tRNA-Derived Small RNAs: Biogenesis, Modification, Function and Potential Impact on Human Disease Development

Diversity and signature of small RNA in different bodily fluids using next generation sequencing

(2018) Mohamed El-Mogy et al.   BMC GENOMICS

tRNA-derived small non-coding RNAs in human disease

(2018) Lei Zhu et al.   CANCER LETTERS

Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells

(2018) Nicola Guzzi et al.   CELL

Modifications and functional genomics of human transfer RNA

(2018) Tao Pan   CELL RESEARCH

Elongator subunit 3 (ELP3) modifies ALS through tRNA modification

(2018) Andre Bento-Abreu et al.   HUMAN MOLECULAR GENETICS

Human tRNA-Derived Small RNAs Modulate Host–Oral Microbial Interactions

(2018) X. He et al.   JOURNAL OF DENTAL RESEARCH

Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

(2018) Yunfang Zhang et al.   NATURE CELL BIOLOGY

Dimerization confers increased stability to nucleases in 5′ halves from glycine and glutamic acid tRNAs

(2018) Juan Pablo Tosar et al.   NUCLEIC ACIDS RESEARCH

Circulating miRNAs, isomiRs and small RNA clusters in human plasma and breast milk

(2018) Mercedes Rubio et al.   PLoS One

Queuosine modification protects cognate tRNAs against ribonuclease cleavage

(2018) Xiaoyun Wang et al.   RNA

Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway

(2018) Lu Han et al.   PLoS Genetics

tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA

(2018) Siqi Li et al.   Genes

Interaction between Host MicroRNAs and the Gut Microbiota in Colorectal Cancer

(2018) Ce Yuan et al.   mSystems

Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm

(2018) Upasna Sharma et al.   DEVELOPMENTAL CELL

Small RNAs Gained during Epididymal Transit of Sperm Are Essential for Embryonic Development in Mice

(2018) Colin C. Conine et al.   DEVELOPMENTAL CELL

The role of RNA modifications in the regulation of tRNA cleavage

(2018) Shawn M. Lyons et al.   FEBS LETTERS

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

Genetic and transcriptional evolution alters cancer cell line drug response

(2018) Uri Ben-David et al.   NATURE

Progress and potential in organoid research

(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

Translation deregulation in human disease

(2018) Soroush Tahmasebi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

(2018) Cristina Cosentino et al.   NUCLEIC ACIDS RESEARCH

Paternal Exercise Improves Glucose Metabolism in Adult Offspring

(2018) Kristin I. Stanford et al.   DIABETES

Plant RNases T2, but not Dicer-like proteins, are major players of tRNA-derived fragments biogenesis

(2018) Cyrille Megel et al.   NUCLEIC ACIDS RESEARCH

Large Differences in Small RNA Composition Between Human Biofluids

(2018) Paula M. Godoy et al.   Cell Reports

TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival

(2017) Joshua M. Dewe et al.   MOLECULAR AND CELLULAR BIOLOGY

A transfer-RNA-derived small RNA regulates ribosome biogenesis

(2017) Hak Kyun Kim et al.   NATURE

5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo

(2017) Katharina Iwan et al.   Nature Chemical Biology

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

Detecting RNA modifications in the epitranscriptome: predict and validate

(2017) Mark Helm et al.   NATURE REVIEWS GENETICS

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

MINTbase v2.0: a comprehensive database for tRNA-derived fragments that includes nuclear and mitochondrial fragments from all The Cancer Genome Atlas projects

(2017) Venetia Pliatsika et al.   NUCLEIC ACIDS RESEARCH

tRNA-derived small RNAs target transposable element transcripts

(2017) German Martinez et al.   NUCLEIC ACIDS RESEARCH

A comprehensive profile of circulating RNAs in human serum

(2017) Sinan Uğur Umu et al.   RNA Biology

Rapid RNase L–driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery

(2017) Jesse Donovan et al.   RNA

Ovarian cancer proliferation and apoptosis are regulated by human transfer RNA methyltransferase 9-likevia LIN9

(2017) Huai Mei Chen et al.   Oncology Letters

Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs

(2017) Shawn M. Lyons et al.   Nature Communications

Understanding RNA modifications: the promises and technological bottlenecks of the ‘epitranscriptome’

(2017) Matthias Schaefer et al.   Open Biology

Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA Processing and Multiple Respiratory Chain Deficiencies

(2016) Metodi D. Metodiev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ADAT3-related intellectual disability: Further delineation of the phenotype

(2016) Ayman W. El-Hattab et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin

(2016) Ikumi Ohshio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

tRNA biology in the omics era: Stress signalling dynamics and cancer progression

(2016) Andrea Orioli   BIOESSAYS

Consequential considerations when mapping tRNA fragments

(2016) Aristeidis G. Telonis et al.   BMC BIOINFORMATICS

ALKBH1-Mediated tRNA Demethylation Regulates Translation

(2016) Fange Liu et al.   CELL

Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression

(2016) Hani Goodarzi et al.   CELL

IL-4 Inhibits the Biogenesis of an Epigenetically Suppressive PIWI-Interacting RNA To Upregulate CD1a Molecules on Monocytes/Dendritic Cells

(2016) Xue Zhang et al.   JOURNAL OF IMMUNOLOGY

tRNA-Derived RNA Fragments Associate with Human Multisynthetase Complex (MSC) and Modulate Ribosomal Protein Translation

(2016) Simon P. Keam et al.   JOURNAL OF PROTEOME RESEARCH

The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway

(2016) Daniele Hasler et al.   MOLECULAR CELL

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

(2016) Jan Mauer et al.   NATURE

Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome

(2016) Xiaoyu Li et al.   Nature Chemical Biology

m1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs

(2016) Huiqing Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers

(2016) Ling-Ling Zheng et al.   NUCLEIC ACIDS RESEARCH

Dysregulation of a family of short noncoding RNAs, tsRNAs, in human cancer

(2016) Yuri Pekarsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A tRNA-derived fragment competes with mRNA for ribosome binding and regulates translation during stress

(2016) Jennifer Gebetsberger et al.   RNA Biology

Small RNA Modifications: Integral to Function and Disease

(2016) Xudong Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

(2016) Lindsey Van Haute et al.   Nature Communications

m1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs

(2016) Huiqing Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intergenerational Transfer of Epigenetic Information in Sperm

(2016) Oliver J. Rando   Cold Spring Harbor Perspectives in Medicine

Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity

(2016) Jennifer E. Cropley et al.   Molecular Metabolism

Age-driven modulation of tRNA-derived fragments in Drosophila and their potential targets

(2015) Spyros Karaiskos et al.   Biology Direct

tDRmapper: challenges and solutions to mapping, naming, and quantifying tRNA-derived RNAs from human small RNA-sequencing data

(2015) Sara R. Selitsky et al.   BMC BIOINFORMATICS

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement

(2015) Hani Goodarzi et al.   CELL

TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms

(2015) B. Kim et al.   EMBO JOURNAL

The evolution of Class II Aminoacyl-tRNA synthetases and the first code

(2015) Temple F. Smith et al.   FEBS LETTERS

Defects in tRNA Anticodon Loop 2′-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations inFTSJ1

(2015) Michael P. Guy et al.   HUMAN MUTATION

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond

(2015) Bogdan I. Fedeles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification

(2015) Caroline Roost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Respiratory Syncytial Virus Utilizes a tRNA Fragment to Suppress Antiviral Responses Through a Novel Targeting Mechanism

(2015) Junfang Deng et al.   MOLECULAR THERAPY

ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments

(2015) Aaron E Cozen et al.   NATURE METHODS

A mass spectrometry-based method for comprehensive quantitative determination of post-transcriptional RNA modifications: the complete chemical structure ofSchizosaccharomyces pomberibosomal RNAs

(2015) Masato Taoka et al.   NUCLEIC ACIDS RESEARCH

Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine

(2015) Martin Müller et al.   NUCLEIC ACIDS RESEARCH

Molecular insights into HSD10 disease: impact of SDR5C1 mutations on the human mitochondrial RNase P complex

(2015) Elisa Vilardo et al.   NUCLEIC ACIDS RESEARCH

Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers

(2015) Shozo Honda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable presence of 5-methylcytosine in commercial RNA and DNA

(2015) Katharina Schmid et al.   RNA Biology

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

(2015) Q. Chen et al.   SCIENCE

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

(2015) U. Sharma et al.   SCIENCE

The Queuine Micronutrient: Charting a Course from Microbe to Man

(2015) Claire Fergus et al.   Nutrients

Small tRNA-derived RNAs are increased and more abundant than microRNAs in chronic hepatitis B and C

(2015) Sara R. Selitsky et al.   Scientific Reports

5′ tRNA Halves: The Next Generation of Immune Signaling Molecules

(2015) Joseph Mohsen Dhahbi   Frontiers in Immunology

The Role of a Novel TRMT1 Gene Mutation and Rare GRM1 Gene Defect in Intellectual Disability in Two Azeri Families

(2015) Behzad Davarniya et al.   PLoS One

Modify or die? - RNA modification defects in metazoans

(2015) L Peter Sarin et al.   RNA Biology

Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function

(2014) Ender Karaca et al.   CELL

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

(2014) Ashleigh E. Schaffer et al.   CELL

Nanodiamond-mediated impairment of nucleolar activity is accompanied by oxidative stress and DNMT2 upregulation in human cervical carcinoma cells

(2014) Jennifer Mytych et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders

(2014) S. Blanco et al.   EMBO JOURNAL

tRNA fragments in human health and disease

(2014) Paul Anderson et al.   FEBS LETTERS

Identification of the determinants of tRNA function and susceptibility to rapid tRNA decay by high-throughput in vivo analysis

(2014) Michael P. Guy et al.   GENES & DEVELOPMENT

TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly

(2014) David Gillis et al.   JOURNAL OF MEDICAL GENETICS

Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage

(2014) E. Mishima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Small Noncoding RNAs in Cells Transformed by Human T-Cell Leukemia Virus Type 1: a Role for a tRNA Fragment as a Primer for Reverse Transcriptase

(2014) K. Ruggero et al.   JOURNAL OF VIROLOGY

Angiogenin-Cleaved tRNA Halves Interact with Cytochrome c, Protecting Cells from Apoptosis during Osmotic Stress

(2014) M. Saikia et al.   MOLECULAR AND CELLULAR BIOLOGY

The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells

(2014) Simon P. Keam et al.   NUCLEIC ACIDS RESEARCH

tRFdb: a database for transfer RNA fragments

(2014) Pankaj Kumar et al.   NUCLEIC ACIDS RESEARCH

A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs

(2014) T. Suzuki et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of tRNA modifications in human diseases

(2014) Adrian Gabriel Torres et al.   TRENDS IN MOLECULAR MEDICINE

Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection

(2014) Yunfang Zhang et al.   Journal of Molecular Cell Biology

Structure, Mechanism, and Specificity of a Eukaryal tRNA Restriction Enzyme Involved in Self-Nonself Discrimination

(2014) Anupam K. Chakravarty et al.   Cell Reports

Trans-kingdom Cross-Talk: Small RNAs on the Move

(2014) Marijn Knip et al.   PLoS Genetics

Transfer RNA and human disease

(2014) Jamie A. Abbott et al.   Frontiers in Genetics

Description of plant tRNA-derived RNA fragments (tRFs) associated with argonaute and identification of their putative targets

(2013) Guilherme Loss-Morais et al.   Biology Direct

Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine

(2013) MVE Veenendaal et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

(2013) Joseph M Dhahbi et al.   BMC GENOMICS

Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar

(2013) S. Fahiminiya et al.   CLINICAL GENETICS

A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α

(2013) Ulrike Begley et al.   EMBO Molecular Medicine

Direction of aminoacylated transfer RNAs into antibiotic synthesis and peptidoglycan-mediated antibiotic resistance

(2013) Jennifer Shepherd et al.   FEBS LETTERS

Mutation inADAT3, encoding adenosine deaminase acting on transfer RNA, causes intellectual disability and strabismus

(2013) Anas M Alazami et al.   JOURNAL OF MEDICAL GENETICS

The Clinical Relevance of Cancer Cell Lines

(2013) J.-P. Gillet et al.   JNCI-Journal of the National Cancer Institute

CLP1 links tRNA metabolism to progressive motor-neuron loss

(2013) Toshikatsu Hanada et al.   NATURE

Identification of direct targets and modified bases of RNA cytosine methyltransferases

(2013) Vahid Khoddami et al.   NATURE BIOTECHNOLOGY

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma

(2013) Roy L. Maute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small RNAs derived from the 5′ end of tRNA can inhibit protein translation in human cells

(2013) Andrew Sobala et al.   RNA Biology

Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells

(2013) M. Pavon-Eternod et al.   RNA

Is There Social RNA?

(2013) P. Sarkies et al.   SCIENCE

The RNA Methyltransferase Dnmt2 Is Required for Efficient Dicer-2-Dependent siRNA Pathway Activity in Drosophila

(2013) Zeljko Durdevic et al.   Cell Reports

NSun2-Mediated Cytosine-5 Methylation of Vault Noncoding RNA Determines Its Processing into Regulatory Small RNAs

(2013) Shobbir Hussain et al.   Cell Reports

Mutation in NSUN2, which Encodes an RNA Methyltransferase, Causes Autosomal-Recessive Intellectual Disability

(2012) Muzammil Ahmad Khan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in NSUN2 Cause Autosomal- Recessive Intellectual Disability

(2012) Lia Abbasi-Moheb et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The N-End Rule Pathway

(2012) Takafumi Tasaki et al.   Annual Review of Biochemistry

Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response

(2012) Ashish Patil et al.   CELL CYCLE

Regulation of small RNA stability: methylation and beyond

(2012) Lijuan Ji et al.   CELL RESEARCH

A novel class of tRNA-derived small RNAs extremely enriched in mature mouse sperm

(2012) Hongying Peng et al.   CELL RESEARCH

Genome-wide Identification and Quantitative Analysis of Cleaved tRNA Fragments Induced by Cellular Stress

(2012) Mridusmita Saikia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity

(2012) Stefanie Gehrig et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole exome sequencing identifies a splicing mutation inNSUN2as a cause of a Dubowitz-like syndrome

(2012) Fernando Jose Martinez et al.   JOURNAL OF MEDICAL GENETICS

A Tetrahymena Piwi Bound to Mature tRNA 3′ Fragments Activates the Exonuclease Xrn2 for RNA Processing in the Nucleus

(2012) Mary T. Couvillion et al.   MOLECULAR CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Identification and Functional Characterization of tRNA-derived RNA Fragments (tRFs) in Respiratory Syncytial Virus Infection

(2012) Qingrong Wang et al.   MOLECULAR THERAPY

Understanding transgenerational epigenetic inheritance via the gametes in mammals

(2012) Lucia Daxinger et al.   NATURE REVIEWS GENETICS

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

(2012) Francesca Tuorto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling

(2012) Maria Becker et al.   NUCLEIC ACIDS RESEARCH

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

RNA mediated toll-like receptor stimulation in health and disease

(2012) Alexander H. Dalpke et al.   RNA Biology

Speeding with control: codon usage, tRNAs, and ribosomes

(2012) Eva Maria Novoa et al.   TRENDS IN GENETICS

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

(2012) Clement T.Y. Chan et al.   Nature Communications

Roles of tRNA in cell wall biosynthesis

(2012) Kiley Dare et al.   Wiley Interdisciplinary Reviews-RNA

Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis

(2011) Michael A. van Es et al.   ANNALS OF NEUROLOGY

Arginine Residues Are More Effective than Lysine Residues in Eliciting the Cellular Uptake of Onconase

(2011) Nadia K. Sundlass et al.   BIOCHEMISTRY

The N-end rule pathway: From recognition by N-recognins, to destruction by AAA+proteases

(2011) D.A. Dougan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Functional loss of Cdkal1, a novel tRNA modification enzyme, causes the development of type 2 diabetes [Review]

(2011) Fan-Yan Wei et al.   ENDOCRINE JOURNAL

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Broad-spectrum antimicrobial peptide resistance by MprF-mediated aminoacylation and flipping of phospholipids

(2011) Christoph M. Ernst et al.   MOLECULAR MICROBIOLOGY

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA

(2011) K. S. Winther et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A miRNA-tRNA mix-up: tRNA origin of proposed miRNA

(2011) Nick C.T. Schopman et al.   RNA Biology

Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans

(2011) M. Kato et al.   RNA

tRNA Stabilization by Modified Nucleotides

(2010) Yuri Motorin et al.   BIOCHEMISTRY

The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence

(2010) David G Hicks et al.   BMC CANCER

Hen1 is required for oocyte development and piRNA stability in zebrafish

(2010) Leonie M Kamminga et al.   EMBO JOURNAL

tRNA biology charges to the front

(2010) E. M. Phizicky et al.   GENES & DEVELOPMENT

A growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo

(2010) M. T. Couvillion et al.   GENES & DEVELOPMENT

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

Angiogenin-induced tRNA-derived Stress-induced RNAs Promote Stress-induced Stress Granule Assembly

(2010) Mohamed M. Emara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis

(2010) Shozo Honda et al.   JOURNAL OF HUMAN GENETICS

Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci

(2010) Marianne Berg et al.   Molecular Cancer

tRNA Binds to Cytochrome c and Inhibits Caspase Activation

(2010) Yide Mei et al.   MOLECULAR CELL

Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans

(2010) Ryan J Taft et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Relative quantitation of transfer RNAs using liquid chromatography mass spectrometry and signature digestion products

(2010) Colette M. Castleberry et al.   NUCLEIC ACIDS RESEARCH

Deep Sequencing of Human Nuclear and Cytoplasmic Small RNAs Reveals an Unexpectedly Complex Subcellular Distribution of miRNAs and tRNA 3′ Trailers

(2010) Jian-You Liao et al.   PLoS One

Deletion of CDKAL1 Affects Mitochondrial ATP Generation and First-Phase Insulin Exocytosis

(2010) Mica Ohara-Imaizumi et al.   PLoS One

Human tRNA-derived small RNAs in the global regulation of RNA silencing

(2010) D. Haussecker et al.   RNA

Target RNA-Directed Trimming and Tailing of Small Silencing RNAs

(2010) S. L. Ameres et al.   SCIENCE

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

(2010) Clement T. Y. Chan et al.   PLoS Genetics

Acute Infantile Liver Failure Due to Mutations in the TRMU Gene

(2009) Avraham Zeharia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

High levels of tRNA abundance and alteration of tRNA charging by bortezomib in multiple myeloma

(2009) Ying Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines

(2009) M. Schaefer et al.   CANCER RESEARCH

A Novel Human AlkB Homologue, ALKBH8, Contributes to Human Bladder Cancer Progression

(2009) K. Shimada et al.   CANCER RESEARCH

Centrotemporal sharp wave EEG trait in rolandic epilepsy maps to Elongator Protein Complex 4 (ELP4)

(2009) Lisa J Strug et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

tRNAs: Cellular barcodes for amino acids

(2009) Rajat Banerjee et al.   FEBS LETTERS

The T box mechanism: tRNA as a regulatory molecule

(2009) Nicholas J. Green et al.   FEBS LETTERS

A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)

(2009) Yong Sun Lee et al.   GENES & DEVELOPMENT

A new mouse model for the trisomy of the Abcg1–U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

(2009) Patricia Lopes Pereira et al.   HUMAN MOLECULAR GENETICS

Colicin E5 Ribonuclease Domain Cleaves Saccharomyces cerevisiae tRNAs Leading to Impairment of the Cell Growth

(2009) T. Ogawa et al.   JOURNAL OF BIOCHEMISTRY

The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress inSaccharomyces cerevisiae

(2009) Debrah M. Thompson et al.   JOURNAL OF CELL BIOLOGY

Angiogenin cleaves tRNA and promotes stress-induced translational repression

(2009) Satoshi Yamasaki et al.   JOURNAL OF CELL BIOLOGY

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

(2009) Sebastian Leidel et al.   NATURE

Tiny RNAs associated with transcription start sites in animals

(2009) Ryan J Taft et al.   NATURE GENETICS

tRNA over-expression in breast cancer and functional consequences

(2009) Mariana Pavon-Eternod et al.   NUCLEIC ACIDS RESEARCH

Uncovering Small RNA-Mediated Responses to Phosphate Deficiency in Arabidopsis by Deep Sequencing

(2009) L.-C. Hsieh et al.   PLANT PHYSIOLOGY

The Phloem-Delivered RNA Pool Contains Small Noncoding RNAs and Interferes with Translation

(2009) S. Zhang et al.   PLANT PHYSIOLOGY

Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

(2009) C. Cole et al.   RNA

Cellular and transcriptional responses of yeast to the cleavage of cytosolic tRNAs induced by colicin D

(2009) Megumi Shigematsu et al.   YEAST

RNA Induction and Inheritance of Epigenetic Cardiac Hypertrophy in the Mouse

(2008) Kay D. Wagner et al.   DEVELOPMENTAL CELL

Stress induces tRNA cleavage by angiogenin in mammalian cells

(2008) Hanjiang Fu et al.   FEBS LETTERS

Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

(2008) J. E. Babiarz et al.   GENES & DEVELOPMENT

Variants of the elongator protein 3 ( ELP3 ) gene are associated with motor neuron degeneration

(2008) Claire L. Simpson et al.   HUMAN MOLECULAR GENETICS

Positive association of the FTSJ1 gene polymorphisms with nonsyndromic X-linked mental retardation in young Chinese male subjects

(2008) Ling Dai et al.   JOURNAL OF HUMAN GENETICS

Genetic Variations in FTSJ1 Influence Cognitive Ability in Young Males in the Chinese Han Population

(2008) Pingyuan Gong et al.   JOURNAL OF NEUROGENETICS

Control of Motoneuron Survival by Angiogenin

(2008) D. Kieran et al.   JOURNAL OF NEUROSCIENCE

The primary target of the killer toxin fromPichia acaciaeis tRNAGln

(2008) Roland Klassen et al.   MOLECULAR MICROBIOLOGY

An endogenous small interfering RNA pathway in Drosophila

(2008) Benjamin Czech et al.   NATURE

Toward a more complete view of tRNA biology

(2008) Richard Giegé   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TRAMP-mediated RNA surveillance prevents spurious entry of RNAs into the Schizosaccharomyces pombe siRNA pathway

(2008) Marc Bühler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA major groove modifications improve siRNA stability and biological activity

(2008) Montserrat Terrazas et al.   NUCLEIC ACIDS RESEARCH

Stress-induced tRNA-derived RNAs: a novel class of small RNAs in the primitive eukaryote Giardia lamblia

(2008) Yan Li et al.   NUCLEIC ACIDS RESEARCH

Small ncRNA transcriptome analysis from Aspergillus fumigatus suggests a novel mechanism for regulation of protein synthesis

(2008) Christoph Jöchl et al.   NUCLEIC ACIDS RESEARCH

A response to ‘Mammalian paramutation: a tail’s tale?’- a commentary by H. Arnheiter on our paramutation paper

(2008) Minoo Rassoulzadegan   Pigment Cell & Melanoma Research

tRNA cleavage is a conserved response to oxidative stress in eukaryotes

(2008) D. M. Thompson et al.   RNA

Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells

(2008) M. Ghildiyal et al.   SCIENCE