Reciprocal regulation of TORC signaling and tRNA modifications by Elongator enforces nutrient-dependent cell fate

tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway

(2018) Yoko Otsubo et al.   EMBO REPORTS

Codon-specific translation reprogramming promotes resistance to targeted therapy

(2018) Francesca Rapino et al.   NATURE

Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway

(2016) Nathalia Chica et al.   CURRENT BIOLOGY

Architecture of the yeast Elongator complex

(2016) Maria I Dauden et al.   EMBO REPORTS

Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

(2015) Danny D. Nedialkova et al.   CELL

Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeastSchizosaccharomyces pombe

(2015) Akira Doi et al.   GENES TO CELLS

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine

(2015) Aurélie Ladang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fission Yeast Cdk7 Controls Gene Expression through both Its CAK and C-Terminal Domain Kinase Activities

(2015) Maxime Devos et al.   MOLECULAR AND CELLULAR BIOLOGY

TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1

(2015) Dana Laor et al.   mBio

Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast

(2015) Wael Abdel-Fattah et al.   PLoS Genetics

Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation

(2015) Wenjun Deng et al.   PLoS Genetics

Absolute Proteome and Phosphoproteome Dynamics during the Cell Cycle ofSchizosaccharomyces pombe(Fission Yeast)

(2014) Alejandro Carpy et al.   MOLECULAR & CELLULAR PROTEOMICS

TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast

(2013) Charalampos Rallis et al.   AGING CELL

Modification of tRNALysUUU by Elongator Is Essential for Efficient Translation of Stress mRNAs

(2013) Jorge Fernández-Vázquez et al.   PLoS Genetics

A coordinated codon-dependent regulation of translation by Elongator

(2012) Fanelie Bauer et al.   CELL CYCLE

Environmental control of cell size at division

(2012) Elizabeth Davie et al.   CURRENT OPINION IN CELL BIOLOGY

DERP6 (ELP5) and C3ORF75 (ELP6) Regulate Tumorigenicity and Migration of Melanoma Cells as Subunits of Elongator

(2012) Pierre Close et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determining proteome-wide expression levels using reverse protein arrays in fission yeast

(2012) Fanelie Bauer et al.   Nature Protocols

Schizosaccharomyces pombe reporter strains for relative quantitative assessment of heterochromatin silencing

(2012) Yukiko Shimada et al.   YEAST

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

(2012) Clement T.Y. Chan et al.   Nature Communications

Translational Control of Cell Division by Elongator

(2012) Fanelie Bauer et al.   Cell Reports

GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways

(2011) François Vigneron et al.   CARDIOVASCULAR RESEARCH

GSK-3b inhibition: At the crossroad between Akt and mTOR constitutive activation to enhance cyclin D1 protein stability in mantle cell lymphoma

(2011) Jessica Dal Col et al.   CELL CYCLE

Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases

(2011) M. Yanagida et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mitotic Substrates of the Kinase Aurora with Roles in Chromatin Regulation Identified Through Quantitative Phosphoproteomics of Fission Yeast

(2011) A. Koch et al.   Science Signaling

The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe

(2011) N. Ikai et al.   Open Biology

Rab-Family GTPase Regulates TOR Complex 2 Signaling in Fission Yeast

(2010) Hisashi Tatebe et al.   CURRENT BIOLOGY

The Rapamycin-sensitive Phosphoproteome Reveals That TOR Controls Protein Kinase A Toward Some But Not All Substrates

(2010) Alexandre Soulard et al.   MOLECULAR BIOLOGY OF THE CELL

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

(2010) Clement T. Y. Chan et al.   PLoS Genetics

TOR signalling regulates mitotic commitment through stress-activated MAPK and Polo kinase in response to nutrient stress

(2009) Janni Petersen   BIOCHEMICAL SOCIETY TRANSACTIONS

TOR Signaling in Fission Yeast

(2008) Yoko Otsubo et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity

(2008) M. Dewez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae

(2008) B. Huang et al.   RNA