Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations

DNA Damage and Repair in Vascular Disease

(2016) Anna Uryga et al.   Annual Review of Physiology

Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9

(2016) Carole L. Yauk et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Predicting Hepatotoxicity Using ToxCast in Vitro Bioactivity and Chemical Structure

(2015) Jie Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Development of the adverse outcome pathway “alkylation of DNA in male premeiotic germ cells leading to heritable mutations” using the OECD's users' handbook supplement

(2015) Carole L. Yauk et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

DNA damage in non-communicable diseases: A clinical and epidemiological perspective

(2015) Mirta Milic et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure–response relationships and points of departure (PoDs)

(2015) James T. MacGregor et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Approaches for identifying germ cell mutagens: Report of the 2013 IWGT workshop on germ cell assays☆

(2015) Carole L. Yauk et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk

(2015) James T. MacGregor et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Non-coding RNAs: An emerging player in DNA damage response

(2015) Chunzhi Zhang et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

(2015) Grace Patlewicz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The genome-wide effects of ionizing radiation on mutation induction in the mammalian germline

(2015) Adeolu B. Adewoye et al.   Nature Communications

New approaches to advance the use of genetic toxicology analyses for human health risk assessment

(2015) George E. Johnson et al.   Toxicology Research

An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride

(2014) Lynn H. Pottenger et al.   CRITICAL REVIEWS IN TOXICOLOGY

Risk assessment in the 21st century: Roadmap and matrix

(2014) Michelle R. Embry et al.   CRITICAL REVIEWS IN TOXICOLOGY

The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events

(2014) Ted W. Simon et al.   CRITICAL REVIEWS IN TOXICOLOGY

Opportunities to integrate new approaches in genetic toxicology: An ILSI-HESI workshop report

(2014) Errol Zeiger et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment

(2014) G.E. Johnson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Adverse Outcome Pathway (AOP) Development I: Strategies and Principles

(2014) Daniel L. Villeneuve et al.   TOXICOLOGICAL SCIENCES

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability

(2014) Manoranjenni Chetty et al.   Frontiers in Pharmacology

The development of adverse outcome pathways for mutagenic effects for the organization for economic co-operation and development

(2013) Carole L. Yauk et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Prediction of noncovalent Drug/DNA interaction using computational docking models: Studies with over 1350 launched drugs

(2013) Ronald D. Snyder et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis

(2013) M. E. Meek et al.   JOURNAL OF APPLIED TOXICOLOGY

Epigenetic profiles as defined signatures of xenobiotic exposure

(2013) John P. Thomson et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Genome maintenance and transcription integrity in aging and disease

(2013) Stefanie Wolters et al.   Frontiers in Genetics

The role of DNA damage and repair in aging through the prism of Koch-like criteria

(2012) Alexey A. Moskalev et al.   AGEING RESEARCH REVIEWS

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

Quantitative approaches for assessing dose-response relationships in genetic toxicology studies

(2012) B.B. Gollapudi et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

(2012) D. G. MacArthur et al.   SCIENCE

Epigenetics – relevance to drug safety science

(2012) Catherine C. Priestley et al.   Toxicology Research

Assessment of heritable genetic effects using new genetic tools and sentinels in an era of personalized medicine

(2011) Rosalie K. Elespuru   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

USEtox human exposure and toxicity factors for comparative assessment of toxic emissions in life cycle analysis: sensitivity to key chemical properties

(2011) Ralph K. Rosenbaum et al.   INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT

Epigenetic screening in product safety assessment: are we there yet?

(2011) Reza J. Rasoulpour et al.   TOXICOLOGY MECHANISMS AND METHODS

Follow-up actions from positive results of in vitro genetic toxicity testing

(2010) Kerry L. Dearfield et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Epigenetics and chemical safety assessment

(2010) Matthew J. LeBaron et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

What Do We Need to Know prior to Thinking about Incorporating an Epigenetic Evaluation into Safety Assessments?2

(2010) Jay I. Goodman et al.   TOXICOLOGICAL SCIENCES

The Key Events Dose-Response Framework: A Cross-Disciplinary Mode-of-Action Based Approach to Examining Dose-Response and Thresholds

(2009) Elizabeth Julien* et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme

(2009) D. A. Eastmond et al.   MUTAGENESIS

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

(2008) Alan R. Boobis et al.   CRITICAL REVIEWS IN TOXICOLOGY

USEtox—the UNEP-SETAC toxicity model: recommended characterisation factors for human toxicity and freshwater ecotoxicity in life cycle impact assessment

(2008) Ralph K. Rosenbaum et al.   INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT