The gut microbiota contributes to the modulation of intestinal CYP3A1 and P-gp in streptozotocin-induced type 1 diabetic rats

The role of the microbiome and psychosocial stress in the expression and activity of drug metabolizing enzymes in mice

(2020) Nina Zemanová et al.   Scientific Reports

Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug Absorption

(2019) Yvonne Arnold et al.   Pharmaceutics

Prediction of Atorvastatin Pharmacokinetics in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats Using a Semiphysiologically Based Pharmacokinetic Model Involving Both Enzymes and Transporters

(2019) Zhongjian Wang et al.   DRUG METABOLISM AND DISPOSITION

Phellinus linteus polysaccharide extract improves insulin resistance by regulating gut microbiota composition

(2019) Yangyang Liu et al.   FASEB JOURNAL

Modulation of expression/function of intestinal P-glycoprotein under disease states

(2019) Teruo Murakami et al.   Expert Opinion on Drug Metabolism & Toxicology

Gut microbiota profiling in Han Chinese with type 1 diabetes

(2018) Yun Huang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Physiological Regulation of Drug Metabolism and Transport: Pregnancy, Microbiome, Inflammation, Infection, and Fasting

(2018) Edward T. Morgan et al.   DRUG METABOLISM AND DISPOSITION

Pumpkin polysaccharide modifies the gut microbiota during alleviation of type 2 diabetes in rats

(2018) Guimei Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Reduction in hepatic secondary bile acids caused by short-term antibiotic-induced dysbiosis decreases mouse serum glucose and triglyceride levels

(2018) Takuya Kuno et al.   Scientific Reports

Gut Microbiota Differs in Composition and Functionality Between Children With Type 1 Diabetes, MODY2, and Healthy Control Subjects: A Case-Control Study

(2018) Isabel Leiva-Gea et al.   DIABETES CARE

Alterations of drug-metabolizing enzymes and transporters under diabetic conditions: what is the potential clinical significance?

(2018) Feng Chen et al.   DRUG METABOLISM REVIEWS

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo

(2017) Ming Li et al.   TOXICOLOGY IN VITRO

Mori Cortex regulates P-glycoprotein in Caco-2 cells and colons from rats with experimental colitis via direct and gut microbiota-mediated mechanisms

(2017) Wanghui Jing et al.   RSC Advances

Oral imazalil exposure induces gut microbiota dysbiosis and colonic inflammation in mice

(2016) Cuiyuan Jin et al.   CHEMOSPHERE

Effect of Intestinal Flora on Protein Expression of Drug-Metabolizing Enzymes and Transporters in the Liver and Kidney of Germ-Free and Antibiotics-Treated Mice

(2016) Takuya Kuno et al.   MOLECULAR PHARMACEUTICS

Streptozotocin-induced type-1-diabetes disease onset in Sprague–Dawley rats is associated with an altered intestinal microbiota composition and decreased diversity

(2015) Elaine Patterson et al.   MICROBIOLOGY-SGM

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

(2015) Troy D. Hubbard et al.   Scientific Reports

Aberrant gut microbiota composition at the onset of type 1 diabetes in young children

(2014) Marcus C. de Goffau et al.   DIABETOLOGIA

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Increased Levels of Fatty Acids Contributed to Induction of Hepatic CYP3A4 Activity Induced by Diabetes — In Vitro Evidence From HepG2 Cell and Fa2N-4 Cell Lines

(2014) Nan Hu et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Comparative pharmacokinetic study of paclitaxel and docetaxel in streptozotocin-induced diabetic rats

(2012) Joo Hyun Lee et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Hepatic expression of cytochrome P450 in type 2 diabetic Goto–Kakizaki rats

(2012) Soo Jin Oh et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Involvement of Ubiquitination in the Decrease of Intestinal P-Glycoprotein in a Streptozotocin-induced Diabetic Mouse Model

(2012) Ayaka Nawa et al.   Drug Metabolism and Pharmacokinetics

The Role of Inter-segmental Differences in P-glycoprotein Expression and Activity along the Rat Small Intestine in Causing the Double-peak Phenomenon of Substrate Plasma Concentration

(2012) Sho Wada et al.   Drug Metabolism and Pharmacokinetics

Tissue-specific alterations in expression and function of P-glycoprotein in streptozotocin-induced diabetic rats

(2011) Lu-lu Zhang et al.   ACTA PHARMACOLOGICA SINICA

Decreased Expression of Intestinal P-glycoprotein Increases the Analgesic Effects of Oral Morphine in a Streptozotocin-induced Diabetic Mouse Model

(2011) Ayaka Nawa et al.   Drug Metabolism and Pharmacokinetics

Colonization-Induced Host-Gut Microbial Metabolic Interaction

(2011) S. P. Claus et al.   mBio

Opposite Effect of Diabetes Mellitus Induced by Streptozotocin on Oral and Intravenous Pharmacokinetics of Verapamil in Rats

(2010) N. Hu et al.   DRUG METABOLISM AND DISPOSITION

Differences in the pharmacokinetics of Cyp3a substrates in TSOD and streptozotocin-induced diabetic mice

(2010) T. Kudo et al.   XENOBIOTICA

Increase in P-glycoprotein accompanied by activation of protein kinase Cα and NF-κB p65 in the livers of rats with streptozotocin-induced diabetes

(2008) Natsumi Kameyama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE