Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays

Cholesterol-rich domain formation mediated by ZO proteins is essential for tight junction formation

(2023) Kenta Shigetomi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Demethylation at enhancer upregulates MCM2 and NUP37 expression predicting poor survival in hepatocellular carcinoma patients

(2022) Zengwei Tang et al.   Journal of Translational Medicine

SHMT2 Drives the Progression of Colorectal Cancer by Regulating UHRF1 Expression

(2022) Ximao Cui et al.   Canadian Journal of Gastroenterology and Hepatology

Ten-Week Sucralose Consumption Induces Gut Dysbiosis and Altered Glucose and Insulin Levels in Healthy Young Adults

(2022) Lucía A. Méndez-García et al.   Microorganisms

Serine hydroxymethyltransferase 2 (SHMT2) potentiates the aggressive process of oral squamous cell carcinoma by binding to interleukin enhancer-binding factor 2 (ILF2)

(2022) Hui Zhang et al.   Bioengineered

Low Dose of Sucralose Alter Gut Microbiome in Mice

(2022) Zibin Zheng et al.   Frontiers in Nutrition

The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies

(2022) Carlo Giulioni et al.   Andrology

Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance

(2022) Jotham Suez et al.   CELL

Is early-onset cancer an emerging global epidemic? Current evidence and future implications

(2022) Tomotaka Ugai et al.   Nature Reviews Clinical Oncology

The Role of P-Glycoprotein in Decreasing Cell Membranes Permeability during Oxidative Stress

(2021) Alexey V. Shchulkin et al.   BIOCHEMISTRY-MOSCOW

Artificial Sweeteners Negatively Regulate Pathogenic Characteristics of Two Model Gut Bacteria, E. coli and E. faecalis

(2021) Aparna Shil et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The gut microbiota contributes to the modulation of intestinal CYP3A1 and P-gp in streptozotocin-induced type 1 diabetic rats

(2021) Nan Hu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion

(2021) Annelise Y. Mah-Som et al.   Cell Reports

Influence of Inflammation on Cytochromes P450 Activity in Adults: A Systematic Review of the Literature

(2021) Camille Lenoir et al.   Frontiers in Pharmacology

Metallothionein 1: A New Spotlight on Inflammatory Diseases

(2021) Hanying Dai et al.   Frontiers in Immunology

Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans

(2020) Jelle R. Dalenberg et al.   Cell Metabolism

Metallothionein Isoforms as Double Agents - Their Roles in Carcinogenesis, Cancer Progression and Chemoresistance

(2020) Miguel Angel Merlos Rodrigo et al.   DRUG RESISTANCE UPDATES

Exposure to Dichlorodiphenyldichloroethylene (DDE) and Metallothionein Levels in Rats Fed with Normocaloric or High-Fat Diet: A Review

(2020) Vincenzo Migliaccio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nonnutritive sweetener consumption during pregnancy, adiposity, and adipocyte differentiation in offspring: evidence from humans, mice, and cells

(2020) Meghan B. Azad et al.   INTERNATIONAL JOURNAL OF OBESITY

Consumption of Diet Soda Sweetened with Sucralose and Acesulfame‐Potassium Alters Inflammatory Transcriptome Pathways in Females with Overweight and Obesity

(2020) Allison C. Sylvetsky et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Maternal sucralose intake alters gut microbiota of offspring and exacerbates hepatic steatosis in adulthood

(2020) Xin Dai et al.   Gut Microbes

Effects of gut microbiota on in vivo metabolism and tissue accumulation of cytochrome P450 3A metabolized drug: Midazolam

(2020) Masao Togao et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Sucralose causes non‐selective CD4 and CD8 lymphotoxicity via probable regulation of the MAPK8/APTX/EID1 genes: An in vitro/in silico study

(2020) Thaís Pasqualli et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Heating of food containing sucralose might result in the generation of potentially toxic chlorinated compounds

(2020) Andreas Eisenreich et al.   FOOD CHEMISTRY

The impact of TNFSF14 on prognosis and immune microenvironment in clear cell renal cell carcinoma

(2020) Fangshi Xu et al.   Genes & Genomics

In vitro and in silico genetic toxicity screening of flavor compounds and other ingredients in tobacco products with emphasis on ENDS

(2020) Pei‐Hsuan Hung et al.   JOURNAL OF APPLIED TOXICOLOGY

Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3

(2020) Aparna Shil et al.   Nutrients

Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells

(2020) Nabanita Kundu et al.   Stem Cell Research & Therapy

Sucralose Promotes Colitis-Associated Colorectal Cancer Risk in a Murine Model Along With Changes in Microbiota

(2020) Xueting Li et al.   Frontiers in Oncology

Gut Microbiota-Mediated Inflammation and Gut Permeability in Patients with Obesity and Colorectal Cancer

(2020) Lidia Sánchez-Alcoholado et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity

(2020) Zhi-Bin Tong et al.   NEUROTOXICITY RESEARCH

The hidden hazardous effects of stevia and sucralose consumption in male and female albino mice in comparison to sucrose

(2020) Alyaa Farid et al.   SAUDI PHARMACEUTICAL JOURNAL

The Gut Microbiota and Inflammation: An Overview

(2020) Zahraa Al Bander et al.   International Journal of Environmental Research and Public Health

Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer

(2020) Hui-Chen Ku et al.   Frontiers in Endocrinology

Quantitative proteomics reveals systematic dysregulations of liver protein metabolism in sucralose-treated mice

(2019) Chih-Wei Liu et al.   Journal of Proteomics

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

(2019) Uku Raudvere et al.   NUCLEIC ACIDS RESEARCH

Maternal Exposure to Non-nutritive Sweeteners Impacts Progeny’s Metabolism and Microbiome

(2019) Stephanie Olivier-Van Stichelen et al.   Frontiers in Microbiology

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

Expression and function of chondroitin 4‐sulfate and chondroitin 6‐sulfate in human glioma

(2019) Hongchao Pan et al.   FASEB JOURNAL

The gut microbiome: an orchestrator of xenobiotic metabolism

(2019) Stephanie L. Collins et al.   Acta Pharmaceutica Sinica B

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Sudabeh Alatab et al.   Lancet Gastroenterology & Hepatology

OUP accepted manuscript

(2018)   AMERICAN JOURNAL OF CLINICAL NUTRITION

OUP accepted manuscript

(2018)   BIOINFORMATICS

The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn’s Disease–Like Ileitis

(2018) Alexander Rodriguez-Palacios et al.   INFLAMMATORY BOWEL DISEASES

Sucralose Increased Susceptibility to Colitis in Rats

(2018) Xiuhong Wang et al.   INFLAMMATORY BOWEL DISEASES

Effects of sucralose on insulin and glucagon-like peptide-1 secretion in healthy subjects: A randomized, double-blind, placebo-controlled trial

(2018) Amornpan Lertrit et al.   NUTRITION

Chronic Consumption of Sweeteners and Its Effect on Glycaemia, Cytokines, Hormones, and Lymphocytes of GALT in CD1 Mice

(2018) Cristian Angel Rosales-Gómez et al.   Biomed Research International

The roles of metallothioneins in carcinogenesis

(2018) Manfei Si et al.   Journal of Hematology & Oncology

Up-regulation of P-gp via NF-κB activation confers protection against oxidative damage in the retinal pigment epithelium cells

(2018) Qiting Feng et al.   EXPERIMENTAL EYE RESEARCH

The Gene Ontology Resource: 20 years and still GOing strong

(2018)   NUCLEIC ACIDS RESEARCH

Gut Mechanisms Linking Intestinal Sweet Sensing to Glycemic Control

(2018) Denise Kreuch et al.   Frontiers in Endocrinology

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay

(2017) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Acetylation and deacetylation for sucralose preparation by a newly isolated Bacillus amyloliquefaciens WZS01

(2017) Jie Sun et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Chemical transformation of xenobiotics by the human gut microbiota

(2017) Nitzan Koppel et al.   SCIENCE

Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals

(2017) Steven M Bryce et al.   TOXICOLOGICAL SCIENCES

Gut Microbiome Response to Sucralose and Its Potential Role in Inducing Liver Inflammation in Mice

(2017) Xiaoming Bian et al.   Frontiers in Physiology

γH2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9

(2016) Derek T. Bernacki et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

(2016) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations

(2016) Kerry L. Dearfield et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Type of sweet flavour carrier affects thyroid axis activity in male rats

(2016) Ewelina Pałkowska-Goździk et al.   EUROPEAN JOURNAL OF NUTRITION

Increased Digestive Proteases and Decreased β-Glucuronidase in Feces of Rats Treated with Sucralose and Saccharin—Another Critical Evidence That These Dietary Chemicals May Be Important Causative Factors for Inflammatory Bowel Disease

(2016) Rongyan Li et al.   INFLAMMATORY BOWEL DISEASES

Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice

(2016) Soffritti M. et al.   INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH

MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder

(2016) Ziru Liu et al.   Molecular Medicine Reports

Effect of Intestinal Flora on Protein Expression of Drug-Metabolizing Enzymes and Transporters in the Liver and Kidney of Germ-Free and Antibiotics-Treated Mice

(2016) Takuya Kuno et al.   MOLECULAR PHARMACEUTICS

Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown

(2016) Mihaela Pertea et al.   Nature Protocols

Nonnutritive Sweeteners in Breast Milk

(2015) Allison C. Sylvetsky et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

Ballgown bridges the gap between transcriptome assembly and expression analysis

(2015) Alyssa C Frazee et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Thermal degradation of sucralose: a combination of analytical methods to determine stability and chlorinated byproducts

(2015) Diogo N. de Oliveira et al.   Scientific Reports

The effect of five artificial sweeteners on Caco-2, HT-29 and HEK-293 cells

(2014) Armorel Diane van Eyk   DRUG AND CHEMICAL TOXICOLOGY

Interpreting in vitro micronucleus positive results: Simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

(2014) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Artificial sweeteners induce glucose intolerance by altering the gut microbiota

(2014) Jotham Suez et al.   NATURE

Sucralose Affects Glycemic and Hormonal Responses to an Oral Glucose Load

(2013) M. Yanina Pepino et al.   DIABETES CARE

The Role of Metallothionein in Oxidative Stress

(2013) Branislav Ruttkay-Nedecky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues

(2013) Susan S. Schiffman et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress

(2012) K Ketola et al.   BRITISH JOURNAL OF CANCER

DERP6 (ELP5) and C3ORF75 (ELP6) Regulate Tumorigenicity and Migration of Melanoma Cells as Subunits of Elongator

(2012) Pierre Close et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What caused the recent worldwide increase of inflammatory bowel disease: Should sucralose be added as a suspect?

(2011) Xiaofa Qin   INFLAMMATORY BOWEL DISEASES

Intestinal inflammation induces genotoxicity to extraintestinal tissues and cell types in mice

(2011) Aya M. Westbrook et al.   INTERNATIONAL JOURNAL OF CANCER

Colonization-Induced Host-Gut Microbial Metabolic Interaction

(2011) S. P. Claus et al.   mBio

Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation

(2010) Rachel C Anderson et al.   BMC MICROBIOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Thermal degradation of sucralose and its potential in generating chloropropanols in the presence of glycerol

(2009) Anja Rahn et al.   FOOD CHEMISTRY

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

(2009) T. Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal flora induces the expression of Cyp3a in the mouse liver

(2009) T. Toda et al.   XENOBIOTICA

Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function

(2008) Julia B. Ewaschuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The TRANSFAC project as an example of framework technology that supports the analysis of genomic regulation

(2008) E. Wingender   BRIEFINGS IN BIOINFORMATICS

RNA-seq: An assessment of technical reproducibility and comparison with gene expression arrays

(2008) J. C. Marioni et al.   GENOME RESEARCH

Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats

(2008) Mohamed B. Abou-Donia et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

P-glycoprotein: So Many Ways to Turn It On

(2007) Richard Callaghan et al.   JOURNAL OF CLINICAL PHARMACOLOGY