Molecular Medicine

tRNA gene copy number variation in humans

(2013) James R. Iben et al.   GENE

Genome-Wide Analysis Reveals Origin of Transfer RNA Genes from tRNA Halves

(2013) Zhixiang Zuo et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Mycobacterium tuberculosis regulatory network and hypoxia

(2013) James E. Galagan et al.   NATURE

Essential nontranslational functions of tRNA synthetases

(2013) Min Guo et al.   Nature Chemical Biology

Non-canonical roles of lysyl-tRNA synthetase in health and disease

(2013) Alex Motzik et al.   TRENDS IN MOLECULAR MEDICINE

Human cytoplasmic ProX edits mischarged tRNAProwith amino acid but not tRNA specificity

(2012) Liang-Liang Ruan et al.   BIOCHEMICAL JOURNAL

A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm

(2012) Hongying Peng et al.   CELL RESEARCH

In silico analysis of DosR regulon proteins of Mycobacterium tuberculosis

(2012) Suganya Selvaraj et al.   GENE

Genome-wide Identification and Quantitative Analysis of Cleaved tRNA Fragments Induced by Cellular Stress

(2012) Mridusmita Saikia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strong YB-1 expression is associated with liver metastasis progression and predicts shorter disease-free survival in advanced gastric cancer

(2012) Ying Wu et al.   JOURNAL OF SURGICAL ONCOLOGY

Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription

(2012) Yifat Ofir-Birin et al.   MOLECULAR CELL

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

(2012) Francesca Tuorto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MODOMICS: a database of RNA modification pathways—2013 update

(2012) Magdalena A. Machnicka et al.   NUCLEIC ACIDS RESEARCH

Appropriate DevR (DosR)-Mediated Signaling Determines Transcriptional Response, Hypoxic Viability and Virulence of Mycobacterium tuberculosis

(2012) Shyamasree De Majumdar et al.   PLoS One

Speeding with control: codon usage, tRNAs, and ribosomes

(2012) Eva Maria Novoa et al.   TRENDS IN GENETICS

Human Mitochondrial tRNAs: Biogenesis, Function, Structural Aspects, and Diseases

(2011) Tsutomu Suzuki et al.   Annual Review of Genetics

The Presence in tRNA Molecule Sequences of the Double Hairpin, an Evolutionary Stage Through Which the Origin of this Molecule is Thought to have Passed

(2011) Sergio Branciamore et al.   JOURNAL OF MOLECULAR EVOLUTION

YB-1, the E2F Pathway, and Regulation of Tumor Cell Growth

(2011) Annette Lasham et al.   JNCI-Journal of the National Cancer Institute

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Naturally occurring aminoacyl-tRNA synthetases editing-domain mutations that cause mistranslation in Mycoplasma parasites

(2011) L. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

(2011) Sandra Blanco et al.   PLoS Genetics

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

tRNA Binds to Cytochrome c and Inhibits Caspase Activation

(2010) Yide Mei et al.   MOLECULAR CELL

Translational Regulation of Gene Expression during Conditions of Cell Stress

(2010) Keith A. Spriggs et al.   MOLECULAR CELL

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

The RNA modification database, RNAMDB: 2011 update

(2010) W. A. Cantara et al.   NUCLEIC ACIDS RESEARCH

Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs

(2010) M. Saikia et al.   RNA

Identification of Y-Box Binding Protein 1 As a Core Regulator of MEK/ERK Pathway-Dependent Gene Signatures in Colorectal Cancer Cells

(2010) Karsten Jürchott et al.   PLoS Genetics

Formation of the tRNALys packaging complex in HIV-1

(2009) Lawrence Kleiman et al.   FEBS LETTERS

The Mycobacterium tuberculosis DosR Regulon Assists in Metabolic Homeostasis and Enables Rapid Recovery from Nonrespiring Dormancy

(2009) R. L. Leistikow et al.   JOURNAL OF BACTERIOLOGY

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

Functional Analysis of Human tRNA Isodecoders

(2009) Renaud Geslain et al.   JOURNAL OF MOLECULAR BIOLOGY

Innate immune and chemically triggered oxidative stress modifies translational fidelity

(2009) Nir Netzer et al.   NATURE

Tri-split tRNA is a transfer RNA made from 3 transcripts that provides insight into the evolution of fragmented tRNAs in archaea

(2009) Kosuke Fujishima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transfer RNA genes in pieces

(2008) Lennart Randau et al.   EMBO REPORTS

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

Distinct domains of tRNA synthetase recognize the same base pair

(2008) Kirk Beebe et al.   NATURE