Interpreting in vitro micronucleus positive results: Simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: Protocol optimization and transferability assessment

(2013) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Validation of high-throughput genotoxicity assay screening using γH2AX in-cell western assay on HepG2 cells

(2013) Laure Khoury et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays

(2013) Grace Ka Yan Chan et al.   PLoS One

A Mode-of-Action Approach for the Identification of Genotoxic Carcinogens

(2013) Lya G. Hernández et al.   PLoS One

Efficient Monitoring of In Vivo Pig-a Gene Mutation and Chromosomal Damage: Summary of 7 Published Studies and Results From 11 New Reference Compounds

(2012) Stephen D. Dertinger et al.   TOXICOLOGICAL SCIENCES

Regulation of brefeldin A-induced ER stress and apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase

(2011) Jung Lee Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes

(2011) Stephen D. Dertinger et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells

(2011) Sabry M. Attia   JOURNAL OF APPLIED TOXICOLOGY

In vitro primary human lymphocyte flow cytometry based micronucleus assay: simultaneous assessment of cell proliferation, apoptosis and MN frequency

(2011) M. Lukamowicz et al.   MUTAGENESIS

Genotoxicity screening via the γH2AX by flow assay

(2011) D.J. Smart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus)

(2011) Sheila Galloway et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future

(2010) S. Avlasevich et al.   MUTAGENESIS

In vitro genotoxicity testing using the micronucleus assay in cell lines, human lymphocytes and 3D human skin models

(2010) M. Kirsch-Volders et al.   MUTAGENESIS

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): Summary of results in the collaborative trial

(2010) David Kirkland   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Comparison of different cytotoxicity measurements for the in vitro micronucleus assay using L5178Y and TK6 cells in support of OECD draft Test Guideline 487

(2010) Elisabeth Lorge   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

5-Fluorouracil, colchicine, benzo[a]pyrene and cytosine arabinoside tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster V79 cells at Covance Laboratories, Harrogate, UK in support of OECD draft Test Guideline 487

(2010) James Whitwell et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose–response relationships

(2010) Steven M. Bryce et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Coupling cytotoxicity biomarkers with DNA damage assessment in TK6 human lymphoblast cells

(2010) Jing Shi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Use of the γH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines

(2010) M. Audebert et al.   TOXICOLOGY LETTERS

Molecular cytogenetic evaluation of the mechanism of micronuclei formation induced by camptothecin, topotecan, and irinotecan

(2009) Sabry M. Attia et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Caffeine Induces Cell Death via Activation of Apoptotic Signal and Inactivation of Survival Signal in Human Osteoblasts

(2008) Pin-Zhen Lu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ECVAM retrospective validation of in vitro micronucleus test (MNT)

(2008) R. Corvi et al.   MUTAGENESIS

Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test

(2008) E. Lorge et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS