Structural basis of RNA processing by human mitochondrial RNase P

Pentatricopeptide repeats of protein-only RNase P use a distinct mode to recognize conserved bases and structural elements of pre-tRNA

(2020) Takamasa Teramoto et al.   NUCLEIC ACIDS RESEARCH

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Complete chemical structures of human mitochondrial tRNAs

(2020) Takeo Suzuki et al.   Nature Communications

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Real-time cryo-electron microscopy data preprocessing with Warp

(2019) Dimitry Tegunov et al.   NATURE METHODS

Mitochondrial transcription and translation: overview

(2018) Aaron R. D’Souza et al.   Essays in Biochemistry

Structural insight into the human mitochondrial tRNA purine N1-methyltransferase and Ribonuclease P complexes

(2018) Stephanie Oerum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and biochemical analysis of the dual-specificity Trm10 enzyme fromThermococcus kodakaraensisprompts reconsideration of its catalytic mechanism

(2018) Ranjan Kumar Singh et al.   RNA

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

A Family Divided: Distinct Structural and Mechanistic Features of the SpoU-TrmD (SPOUT) Methyltransferase Superfamily

(2018) Aiswarya Krishnamohan et al.   BIOCHEMISTRY

Cryo-EM Structure of the Human Ribonuclease P Holoenzyme

(2018) Jian Wu et al.   CELL

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Mechanistic features of the atypical tRNA m1G9 SPOUT methyltransferase, Trm10

(2017) Aiswarya Krishnamohan et al.   NUCLEIC ACIDS RESEARCH

The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria

(2017) Linda Reinhard et al.   NUCLEIC ACIDS RESEARCH

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Molecular recognition of pre-tRNA by Arabidopsis protein-only Ribonuclease P

(2017) Bradley P. Klemm et al.   RNA

Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies

(2016) Metodi D. Metodiev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Substrate recognition and cleavage-site selection by a single-subunit protein-only RNase P

(2016) Nadia Brillante et al.   NUCLEIC ACIDS RESEARCH

A novelHSD17B10mutation impairing the activities of the mitochondrial RNase P complex causes X-linked intractable epilepsy and neurodevelopmental regression

(2016) Marni J. Falk et al.   RNA Biology

Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly

(2016) Oliver Rackham et al.   Cell Reports

Structure of the nuclease subunit of human mitochondrial RNase P

(2015) L. Reinhard et al.   NUCLEIC ACIDS RESEARCH

Molecular insights into HSD10 disease: impact of SDR5C1 mutations on the human mitochondrial RNase P complex

(2015) Elisa Vilardo et al.   NUCLEIC ACIDS RESEARCH

Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue

(2015) Bart Van Laer et al.   NUCLEIC ACIDS RESEARCH

The first case in Asia of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (HSD10 disease) with atypical presentation

(2014) Toshiyuki Fukao et al.   JOURNAL OF HUMAN GENETICS

Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate

(2013) Zhenhua Shao et al.   NUCLEIC ACIDS RESEARCH

Structural insights into protein-only RNase P complexed with tRNA

(2013) Anthony Gobert et al.   Nature Communications

tRNA Processing by Protein-Only versus RNA-Based RNase P: Kinetic Analysis Reveals Mechanistic Differences

(2012) Liudmila V. Pavlova et al.   CHEMBIOCHEM

A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase—extensive moonlighting in mitochondrial tRNA biogenesis

(2012) Elisa Vilardo et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial ribonuclease P structure provides insight into the evolution of catalytic strategies for precursor-tRNA 5' processing

(2012) M. J. Howard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear RNase P of Trypanosoma brucei: A Single Protein in Place of the Multicomponent RNA-Protein Complex

(2012) Andreas Taschner et al.   Cell Reports

A Combinatorial Amino Acid Code for RNA Recognition by Pentatricopeptide Repeat Proteins

(2012) Alice Barkan et al.   PLoS Genetics

RNA processing in human mitochondria

(2011) Maria I.G. Lopez Sanchez et al.   CELL CYCLE

Crystal Structure of Human Mitochondrial PheRS Complexed with tRNAPhe in the Active “Open” State

(2011) Liron Klipcan et al.   JOURNAL OF MOLECULAR BIOLOGY

Localization of Human RNase Z Isoforms: Dual Nuclear/Mitochondrial Targeting of the ELAC2 Gene Product by Alternative Translation Initiation

(2011) Walter Rossmanith   PLoS One

Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs

(2011) Lien K. Brzezniak et al.   RNA Biology

Structure of transfer RNAs: similarity and variability

(2011) Richard Giegé et al.   Wiley Interdisciplinary Reviews-RNA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure of a bacterial ribonuclease P holoenzyme in complex with tRNA

(2010) Nicholas J. Reiter et al.   NATURE

A single Arabidopsis organellar protein has RNase P activity

(2010) Anthony Gobert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA

(2010) M. Kempenaers et al.   NUCLEIC ACIDS RESEARCH

RNase P without RNA: Identification and Functional Reconstitution of the Human Mitochondrial tRNA Processing Enzyme

(2008) Johann Holzmann et al.   CELL

Crystal Structure of Thermus thermophilus tRNA m1A58 Methyltransferase and Biophysical Characterization of Its Interaction with tRNA

(2008) Pierre Barraud et al.   JOURNAL OF MOLECULAR BIOLOGY