Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3

Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium

(2018) Elizabeth O. Harrington et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Glycemic impact of non-nutritive sweeteners: a systematic review and meta-analysis of randomized controlled trials

(2018) Alexander D. Nichol et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Artificial sweetener saccharin disrupts intestinal epithelial cells’ barrier function in vitro

(2018) P. S. Santos et al.   Food & Function

Low-/No-Calorie Sweeteners: A Review of Global Intakes

(2018) Danika Martyn et al.   Nutrients

Epithelial barrier dysfunction in lymphocytic colitis through cytokine-dependent internalization of claudin-5 and -8

(2017) Christian Barmeyer et al.   JOURNAL OF GASTROENTEROLOGY

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching

(2017) Rizwan Ahmad et al.   Scientific Reports

Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling

(2016) Zi-yu Zhou et al.   ACTA PHARMACOLOGICA SINICA

Rapid disruption of intestinal epithelial tight junction and barrier dysfunction by ionizing radiation in mouse colon in vivo: protection by N-acetyl-l-cysteine

(2016) Pradeep K. Shukla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression

(2016) Richard L Wu et al.   LABORATORY INVESTIGATION

Biological fate of low-calorie sweeteners

(2016) Bernadene A. Magnuson et al.   NUTRITION REVIEWS

Reshaping the gut microbiota: Impact of low calorie sweeteners and the link to insulin resistance?

(2016) Jodi E. Nettleton et al.   PHYSIOLOGY & BEHAVIOR

Acute Effects of Sugars and Artificial Sweeteners on Small Intestinal Sugar Transport: A Study Using CaCo-2 Cells As an In Vitro Model of the Human Enterocyte

(2016) Patrick O’Brien et al.   PLoS One

Human Intestinal Barrier Function in Health and Disease

(2016) Julia König et al.   Clinical and Translational Gastroenterology

HNF4α Regulates Claudin-7 Protein Expression during Intestinal Epithelial Differentiation

(2015) Attila E. Farkas et al.   AMERICAN JOURNAL OF PATHOLOGY

Intestinal deletion ofClaudin-7enhances paracellular organic solute flux and initiates colonic inflammation in mice

(2015) Hiroo Tanaka et al.   GUT

Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic  -cells

(2015) K. Hamano et al.   JOURNAL OF ENDOCRINOLOGY

Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88

(2015) Shuhong Guo et al.   JOURNAL OF IMMUNOLOGY

Increased oxidative stress and disrupted small intestinal tight junctions in cigarette smoke-exposed rats

(2015) HONGWEI LI et al.   Molecular Medicine Reports

Claudin-1 enhances tumor proliferation and metastasis by regulating cell anoikis in gastric cancer

(2015) Jie Huang et al.   Oncotarget

Intestinal permeability – a new target for disease prevention and therapy

(2014) Stephan C Bischoff et al.   BMC GASTROENTEROLOGY

Artificial sweeteners induce glucose intolerance by altering the gut microbiota

(2014) Jotham Suez et al.   NATURE

The Intestinal Mucus Layer is a Critical Component of the Gut Barrier that is Damaged During Acute Pancreatitis

(2014) Jordan E. Fishman et al.   SHOCK

MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C

(2013) S C Corr et al.   Mucosal Immunology

Changes of Tight Junction Protein Claudins in Small Intestine and Kidney Tissues of Mice Fed a DDC Diet

(2013) Yukie Abiko et al.   Journal of Toxicologic Pathology

Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion

(2012) Kristian Daly et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Oxidative Stress Contributes to Lung Injury and Barrier Dysfunction via Microtubule Destabilization

(2012) Eric Kratzer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Influence of a high-fat diet on gut microbiota, intestinal permeability and metabolic endotoxaemia

(2012) Ana Paula Boroni Moreira et al.   BRITISH JOURNAL OF NUTRITION

Nonnutritive Sweeteners: Current Use and Health Perspectives: A Scientific Statement from the American Heart Association and the American Diabetes Association

(2012) C. Gardner et al.   DIABETES CARE

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut

(2012) Swaroop Pendyala et al.   GASTROENTEROLOGY

Acute Alcohol-Induced Liver Injury

(2012) Veronica L. Massey et al.   Frontiers in Physiology

Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions

(2011) Suneet Jain et al.   BIOCHEMICAL JOURNAL

Non-nutritive sweeteners, energy balance, and glucose homeostasis

(2011) Marta Y Pepino et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Predicted expansion of the claudin multigene family

(2011) Katsuhiko Mineta et al.   FEBS LETTERS

Alterations of sucrose preference after Roux-en-Y gastric bypass

(2011) M. Bueter et al.   PHYSIOLOGY & BEHAVIOR

Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization

(2010) J. Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress induces gastric epithelial permeability through claudin-3

(2008) Kayo Hashimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Unique Role of Junctional Adhesion Molecule-A in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease

(2008) Stefania Vetrano et al.   GASTROENTEROLOGY

Structure and function of claudins

(2007) Gerd Krause et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Megaintestine in Claudin-15–Deficient Mice

(2007) Atsushi Tamura et al.   GASTROENTEROLOGY