Controlling translation via modulation of tRNA levels

On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme

(2015) Claus-D. Kuhn et al.   CELL

The 3′ addition of CCA to mitochondrial tRNASer(AGY) is specifically impaired in patients with mutations in the tRNA nucleotidyl transferase TRNT1

(2015) Florin Sasarman et al.   HUMAN MOLECULAR GENETICS

tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae

(2015) Jadyn R. Damon et al.   MOLECULAR BIOLOGY OF THE CELL

Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1

(2015) Sunny Sharma et al.   NUCLEIC ACIDS RESEARCH

Mutations in TRNT1 cause congenital sideroblastic anemia with immunodeficiency, fevers, and developmental delay (SIFD)

(2014) P. K. Chakraborty et al.   BLOOD

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

(2014) Hila Gingold et al.   CELL

Uridylation by TUT4 and TUT7 Marks mRNA for Degradation

(2014) Jaechul Lim et al.   CELL

Argonaute-Bound Small RNAs from Promoter-Proximal RNA Polymerase II

(2014) Jesse R. Zamudio et al.   CELL

tRNA fragments in human health and disease

(2014) Paul Anderson et al.   FEBS LETTERS

Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis

(2014) Michael P. Guy et al.   GENES & DEVELOPMENT

High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA–tRNA interface

(2014) Bianca M. Schmitt et al.   GENOME RESEARCH

From End to End: tRNA Editing at 5'- and 3'-Terminal Positions

(2014) Heike Betat et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

(2014) M. Saikia et al.   MOLECULAR AND CELLULAR BIOLOGY

Deep Sequencing Shows Multiple Oligouridylations Are Required for 3′ to 5′ Degradation of Histone mRNAs on Polyribosomes

(2014) Michael K. Slevin et al.   MOLECULAR CELL

Mechanism of Dis3l2 substrate recognition in the Lin28–let-7 pathway

(2014) Christopher R. Faehnle et al.   NATURE

Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry

(2014) Dan Su et al.   Nature Protocols

Coupling mRNA processing with transcription in time and space

(2014) David L. Bentley   NATURE REVIEWS GENETICS

Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo

(2014) Sebastian Pechmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An evolutionary approach uncovers a diverse response of tRNA 2-thiolation to elevated temperatures in yeast

(2014) Fiona Alings et al.   RNA

Functional importance of Ψ38and Ψ39in distinct tRNAs, amplified for tRNAGln(UUG)by unexpected temperature sensitivity of the s2U modification in yeast

(2014) Lu Han et al.   RNA

Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration

(2014) R. Ishimura et al.   SCIENCE

Selenium and selenocysteine: roles in cancer, health, and development

(2014) Dolph L. Hatfield et al.   TRENDS IN BIOCHEMICAL SCIENCES

Role of tRNA modifications in human diseases

(2014) Adrian Gabriel Torres et al.   TRENDS IN MOLECULAR MEDICINE

Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases

(2014) Kozo Tomita et al.   Frontiers in Genetics

tRNAs as regulators of biological processes

(2014) Medha Raina et al.   Frontiers in Genetics

Adaptive Translation as a Mechanism of Stress Response and Adaptation

(2013) Tao Pan   Annual Review of Genetics

Transfer RNA Post-Transcriptional Processing, Turnover, and Subcellular Dynamics in the YeastSaccharomyces cerevisiae

(2013) Anita K. Hopper   GENETICS

Genome-Wide Investigation of the Role of the tRNA Nuclear-Cytoplasmic Trafficking Pathway in Regulation of the Yeast Saccharomyces cerevisiae Transcriptome and Proteome

(2013) H.-Y. Chu et al.   MOLECULAR AND CELLULAR BIOLOGY

Non-optimal codon usage affects expression, structure and function of clock protein FRQ

(2013) Mian Zhou et al.   NATURE

Non-optimal codon usage is a mechanism to achieve circadian clock conditionality

(2013) Yao Xu et al.   NATURE

tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma

(2013) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retrograde transfer RNA nuclear import provides a new level of tRNA quality control in Saccharomyces cerevisiae

(2013) E. B. Kramer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells

(2013) Andrew Sobala et al.   RNA Biology

Slicing tRNAs to boost functional ncRNA diversity

(2013) Jennifer Gebetsberger et al.   RNA Biology

Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells

(2013) M. Pavon-Eternod et al.   RNA

Reversible and Rapid Transfer-RNA Deactivation as a Mechanism of Translational Repression in Stress

(2013) Andreas Czech et al.   PLoS Genetics

Regulation of pol III transcription by nutrient and stress signaling pathways

(2012) Robyn D. Moir et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Maf1, a general negative regulator of RNA polymerase III in yeast

(2012) Magdalena Boguta   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails

(2012) J. E. Wilusz et al.   GENES & DEVELOPMENT

Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs

(2012) Zhihua Li et al.   NUCLEIC ACIDS RESEARCH

Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling

(2012) E. J. Rideout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

tRNAHis 5-methylcytidine levels increase in response to several growth arrest conditions in Saccharomyces cerevisiae

(2012) M. A. Preston et al.   RNA

The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications

(2012) J. M. Dewe et al.   RNA

Widespread RNA 3'-end oligouridylation in mammals

(2012) Y. S. Choi et al.   RNA

Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway

(2012) T. W. Turowski et al.   RNA

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

(2012) Clement T.Y. Chan et al.   Nature Communications

tRNA-Derived Fragments Target the Ribosome and Function as Regulatory Non-Coding RNA inHaloferax volcanii

(2012) Jennifer Gebetsberger et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the Adult

(2012) Bin Zhang et al.   Cell Reports

Roles of tRNA in cell wall biosynthesis

(2012) Kiley Dare et al.   Wiley Interdisciplinary Reviews-RNA

The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA

(2011) J. M. Whipple et al.   GENES & DEVELOPMENT

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Determinants of translation efficiency and accuracy

(2011) H. Gingold et al.   Molecular Systems Biology

tRNAs Marked with CCACCA Are Targeted for Degradation

(2011) J. E. Wilusz et al.   SCIENCE

The Dynamics of Supply and Demand in mRNA Translation

(2011) Chris A. Brackley et al.   PLoS Computational Biology

Quality control in tRNA charging

(2011) Hieronim Jakubowski   Wiley Interdisciplinary Reviews-RNA

tRNA Stabilization by Modified Nucleotides

(2010) Yuri Motorin et al.   BIOCHEMISTRY

tRNA nucleotidyltransferases: ancient catalysts with an unusual mechanism of polymerization

(2010) Heike Betat et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

tRNA biology charges to the front

(2010) E. M. Phizicky et al.   GENES & DEVELOPMENT

How the CCA-Adding Enzyme Selects Adenine over Cytosine at Position 76 of tRNA

(2010) B. Pan et al.   SCIENCE

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

(2010) Clement T. Y. Chan et al.   PLoS Genetics

3′ processing of eukaryotic precursor tRNAs

(2010) Richard J. Maraia et al.   Wiley Interdisciplinary Reviews-RNA

Mitochondrial tRNA mutations and disease

(2010) John W. Yarham et al.   Wiley Interdisciplinary Reviews-RNA

Stressing Out over tRNA Cleavage

(2009) Debrah M. Thompson et al.   CELL

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

Do all modifications benefit all tRNAs?

(2009) Eric M. Phizicky et al.   FEBS LETTERS

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

(2009) Yong Sun Lee et al.   GENES & DEVELOPMENT

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

Innate immune and chemically triggered oxidative stress modifies translational fidelity

(2009) Nir Netzer et al.   NATURE

Decapping is preceded by 3′ uridylation in a novel pathway of bulk mRNA turnover

(2009) Olivia S Rissland et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

tRNA over-expression in breast cancer and functional consequences

(2009) Mariana Pavon-Eternod et al.   NUCLEIC ACIDS RESEARCH

The Phloem-Delivered RNA Pool Contains Small Noncoding RNAs and Interferes with Translation

(2009) S. Zhang et al.   PLANT PHYSIOLOGY

Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

(2009) C. Cole et al.   RNA

3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA

(2008) Jeremy E. Wilusz et al.   CELL

Molecular basis for maintenance of fidelity during the CCA-adding reaction by a CCA-adding enzyme

(2008) Yukimatsu Toh et al.   EMBO JOURNAL

Stress induces tRNA cleavage by angiogenin in mammalian cells

(2008) Hanjiang Fu et al.   FEBS LETTERS

Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1

(2008) I. Chernyakov et al.   GENES & DEVELOPMENT

MEN  /  nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles

(2008) H. Sunwoo et al.   GENOME RESEARCH

tRNA Integrity Is a Prerequisite for Rapid CCA Addition: Implication for Quality Control

(2008) Marcel Dupasquier et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the Active Subunit of the Yeast Exosome Core, Rrp44: Diverse Modes of Substrate Recruitment in the RNase II Nuclease Family

(2008) Esben Lorentzen et al.   MOLECULAR CELL

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

GtRNAdb: a database of transfer RNA genes detected in genomic sequence

(2008) P. P. Chan et al.   NUCLEIC ACIDS RESEARCH

tRNA cleavage is a conserved response to oxidative stress in eukaryotes

(2008) D. M. Thompson et al.   RNA

RNA polymerases I and III, non-coding RNAs and cancer

(2008) Robert J. White   TRENDS IN GENETICS