Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells

(2015) Heng-Hong Li et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay

(2015) Jennifer R. Cheung et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Interpreting in vitro micronucleus positive results: Simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

(2014) Steven M. Bryce et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

A comparative study of the aneugenic and polyploidy-inducing effects of fisetin and two model Aurora kinase inhibitors

(2014) P. Gollapudi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis

(2014) Z. D. Nagel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response

(2014) Teodora Nikolova et al.   TOXICOLOGICAL SCIENCES

A combination of in vitro comet assay and micronucleus test using human lymphoblastoid TK6 cells

(2013) A. Kimura et al.   MUTAGENESIS

Assessment of the in vitro γH2AX assay by High Content Screening as a novel genotoxicity test

(2013) Carolina Garcia-Canton et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A Mode-of-Action Approach for the Identification of Genotoxic Carcinogens

(2013) Lya G. Hernández et al.   PLoS One

Efficient Monitoring of In Vivo Pig-a Gene Mutation and Chromosomal Damage: Summary of 7 Published Studies and Results From 11 New Reference Compounds

(2012) Stephen D. Dertinger et al.   TOXICOLOGICAL SCIENCES

Regulation of brefeldin A-induced ER stress and apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase

(2011) Jung Lee Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes

(2011) Stephen D. Dertinger et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells

(2011) Sabry M. Attia   JOURNAL OF APPLIED TOXICOLOGY

Genotoxicity screening via the γH2AX by flow assay

(2011) D.J. Smart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type

(2011) Paul Fowler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals

(2011) Giel Hendriks et al.   TOXICOLOGICAL SCIENCES

Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines

(2010) M. Payton et al.   CANCER RESEARCH

Convenient, multi-well plate-based DNA damage response analysis using DT40 mutants is applicable to a high-throughput genotoxicity assay with characterization of modes of action

(2010) John R. Ridpath et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Single cell trapping and DNA damage analysis using microwell arrays

(2010) D. K. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of the γH2AX assay for assessing the genotoxicity of polycyclic aromatic hydrocarbons in human cell lines

(2010) M. Audebert et al.   TOXICOLOGY LETTERS

Molecular cytogenetic evaluation of the mechanism of micronuclei formation induced by camptothecin, topotecan, and irinotecan

(2009) Sabry M. Attia et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Evaluation of the Vitotox™ and RadarScreen assays for the rapid assessment of genotoxicity in the early research phase of drug development

(2009) Walter M.A. Westerink et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Literature review on the genotoxicity, reproductive toxicity, and carcinogenicity of ethyl methanesulfonate

(2009) Elmar Gocke et al.   TOXICOLOGY LETTERS

Cytotoxic and genotoxic effects of matrices for cartilage tissue engineering

(2009) Amelie S. Lotz et al.   TOXICOLOGY LETTERS

Caffeine Induces Cell Death via Activation of Apoptotic Signal and Inactivation of Survival Signal in Human Osteoblasts

(2008) Pin-Zhen Lu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test

(2008) E. Lorge et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop

(2008) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay

(2007) Steven M. Bryce et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS